KR970703367A - 폐 계면활성제 단백질 sp-c의 합성 펩타이드 유사체(synthetic peptide analogs of lung surfactant protein sp-c) - Google Patents
폐 계면활성제 단백질 sp-c의 합성 펩타이드 유사체(synthetic peptide analogs of lung surfactant protein sp-c) Download PDFInfo
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- KR970703367A KR970703367A KR1019960706778A KR19960706778A KR970703367A KR 970703367 A KR970703367 A KR 970703367A KR 1019960706778 A KR1019960706778 A KR 1019960706778A KR 19960706778 A KR19960706778 A KR 19960706778A KR 970703367 A KR970703367 A KR 970703367A
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- lung surfactant
- synthetic peptide
- surfactant protein
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract
본 발명은 폐 활성의 성질을 지닌 하기 서열표 1의 신규한 폴리펩타이드에 관한 것이다. 이 폴리펩타이드는 다량으로 매우 순수한 형태로 제조할 수 있고, 천연의 폐 계면활성제 만큼 효과적이다. 이 폴리펩타이드는 또한 미숙아 및 성인중이 호흡곤란증을 치료하기 위한 약학적 조성물의 생산에 사용할 수 있다. 하기 서열표 1에서 A는 H 또는 Phe이고, B는 Phe 또는 Trp이며, C는 Ile, Leu 또는 Ser이다.
서열표 1
Description
폐 계면활성제 단백질 SP-C의 합성 펩타이드 유사체(SYNTHETIC PEPTIDE ANALOGS OF LUNG SURFACTANT PROTEIN SP-C)
[도면의 간단한 설명]
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 폐 계면활성제 활성을 지닌 하기 서열표 1의 폴리펩타이드:서열표 1상기 식 중에서, A는 H 또는 Phe이고, B는 Phe 또는 Trp이며, C는 Ile, Leu 또는 Ser이다.
- 제1항에 있어서, A가 H 또는 Phe이고, B가 Phe이며, C가 Ile인 폴리펩타이드.
- 제1항에 있어서, A가 Phe이고, B가 Phe이며, C가 Ile인 폴리펩타이드.
- 제1항 내지 제3항 중 어느 한 항의 폐 계면활성제 활성을 지닌 폴리펩타이드를 함유하는, 포유류 중의 호흡곤란증(RDS)을 치료하기 위한 약학적 조성물.
- 제4항에 있어서, SP-A 및 SP-B 중에서 선택되는 폐 계면활성제 활성을 지닌 다른 폴리펩타이드를 하나 이상 함유하는 약학적 조성물.
- 제5항에 있어서, SP-B를 함유하는 약학적 조성물.
- 제4항 또는 제5항에 있어서, 인지질을 함유하는 약학적 조성물.
- 제7항에 있어서, 디팔미토일모스파티딜콜린(DPPC), 팔미토일올레일포스파티딜글리세롤(POPG) 및/또는 포스파티딜글리세롤(PG)을 함유하는 약학적 조성물.
- 제7항에 있어서, 팔미트산 및 전해질을 함유하는 약학적 조성물.
- 제9항에 있어서, 전해질로서 칼슘 및/또는 나트륨염을 함유하는 약학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4418936A DE4418936A1 (de) | 1994-05-31 | 1994-05-31 | Polypeptid |
DEP4418936.2 | 1994-05-31 | ||
PCT/EP1995/002028 WO1995032992A1 (de) | 1994-05-31 | 1995-05-27 | Synthetische peptidanaloge des lungenoberflächenproteins sp-c |
Publications (2)
Publication Number | Publication Date |
---|---|
KR970703367A true KR970703367A (ko) | 1997-07-03 |
KR100355626B1 KR100355626B1 (ko) | 2002-12-26 |
Family
ID=6519392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019960706778A KR100355626B1 (ko) | 1994-05-31 | 1995-05-27 | 폐의계면단백질sp-c의합성펩타이드유사체 |
Country Status (29)
Country | Link |
---|---|
US (1) | US5874406A (ko) |
EP (1) | EP0764172B1 (ko) |
JP (1) | JP3359638B2 (ko) |
KR (1) | KR100355626B1 (ko) |
CN (1) | CN1130374C (ko) |
AT (1) | ATE275154T1 (ko) |
AU (1) | AU690280B2 (ko) |
BG (1) | BG63210B1 (ko) |
BR (1) | BR9507811B1 (ko) |
CA (1) | CA2191344C (ko) |
CY (1) | CY2552B1 (ko) |
CZ (1) | CZ286976B6 (ko) |
DE (2) | DE4418936A1 (ko) |
DK (1) | DK0764172T3 (ko) |
EE (1) | EE03775B1 (ko) |
ES (1) | ES2227548T3 (ko) |
FI (1) | FI118126B (ko) |
HK (1) | HK1000891A1 (ko) |
HU (1) | HU220191B (ko) |
NO (1) | NO317149B1 (ko) |
NZ (1) | NZ287447A (ko) |
PL (1) | PL181234B1 (ko) |
PT (1) | PT764172E (ko) |
RO (1) | RO118752B1 (ko) |
RU (1) | RU2145611C1 (ko) |
SI (1) | SI0764172T1 (ko) |
SK (1) | SK282441B6 (ko) |
UA (1) | UA35636C2 (ko) |
WO (1) | WO1995032992A1 (ko) |
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WO2001039573A2 (de) * | 1999-12-01 | 2001-06-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Verwendung von lungensurfactant zur behandlung von legionärskrankheit |
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-
1994
- 1994-05-31 DE DE4418936A patent/DE4418936A1/de not_active Withdrawn
-
1995
- 1995-05-27 RU RU96124768A patent/RU2145611C1/ru active
- 1995-05-27 US US08/750,194 patent/US5874406A/en not_active Expired - Lifetime
- 1995-05-27 ES ES95920906T patent/ES2227548T3/es not_active Expired - Lifetime
- 1995-05-27 RO RO96-02248A patent/RO118752B1/ro unknown
- 1995-05-27 SK SK1524-96A patent/SK282441B6/sk not_active IP Right Cessation
- 1995-05-27 PT PT95920906T patent/PT764172E/pt unknown
- 1995-05-27 UA UA96114479A patent/UA35636C2/uk unknown
- 1995-05-27 HU HU9603249A patent/HU220191B/hu unknown
- 1995-05-27 KR KR1019960706778A patent/KR100355626B1/ko not_active IP Right Cessation
- 1995-05-27 SI SI9530712T patent/SI0764172T1/xx unknown
- 1995-05-27 PL PL95317420A patent/PL181234B1/pl unknown
- 1995-05-27 CN CN95194374A patent/CN1130374C/zh not_active Expired - Lifetime
- 1995-05-27 JP JP50030596A patent/JP3359638B2/ja not_active Expired - Lifetime
- 1995-05-27 CA CA002191344A patent/CA2191344C/en not_active Expired - Lifetime
- 1995-05-27 EP EP95920906A patent/EP0764172B1/de not_active Expired - Lifetime
- 1995-05-27 DK DK95920906T patent/DK0764172T3/da active
- 1995-05-27 AU AU26169/95A patent/AU690280B2/en not_active Expired
- 1995-05-27 BR BRPI9507811-8A patent/BR9507811B1/pt not_active IP Right Cessation
- 1995-05-27 CZ CZ19963502A patent/CZ286976B6/cs not_active IP Right Cessation
- 1995-05-27 EE EE9600175A patent/EE03775B1/xx unknown
- 1995-05-27 WO PCT/EP1995/002028 patent/WO1995032992A1/de active IP Right Grant
- 1995-05-27 AT AT95920906T patent/ATE275154T1/de active
- 1995-05-27 NZ NZ287447A patent/NZ287447A/en not_active IP Right Cessation
- 1995-05-27 DE DE59510941T patent/DE59510941D1/de not_active Expired - Lifetime
-
1996
- 1996-11-27 NO NO19965052A patent/NO317149B1/no not_active IP Right Cessation
- 1996-11-29 FI FI964766A patent/FI118126B/fi not_active IP Right Cessation
- 1996-12-04 BG BG101028A patent/BG63210B1/bg unknown
-
1997
- 1997-12-18 HK HK97102503A patent/HK1000891A1/xx not_active IP Right Cessation
-
2006
- 2006-02-20 CY CY0600006A patent/CY2552B1/xx unknown
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