RU96124768A - Синтетические пептидные аналоги легочного поверхностного белка sp-c - Google Patents
Синтетические пептидные аналоги легочного поверхностного белка sp-cInfo
- Publication number
- RU96124768A RU96124768A RU96124768/04A RU96124768A RU96124768A RU 96124768 A RU96124768 A RU 96124768A RU 96124768/04 A RU96124768/04 A RU 96124768/04A RU 96124768 A RU96124768 A RU 96124768A RU 96124768 A RU96124768 A RU 96124768A
- Authority
- RU
- Russia
- Prior art keywords
- phe
- pharmaceutical composition
- composition according
- ile
- pulmonary surface
- Prior art date
Links
- 230000002685 pulmonary Effects 0.000 title claims 3
- 101700079760 EFCB Proteins 0.000 title 1
- 101710005090 ERVFC1-1 Proteins 0.000 title 1
- 102100014722 ERVS71-1 Human genes 0.000 title 1
- 101710013371 ERVS71-1 Proteins 0.000 title 1
- 102000007620 Pulmonary Surfactant-Associated Protein C Human genes 0.000 title 1
- 108010007125 Pulmonary Surfactant-Associated Protein C Proteins 0.000 title 1
- 101700016463 pls Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 6
- 125000002068 L-phenylalanino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- ZAKBPRIDLSBYQQ-VHSXEESVSA-N 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CC(=O)OC[C@@H](OC(C)=O)COP(O)(=O)OC[C@@H](O)CO ZAKBPRIDLSBYQQ-VHSXEESVSA-N 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- KILNVBDSWZSGLL-KXQOOQHDSA-N Dipalmitoylphosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N Palmitic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- 239000003792 electrolyte Substances 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 229940067631 Phospholipids Drugs 0.000 claims 1
- 102000007615 Pulmonary Surfactant-Associated Protein A Human genes 0.000 claims 1
- 108010007100 Pulmonary Surfactant-Associated Protein A Proteins 0.000 claims 1
- 159000000007 calcium salts Chemical class 0.000 claims 1
- 239000003580 lung surfactant Substances 0.000 claims 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 230000015227 regulation of liquid surface tension Effects 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
Claims (11)
1. Полипептиды, обладающие активностью легочного поверхностно-активного вещества, общей формулы I
где A обозначает H или Phe;
B обозначает Phe или Tpp;
C обозначает Ile, Leu или Ser.
где A обозначает H или Phe;
B обозначает Phe или Tpp;
C обозначает Ile, Leu или Ser.
2. Полипептид по п. 1, отличающийся тем, что A обозначает H или Phe, B обозначает Phe и C обозначает Ile.
3. Полипептид по п. 1, отличающийся тем, что A обозначает Phe, B обозначает Phe и C обозначает Ile.
4. Полипептид по п. 1, отличающийся тем, что A обозначает H, B обозначает Phe и C обозначает Ile.
5. Фармацевтическая композиция для лечения респираторного дистресс-синдрома (РДС) у млекопитающих, отличающаяся тем, что она содержит легочный поверхностно-активный полипептид по одному из п.п. 1 - 3.
6. Фармацевтическая композиция по п. 5, отличающаяся тем, что она дополнительно содержит по меньшей мере один легочный поверхностно-активный полипептид из группы SP-A и SP-B.
7. Фармацевтическая композиция по п. 6, отличающаяся тем, что она содержит SP-B.
8. Фармацевтическая композиция по п.п. 5 и 6, отличающаяся тем, она содержит фосфолипиды.
9. Фармацевтическая композиция по п. 8, отличающаяся тем, что она содержит дипальмитоилфосфатидилхолин (ДПФХ), пальмитоилолеилфосфатидилглицерин (ПОФГ) и/или фосфатидилглицерин (ФГ).
10. Фармацевтическая композиция по п. 8, отличающаяся тем, что она содержит пальмитиновую кислоту и электролиты.
11. Фармацевтическая композиция по п. 10, отличающаяся тем, что в качестве электролитов она содержит соли кальция и/или натрия.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4418936A DE4418936A1 (de) | 1994-05-31 | 1994-05-31 | Polypeptid |
| DEP4418936.2 | 1994-05-31 | ||
| PCT/EP1995/002028 WO1995032992A1 (de) | 1994-05-31 | 1995-05-27 | Synthetische peptidanaloge des lungenoberflächenproteins sp-c |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU96124768A true RU96124768A (ru) | 1999-03-10 |
| RU2145611C1 RU2145611C1 (ru) | 2000-02-20 |
Family
ID=6519392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU96124768A RU2145611C1 (ru) | 1994-05-31 | 1995-05-27 | Полипептиды, обладающие активностью легочно-поверхностно активного вещества, и фармкомпозиция |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5874406A (ru) |
| EP (1) | EP0764172B1 (ru) |
| JP (1) | JP3359638B2 (ru) |
| KR (1) | KR100355626B1 (ru) |
| CN (1) | CN1130374C (ru) |
| AT (1) | ATE275154T1 (ru) |
| AU (1) | AU690280B2 (ru) |
| BG (1) | BG63210B1 (ru) |
| BR (1) | BR9507811B1 (ru) |
| CA (1) | CA2191344C (ru) |
| CY (1) | CY2552B1 (ru) |
| CZ (1) | CZ286976B6 (ru) |
| DE (2) | DE4418936A1 (ru) |
| DK (1) | DK0764172T3 (ru) |
| EE (1) | EE03775B1 (ru) |
| ES (1) | ES2227548T3 (ru) |
| FI (1) | FI118126B (ru) |
| HK (1) | HK1000891A1 (ru) |
| HU (1) | HU220191B (ru) |
| NO (1) | NO317149B1 (ru) |
| NZ (1) | NZ287447A (ru) |
| PL (1) | PL181234B1 (ru) |
| PT (1) | PT764172E (ru) |
| RO (1) | RO118752B1 (ru) |
| RU (1) | RU2145611C1 (ru) |
| SI (1) | SI0764172T1 (ru) |
| SK (1) | SK282441B6 (ru) |
| UA (1) | UA35636C2 (ru) |
| WO (1) | WO1995032992A1 (ru) |
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|---|---|---|---|---|
| WO1997035882A1 (en) * | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
| DE19851119C2 (de) | 1998-11-06 | 2001-05-31 | Byk Gulden Lomberg Chem Fab | Behälter und Vorrichtung zur Blindung der Verabreichung von nicht festen pharmazeutischen Darreichungsformen bei der klinischen Prüfung |
| IT1308180B1 (it) * | 1999-02-12 | 2001-12-07 | Chiesi Farma Spa | Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante |
| CA2372558A1 (en) * | 1999-06-11 | 2000-12-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c) |
| AU5074400A (en) * | 1999-06-17 | 2001-01-09 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Surfactant protein c esters |
| CA2384861A1 (en) | 1999-09-16 | 2001-03-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Combination of c1-inh and lung surfactant for the treatment of respiratory disorders |
| WO2001039573A2 (de) * | 1999-12-01 | 2001-06-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Verwendung von lungensurfactant zur behandlung von legionärskrankheit |
| US20030091509A1 (en) * | 2000-02-11 | 2003-05-15 | Haefner Dietrich | Novel use of pulmonary surfactant for the prophylaxis and treatment of chronic pulmonary diseases |
| US6660833B1 (en) | 2000-02-29 | 2003-12-09 | Harbor-Ucla Research And Education Institute | Respiratory distress syndrome therapy with peptide analogs of human SP-B |
| CA2405811C (en) * | 2000-04-12 | 2011-09-27 | Altana Pharma Ag | Novel use of pulmonary surfactant for the prophylaxis or early treatment of acute pulmonary diseases |
| DE10018022A1 (de) * | 2000-04-12 | 2001-10-31 | Byk Gulden Lomberg Chem Fab | Neue Verwendung von Lungensurfactant zur Prophylaxe oder Frühbehandlung von akuten Lungenerkrankungen |
| US20040254112A1 (en) * | 2000-04-12 | 2004-12-16 | Dietrich Hafner | Use of pulmonary surfactant for the early treatment of acute pulmonary diseases |
| AU2002338882B2 (en) | 2001-10-11 | 2008-04-03 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Novel use of pulmonary surfactant |
| AU2002357168A1 (en) | 2001-12-12 | 2003-07-09 | Penn State Research Foundation | Surfactant prevention of lung complications from cancer chemotherapy |
| AU2005268755B2 (en) | 2004-08-06 | 2011-04-07 | Takeda Gmbh | Composition comprising a pulmonary surfactant and a TNF-derived peptide |
| US7582312B2 (en) * | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
| US7464012B2 (en) * | 2004-12-10 | 2008-12-09 | L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude | Simplified process simulator |
| US8337815B2 (en) | 2004-12-23 | 2012-12-25 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations |
| AU2006203978B2 (en) | 2005-01-06 | 2011-11-03 | Discovery Laboratories, Inc. | Surfactant treatment regimen for treating or preventing bronchopulmonary dysplasia |
| DE102005014650B3 (de) * | 2005-03-31 | 2006-08-17 | Altana Pharma Ag | Anordnung aus Katheter und Anschlussstück sowie Ventil zum Durchführen eines Katheters |
| DE102005016229B3 (de) | 2005-04-08 | 2006-06-14 | Altana Pharma Ag | Trockenvernebler |
| MX2009003002A (es) * | 2006-09-19 | 2009-06-01 | Discovery Lab Inc | Formulaciones de tensioactivos pulmonares y metodos para promover la aclaracion del moco. |
| US7951781B2 (en) | 2006-11-02 | 2011-05-31 | University Of Iowa Research Foundation | Methods and compositions related to PLUNC surfactant polypeptides |
| EP2009023A1 (en) * | 2007-06-04 | 2008-12-31 | Rentschler Beteiligungs GmbH | Novel peptides and their use for the treatment of edema |
| US8048043B2 (en) | 2007-06-08 | 2011-11-01 | Chiesi Farmaceutici S. P. A. | Method of administration of a pulmonary surfactant |
| AU2009324637B2 (en) | 2008-12-10 | 2016-09-08 | Paka Pulmonary Pharmaceuticals, Inc. | Methods and compositions for delivery of medicaments to the lungs |
| BR112012004651B1 (pt) | 2009-09-08 | 2022-02-08 | Chiesi Farmaceutici S.P.A. | Surfactante pulmonar exógeno, uso de uma combinação terapêutica, medicamento e kit |
| WO2012025496A1 (en) | 2010-08-23 | 2012-03-01 | Nycomed Gmbh | Humidified particles comprising a therapeutically active substance |
| US9815869B2 (en) * | 2012-02-09 | 2017-11-14 | University Of Rochester | SP-B and SP-C peptides, synthetic lung surfactants, and use thereof |
| US20130303726A1 (en) * | 2012-04-17 | 2013-11-14 | Chiesi Farmaceutici S.P.A. | Method for the preparation of surfactant peptides |
| WO2013188016A2 (en) | 2012-05-04 | 2013-12-19 | Discovery Laboratories, Inc. | Surfactant therapy for exposure to ionizing radiation |
| BR112016020393B1 (pt) | 2014-03-05 | 2022-03-29 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Umidificador para umidificar um aerossol |
| EP3106090A1 (en) | 2015-06-15 | 2016-12-21 | CHIESI FARMACEUTICI S.p.A. | System for effective breath-synchronized delivery of medicament to the lungs |
| US20180110948A1 (en) | 2015-04-22 | 2018-04-26 | Chiesi Farmaceutici S.P.A | Method and system for effective breath-synchronized delivery of medicament to the lungs |
| WO2016173634A1 (en) | 2015-04-28 | 2016-11-03 | Chiesi Farmaceutici S.P.A | Device for facilitating the administration of a medicament to the lung by a catheter |
| WO2016174269A1 (en) | 2015-04-30 | 2016-11-03 | University Of Bremen | A novel skin medical and cosmetic care product |
| WO2018019719A1 (en) | 2016-07-28 | 2018-02-01 | Chiesi Farmaceutici S.P.A | Method and system for delivery of an aerosolized medicament |
| WO2018077623A1 (en) | 2016-10-26 | 2018-05-03 | Chiesi Farmaceutici S.P.A. | Device for facilitating the administration of a medicament to the lung by a catheter |
| CN110099695B (zh) | 2016-12-22 | 2022-01-25 | 奇斯药制品公司 | 用于治疗进展性bpd的包含肺表面活性物质和类固醇的治疗组合 |
| CN107163148A (zh) * | 2017-05-15 | 2017-09-15 | 重庆理工大学 | 肺表面活性蛋白b前肽的重组蛋白及其制备方法和应用 |
| TW201927286A (zh) | 2017-12-15 | 2019-07-16 | 義大利商凱西製藥公司 | 用於噴霧投藥之包含肺表面張力素的藥學調配物 |
| WO2019115771A1 (en) | 2017-12-15 | 2019-06-20 | Pari Pharma Gmbh | Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method |
| MX2020011127A (es) | 2018-04-23 | 2021-01-15 | Chiesi Farm Spa | Combinacion terapeutica que comprende agente tensioactivo pulmonar y esteroide para la profilaxis de displasia broncopulmonar (bpd). |
| CN109001466A (zh) * | 2018-07-19 | 2018-12-14 | 新疆维吾尔自治区人民医院 | 一种用于osa的肺表面活性蛋白试剂盒及其应用 |
| EP3666316A1 (en) | 2018-12-14 | 2020-06-17 | PARI Pharma GmbH | Aerosol delivery device and method of operating the aerosol delivery device |
| EP3666315A1 (en) | 2018-12-14 | 2020-06-17 | PARI Pharma GmbH | Aerosol delivery device and method of operating the aerosol delivery device |
| EP3843105A1 (en) | 2019-12-23 | 2021-06-30 | PARI Pharma GmbH | Control device for aerosol nebulizer system |
| WO2021151853A1 (en) | 2020-01-28 | 2021-08-05 | Chiesi Farmaceutici S.P.A. | Polypeptides having improved properties |
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| JPS59164724A (ja) * | 1983-03-10 | 1984-09-17 | Tokyo Tanabe Co Ltd | サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤 |
| US4933280A (en) * | 1984-12-11 | 1990-06-12 | California Biotechnology Inc. | Recombinant DNA sequence encoding Alveolar Surfactant Protein |
| US4659805A (en) * | 1984-12-11 | 1987-04-21 | California Biotechnology, Inc. | Recombinant alveolar surfactant protein |
| US5169761A (en) * | 1984-12-11 | 1992-12-08 | California Biotechnology Inc. | Dna encoding and expression systems for alveolar surfactant proteins |
| US5104853A (en) * | 1984-12-11 | 1992-04-14 | California Biotechnology Inc. | Alveolar surfactant proteins having cys to ser mutations |
| US5013720A (en) * | 1986-05-06 | 1991-05-07 | Abbott Laboratories | SAP-6-Val proteins and methods |
| EP0383837B1 (en) * | 1987-11-04 | 1998-02-04 | Byk Gulden Lomberg Chemische Fabrik GmbH | Alveolar surfactant proteins |
| SE8803713D0 (sv) * | 1988-10-18 | 1988-10-18 | Kabigen Ab | Biologically active lipoprotein and its use |
| DE3921954A1 (de) * | 1989-07-04 | 1991-01-17 | Thomae Gmbh Dr K | Niedrig-viskose, hochkonzentrierte surfactant-suspension |
| JPH05294996A (ja) * | 1992-04-17 | 1993-11-09 | Tokyo Tanabe Co Ltd | 合成ペプチド、それを含有する肺サーファクタント及び呼吸窮迫症候群治療剤 |
-
1994
- 1994-05-31 DE DE4418936A patent/DE4418936A1/de not_active Withdrawn
-
1995
- 1995-05-27 SK SK1524-96A patent/SK282441B6/sk not_active IP Right Cessation
- 1995-05-27 RO RO96-02248A patent/RO118752B1/ro unknown
- 1995-05-27 DK DK95920906T patent/DK0764172T3/da active
- 1995-05-27 EP EP95920906A patent/EP0764172B1/de not_active Expired - Lifetime
- 1995-05-27 KR KR1019960706778A patent/KR100355626B1/ko not_active IP Right Cessation
- 1995-05-27 RU RU96124768A patent/RU2145611C1/ru active
- 1995-05-27 NZ NZ287447A patent/NZ287447A/en not_active IP Right Cessation
- 1995-05-27 CA CA002191344A patent/CA2191344C/en not_active Expired - Lifetime
- 1995-05-27 EE EE9600175A patent/EE03775B1/xx unknown
- 1995-05-27 UA UA96114479A patent/UA35636C2/ru unknown
- 1995-05-27 SI SI9530712T patent/SI0764172T1/xx unknown
- 1995-05-27 AU AU26169/95A patent/AU690280B2/en not_active Expired
- 1995-05-27 JP JP50030596A patent/JP3359638B2/ja not_active Expired - Lifetime
- 1995-05-27 CZ CZ19963502A patent/CZ286976B6/cs not_active IP Right Cessation
- 1995-05-27 HU HU9603249A patent/HU220191B/hu unknown
- 1995-05-27 CN CN95194374A patent/CN1130374C/zh not_active Expired - Lifetime
- 1995-05-27 PL PL95317420A patent/PL181234B1/pl unknown
- 1995-05-27 DE DE59510941T patent/DE59510941D1/de not_active Expired - Lifetime
- 1995-05-27 PT PT95920906T patent/PT764172E/pt unknown
- 1995-05-27 WO PCT/EP1995/002028 patent/WO1995032992A1/de active IP Right Grant
- 1995-05-27 BR BRPI9507811-8A patent/BR9507811B1/pt not_active IP Right Cessation
- 1995-05-27 ES ES95920906T patent/ES2227548T3/es not_active Expired - Lifetime
- 1995-05-27 AT AT95920906T patent/ATE275154T1/de active
- 1995-05-27 US US08/750,194 patent/US5874406A/en not_active Expired - Lifetime
-
1996
- 1996-11-27 NO NO19965052A patent/NO317149B1/no not_active IP Right Cessation
- 1996-11-29 FI FI964766A patent/FI118126B/fi not_active IP Right Cessation
- 1996-12-04 BG BG101028A patent/BG63210B1/bg unknown
-
1997
- 1997-12-18 HK HK97102503A patent/HK1000891A1/xx not_active IP Right Cessation
-
2006
- 2006-02-20 CY CY0600006A patent/CY2552B1/xx unknown
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