CO2020000240A2 - Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico - Google Patents

Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico

Info

Publication number
CO2020000240A2
CO2020000240A2 CONC2020/0000240A CO2020000240A CO2020000240A2 CO 2020000240 A2 CO2020000240 A2 CO 2020000240A2 CO 2020000240 A CO2020000240 A CO 2020000240A CO 2020000240 A2 CO2020000240 A2 CO 2020000240A2
Authority
CO
Colombia
Prior art keywords
combination
annulene
palbociclib
oxyphenyl
fluoropropyl
Prior art date
Application number
CONC2020/0000240A
Other languages
English (en)
Inventor
Monsif Bouaboula
Maysoun Shomali
Fangxian Sun
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of CO2020000240A2 publication Critical patent/CO2020000240A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proporcionan en la presente memoria una combinación de palbociclib y del ácido 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxílico o una de sus sales farmacéuticamente aceptables, una composición farmacéutica que contiene dicha combinación, y sus usos terapéuticos, en particular para el tratamiento del cáncer, incluyendo el cáncer de mama.
CONC2020/0000240A 2017-07-24 2020-01-13 Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico CO2020000240A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762536121P 2017-07-24 2017-07-24
EP17305998.1A EP3434272A1 (en) 2017-07-25 2017-07-25 Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
PCT/EP2018/069901 WO2019020559A1 (en) 2017-07-24 2018-07-23 COMBINATION COMPRISING PALBOCICLIB AND 6- (2,4-DICHLOROPHENYL) -5- [4 - [(3S) -1- (3-FLUOROPROPYL) PYRROLIDIN-3-YL] OXYPHENYL] -8,9-DIHYDRO ACID -7H-BENZO [7] ANNULENE-2-CARBOXYLIC AND ITS USE FOR THE TREATMENT OF CANCER

Publications (1)

Publication Number Publication Date
CO2020000240A2 true CO2020000240A2 (es) 2020-04-24

Family

ID=59569252

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0000240A CO2020000240A2 (es) 2017-07-24 2020-01-13 Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico

Country Status (29)

Country Link
US (2) US11260057B2 (es)
EP (2) EP3434272A1 (es)
JP (1) JP6741897B1 (es)
KR (1) KR20200031622A (es)
CN (1) CN111107851B (es)
AR (1) AR112284A1 (es)
AU (1) AU2018308871A1 (es)
BR (1) BR112020001398A2 (es)
CA (1) CA3070754A1 (es)
CO (1) CO2020000240A2 (es)
DK (1) DK3658147T3 (es)
ES (1) ES2906279T3 (es)
HR (1) HRP20212030T1 (es)
HU (1) HUE057271T2 (es)
IL (1) IL272166B2 (es)
LT (1) LT3658147T (es)
MA (1) MA49673B1 (es)
MY (1) MY195271A (es)
PH (1) PH12020500091A1 (es)
PL (1) PL3658147T3 (es)
PT (1) PT3658147T (es)
RS (1) RS62837B1 (es)
RU (1) RU2764116C2 (es)
SG (1) SG11202000367RA (es)
SI (1) SI3658147T1 (es)
TW (1) TWI768087B (es)
UY (1) UY37818A (es)
WO (1) WO2019020559A1 (es)
ZA (1) ZA202000145B (es)

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EP3434272A1 (en) * 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
AR116300A1 (es) * 2018-09-07 2021-04-21 Sanofi Sa Proceso para la preparación de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxilato de metilo
JP2022531898A (ja) * 2019-05-09 2022-07-12 サノフイ 転移性または進行性乳房がん患者において使用するための６－（２，４－ジクロロフェニル）－５－［４－［（３ｓ）－１－（３－フルオロプロピル）ピロリジン－３－イル］オキシフェニル］－８，９－ジヒドロ－７ｈ－ベンゾ［７］アヌレン－２－カルボン酸
TW202138346A (zh) * 2019-12-09 2021-10-16 法商賽諾菲公司 ７ｈ－苯並［７］輪烯－２－羧酸衍生物之晶形
TW202146007A (zh) * 2020-02-27 2021-12-16 法商賽諾菲公司 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合
IL303041A (en) * 2020-11-23 2023-07-01 Sanofi Sa Combinations containing abamciclib, and 6-(2,4-DICHLOROPHENYL)-5-[4-[(3S)-1-(3-FLUOROPROPYL)PYRROLIDIN-3-YL]OXYPHENYL]-8,9-DIHYDRO-7H-BENZO [7]ANNULENE-2-CARBOXYLIC ACID
TW202302084A (zh) * 2021-03-02 2023-01-16 法商賽諾菲公司 以安森司坦和帕博西尼治療乳癌
TW202304425A (zh) * 2021-04-12 2023-02-01 法商賽諾菲公司 包含瑞博西尼和安森司群（ａｍｃｅｎｅｓｔｒａｎｔ）的組合
KR20230130261A (ko) 2022-03-03 2023-09-12 인하대학교 산학협력단 암의 예방 또는 치료용 조성물

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AR112284A1 (es) 2019-10-09
RU2020107416A3 (es) 2021-08-25
UY37818A (es) 2020-08-31
BR112020001398A2 (pt) 2020-07-28
TW201919612A (zh) 2019-06-01
DK3658147T3 (da) 2022-01-31
RU2020107416A (ru) 2021-08-25
SI3658147T1 (sl) 2022-02-28
US11260057B2 (en) 2022-03-01
CN111107851A (zh) 2020-05-05
RS62837B1 (sr) 2022-02-28
RU2764116C2 (ru) 2022-01-13
JP6741897B1 (ja) 2020-08-19
JP2020526572A (ja) 2020-08-31
IL272166B (en) 2022-12-01
WO2019020559A1 (en) 2019-01-31
HUE057271T2 (hu) 2022-04-28
MA49673B1 (fr) 2022-02-28
CA3070754A1 (en) 2019-01-31
EP3658147A1 (en) 2020-06-03
US20220362248A1 (en) 2022-11-17
EP3434272A1 (en) 2019-01-30
PT3658147T (pt) 2022-02-02
TWI768087B (zh) 2022-06-21
SG11202000367RA (en) 2020-02-27
KR20200031622A (ko) 2020-03-24
LT3658147T (lt) 2022-01-10
ZA202000145B (en) 2021-07-28
ES2906279T3 (es) 2022-04-18
CN111107851B (zh) 2023-05-12
IL272166B2 (en) 2023-04-01
IL272166A (en) 2020-03-31
HRP20212030T1 (hr) 2022-04-01
MY195271A (en) 2023-01-11
EP3658147B1 (en) 2021-11-10
AU2018308871A1 (en) 2020-02-06
PL3658147T3 (pl) 2022-03-07
MA49673A (fr) 2021-03-24
US20200171033A1 (en) 2020-06-04
PH12020500091A1 (en) 2020-09-14

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