LT3658147T - Derinys, apimantis palbociklibą ir 6-(2,4-dichlorfenil)-5-[4-[(3s)-1-(3-fluorpropil)pirolidin-3-il]oksifenil]- 8,9-dihidro-7h-benzo[7]anulen-2-karboksirūgštį, ir jo panaudojimas vėžio gydymui - Google Patents

Derinys, apimantis palbociklibą ir 6-(2,4-dichlorfenil)-5-[4-[(3s)-1-(3-fluorpropil)pirolidin-3-il]oksifenil]- 8,9-dihidro-7h-benzo[7]anulen-2-karboksirūgštį, ir jo panaudojimas vėžio gydymui

Info

Publication number
LT3658147T
LT3658147T LTEPPCT/EP2018/069901T LT18069901T LT3658147T LT 3658147 T LT3658147 T LT 3658147T LT 18069901 T LT18069901 T LT 18069901T LT 3658147 T LT3658147 T LT 3658147T
Authority
LT
Lithuania
Prior art keywords
annulene
palbociclib
oxyphenyl
fluoropropyl
pyrrolidin
Prior art date
Application number
LTEPPCT/EP2018/069901T
Other languages
English (en)
Inventor
Monsif Bouaboula
Maysoun SHOMALI
Fangxian SUN
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of LT3658147T publication Critical patent/LT3658147T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LTEPPCT/EP2018/069901T 2017-07-24 2018-07-23 Derinys, apimantis palbociklibą ir 6-(2,4-dichlorfenil)-5-[4-[(3s)-1-(3-fluorpropil)pirolidin-3-il]oksifenil]- 8,9-dihidro-7h-benzo[7]anulen-2-karboksirūgštį, ir jo panaudojimas vėžio gydymui LT3658147T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762536121P 2017-07-24 2017-07-24
EP17305998.1A EP3434272A1 (en) 2017-07-25 2017-07-25 Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
PCT/EP2018/069901 WO2019020559A1 (en) 2017-07-24 2018-07-23 COMBINATION COMPRISING PALBOCICLIB AND 6- (2,4-DICHLOROPHENYL) -5- [4 - [(3S) -1- (3-FLUOROPROPYL) PYRROLIDIN-3-YL] OXYPHENYL] -8,9-DIHYDRO ACID -7H-BENZO [7] ANNULENE-2-CARBOXYLIC AND ITS USE FOR THE TREATMENT OF CANCER

Publications (1)

Publication Number Publication Date
LT3658147T true LT3658147T (lt) 2022-01-10

Family

ID=59569252

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/EP2018/069901T LT3658147T (lt) 2017-07-24 2018-07-23 Derinys, apimantis palbociklibą ir 6-(2,4-dichlorfenil)-5-[4-[(3s)-1-(3-fluorpropil)pirolidin-3-il]oksifenil]- 8,9-dihidro-7h-benzo[7]anulen-2-karboksirūgštį, ir jo panaudojimas vėžio gydymui

Country Status (29)

Country Link
US (2) US11260057B2 (lt)
EP (2) EP3434272A1 (lt)
JP (1) JP6741897B1 (lt)
KR (1) KR20200031622A (lt)
CN (1) CN111107851B (lt)
AR (1) AR112284A1 (lt)
AU (1) AU2018308871A1 (lt)
BR (1) BR112020001398A2 (lt)
CA (1) CA3070754A1 (lt)
CO (1) CO2020000240A2 (lt)
DK (1) DK3658147T3 (lt)
ES (1) ES2906279T3 (lt)
HR (1) HRP20212030T1 (lt)
HU (1) HUE057271T2 (lt)
IL (1) IL272166B2 (lt)
LT (1) LT3658147T (lt)
MA (1) MA49673B1 (lt)
MY (1) MY195271A (lt)
PH (1) PH12020500091A1 (lt)
PL (1) PL3658147T3 (lt)
PT (1) PT3658147T (lt)
RS (1) RS62837B1 (lt)
RU (1) RU2764116C2 (lt)
SG (1) SG11202000367RA (lt)
SI (1) SI3658147T1 (lt)
TW (1) TWI768087B (lt)
UY (1) UY37818A (lt)
WO (1) WO2019020559A1 (lt)
ZA (1) ZA202000145B (lt)

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EP3434272A1 (en) * 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
WO2020049150A1 (en) 2018-09-07 2020-03-12 Sanofi Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and preparation process thereof
JP2022531898A (ja) * 2019-05-09 2022-07-12 サノフイ 転移性または進行性乳房がん患者において使用するための６－（２，４－ジクロロフェニル）－５－［４－［（３ｓ）－１－（３－フルオロプロピル）ピロリジン－３－イル］オキシフェニル］－８，９－ジヒドロ－７ｈ－ベンゾ［７］アヌレン－２－カルボン酸
AU2020399168A1 (en) * 2019-12-09 2022-07-28 Sanofi Crystalline form of a 7H-benzo[7]annulene-2-carboxylic acid derivative
TW202146007A (zh) * 2020-02-27 2021-12-16 法商賽諾菲公司 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合
MX2023006020A (es) * 2020-11-23 2023-06-08 Sanofi Sa Combinacion que comprende abemaciclib y acido 6-(2,4-diclorofenil)-5-[4-[(3s)- 1-(3-fluoropropil)pirrolidin-3-il ]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxilico.
TW202302084A (zh) * 2021-03-02 2023-01-16 法商賽諾菲公司 以安森司坦和帕博西尼治療乳癌
TW202304425A (zh) * 2021-04-12 2023-02-01 法商賽諾菲公司 包含瑞博西尼和安森司群（ａｍｃｅｎｅｓｔｒａｎｔ）的組合
KR20230130261A (ko) 2022-03-03 2023-09-12 인하대학교 산학협력단 암의 예방 또는 치료용 조성물

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WO2020049150A1 (en) 2018-09-07 2020-03-12 Sanofi Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and preparation process thereof
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Also Published As

Publication number Publication date
BR112020001398A2 (pt) 2020-07-28
JP6741897B1 (ja) 2020-08-19
MA49673B1 (fr) 2022-02-28
CN111107851B (zh) 2023-05-12
US20220362248A1 (en) 2022-11-17
TW201919612A (zh) 2019-06-01
IL272166B2 (en) 2023-04-01
AR112284A1 (es) 2019-10-09
MA49673A (fr) 2021-03-24
RU2020107416A3 (lt) 2021-08-25
RS62837B1 (sr) 2022-02-28
UY37818A (es) 2020-08-31
RU2764116C2 (ru) 2022-01-13
AU2018308871A1 (en) 2020-02-06
HUE057271T2 (hu) 2022-04-28
CO2020000240A2 (es) 2020-04-24
TWI768087B (zh) 2022-06-21
KR20200031622A (ko) 2020-03-24
PL3658147T3 (pl) 2022-03-07
RU2020107416A (ru) 2021-08-25
EP3658147A1 (en) 2020-06-03
EP3658147B1 (en) 2021-11-10
IL272166B (en) 2022-12-01
EP3434272A1 (en) 2019-01-30
ZA202000145B (en) 2021-07-28
HRP20212030T1 (hr) 2022-04-01
CN111107851A (zh) 2020-05-05
MY195271A (en) 2023-01-11
CA3070754A1 (en) 2019-01-31
US20200171033A1 (en) 2020-06-04
JP2020526572A (ja) 2020-08-31
PT3658147T (pt) 2022-02-02
ES2906279T3 (es) 2022-04-18
DK3658147T3 (da) 2022-01-31
SI3658147T1 (sl) 2022-02-28
SG11202000367RA (en) 2020-02-27
PH12020500091A1 (en) 2020-09-14
WO2019020559A1 (en) 2019-01-31
US11260057B2 (en) 2022-03-01
IL272166A (en) 2020-03-31

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