KR970705979A - 치료용 매개체로서의 분무-건조 미소입자 (Spray-dried microparticles as therapeutic vehicles) - Google Patents
치료용 매개체로서의 분무-건조 미소입자 (Spray-dried microparticles as therapeutic vehicles) Download PDFInfo
- Publication number
- KR970705979A KR970705979A KR1019970702043A KR19970702043A KR970705979A KR 970705979 A KR970705979 A KR 970705979A KR 1019970702043 A KR1019970702043 A KR 1019970702043A KR 19970702043 A KR19970702043 A KR 19970702043A KR 970705979 A KR970705979 A KR 970705979A
- Authority
- KR
- South Korea
- Prior art keywords
- microparticle
- water
- therapeutic agent
- soluble
- soluble substance
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title claims abstract 22
- 239000003814 drug Substances 0.000 title claims abstract 12
- 229940124597 therapeutic agent Drugs 0.000 title claims abstract 11
- 230000001225 therapeutic effect Effects 0.000 title claims abstract 3
- 239000000126 substance Substances 0.000 claims abstract 7
- 239000002245 particle Substances 0.000 claims abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000000032 diagnostic agent Substances 0.000 claims abstract 3
- 229940039227 diagnostic agent Drugs 0.000 claims abstract 3
- 239000002195 soluble material Substances 0.000 claims abstract 3
- 230000000747 cardiac effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000002198 insoluble material Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Radiology & Medical Imaging (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94307126.6 | 1994-09-20 | ||
| EP94307126 | 1994-09-29 | ||
| PCT/GB1995/002279 WO1996009814A1 (en) | 1994-09-29 | 1995-09-26 | Spray-dried microparticles as therapeutic vehicles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR970705979A true KR970705979A (ko) | 1997-11-03 |
Family
ID=8217866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019970702043A KR970705979A (ko) | 1994-09-29 | 1995-09-26 | 치료용 매개체로서의 분무-건조 미소입자 (Spray-dried microparticles as therapeutic vehicles) |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0783298A1 (no) |
| JP (1) | JPH10506406A (no) |
| KR (1) | KR970705979A (no) |
| AU (1) | AU701440B2 (no) |
| BR (1) | BR9509171A (no) |
| CA (1) | CA2199954A1 (no) |
| CZ (1) | CZ92497A3 (no) |
| FI (1) | FI971332A (no) |
| HU (1) | HUT77373A (no) |
| MX (1) | MX9702357A (no) |
| NO (1) | NO971438D0 (no) |
| NZ (1) | NZ292980A (no) |
| PL (1) | PL319600A1 (no) |
| RU (1) | RU2147226C1 (no) |
| WO (1) | WO1996009814A1 (no) |
| ZA (1) | ZA958239B (no) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| US5955108A (en) * | 1994-12-16 | 1999-09-21 | Quadrant Healthcare (Uk) Limited | Cross-linked microparticles and their use as therapeutic vehicles |
| GB9606188D0 (en) * | 1996-03-23 | 1996-05-29 | Danbiosyst Uk | Pollysaccharide microspheres for the pulmonary delivery of drugs |
| GB9606677D0 (en) * | 1996-03-29 | 1996-06-05 | Glaxo Wellcome Inc | Process and device |
| GB9607035D0 (en) * | 1996-04-03 | 1996-06-05 | Andaris Ltd | Spray-dried microparticles as therapeutic vehicles |
| GB9610341D0 (en) * | 1996-05-17 | 1996-07-24 | Andaris Ltd | Formulation for inhalation |
| AU702955B2 (en) * | 1996-05-17 | 1999-03-11 | Quadrant Healthcare (Uk) Limited | Microparticles and their use in wound therapy |
| US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
| US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| USRE37053E1 (en) | 1996-05-24 | 2001-02-13 | Massachusetts Institute Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5855913A (en) * | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| GB9615435D0 (en) | 1996-07-23 | 1996-09-04 | Andaris Ltd | Spray-dried product and its therapeutic use |
| GB9621825D0 (en) * | 1996-10-19 | 1996-12-11 | Andaris Ltd | Microparticles and their use as therapeutic vehicles |
| JP2002515887A (ja) * | 1996-10-19 | 2002-05-28 | クウォドラント、ヘルスケアー、（ユーケー）、リミテッド | 診断および治療における中空マイクロカプセルの使用 |
| WO1998029141A1 (en) * | 1996-12-31 | 1998-07-09 | Inhale Therapeutic Systems, Inc. | Processes for spray drying solutions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes |
| ATE287257T1 (de) * | 1997-01-16 | 2005-02-15 | Massachusetts Inst Technology | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
| EP1498115A1 (en) * | 1997-01-16 | 2005-01-19 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| SE9700133D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| ATE239447T1 (de) * | 1997-09-29 | 2003-05-15 | Inhale Therapeutic Syst | In verneblern verwendbare, stabilisierte zubereitungen |
| US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| SE9704186D0 (sv) | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
| GB9727102D0 (en) * | 1997-12-22 | 1998-02-25 | Andaris Ltd | Microparticles and their therapeutic use |
| CA2320219A1 (en) * | 1998-02-20 | 1999-08-26 | Quadrant Healthcare (Uk) Limited | Products comprising fibrinogen for use in therapy |
| AU747231B2 (en) * | 1998-06-24 | 2002-05-09 | Alkermes, Inc. | Large porous particles emitted from an inhaler |
| EP1273290A1 (en) * | 1998-06-24 | 2003-01-08 | Advanced Inhalation Research, Inc. | Large porous particles emitted from an inhaler |
| AU772798B2 (en) * | 1999-04-21 | 2004-05-06 | 1355540 Ontario Inc. | Formulations for detecting asthma |
| US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
| JP2003518038A (ja) | 1999-12-20 | 2003-06-03 | ニコラス， ジェイ カークホフ， | 流動床噴霧乾燥によるナノ粒子製造方法 |
| US8771740B2 (en) * | 1999-12-20 | 2014-07-08 | Nicholas J. Kerkhof | Process for producing nanoparticles by spray drying |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| WO2001093837A2 (en) * | 2000-06-08 | 2001-12-13 | Eli Lilly And Company | Protein powder for pulmonary delivery |
| AU2002241723A1 (en) * | 2000-12-21 | 2002-07-24 | Inhale Therapeutic Systems, Inc. | Storage stable powder compositions of interleukin-4 receptor |
| GB0111420D0 (en) * | 2001-05-10 | 2001-07-04 | Biovector Solutions Ltd | Soluble polymer systems for drug delivery |
| US20050233945A1 (en) | 2003-07-18 | 2005-10-20 | Larry Brown | Methods for fabrication, uses and compositions of small spherical particles of insulin prepared by controlled phase separation |
| US8524279B2 (en) | 2001-11-01 | 2013-09-03 | Novartis Ag | Spray drying methods and related compositions |
| TWI324518B (en) | 2001-12-19 | 2010-05-11 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
| US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
| US8110209B2 (en) | 2002-12-20 | 2012-02-07 | Xeris Pharmaceuticals Inc. | Intracutaneous injection |
| AU2004251623B2 (en) | 2003-05-28 | 2010-03-18 | Novartis Ag | Spray drying of an alcoholic aqueous solution for the manufacture of a water-in-soluble active agentmicroparticle with a partial or complete amino acid and/or phospholipid coat |
| DE10339197A1 (de) * | 2003-08-22 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Sprühgetrocknete amorphe Pulver mit geringer Restfeuchte und guter Lagerstabilität |
| US7727962B2 (en) | 2004-05-10 | 2010-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder comprising new compositions of oligosaccharides and methods for their preparation |
| US7723306B2 (en) | 2004-05-10 | 2010-05-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation |
| US7611709B2 (en) | 2004-05-10 | 2009-11-03 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives |
| US8333995B2 (en) | 2004-05-12 | 2012-12-18 | Baxter International, Inc. | Protein microspheres having injectable properties at high concentrations |
| EP2077821B1 (en) | 2006-10-12 | 2019-08-14 | The University Of Queensland | Compositions and methods for modulating immune responses |
| EP2050437A1 (en) * | 2007-10-15 | 2009-04-22 | Laboratoires SMB | Improved pharmaceutical dry powder compositions for inhalation. |
| UA90013C2 (ru) * | 2008-03-19 | 2010-03-25 | Давид Анатолійович Нога | Фармацевтическая композиция, содержащая инсулин, и способ его получения |
| US10004790B2 (en) | 2008-09-29 | 2018-06-26 | The Corporation Of Mercer University | Nanospheres encapsulating bioactive material and method for formulation of nanospheres |
| US10463608B2 (en) | 2008-09-29 | 2019-11-05 | The Corporation Of Mercer University | Microneedle-based transdermal delivery system and method of making same |
| WO2010037142A1 (en) | 2008-09-29 | 2010-04-01 | The Corporation Of Mercer University | Nanospheres encapsulating bioactive material and method for formulation of nanospheres |
| US11524058B2 (en) | 2008-09-29 | 2022-12-13 | The Corporation Of Mercer University | Oral dissolving films containing microencapsulated vaccines and methods of making same |
| US9827205B2 (en) | 2008-12-12 | 2017-11-28 | Mallinckrodt Pharma Ip Trading D.A.C. | Dry powder fibrin sealant |
| EP2216054A1 (en) | 2009-02-06 | 2010-08-11 | ProFibrix BV | Biodegradable extravascular support |
| GB0909136D0 (en) | 2009-05-28 | 2009-07-01 | Profibrix Bv | Dry powder composition |
| ES2593584T3 (es) * | 2009-05-28 | 2016-12-09 | Profibrix Bv | Sellante de fibrina en polvo seco |
| GB0909131D0 (en) | 2009-05-28 | 2009-07-01 | Quadrant Drug Delivery Ltd | Dry powder fibrin sealant |
| WO2011005756A1 (en) | 2009-07-06 | 2011-01-13 | Puretech Ventures, Llc | Delivery of agents targeted to microbiota niches |
| CN102724968A (zh) | 2010-01-08 | 2012-10-10 | 普罗菲布瑞克斯公司 | 干粉血纤蛋白密封剂 |
| WO2012012460A1 (en) | 2010-07-19 | 2012-01-26 | Xeris Pharmaceuticals, Inc. | Stable glucagon formulations for the treatment of hypoglycemia |
| BR112013010926A2 (pt) | 2010-11-01 | 2016-08-23 | Univ Technology Sidney | agentes imunomoduladores e seus usos |
| EP3225235B1 (en) | 2011-03-10 | 2020-12-16 | Xeris Pharmaceuticals, Inc. | Stable peptide formulations for parenteral injection |
| BR112013023062B1 (pt) | 2011-03-10 | 2022-01-18 | Xeris Pharmaceuticals, Inc | Solução estável para a injeção parenteral e método de fabricação da mesma |
| RU2013155713A (ru) | 2011-07-06 | 2015-08-20 | Профибрикс Бв | Составы для лечения ран |
| SG11201401921YA (en) | 2011-10-31 | 2014-05-29 | Xeris Pharmaceuticals Inc | Formulations for the treatment of diabetes |
| CA2869849A1 (en) | 2012-04-13 | 2013-10-17 | Glaxosmithkline Intellectual Property Development Limited | Aggregate particles comprising nanoparticulate drug particles of umeclidinium bromide, vilanterol trifenatate and fluticasone furoate |
| CN104519989B (zh) | 2012-06-26 | 2016-10-26 | 通用电气医疗集团股份有限公司 | 制备包含气体微泡的组合物 |
| US9125805B2 (en) | 2012-06-27 | 2015-09-08 | Xeris Pharmaceuticals, Inc. | Stable formulations for parenteral injection of small molecule drugs |
| CN105163735B (zh) | 2013-02-01 | 2018-12-11 | 格力尔罗格克斯股份有限公司 | 用于治疗神经退行性疾病和其他疾病的组合物和方法 |
| US9956287B2 (en) | 2013-02-06 | 2018-05-01 | Perosphere Inc. | Stable glucagon formulations |
| US9018162B2 (en) | 2013-02-06 | 2015-04-28 | Xeris Pharmaceuticals, Inc. | Methods for rapidly treating severe hypoglycemia |
| CN113768881A (zh) | 2013-10-08 | 2021-12-10 | 人工智能治疗公司 | 用于治疗淋巴管平滑肌瘤病的雷帕霉素 |
| RU2718583C2 (ru) | 2014-04-04 | 2020-04-08 | ЭйАй ТЕРАПЬЮТИКС, ИНК. | Рапамицин-содержащая композиция, вводимая путем ингаляции для лечения возрастных заболеваний |
| EP3149049B1 (en) | 2014-05-27 | 2022-10-26 | The University Of Queensland | Il-22 for use in treating metabolic disorders |
| CN106573106B (zh) | 2014-08-06 | 2021-06-22 | Xeris药物公司 | 用于皮内和/或皮下注射糊剂的注射器、试剂盒和方法 |
| WO2016057712A1 (en) | 2014-10-07 | 2016-04-14 | Lam Therapeutics, Inc. | An inhalable rapamycin formulation for the treatment of pulmonary hypertension |
| WO2016196976A1 (en) | 2015-06-04 | 2016-12-08 | Xeris Pharmaceuticals, Inc. | Glucagon delivery apparatuses and related methods |
| US9649364B2 (en) | 2015-09-25 | 2017-05-16 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic formulations in aprotic polar solvents |
| WO2016201248A1 (en) | 2015-06-10 | 2016-12-15 | Xeris Pharmaceuticals, Inc. | Use of low dose glucagon |
| US11590205B2 (en) | 2015-09-25 | 2023-02-28 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents |
| US11628208B2 (en) | 2015-10-05 | 2023-04-18 | The Corporation Of Mercer University | System and method for microneedle delivery of microencapsulated vaccine and bioactive proteins |
| WO2017062463A1 (en) | 2015-10-05 | 2017-04-13 | The Corporation Of Mercer University | Nanospheres encapsulating bioactive material and method for formulation of nanospheres |
| TW201818933A (zh) | 2016-10-21 | 2018-06-01 | 美商吉利亞洛吉克斯公司 | 用於神經退化性及其他疾病的治療之組成物和方法 |
| KR20240036128A (ko) | 2017-06-02 | 2024-03-19 | 엑스에리스 파머수티클스, 인크. | 침전 방지 저분자 약물 제제 |
| WO2021090214A2 (en) * | 2019-11-04 | 2021-05-14 | Alesco S.R.L. | Sucrosomial® berberine, its compositions and their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU660824B2 (en) * | 1992-06-12 | 1995-07-06 | Teijin Limited | Pharmaceutical preparation for intra-airway administration |
| ES2177544T3 (es) * | 1992-06-12 | 2002-12-16 | Teijin Ltd | Polvo ultrafinno para inhalar y metodo para su preparacion. |
-
1995
- 1995-09-26 WO PCT/GB1995/002279 patent/WO1996009814A1/en not_active Application Discontinuation
- 1995-09-26 KR KR1019970702043A patent/KR970705979A/ko not_active Application Discontinuation
- 1995-09-26 JP JP8511495A patent/JPH10506406A/ja not_active Ceased
- 1995-09-26 NZ NZ292980A patent/NZ292980A/xx not_active IP Right Cessation
- 1995-09-26 RU RU97106769A patent/RU2147226C1/ru not_active IP Right Cessation
- 1995-09-26 EP EP95932122A patent/EP0783298A1/en not_active Ceased
- 1995-09-26 PL PL95319600A patent/PL319600A1/xx unknown
- 1995-09-26 AU AU35302/95A patent/AU701440B2/en not_active Ceased
- 1995-09-26 BR BR9509171A patent/BR9509171A/pt not_active Application Discontinuation
- 1995-09-26 MX MX9702357A patent/MX9702357A/es unknown
- 1995-09-26 CZ CZ97924A patent/CZ92497A3/cs unknown
- 1995-09-26 CA CA002199954A patent/CA2199954A1/en not_active Abandoned
- 1995-09-26 HU HU9702161A patent/HUT77373A/hu unknown
- 1995-09-29 ZA ZA958239A patent/ZA958239B/xx unknown
-
1997
- 1997-03-26 NO NO971438A patent/NO971438D0/no not_active Application Discontinuation
- 1997-04-01 FI FI971332A patent/FI971332A/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU701440B2 (en) | 1999-01-28 |
| NZ292980A (en) | 1999-02-25 |
| NO971438L (no) | 1997-03-26 |
| MX9702357A (es) | 1997-06-28 |
| CA2199954A1 (en) | 1996-04-04 |
| CZ92497A3 (en) | 1997-08-13 |
| RU2147226C1 (ru) | 2000-04-10 |
| ZA958239B (en) | 1996-09-30 |
| AU3530295A (en) | 1996-04-19 |
| NO971438D0 (no) | 1997-03-26 |
| WO1996009814A1 (en) | 1996-04-04 |
| FI971332A0 (fi) | 1997-04-01 |
| FI971332A (fi) | 1997-04-01 |
| JPH10506406A (ja) | 1998-06-23 |
| PL319600A1 (en) | 1997-08-18 |
| HUT77373A (hu) | 1998-03-30 |
| BR9509171A (pt) | 1997-09-16 |
| EP0783298A1 (en) | 1997-07-16 |
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| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |