LT4020B - Derivatives of human bile-salt stimulated lipase, and pharmaceutical compositions containing them - Google Patents

Derivatives of human bile-salt stimulated lipase, and pharmaceutical compositions containing them Download PDF

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Publication number
LT4020B
LT4020B LTIP1736A LTIP1736A LT4020B LT 4020 B LT4020 B LT 4020B LT IP1736 A LTIP1736 A LT IP1736A LT IP1736 A LTIP1736 A LT IP1736A LT 4020 B LT4020 B LT 4020B
Authority
LT
Lithuania
Prior art keywords
protein
amino acid
tdsl
headings
hernell
Prior art date
Application number
LTIP1736A
Other languages
English (en)
Lithuanian (lt)
Inventor
Gunnar Bjursell
Lars Blaeckberg
Peter Carlsson
Sven Enerbaeck
Olle Hernell
Jeanette Nilsson
Thomas Olivercrona
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of LTIP1736A publication Critical patent/LTIP1736A/xx
Publication of LT4020B publication Critical patent/LT4020B/lt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/596—Mixtures of surface active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LTIP1736A 1990-06-01 1993-12-30 Derivatives of human bile-salt stimulated lipase, and pharmaceutical compositions containing them LT4020B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9001985A SE9001985D0 (sv) 1990-06-01 1990-06-01 New chemical products

Publications (2)

Publication Number Publication Date
LTIP1736A LTIP1736A (en) 1995-08-25
LT4020B true LT4020B (en) 1996-08-26

Family

ID=20379662

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1736A LT4020B (en) 1990-06-01 1993-12-30 Derivatives of human bile-salt stimulated lipase, and pharmaceutical compositions containing them

Country Status (44)

Country Link
EP (1) EP0535048B1 (sh)
JP (1) JPH05507201A (sh)
KR (1) KR100212411B1 (sh)
CN (2) CN1075113C (sh)
AP (1) AP207A (sh)
AT (1) ATE151077T1 (sh)
AU (1) AU651979B2 (sh)
BG (1) BG61165B1 (sh)
CA (1) CA2083396C (sh)
CZ (1) CZ287470B6 (sh)
DE (1) DE69125489T2 (sh)
DK (1) DK0535048T3 (sh)
DZ (1) DZ1503A1 (sh)
EG (1) EG19937A (sh)
ES (1) ES2099159T3 (sh)
FI (1) FI114639B (sh)
GR (1) GR3023618T3 (sh)
HK (1) HK62497A (sh)
HR (1) HRP920771B1 (sh)
HU (1) HU215258B (sh)
IE (1) IE911844A1 (sh)
IL (1) IL98273A (sh)
IS (1) IS1751B (sh)
JO (1) JO1694B1 (sh)
LT (1) LT4020B (sh)
LV (1) LV10292B (sh)
MA (1) MA22166A1 (sh)
MY (1) MY111245A (sh)
NO (1) NO322962B1 (sh)
NZ (1) NZ238223A (sh)
PH (1) PH30761A (sh)
PL (1) PL166534B1 (sh)
PT (1) PT97836B (sh)
RO (1) RO114793B1 (sh)
RU (1) RU2140983C1 (sh)
SE (1) SE9001985D0 (sh)
SG (1) SG48078A1 (sh)
SK (1) SK281089B6 (sh)
TN (1) TNSN91041A1 (sh)
TW (1) TW221712B (sh)
UA (1) UA39165C2 (sh)
WO (1) WO1991018923A1 (sh)
YU (1) YU49138B (sh)
ZA (1) ZA913778B (sh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616483A (en) * 1992-06-11 1997-04-01 Aktiebolaget Astra Genomic DNA sequences encoding human BSSL/CEL
SE9300686D0 (sv) 1993-03-01 1993-03-01 Astra Ab Novel polypeptides
IS4130A (is) * 1993-03-01 1994-09-02 Ab Astra Ný fjölpeptíð
FR2754827B1 (fr) * 1996-10-17 1998-12-24 Biocem Lipases pancreatiques et/ou colipases recombinantes et polypeptides dervies produits par les plantes, leurs procedes d'obtention et leurs utilisations
JP2000026311A (ja) 1998-07-02 2000-01-25 Amano Pharmaceut Co Ltd 胃排出能亢進剤組成物
US20090226904A1 (en) * 2005-12-01 2009-09-10 University Of Bergen Diagnosis and treatment of exocrine pancreatic dysfunction and diabetes
US20130209436A1 (en) * 2010-04-23 2013-08-15 Synageva Biopharma Corp. Lysosomal storage disease enzymes
BR112013005673B1 (pt) 2010-09-09 2020-12-15 Alexion Pharmaceuticals, Inc Uso de lipase ácida lisossomal (lal) humana recombinante no tratamento da deficiência de lipase ácida lisossomal
CA2812852A1 (en) 2010-10-21 2012-04-26 Swedish Orphan Biovitrum Ab (Publ) Method to increase the absorption of unsaturated fatty acids by human infants
ES2603328T3 (es) 2010-10-21 2017-02-27 Swedish Orphan Biovitrum Ab (Publ) Método para incrementar la tasa de crecimiento de lactantes humanos
UY37680A (es) * 2017-06-19 2019-01-31 Swedish Orphan Biovitrum Ab Publ Proteína de fusión con polipéptido de extensión de vida media
JP2022545718A (ja) 2019-08-30 2022-10-28 コデクシス， インコーポレイテッド 操作されたリパーゼ改変体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000381A1 (en) * 1983-07-01 1985-01-31 Celltech Limited Proteins, pharmaceutical compositions, genes, vectors, host organisms and processes for their production

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ABOUAKIL N, ET AL.: "Purification of pancreatic carboxylic-ester hydrolase by immunoaffinity and its application to the human bile-salt-stimulated lipase.", BIOCHIM. BIOPHYS. ACTA, 1988, pages 299 - 388
BLÄCKBERG L, ET AL.: "Bile salt-stimulated lipase in human milk and carboxyl ester hydrolase in pancreatic juice: are they identical enzymes?", FEBS LETTERS, 1981, pages 284 - 288
BLÄCKBERG L, ET AL.: "Bile-salt-stimulated lipase in human milk: evidence for its synthesis in the lactating mammary gland", FEBS LETT., 1987, pages 37 - 41, XP025602095, DOI: doi:10.1016/0014-5793(87)81237-1
BLÄCKBERG, L., HERNELL, O: "Further characterization of the bile salt-stimulated lipase in human milk", FEBS LETTERS, 1983, pages 337 - 341, XP025594547, DOI: doi:10.1016/0014-5793(83)80571-7

Also Published As

Publication number Publication date
YU95191A (sh) 1994-06-10
RU2140983C1 (ru) 1999-11-10
CN1326782A (zh) 2001-12-19
IS1751B (is) 2000-07-21
PT97836A (pt) 1992-02-28
EP0535048B1 (en) 1997-04-02
AU651979B2 (en) 1994-08-11
KR100212411B1 (en) 1999-08-02
CN1075113C (zh) 2001-11-21
EP0535048A1 (en) 1993-04-07
TW221712B (sh) 1994-03-11
NO924528D0 (no) 1992-11-24
ZA913778B (en) 1992-02-26
DE69125489D1 (de) 1997-05-07
SE9001985D0 (sv) 1990-06-01
DK0535048T3 (da) 1997-09-29
SK164491A3 (en) 1995-07-11
IE911844A1 (en) 1991-12-04
HK62497A (en) 1997-05-16
CZ164491A3 (cs) 1999-07-14
LV10292A (lv) 1994-10-20
CA2083396A1 (en) 1991-12-02
LV10292B (en) 1995-08-20
ATE151077T1 (de) 1997-04-15
BG97123A (bg) 1993-12-24
SG48078A1 (en) 1998-04-17
CA2083396C (en) 2006-09-19
AP207A (en) 1992-08-18
HU215258B (hu) 1998-11-30
HRP920771A2 (en) 1997-04-30
ES2099159T3 (es) 1997-05-16
NO322962B1 (no) 2006-12-18
AU7964591A (en) 1991-12-31
MA22166A1 (fr) 1991-12-31
SK281089B6 (sk) 2000-11-07
PH30761A (en) 1997-10-17
BG61165B1 (bg) 1997-01-31
WO1991018923A1 (en) 1991-12-12
HUT63184A (en) 1993-07-28
FI925453A0 (fi) 1992-11-30
PL166534B1 (pl) 1995-05-31
AP9100270A0 (en) 1991-07-31
HRP920771B1 (en) 1999-10-31
PT97836B (pt) 1998-11-30
EG19937A (en) 2000-12-31
LTIP1736A (en) 1995-08-25
NZ238223A (en) 1993-05-26
MY111245A (en) 1999-10-30
IL98273A0 (en) 1992-06-21
NO924528L (no) 1992-11-24
GR3023618T3 (en) 1997-08-29
CZ287470B6 (cs) 2000-12-13
JPH05507201A (ja) 1993-10-21
IS3710A7 (is) 1991-12-02
RO114793B1 (ro) 1999-07-30
HU9203774D0 (en) 1993-03-29
YU49138B (sh) 2004-03-12
UA39165C2 (uk) 2001-06-15
CN1064313A (zh) 1992-09-09
JO1694B1 (en) 1992-08-09
IL98273A (en) 2005-11-20
FI925453A (fi) 1992-11-30
DZ1503A1 (fr) 2004-09-13
FI114639B (fi) 2004-11-30
TNSN91041A1 (fr) 1992-10-25
DE69125489T2 (de) 1997-08-14

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Legal Events

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PC9A Transfer of patents

Owner name: AREXIS AB, SE

Effective date: 20070307

PD9A Change of patent owner

Owner name: ASTRAZENECA AB, SE

Effective date: 20070307

MK9A Expiry of a patent

Effective date: 20131230