KR970704674A - 신규한 화합물, 이의 제조방법 및 약제로서의 이의 용도(Novel chemical compound, its preparation and use as a drug) - Google Patents

신규한 화합물, 이의 제조방법 및 약제로서의 이의 용도(Novel chemical compound, its preparation and use as a drug) Download PDF

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KR970704674A
KR970704674A KR1019970700123A KR19970700123A KR970704674A KR 970704674 A KR970704674 A KR 970704674A KR 1019970700123 A KR1019970700123 A KR 1019970700123A KR 19970700123 A KR19970700123 A KR 19970700123A KR 970704674 A KR970704674 A KR 970704674A
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formula
treatment
diseases
compound
compound according
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KR1019970700123A
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랄프 안데르스케비츠
쿠르트 슈롬
에른스트-오토 렌트
프란츠 비르케
아르민 퓌그너
후베르트 호이어
크리스토퍼 메아데
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라우딘 디터, 호프만 루돌프
베링거 인겔하임 카게
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Publication of KR970704674A publication Critical patent/KR970704674A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

화학식(Ⅰ)의 신규한 화합물은 통상적인 방법에 의해 제조되고, LTB4- 수용체 길항제로서 치료학적으로 사용될 수 있다.

Description

신규한 화합물, 이의 제조방법 및 약제로서의 이의 용도 (Novel chemical compound, its preparation and use as a drug)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 화학식(Ⅰ)의 벤즈아미딘 및 이의 토우토머형 및 이의 산부가염.
  2. 약리학적으로 허용되는 생약성 부형제, 희석제 및/또는 담체와 혼합된 제1항에서 정의된 바와 같은 화학식(Ⅰ)의 화합물을 포함하는 약제학적 조성물.
  3. 염증 및/또는 알레르기 반응, 특히 관절염, 천식, 만성 호흡기 폐쇄증, 건선, 궤양성 대장염, 알쯔하이머병, 쇼크, 아테롬성 경화증, 다발성 경화증을 포함하는 질병을 치료하고, 비-스테로이드성 소염제에 의해 유발된 위질환을 치료하고, 전이와 만성 골수백혈병을 치료하기 위한 약제학적 조성물의 제조에 있어서의 제1항에 따르는 화합물의 용도.
  4. LTB4- 수용체 길항 치료법이 필요한 질환을 치료하기 위한 제1항에 따르는 화합물의 유효량의 용도.
  5. 염증 및/또는 알레르기 반응, 특히 관절염, 천식, 만성 호흡기 폐쇄정, 건선, 궤양성 대장염, 알쯔하이머병, 쇼크, 아테롬성 경화증, 다발성 경화증을 포함하는 질환의 치료, 비-스테로이드성 소염제에 의해 유발된 위질환의 치료, 및 전이와 만성 골수백혈병의 치료에 있어서의 제1항에 따르는 화합물의 유효량의 용도.
  6. a) 화학식(Ⅱ)의 아미독심을 촉매적으로 수소화시키거나, b) 화학식(Ⅲ)의 화합물을 화학식(Ⅳ)의 페놀과 화학식(Ⅳ)의 화합물과 반응시키고, 수득된 생성물로부터 상이한 토우토머형을 분리 또는 단리시킬 수 있고, 염기가 수득된 경우 산 부가염을 제조할 수 있고, 산 부가염이 처음에 수득될 경우 유리 염기를 수득할 수 있음을 특징으로 하여, 제1항에 따르는 화합물을 제조하는 방법.
    상기 식에서, Y는 할로겐, 바람직하게는 염소 또는 브롬이거나,-O-SO2-R2(여기서, R2는 알킬, 아릴이다)이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970700123A 1994-07-13 1995-06-03 신규한 화합물, 이의 제조방법 및 약제로서의 이의 용도(Novel chemical compound, its preparation and use as a drug) KR970704674A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4424714A DE4424714A1 (de) 1994-07-13 1994-07-13 Neue chemische Verbindung, ihre Herstellung und ihre Verwendung als Arnzneistoff
DEP4424714.1 1994-07-13
PCT/EP1995/002113 WO1996002496A1 (de) 1994-07-13 1995-06-03 Neue chemische verbindung, ihre herstellung und ihre verwendung als arzneistoff

Publications (1)

Publication Number Publication Date
KR970704674A true KR970704674A (ko) 1997-09-06

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KR1019970700123A KR970704674A (ko) 1994-07-13 1995-06-03 신규한 화합물, 이의 제조방법 및 약제로서의 이의 용도(Novel chemical compound, its preparation and use as a drug)

Country Status (25)

Country Link
US (1) US5686496A (ko)
EP (1) EP0770058A1 (ko)
JP (1) JPH10502646A (ko)
KR (1) KR970704674A (ko)
CN (1) CN1152303A (ko)
AU (1) AU2736895A (ko)
BG (1) BG101104A (ko)
BR (1) BR9508395A (ko)
CA (1) CA2194886A1 (ko)
CO (1) CO4410185A1 (ko)
CZ (1) CZ8297A3 (ko)
DE (1) DE4424714A1 (ko)
EE (1) EE9700065A (ko)
FI (1) FI970095A0 (ko)
HR (1) HRP950363A2 (ko)
HU (1) HUT76827A (ko)
IL (1) IL114572A0 (ko)
MX (1) MX9700245A (ko)
NO (1) NO970123D0 (ko)
PE (1) PE35196A1 (ko)
PL (1) PL318114A1 (ko)
SK (1) SK1897A3 (ko)
WO (1) WO1996002496A1 (ko)
YU (1) YU45395A (ko)
ZA (1) ZA955781B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191169B1 (en) 1992-08-28 2001-02-20 City Of Hope Human leukocyte 12-lipoxygenase and its role in the pathogenesis of disease states
US6486181B1 (en) 1992-08-28 2002-11-26 City Of Hope Human leukocutye 12-lipoxygenase and its role in the pathogenesis of disease states
AU5857296A (en) * 1995-05-17 1996-11-29 Eli Lilly And Company Use of leukotriene antagonists for alzheimer's disease
DE19546452A1 (de) * 1995-12-13 1997-06-19 Boehringer Ingelheim Kg Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel
DE19636689A1 (de) * 1996-09-10 1998-03-12 Boehringer Ingelheim Kg Neue Benzamidinderivate
DE19718334A1 (de) * 1997-04-30 1998-11-05 Boehringer Ingelheim Pharma Neue Benzylaminderivate und Phenylethylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ID24720A (id) 1997-12-12 2000-08-03 Novartis Ag Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis
DE19834713A1 (de) * 1998-07-31 2000-02-03 Boehringer Ingelheim Pharma Neue Phenylethylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6528491B2 (en) * 2000-10-24 2003-03-04 Boehringer Ingelheim Pharma Kg Pyranoside derivatives
EP1353661A2 (en) * 2001-01-16 2003-10-22 Boehringer Ingelheim Pharma GmbH & Co.KG Use of an ltb4 antagonist for the treatment and/or prevention of diseases caused by increased expression of mucin genes
IL160208A0 (en) * 2001-08-31 2004-07-25 Neurochem Int Ltd Amidine derivatives for treating amyloidosis
EP1623231A2 (en) * 2003-05-06 2006-02-08 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor ltb4 (ltb4)
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
US20080200526A1 (en) * 2004-07-05 2008-08-21 Jin Soo Lee Composition for the Prevention and Treatment of Allergic Inflammatory Disease
JP3983272B2 (ja) * 2004-07-14 2007-09-26 有限会社 炎症研究所 腫瘍転移の抑制方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0518818A3 (en) * 1991-06-11 1993-04-28 Ciba-Geigy Ag Arylethers, their manufacture and use as medicament
HU216191B (hu) * 1992-02-05 1999-05-28 Boehringer Ingelheim Kg Eljárás új amidinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására

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Publication number Publication date
SK1897A3 (en) 1997-08-06
ZA955781B (en) 1996-02-22
CN1152303A (zh) 1997-06-18
FI970095A (fi) 1997-01-10
EE9700065A (et) 1997-08-15
EP0770058A1 (de) 1997-05-02
WO1996002496A1 (de) 1996-02-01
FI970095A0 (fi) 1997-01-10
US5686496A (en) 1997-11-11
PL318114A1 (en) 1997-05-12
YU45395A (sh) 1997-12-05
IL114572A0 (en) 1995-11-27
HU9700060D0 (en) 1997-02-28
JPH10502646A (ja) 1998-03-10
BG101104A (en) 1998-04-30
AU2736895A (en) 1996-02-16
DE4424714A1 (de) 1996-01-18
HUT76827A (en) 1997-11-28
CO4410185A1 (es) 1997-01-09
PE35196A1 (es) 1996-09-05
HRP950363A2 (en) 1997-08-31
CZ8297A3 (en) 1997-09-17
BR9508395A (pt) 1997-12-23
NO970123L (no) 1997-01-10
NO970123D0 (no) 1997-01-10
MX9700245A (es) 1997-05-31
CA2194886A1 (en) 1996-02-01

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