CO4410185A1 - Nueva benzamidina, su preparacion y su empleo como medica- mento - Google Patents

Nueva benzamidina, su preparacion y su empleo como medica- mento

Info

Publication number
CO4410185A1
CO4410185A1 CO95030620A CO95030620A CO4410185A1 CO 4410185 A1 CO4410185 A1 CO 4410185A1 CO 95030620 A CO95030620 A CO 95030620A CO 95030620 A CO95030620 A CO 95030620A CO 4410185 A1 CO4410185 A1 CO 4410185A1
Authority
CO
Colombia
Prior art keywords
formula
preparation
employment
medicine
compound
Prior art date
Application number
CO95030620A
Other languages
English (en)
Inventor
Ralf Anderskewitz
Curt Schromm
Ernst Otto Renth
Franz Birke
Armin Fugner
Hubert Heuer
Christopher Meade
Original Assignee
Boehringer Ingelhim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelhim Kg filed Critical Boehringer Ingelhim Kg
Publication of CO4410185A1 publication Critical patent/CO4410185A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. COMO NUEVO COMPUESTO, LA BENZAMIDINA DE LA FOR- MULA FIGURA N.1 COMO BASE LIBRE Y EN FORMA DE SALES POR ADICION DE ACIDOS. 6. PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTO SEGUN LA REIVINDICACION 1, CARACTERIZADO PORQUE A)LA AMIDOXINA DE LA FORMULA FIGURA N.2 SE HIDROGENA CATALITICAMENTE, O PORQUE B)SE HACE REACCIONAR UN COMPUESTO DE LA FORMULA III CON EL FENOL DE LA FORMULA IV FIGURA N.3 O SE HACE REACCIONAR UN FENOL DE LA FORMULA V CON UN COMPUESTO DE LA FORMULA VI FIGURA N.4
CO95030620A 1994-07-13 1995-07-12 Nueva benzamidina, su preparacion y su empleo como medica- mento CO4410185A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4424714A DE4424714A1 (de) 1994-07-13 1994-07-13 Neue chemische Verbindung, ihre Herstellung und ihre Verwendung als Arnzneistoff

Publications (1)

Publication Number Publication Date
CO4410185A1 true CO4410185A1 (es) 1997-01-09

Family

ID=6523048

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95030620A CO4410185A1 (es) 1994-07-13 1995-07-12 Nueva benzamidina, su preparacion y su empleo como medica- mento

Country Status (25)

Country Link
US (1) US5686496A (es)
EP (1) EP0770058A1 (es)
JP (1) JPH10502646A (es)
KR (1) KR970704674A (es)
CN (1) CN1152303A (es)
AU (1) AU2736895A (es)
BG (1) BG101104A (es)
BR (1) BR9508395A (es)
CA (1) CA2194886A1 (es)
CO (1) CO4410185A1 (es)
CZ (1) CZ8297A3 (es)
DE (1) DE4424714A1 (es)
EE (1) EE9700065A (es)
FI (1) FI970095A0 (es)
HR (1) HRP950363A2 (es)
HU (1) HUT76827A (es)
IL (1) IL114572A0 (es)
MX (1) MX9700245A (es)
NO (1) NO970123L (es)
PE (1) PE35196A1 (es)
PL (1) PL318114A1 (es)
SK (1) SK1897A3 (es)
WO (1) WO1996002496A1 (es)
YU (1) YU45395A (es)
ZA (1) ZA955781B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486181B1 (en) 1992-08-28 2002-11-26 City Of Hope Human leukocutye 12-lipoxygenase and its role in the pathogenesis of disease states
US6191169B1 (en) 1992-08-28 2001-02-20 City Of Hope Human leukocyte 12-lipoxygenase and its role in the pathogenesis of disease states
EP0743064A1 (en) * 1995-05-17 1996-11-20 Eli Lilly And Company Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease
DE19546452A1 (de) * 1995-12-13 1997-06-19 Boehringer Ingelheim Kg Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel
DE19636689A1 (de) * 1996-09-10 1998-03-12 Boehringer Ingelheim Kg Neue Benzamidinderivate
DE19718334A1 (de) 1997-04-30 1998-11-05 Boehringer Ingelheim Pharma Neue Benzylaminderivate und Phenylethylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ID24720A (id) 1997-12-12 2000-08-03 Novartis Ag Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis
DE19834713A1 (de) * 1998-07-31 2000-02-03 Boehringer Ingelheim Pharma Neue Phenylethylaminderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6528491B2 (en) * 2000-10-24 2003-03-04 Boehringer Ingelheim Pharma Kg Pyranoside derivatives
JP2004523512A (ja) * 2001-01-16 2004-08-05 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト ムチン遺伝子の増大された発現により生じる疾患の治療及び／又は予防のためのｌｔｂ４アンタゴニストの使用
BR0212078A (pt) * 2001-08-31 2004-09-28 Neurochem Int Ltd Método de tratar ou prevenir uma doença relacionada com amilóide em um paciente, composição farmacêutica, composto quìmico, e, uso de um composto
US20070105104A1 (en) * 2003-05-06 2007-05-10 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor ltb4 (ltb4)
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
US20080200526A1 (en) * 2004-07-05 2008-08-21 Jin Soo Lee Composition for the Prevention and Treatment of Allergic Inflammatory Disease
EP1765333A4 (en) * 2004-07-14 2008-06-18 Inflammation Res Ct Company Lt PROCESS FOR INHIBITING TUMOR METASTASES

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0518818A3 (en) * 1991-06-11 1993-04-28 Ciba-Geigy Ag Arylethers, their manufacture and use as medicament
CZ287209B6 (en) * 1992-02-05 2000-10-11 Boehringer Ingelheim Kg Amidine derivatives, process of their preparation and pharmaceutical preparations containing thereof

Also Published As

Publication number Publication date
HRP950363A2 (en) 1997-08-31
CA2194886A1 (en) 1996-02-01
ZA955781B (en) 1996-02-22
WO1996002496A1 (de) 1996-02-01
HU9700060D0 (en) 1997-02-28
PL318114A1 (en) 1997-05-12
JPH10502646A (ja) 1998-03-10
US5686496A (en) 1997-11-11
SK1897A3 (en) 1997-08-06
PE35196A1 (es) 1996-09-05
YU45395A (sh) 1997-12-05
FI970095A (fi) 1997-01-10
BG101104A (en) 1998-04-30
EE9700065A (et) 1997-08-15
EP0770058A1 (de) 1997-05-02
IL114572A0 (en) 1995-11-27
NO970123D0 (no) 1997-01-10
NO970123L (no) 1997-01-10
MX9700245A (es) 1997-05-31
BR9508395A (pt) 1997-12-23
DE4424714A1 (de) 1996-01-18
CN1152303A (zh) 1997-06-18
KR970704674A (ko) 1997-09-06
CZ8297A3 (en) 1997-09-17
HUT76827A (en) 1997-11-28
FI970095A0 (fi) 1997-01-10
AU2736895A (en) 1996-02-16

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