CO2020000240A2 - Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico - Google Patents

Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico

Info

Publication number
CO2020000240A2
CO2020000240A2 CONC2020/0000240A CO2020000240A CO2020000240A2 CO 2020000240 A2 CO2020000240 A2 CO 2020000240A2 CO 2020000240 A CO2020000240 A CO 2020000240A CO 2020000240 A2 CO2020000240 A2 CO 2020000240A2
Authority
CO
Colombia
Prior art keywords
combination
annulene
palbociclib
oxyphenyl
fluoropropyl
Prior art date
Application number
CONC2020/0000240A
Other languages
English (en)
Inventor
Monsif Bouaboula
Maysoun Shomali
Fangxian Sun
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of CO2020000240A2 publication Critical patent/CO2020000240A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proporcionan en la presente memoria una combinación de palbociclib y del ácido 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxílico o una de sus sales farmacéuticamente aceptables, una composición farmacéutica que contiene dicha combinación, y sus usos terapéuticos, en particular para el tratamiento del cáncer, incluyendo el cáncer de mama.
CONC2020/0000240A 2017-07-24 2020-01-13 Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico CO2020000240A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762536121P 2017-07-24 2017-07-24
EP17305998.1A EP3434272A1 (en) 2017-07-25 2017-07-25 Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
PCT/EP2018/069901 WO2019020559A1 (en) 2017-07-24 2018-07-23 COMBINATION COMPRISING PALBOCICLIB AND 6- (2,4-DICHLOROPHENYL) -5- [4 - [(3S) -1- (3-FLUOROPROPYL) PYRROLIDIN-3-YL] OXYPHENYL] -8,9-DIHYDRO ACID -7H-BENZO [7] ANNULENE-2-CARBOXYLIC AND ITS USE FOR THE TREATMENT OF CANCER

Publications (1)

Publication Number Publication Date
CO2020000240A2 true CO2020000240A2 (es) 2020-04-24

Family

ID=59569252

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0000240A CO2020000240A2 (es) 2017-07-24 2020-01-13 Combinación que comprende palbociclib y ácido 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7h-benzo[7]anuleno-2-carboxílico

Country Status (29)

Country Link
US (2) US11260057B2 (es)
EP (2) EP3434272A1 (es)
JP (1) JP6741897B1 (es)
KR (1) KR20200031622A (es)
CN (1) CN111107851B (es)
AR (1) AR112284A1 (es)
AU (1) AU2018308871A1 (es)
BR (1) BR112020001398A2 (es)
CA (1) CA3070754A1 (es)
CO (1) CO2020000240A2 (es)
DK (1) DK3658147T3 (es)
ES (1) ES2906279T3 (es)
HR (1) HRP20212030T1 (es)
HU (1) HUE057271T2 (es)
IL (1) IL272166B2 (es)
LT (1) LT3658147T (es)
MA (1) MA49673B1 (es)
MY (1) MY195271A (es)
PH (1) PH12020500091A1 (es)
PL (1) PL3658147T3 (es)
PT (1) PT3658147T (es)
RS (1) RS62837B1 (es)
RU (1) RU2764116C2 (es)
SG (1) SG11202000367RA (es)
SI (1) SI3658147T1 (es)
TW (1) TWI768087B (es)
UY (1) UY37818A (es)
WO (1) WO2019020559A1 (es)
ZA (1) ZA202000145B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3434272A1 (en) * 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
EP3847156B1 (en) 2018-09-07 2022-05-04 Sanofi Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and preparation process thereof
JP2022531898A (ja) * 2019-05-09 2022-07-12 サノフイ 転移性または進行性乳房がん患者において使用するための６－（２，４－ジクロロフェニル）－５－［４－［（３ｓ）－１－（３－フルオロプロピル）ピロリジン－３－イル］オキシフェニル］－８，９－ジヒドロ－７ｈ－ベンゾ［７］アヌレン－２－カルボン酸
MX2022006990A (es) * 2019-12-09 2022-07-13 Sanofi Sa Forma cristalina de un derivado del acido 7h-benzo[7]anuleno-2-car boxilico.
TW202146007A (zh) * 2020-02-27 2021-12-16 法商賽諾菲公司 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合
JP2023550149A (ja) * 2020-11-23 2023-11-30 サノフイ アベマシクリブと６－（２，４－ジクロロフェニル）－５－［４－［（３ｓ）－１－（３－フルオロプロピル）ピロリジン－３－イル］オキシフェニル］－８，９－ジヒドロ－７ｈ－ベンゾ［７］アヌレン－２－カルボン酸とを含む組み合わせ
TW202302084A (zh) * 2021-03-02 2023-01-16 法商賽諾菲公司 以安森司坦和帕博西尼治療乳癌
TW202304425A (zh) * 2021-04-12 2023-02-01 法商賽諾菲公司 包含瑞博西尼和安森司群（ａｍｃｅｎｅｓｔｒａｎｔ）的組合
KR20230130261A (ko) 2022-03-03 2023-09-12 인하대학교 산학협력단 암의 예방 또는 치료용 조성물

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1752792A (en) 1991-03-08 1992-10-06 Rhone-Poulenc Rorer International (Holdings) Inc. Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
DE19833786A1 (de) 1998-07-18 2000-01-20 Schering Ag Benzocycloheptene, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
DE60108354T2 (de) 2001-01-24 2006-01-05 Chiesi Farmaceutici S.P.A. 2H-1-Benzopyranderivate, Verfahren zu ihrer Herstellung und deren pharmazeutische Zusammensetzungen
AU2002323098A1 (en) 2001-08-11 2003-03-03 Bristol-Myers Squibb Pharma Company Selective estrogen receptor modulators
WO2003091239A1 (en) 2002-04-24 2003-11-06 Merck & Co., Inc. Estrogen receptor modulators
JP4500689B2 (ja) 2002-12-26 2010-07-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 選択的エストロゲン受容体モジュレーター
NZ552173A (en) 2004-06-25 2010-07-30 Janssen Pharmaceutica Nv Quaternary salt CCR2 antagonists
WO2006138427A2 (en) 2005-06-14 2006-12-28 Baylor University Combretastatin analogs with tubulin binding activity
US8127618B1 (en) 2007-05-18 2012-03-06 Pacesetter, Inc. Implantable micro-electromechanical system sensor
EP2048126A1 (de) 2007-10-11 2009-04-15 Bayer Schering Pharma AG Benzocycloheptanderivate als selektiv wirksame Estrogene
DE102010030538A1 (de) 2010-06-25 2011-12-29 Bayer Schering Pharma Aktiengesellschaft 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
GB2483736B (en) 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
AU2011347718B2 (en) 2010-12-24 2016-06-23 Msd Oss B.V. N-substituted azetidine derivatives
DE102011087987A1 (de) 2011-12-08 2013-06-13 Bayer Intellectual Property Gmbh 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
CN102584687A (zh) 2011-12-30 2012-07-18 北京赛林泰医药技术有限公司 作为选择性雌激素受体调节剂的乙烯衍生物
AU2012361344A1 (en) 2011-12-30 2014-07-24 Centaurus Biopharma Co., Ltd. Novel arylalkene derivatives and use thereof as selective estrogen receptor modulators
DK3033086T3 (da) * 2013-08-14 2022-01-03 Novartis Ag Kombinationsterapi til behandling af cancer
WO2015028409A1 (de) 2013-08-27 2015-03-05 Bayer Pharma Aktiengesellschaft 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
WO2016097071A1 (en) 2014-12-18 2016-06-23 F. Hoffmann-La Roche Ag Estrogen receptor modulators and uses thereof
KR102559719B1 (ko) 2014-12-18 2023-07-26 에프. 호프만-라 로슈 아게 테트라하이드로-피리도[3,4-b]인돌 에스트로겐 수용체 조절제 및 이의 용도
WO2016146591A1 (en) * 2015-03-16 2016-09-22 Astrazeneca Ab Combination treatment
AR104068A1 (es) * 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
MX2017013802A (es) 2015-04-29 2018-08-15 Radius Pharmaceuticals Inc Métodos para tratar el cáncer.
CN106924210A (zh) * 2015-12-29 2017-07-07 北京新领先医药科技发展有限公司 一种含有帕布昔利布的胶囊剂及其制备方法
AR107616A1 (es) * 2016-02-15 2018-05-16 Sanofi Sa Compuestos de 6,7-dihidro-5h-benzo[7]anuleno sustituidos, procesos para su preparación y usos terapéuticos de los mismos
MX2019005777A (es) 2016-11-17 2019-08-12 Sanofi Sa Compuestos de n-(3fluoropropil)-pirrolidina sustituidos novedosos, procesos para su preparacion y usos terapeuticos de los mismos.
EP3434272A1 (en) * 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
EP3847156B1 (en) 2018-09-07 2022-05-04 Sanofi Salts of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate and preparation process thereof
EP3880202A2 (en) * 2018-11-16 2021-09-22 ArQule, Inc. Pharmaceutical combination for treatment of cancer

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RU2764116C2 (ru) 2022-01-13
DK3658147T3 (da) 2022-01-31
IL272166B2 (en) 2023-04-01
WO2019020559A1 (en) 2019-01-31
MA49673B1 (fr) 2022-02-28
US11260057B2 (en) 2022-03-01
EP3658147A1 (en) 2020-06-03
UY37818A (es) 2020-08-31
TW201919612A (zh) 2019-06-01
BR112020001398A2 (pt) 2020-07-28
JP2020526572A (ja) 2020-08-31
CA3070754A1 (en) 2019-01-31
RU2020107416A3 (es) 2021-08-25
RS62837B1 (sr) 2022-02-28
HUE057271T2 (hu) 2022-04-28
HRP20212030T1 (hr) 2022-04-01
LT3658147T (lt) 2022-01-10
MY195271A (en) 2023-01-11
IL272166B (en) 2022-12-01
CN111107851A (zh) 2020-05-05
SI3658147T1 (sl) 2022-02-28
ZA202000145B (en) 2021-07-28
US20220362248A1 (en) 2022-11-17
SG11202000367RA (en) 2020-02-27
RU2020107416A (ru) 2021-08-25
AR112284A1 (es) 2019-10-09
PH12020500091A1 (en) 2020-09-14
JP6741897B1 (ja) 2020-08-19
ES2906279T3 (es) 2022-04-18
IL272166A (en) 2020-03-31
EP3658147B1 (en) 2021-11-10
EP3434272A1 (en) 2019-01-30
AU2018308871A1 (en) 2020-02-06
PL3658147T3 (pl) 2022-03-07
US20200171033A1 (en) 2020-06-04
MA49673A (fr) 2021-03-24
CN111107851B (zh) 2023-05-12
TWI768087B (zh) 2022-06-21
PT3658147T (pt) 2022-02-02
KR20200031622A (ko) 2020-03-24

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