LT4042B - A hypotensive composition and a process for the preraration thereof - Google Patents
A hypotensive composition and a process for the preraration thereof Download PDFInfo
- Publication number
- LT4042B LT4042B LT95-084A LT95084A LT4042B LT 4042 B LT4042 B LT 4042B LT 95084 A LT95084 A LT 95084A LT 4042 B LT4042 B LT 4042B
- Authority
- LT
- Lithuania
- Prior art keywords
- weight
- nifedipine
- solution
- ethyl oleate
- percent
- Prior art date
Links
- 230000001077 hypotensive effect Effects 0.000 title claims description 6
- 239000000203 mixture Substances 0.000 title description 19
- 238000000034 method Methods 0.000 title description 6
- 208000001953 Hypotension Diseases 0.000 title 1
- 208000021822 hypotensive Diseases 0.000 title 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims abstract description 46
- 229960001597 nifedipine Drugs 0.000 claims abstract description 45
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims abstract description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 24
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims abstract description 24
- 229940093471 ethyl oleate Drugs 0.000 claims abstract description 24
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 239000007921 spray Substances 0.000 claims description 10
- 239000002202 Polyethylene glycol Substances 0.000 claims description 9
- 239000000654 additive Substances 0.000 claims description 5
- 230000000996 additive effect Effects 0.000 claims description 4
- 239000012456 homogeneous solution Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 abstract description 8
- -1 Poly(ethylene glycol) Polymers 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 26
- 239000008194 pharmaceutical composition Substances 0.000 description 11
- 235000019441 ethanol Nutrition 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000013355 food flavoring agent Nutrition 0.000 description 4
- 210000002200 mouth mucosa Anatomy 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 206010002383 Angina Pectoris Diseases 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 125000004925 dihydropyridyl group Chemical class N1(CC=CC=C1)* 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000004479 aerosol dispenser Substances 0.000 description 1
- OJYGBLRPYBAHRT-IPQSZEQASA-N chloralose Chemical compound O1[C@H](C(Cl)(Cl)Cl)O[C@@H]2[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]21 OJYGBLRPYBAHRT-IPQSZEQASA-N 0.000 description 1
- 229950009941 chloralose Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9402193A HU214582B (hu) | 1994-07-26 | 1994-07-26 | Porlasztható, vérnyomáscsökkentő hatású gyógyszerkészítmény és eljárás előállítására |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LT95084A LT95084A (en) | 1996-06-25 |
| LT4042B true LT4042B (en) | 1996-09-25 |
Family
ID=10985460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LT95-084A LT4042B (en) | 1994-07-26 | 1995-07-20 | A hypotensive composition and a process for the preraration thereof |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPH08169829A (de) |
| AT (1) | AT402690B (de) |
| AU (1) | AU699386B2 (de) |
| BE (1) | BE1011413A4 (de) |
| CZ (1) | CZ286399B6 (de) |
| DE (1) | DE19527140A1 (de) |
| EE (1) | EE9500029A (de) |
| FR (1) | FR2722988B1 (de) |
| GB (1) | GB2291593B (de) |
| HR (1) | HRP950374A2 (de) |
| HU (1) | HU214582B (de) |
| IT (1) | IT1277348B1 (de) |
| LT (1) | LT4042B (de) |
| LV (1) | LV11026B (de) |
| PL (1) | PL181069B1 (de) |
| SK (1) | SK280463B6 (de) |
| UA (1) | UA39880C2 (de) |
| YU (1) | YU50795A (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1036561A1 (de) * | 1997-10-01 | 2000-09-20 | Flemington Pharmaceutical Corporation | Nichtpolare Spray zur bukkalen Anwendung |
| US7632517B2 (en) | 1997-10-01 | 2009-12-15 | Novadel Pharma Inc. | Buccal, polar and non-polar spray containing zolpidem |
| US20030095925A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders |
| JP5577021B2 (ja) | 2005-02-17 | 2014-08-20 | アボット・ラボラトリーズ | 動物における障害を治療および予防するための薬剤組成物の経粘膜投与 |
| DE102006027794A1 (de) * | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Antihypertonie-Kombinationswafer |
| FR2906140B1 (fr) * | 2006-09-22 | 2008-12-05 | Philippe Perovitch | Forme galenique pour l'administration par voie trans-muqueuse de principes actifs |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3307422A1 (de) | 1983-03-03 | 1984-09-06 | Bayer Ag, 5090 Leverkusen | Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen |
| EP0190292A1 (de) | 1984-08-23 | 1986-08-13 | Kuhlemann & Co | Pharmazeutische zubereitung. |
| DE3544692A1 (de) | 1985-12-18 | 1987-06-19 | Bayer Ag | Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2038696T3 (es) * | 1986-03-10 | 1996-07-16 | Burghart Kurt | Procedimiento para producir un preparado farmaceutico. |
| US4863970A (en) * | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
| ATE77559T1 (de) * | 1986-11-14 | 1992-07-15 | Theratech Inc | Erhoehung des penetrationsvermoegens mittels eines aus die zellhuelle veraendernden substanzen und kurzkettigen alkoholen bestehenden binaeren systems. |
| JPS63170316A (ja) * | 1986-12-30 | 1988-07-14 | Fujimoto Seiyaku Kk | ニフエジピン経皮吸収外用製剤 |
| DE3714402A1 (de) * | 1987-04-30 | 1988-11-10 | Kali Chemie Pharma Gmbh | Arzneimittelformulierung |
| GB8828477D0 (en) * | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| AT391269B (de) * | 1988-12-30 | 1990-09-10 | Burghart Kurt | Pharmazeutische zubereitung |
| US5298258A (en) * | 1989-12-28 | 1994-03-29 | Nitto Denko Corporation | Acrylic oily gel bioadhesive material and acrylic oily gel preparation |
| HU205249B (en) * | 1990-11-09 | 1992-04-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing suspensive aerosole composition |
-
1994
- 1994-07-26 HU HU9402193A patent/HU214582B/hu unknown
-
1995
- 1995-06-27 AU AU23269/95A patent/AU699386B2/en not_active Ceased
- 1995-06-30 HR HRP9402193A patent/HRP950374A2/hr not_active Application Discontinuation
- 1995-07-13 CZ CZ19951811A patent/CZ286399B6/cs not_active IP Right Cessation
- 1995-07-17 AT AT0121495A patent/AT402690B/de not_active IP Right Cessation
- 1995-07-17 FR FR9508598A patent/FR2722988B1/fr not_active Expired - Fee Related
- 1995-07-20 LT LT95-084A patent/LT4042B/lt not_active IP Right Cessation
- 1995-07-20 SK SK922-95A patent/SK280463B6/sk unknown
- 1995-07-21 JP JP7185275A patent/JPH08169829A/ja active Pending
- 1995-07-24 PL PL95309757A patent/PL181069B1/pl not_active IP Right Cessation
- 1995-07-24 BE BE9500646A patent/BE1011413A4/fr not_active IP Right Cessation
- 1995-07-25 DE DE19527140A patent/DE19527140A1/de not_active Withdrawn
- 1995-07-25 EE EE9500029A patent/EE9500029A/xx unknown
- 1995-07-25 GB GB9515205A patent/GB2291593B/en not_active Expired - Fee Related
- 1995-07-25 UA UA95073513A patent/UA39880C2/uk unknown
- 1995-07-25 LV LVP-95-225A patent/LV11026B/en unknown
- 1995-07-26 YU YU50795A patent/YU50795A/sh unknown
- 1995-07-26 IT IT95MI001621A patent/IT1277348B1/it active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3307422A1 (de) | 1983-03-03 | 1984-09-06 | Bayer Ag, 5090 Leverkusen | Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen |
| EP0190292A1 (de) | 1984-08-23 | 1986-08-13 | Kuhlemann & Co | Pharmazeutische zubereitung. |
| DE3544692A1 (de) | 1985-12-18 | 1987-06-19 | Bayer Ag | Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung |
Also Published As
| Publication number | Publication date |
|---|---|
| LV11026B (en) | 1996-04-20 |
| AU2326995A (en) | 1996-02-08 |
| IT1277348B1 (it) | 1997-11-10 |
| GB9515205D0 (en) | 1995-09-20 |
| PL309757A1 (en) | 1996-02-05 |
| CZ286399B6 (en) | 2000-04-12 |
| ATA121495A (de) | 1996-12-15 |
| YU50795A (sh) | 1998-05-15 |
| LV11026A (lv) | 1996-02-20 |
| LT95084A (en) | 1996-06-25 |
| ITMI951621A0 (it) | 1995-07-26 |
| PL181069B1 (pl) | 2001-05-31 |
| JPH08169829A (ja) | 1996-07-02 |
| GB2291593B (en) | 1998-03-11 |
| AU699386B2 (en) | 1998-12-03 |
| UA39880C2 (uk) | 2001-07-16 |
| AT402690B (de) | 1997-07-25 |
| GB2291593A (en) | 1996-01-31 |
| EE9500029A (et) | 1996-02-15 |
| HUT75457A (en) | 1997-05-28 |
| BE1011413A4 (fr) | 1999-09-07 |
| ITMI951621A1 (it) | 1997-01-26 |
| CZ181195A3 (en) | 1996-02-14 |
| FR2722988B1 (fr) | 1999-10-08 |
| HRP950374A2 (en) | 1997-10-31 |
| HU9402193D0 (en) | 1994-09-28 |
| SK280463B6 (sk) | 2000-02-14 |
| SK92295A3 (en) | 1996-05-08 |
| HU214582B (hu) | 1998-04-28 |
| FR2722988A1 (fr) | 1996-02-02 |
| DE19527140A1 (de) | 1996-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM9A | Lapsed patents |
Effective date: 19990720 |