LT3977B - Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use - Google Patents

Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use Download PDF

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Publication number
LT3977B
LT3977B LTIP1713A LTIP1713A LT3977B LT 3977 B LT3977 B LT 3977B LT IP1713 A LTIP1713 A LT IP1713A LT IP1713 A LTIP1713 A LT IP1713A LT 3977 B LT3977 B LT 3977B
Authority
LT
Lithuania
Prior art keywords
methyl
compound
benzimidazole
pyridinyl
mmol
Prior art date
Application number
LTIP1713A
Other languages
English (en)
Lithuanian (lt)
Inventor
Arne Elof Braendstroem
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of LTIP1713A publication Critical patent/LTIP1713A/xx
Publication of LT3977B publication Critical patent/LT3977B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
LTIP1713A 1990-06-20 1993-12-30 Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use LT3977B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9002206A SE9002206D0 (sv) 1990-06-20 1990-06-20 New compounds

Publications (2)

Publication Number Publication Date
LTIP1713A LTIP1713A (en) 1995-08-25
LT3977B true LT3977B (en) 1996-06-25

Family

ID=20379831

Family Applications (2)

Application Number Title Priority Date Filing Date
LTIP1713A LT3977B (en) 1990-06-20 1993-12-30 Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use
LTIP1712A LT3952B (en) 1990-06-20 1993-12-30 Substituted benzimidazoles, process for their preparation and their pharmaceutical use

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTIP1712A LT3952B (en) 1990-06-20 1993-12-30 Substituted benzimidazoles, process for their preparation and their pharmaceutical use

Country Status (27)

Country Link
EP (1) EP0535081A1 (cs)
JP (1) JPH05507713A (cs)
CN (1) CN1058212A (cs)
AP (1) AP215A (cs)
AU (1) AU649453B2 (cs)
BG (1) BG97200A (cs)
CA (1) CA2083714A1 (cs)
CZ (1) CZ279772B6 (cs)
FI (1) FI925766A7 (cs)
HU (1) HUT62881A (cs)
IE (1) IE912025A1 (cs)
IL (1) IL98470A0 (cs)
IS (1) IS3721A7 (cs)
LT (2) LT3977B (cs)
LV (1) LV10953A (cs)
MA (1) MA22199A1 (cs)
NO (1) NO924775L (cs)
NZ (1) NZ238546A (cs)
OA (1) OA09682A (cs)
PT (1) PT98035A (cs)
RO (1) RO110493B1 (cs)
SE (1) SE9002206D0 (cs)
TN (1) TNSN91049A1 (cs)
TW (1) TW216418B (cs)
WO (1) WO1991019711A1 (cs)
YU (1) YU104191A (cs)
ZA (2) ZA914296B (cs)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
IS4232A (is) * 1993-12-06 1995-06-07 Astra Aktiebolag Súbstitúerað bensimidasól, aðferðir við framleiðslu þess og lyfjafræðileg notkun
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
PT1257269E (pt) 2000-02-24 2005-03-31 Kopran Res Lab Ltd Derivados do benzimidazole anti-ulcera estavel em relacao ao acido de administracao oral
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
CN100553625C (zh) 2002-04-09 2009-10-28 弗拉梅技术公司 活性成分微囊的口服混悬液
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
US8246986B2 (en) 2003-09-26 2012-08-21 Alza Corporation Drug coating providing high drug loading
TW200606163A (en) 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070015782A1 (en) * 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
WO2007122686A1 (ja) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. ベンズイミダゾール化合物
US9233092B2 (en) 2006-07-25 2016-01-12 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI
JP5492417B2 (ja) * 2006-10-13 2014-05-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 胃酸分泌抑制作用を有するベンズイミダゾール化合物
EP2344139A1 (en) 2008-09-09 2011-07-20 AstraZeneca AB Method for delivering a pharmaceutical composition to patient in need thereof
MX2011013467A (es) 2009-06-25 2012-02-13 Astrazeneca Ab Metodo para tratar un paciente que corre el riesgo de desarollar una ulcera asociada a antiinflamatorio no esteroide (aine).
EP2519229A2 (en) 2009-12-29 2012-11-07 Novartis AG New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
US9539214B2 (en) 2011-12-28 2017-01-10 Pozen Inc. Compositions and methods for delivery of omeprazole plus acetylsalicylic acid
JP7029129B2 (ja) * 2016-09-14 2022-03-03 ユーフェン ジェーン ツェン Ｄ－アミノ酸オキシダーゼ（ｄａａｏ）阻害剤としての新規な置換ベンゾイミダゾール誘導体

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500043A (en) 1974-02-18 1978-02-08 Haessle Ab Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion
GB1525958A (en) 1974-05-16 1978-09-27 Haessle Ab 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
US4182766A (en) 1977-09-19 1980-01-08 Hoffmann-La Roche Inc. Naphth[2,3-d]imidazoles
US4255431A (en) 1978-04-14 1981-03-10 Aktiebolaget Hassle Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
BE898880A (fr) 1983-02-11 1984-08-10 Haessle Ab Nouveaux benzimidazoles, preparations pharmaceutiques qui les contiennent et leur preparation
EP0124495A2 (en) 1983-03-04 1984-11-07 Aktiebolaget Hässle Omeprazole salts
US4599347A (en) 1980-08-21 1986-07-08 Hoffmann-La Roche Inc. Tetrahydro-naphth (2.3-d) imidazole derivatives
EP0208452A2 (en) 1985-07-02 1987-01-14 Takeda Chemical Industries, Ltd. Pyridine derivatives, their production and use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
NZ222495A (en) 1986-11-21 1991-04-26 Haessle Ab Benzimidazole derivatives and pharmaceutical compositions
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
JPH02501930A (ja) * 1987-10-30 1990-06-28 アクチエボラゲツト・ヘツスレ 薬学的化合物のための新規な用途
AU2817989A (en) * 1987-12-11 1989-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel benzimidazole derivatives
EP0415990A1 (de) * 1988-05-25 1991-03-13 Byk Gulden Lomberg Chemische Fabrik GmbH Neue fluoralkoxyverbindungen

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500043A (en) 1974-02-18 1978-02-08 Haessle Ab Benzimidazole derivatives their preparation and their use in affecting gastric acid secretion
GB1525958A (en) 1974-05-16 1978-09-27 Haessle Ab 2-(heterocyclic substituted alkylsulphinyl)-benzimidazoles and their pharmaceutical compositions
US4182766A (en) 1977-09-19 1980-01-08 Hoffmann-La Roche Inc. Naphth[2,3-d]imidazoles
US4255431A (en) 1978-04-14 1981-03-10 Aktiebolaget Hassle Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
US4599347A (en) 1980-08-21 1986-07-08 Hoffmann-La Roche Inc. Tetrahydro-naphth (2.3-d) imidazole derivatives
BE898880A (fr) 1983-02-11 1984-08-10 Haessle Ab Nouveaux benzimidazoles, preparations pharmaceutiques qui les contiennent et leur preparation
EP0124495A2 (en) 1983-03-04 1984-11-07 Aktiebolaget Hässle Omeprazole salts
EP0208452A2 (en) 1985-07-02 1987-01-14 Takeda Chemical Industries, Ltd. Pyridine derivatives, their production and use

Also Published As

Publication number Publication date
IE912025A1 (en) 1992-01-01
TW216418B (cs) 1993-11-21
JPH05507713A (ja) 1993-11-04
LT3952B (en) 1996-05-27
TNSN91049A1 (fr) 1992-10-25
WO1991019711A1 (en) 1991-12-26
HUT62881A (en) 1993-06-28
CA2083714A1 (en) 1991-12-21
FI925766A0 (fi) 1992-12-18
ZA914296B (en) 1992-03-25
HU9204033D0 (en) 1993-03-29
OA09682A (en) 1993-05-15
FI925766A7 (fi) 1992-12-18
AU8009791A (en) 1992-01-07
CZ279772B6 (cs) 1995-06-14
PT98035A (pt) 1992-03-31
IL98470A0 (en) 1992-07-15
LTIP1712A (en) 1995-08-25
SE9002206D0 (sv) 1990-06-20
CN1058212A (zh) 1992-01-29
AU649453B2 (en) 1994-05-26
RO110493B1 (ro) 1996-01-30
MA22199A1 (fr) 1992-04-01
AP215A (en) 1992-09-02
NO924775D0 (no) 1992-12-10
BG97200A (bg) 1993-12-24
LV10953A (lv) 1995-12-20
CS189491A3 (en) 1992-04-15
NO924775L (no) 1992-12-10
AP9100285A0 (en) 1991-07-31
EP0535081A1 (en) 1993-04-07
YU104191A (sh) 1994-01-20
NZ238546A (en) 1994-03-25
IS3721A7 (is) 1991-12-21
LTIP1713A (en) 1995-08-25
ZA914297B (en) 1992-03-25

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Effective date: 19961230