DK3658147T3 - Kombination, som omfatter palbociclib og 6-(2,4-dichlorphenyl)-5-[4-[(3s)-1-(3-fluorpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulen-2-carboxylsyre, og dens anvendelse til behandling af cancer - Google Patents

Kombination, som omfatter palbociclib og 6-(2,4-dichlorphenyl)-5-[4-[(3s)-1-(3-fluorpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulen-2-carboxylsyre, og dens anvendelse til behandling af cancer Download PDF

Info

Publication number
DK3658147T3
DK3658147T3 DK18740615.2T DK18740615T DK3658147T3 DK 3658147 T3 DK3658147 T3 DK 3658147T3 DK 18740615 T DK18740615 T DK 18740615T DK 3658147 T3 DK3658147 T3 DK 3658147T3
Authority
DK
Denmark
Prior art keywords
annulene
oxyphenyl
fluoropropyl
pyrrolidin
dichlorophenyl
Prior art date
Application number
DK18740615.2T
Other languages
English (en)
Inventor
Monsif Bouaboula
Maysoun Shomali
Fangxian Sun
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of DK3658147T3 publication Critical patent/DK3658147T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
DK18740615.2T 2017-07-24 2018-07-23 Kombination, som omfatter palbociclib og 6-(2,4-dichlorphenyl)-5-[4-[(3s)-1-(3-fluorpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulen-2-carboxylsyre, og dens anvendelse til behandling af cancer DK3658147T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762536121P 2017-07-24 2017-07-24
EP17305998.1A EP3434272A1 (en) 2017-07-25 2017-07-25 Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
PCT/EP2018/069901 WO2019020559A1 (en) 2017-07-24 2018-07-23 COMBINATION COMPRISING PALBOCICLIB AND 6- (2,4-DICHLOROPHENYL) -5- [4 - [(3S) -1- (3-FLUOROPROPYL) PYRROLIDIN-3-YL] OXYPHENYL] -8,9-DIHYDRO ACID -7H-BENZO [7] ANNULENE-2-CARBOXYLIC AND ITS USE FOR THE TREATMENT OF CANCER

Publications (1)

Publication Number Publication Date
DK3658147T3 true DK3658147T3 (da) 2022-01-31

Family

ID=59569252

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18740615.2T DK3658147T3 (da) 2017-07-24 2018-07-23 Kombination, som omfatter palbociclib og 6-(2,4-dichlorphenyl)-5-[4-[(3s)-1-(3-fluorpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulen-2-carboxylsyre, og dens anvendelse til behandling af cancer

Country Status (29)

Country Link
US (2) US11260057B2 (da)
EP (2) EP3434272A1 (da)
JP (1) JP6741897B1 (da)
KR (1) KR20200031622A (da)
CN (1) CN111107851B (da)
AR (1) AR112284A1 (da)
AU (1) AU2018308871A1 (da)
BR (1) BR112020001398A2 (da)
CA (1) CA3070754A1 (da)
CO (1) CO2020000240A2 (da)
DK (1) DK3658147T3 (da)
ES (1) ES2906279T3 (da)
HR (1) HRP20212030T1 (da)
HU (1) HUE057271T2 (da)
IL (1) IL272166B2 (da)
LT (1) LT3658147T (da)
MA (1) MA49673B1 (da)
MY (1) MY195271A (da)
PH (1) PH12020500091A1 (da)
PL (1) PL3658147T3 (da)
PT (1) PT3658147T (da)
RS (1) RS62837B1 (da)
RU (1) RU2764116C2 (da)
SG (1) SG11202000367RA (da)
SI (1) SI3658147T1 (da)
TW (1) TWI768087B (da)
UY (1) UY37818A (da)
WO (1) WO2019020559A1 (da)
ZA (1) ZA202000145B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3434272A1 (en) * 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
HUE059362T2 (hu) 2018-09-07 2022-11-28 Sanofi Sa Metil-6-(2,4-diklórfenil)-5-[4-[(3S)-1-(3-fluorpropil)pirrolidin-3-il]oxifenil]-8,9 -dihidro-7H-benzo[7]annulén-2-karboxilát sói és azok elõállítási eljárásai
MX2021013711A (es) * 2019-05-09 2021-12-10 Sanofi Sa Acido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin -3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxilico para su uso en pacientes con cancer de mama metastasico o avanzado.
JP2023504912A (ja) * 2019-12-09 2023-02-07 サノフイ ７ｈ－ベンゾ［７］アヌレン－２－カルボン酸誘導体の結晶形態
TW202146007A (zh) * 2020-02-27 2021-12-16 法商賽諾菲公司 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合
CA3199466A1 (en) * 2020-11-23 2022-05-27 Monsif Bouaboula Combination comprising abemaciclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
TW202302084A (zh) * 2021-03-02 2023-01-16 法商賽諾菲公司 以安森司坦和帕博西尼治療乳癌
TW202304425A (zh) * 2021-04-12 2023-02-01 法商賽諾菲公司 包含瑞博西尼和安森司群（ａｍｃｅｎｅｓｔｒａｎｔ）的組合
KR20230130261A (ko) 2022-03-03 2023-09-12 인하대학교 산학협력단 암의 예방 또는 치료용 조성물

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06506467A (ja) 1991-03-08 1994-07-21 ローヌ−プーラン　ローラー　インターナショナル（ホウルディングス）　インコーポレイテッド 多環式三級アミンポリ芳香族スクアレンシンセターゼインヒビター
DE19833786A1 (de) 1998-07-18 2000-01-20 Schering Ag Benzocycloheptene, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
ATE286893T1 (de) 2001-01-24 2005-01-15 Chiesi Farma Spa 2h-1-benzopyran-derivative, prozesse zu ihrer herstellung und pharmazeutische zusammensetzungen
EE200400061A (et) 2001-08-11 2004-04-15 Bristol-Myers Squibb Pharma Company Trifenüületüleeni derivaadid kui selektiivsed östrogeeniretseptori modulaatorid ja neid sisaldavad ravimkoostised
SI1501819T1 (sl) 2002-04-24 2011-01-31 Merck Sharp & Dohme Modulatorji estrogen receptorjev
CA2512000C (en) 2002-12-26 2011-08-09 Eisai Co., Ltd. Selective estrogen receptor modulator
AU2005267385B2 (en) 2004-06-25 2011-11-10 Janssen Pharmaceutica N.V. Quaternary salt CCR2 antagonists
EP1896391B1 (en) 2005-06-14 2015-08-12 Baylor University Combretastatin analogs with tubulin binding activity
US8127618B1 (en) 2007-05-18 2012-03-06 Pacesetter, Inc. Implantable micro-electromechanical system sensor
EP2048126A1 (de) 2007-10-11 2009-04-15 Bayer Schering Pharma AG Benzocycloheptanderivate als selektiv wirksame Estrogene
DE102010030538A1 (de) 2010-06-25 2011-12-29 Bayer Schering Pharma Aktiengesellschaft 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
GB2483736B (en) 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
ES2586908T3 (es) 2010-12-24 2016-10-19 Merck Sharp & Dohme B.V. Derivados de azetidina N-sustituidos
DE102011087987A1 (de) 2011-12-08 2013-06-13 Bayer Intellectual Property Gmbh 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
JP2015504049A (ja) 2011-12-30 2015-02-05 センタウルス・バイオファーマ・カンパニー・リミテッドＣｅｎｔａｕｒｕｓ Ｂｉｏｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 新規アリールアルケン誘導体およびその選択的エストロゲン受容体調整剤における使用
CN102584687A (zh) 2011-12-30 2012-07-18 北京赛林泰医药技术有限公司 作为选择性雌激素受体调节剂的乙烯衍生物
LT3033086T (lt) * 2013-08-14 2021-12-27 Novartis Ag Kombinuota terapija vėžiui gydyti
WO2015028409A1 (de) 2013-08-27 2015-03-05 Bayer Pharma Aktiengesellschaft 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
RS60824B1 (sr) 2014-12-18 2020-10-30 Hoffmann La Roche Tetrahidro-pirido[3,4-b]indoli kao modulatori estrogenih receptora i njihova upotreba
US9845291B2 (en) 2014-12-18 2017-12-19 Genentech, Inc. Estrogen receptor modulators and uses thereof
WO2016146591A1 (en) * 2015-03-16 2016-09-22 Astrazeneca Ab Combination treatment
AR104068A1 (es) * 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
CN113288887A (zh) * 2015-04-29 2021-08-24 雷迪厄斯制药公司 用于治疗癌症的方法
CN106924210A (zh) * 2015-12-29 2017-07-07 北京新领先医药科技发展有限公司 一种含有帕布昔利布的胶囊剂及其制备方法
HUE057892T2 (hu) 2016-02-15 2022-06-28 Sanofi Sa Eljárások és közitermékek új, helyettesített 6,7-dihidro-5H-benzo[7]annulén-származékok elõállítására
AU2017362460B2 (en) 2016-11-17 2021-07-22 Sanofi Novel substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
EP3434272A1 (en) * 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
HUE059362T2 (hu) 2018-09-07 2022-11-28 Sanofi Sa Metil-6-(2,4-diklórfenil)-5-[4-[(3S)-1-(3-fluorpropil)pirrolidin-3-il]oxifenil]-8,9 -dihidro-7H-benzo[7]annulén-2-karboxilát sói és azok elõállítási eljárásai
CA3119742A1 (en) * 2018-11-16 2020-05-22 Arqule, Inc. Pharmaceutical combination for treatment of cancer

Also Published As

Publication number Publication date
CA3070754A1 (en) 2019-01-31
EP3658147B1 (en) 2021-11-10
ES2906279T3 (es) 2022-04-18
EP3434272A1 (en) 2019-01-30
SI3658147T1 (sl) 2022-02-28
JP2020526572A (ja) 2020-08-31
WO2019020559A1 (en) 2019-01-31
JP6741897B1 (ja) 2020-08-19
HUE057271T2 (hu) 2022-04-28
KR20200031622A (ko) 2020-03-24
AU2018308871A1 (en) 2020-02-06
RU2020107416A (ru) 2021-08-25
BR112020001398A2 (pt) 2020-07-28
MA49673B1 (fr) 2022-02-28
US20220362248A1 (en) 2022-11-17
HRP20212030T1 (hr) 2022-04-01
SG11202000367RA (en) 2020-02-27
TW201919612A (zh) 2019-06-01
PL3658147T3 (pl) 2022-03-07
US20200171033A1 (en) 2020-06-04
AR112284A1 (es) 2019-10-09
PH12020500091A1 (en) 2020-09-14
PT3658147T (pt) 2022-02-02
IL272166B2 (en) 2023-04-01
EP3658147A1 (en) 2020-06-03
LT3658147T (lt) 2022-01-10
UY37818A (es) 2020-08-31
TWI768087B (zh) 2022-06-21
CN111107851B (zh) 2023-05-12
MY195271A (en) 2023-01-11
RU2764116C2 (ru) 2022-01-13
US11260057B2 (en) 2022-03-01
ZA202000145B (en) 2021-07-28
RU2020107416A3 (da) 2021-08-25
CN111107851A (zh) 2020-05-05
IL272166A (en) 2020-03-31
CO2020000240A2 (es) 2020-04-24
RS62837B1 (sr) 2022-02-28
IL272166B (en) 2022-12-01
MA49673A (fr) 2021-03-24

Similar Documents

Publication Publication Date Title
DK3658147T3 (da) Kombination, som omfatter palbociclib og 6-(2,4-dichlorphenyl)-5-[4-[(3s)-1-(3-fluorpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulen-2-carboxylsyre, og dens anvendelse til behandling af cancer
DK3847157T3 (da) Fremgangsmåde til fremstilling af methyl-[6-(2,4-dichlorphenyl)-5-[4-[(3s)-1-(3-fluorpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulen-2-carboxylat] og salt deraf
MA42599A (fr) Dérivés de triazole, leurs intermédiaires et leur utilisation comme fongicides
DK3154959T3 (da) 1-((3s,4r)-4-(3-fluorphenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urinstof som en trka-kinaseinhibitor
DK3330258T3 (da) 1, 3, 5-triazinderivat og fremgangsmåde til anvendelse af samme
DK2467364T3 (da) Nitrogen-holdige forbindelser og farmaceutiske sammensætninger for behandling af atrial flimren.
ZA201805522B (en) Pyridazinone compound or its salt, and herbicide containing it
DK3653613T5 (da) 1,3-disubstitueret ketenforbindelse og anvendelse deraf
DK3268374T3 (da) Kv1.3-inhibitorer og deres medicinske anvendelse
DK3481819T3 (da) Forbindelser og anvendelse deraf til reducering af urisyreniveauer
DK3288825T3 (da) Teleskopisk adgangsbro, enhed forsynet hermed og tilhørende fremgangsmåde
BR112017017317A2 (pt) Ácido (2s,4r)-5-(5'-cloro-2'-fluorobifenil-4-il)-4- (etoxioxalilamino)-2-hidroximetil-2-metilpentanóico como inibidor de neprilisina
IL287805A (en) 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene -2-carboxylic for use in metastatic or advanced breast cancer patients
IT201700117210A1 (it) Fungicida biologico
WO2018189661A3 (en) Methods and compounds for treating diabetes
IT201600099014A1 (it) Sistema di accesso per chirurgia endoscopica
EP3741105A4 (en) DENTAL IMAGING WITHOUT IONIZING RADIATION THROUGH NEAR-INFRARED FLUORESCENCE AND RELATED SYSTEMS
DK3456712T3 (da) Hidtil ukendte 2,4,6-trisubstitueret S-triazinforbindelse, fremgangsmåde til fremstilling deraf og anvendelse deraf
DK3092223T3 (da) (r)-3-((3s,4s)-3-fluor-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4- methylbenzyl)pyrrolidin-2-on og prodrugs heraf til behandling af psykiatriske forstyrrelser
LT3408260T (lt) Kristalinė (2s,4r)-5-(5'-chlor-2-fluor-[1,1'-bifenil]-4-il)-2-(etoksimetil)-4-(3-hidroksi-izoksazol-5-karboksamido)-2-metilpentanoinė rūgštis ir jos panaudojimai
DK3288949T3 (da) Tetrahydrofuran-fusionerede aminohydrothiazin-derivater, som er anvendelige inden for behandling af Alzheimers sygdom
EP3233824A4 (en) (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations
DK3579874T3 (da) 1-(4-amino-5-brom-6-(1h-pyrazol-1-yl)pyrimidin-2-yl)-1h-pyrazol-4-ol og anvendelse deraf til behandling af cancer
EP3233079A4 (en) (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations
EP3453351A4 (en) POROUS TANTAL METAL SCREW FOR FIXING BROKEN BONES AND ITS APPLICATION