RU97106790A - Композиции для лечения респираторного дистресс-синдрома новорожденных и респираторного дистресс-синдрома взрослых, содержащие по крайней мере один глюкокортикостероид в сочетании с легочным поверхностно-активным веществом - Google Patents
Композиции для лечения респираторного дистресс-синдрома новорожденных и респираторного дистресс-синдрома взрослых, содержащие по крайней мере один глюкокортикостероид в сочетании с легочным поверхностно-активным веществомInfo
- Publication number
- RU97106790A RU97106790A RU97106790/14A RU97106790A RU97106790A RU 97106790 A RU97106790 A RU 97106790A RU 97106790/14 A RU97106790/14 A RU 97106790/14A RU 97106790 A RU97106790 A RU 97106790A RU 97106790 A RU97106790 A RU 97106790A
- Authority
- RU
- Russia
- Prior art keywords
- respiratory distress
- distress syndrome
- composition according
- contain
- newborns
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 9
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 title claims 3
- 239000003580 lung surfactant Substances 0.000 claims 5
- 229940067631 Phospholipids Drugs 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- UREBDLICKHMUKA-DVTGEIKXSA-N Betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims 1
- 229960004436 Budesonide Drugs 0.000 claims 1
- VOVIALXJUBGFJZ-VXKMTNQYSA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3O[C@@H](CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-VXKMTNQYSA-N 0.000 claims 1
- 229960003957 Dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N Dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- VHRSUDSXCMQTMA-PJHHCJLFSA-N Methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 claims 1
- 102000007620 Pulmonary Surfactant-Associated Protein C Human genes 0.000 claims 1
- 108010007125 Pulmonary Surfactant-Associated Protein C Proteins 0.000 claims 1
- 229960002537 betamethasone Drugs 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 229960004584 methylprednisolone Drugs 0.000 claims 1
- 201000002652 newborn respiratory distress syndrome Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Claims (7)
1. Композиции для лечения респираторного дистресс-синдрома новорожденных и респираторного дистресс-синдрома взрослых, содержащие по меньшей мере один глюкокортикостероид и одно легочное ПАВ.
2. Композиции по п. 1, отличающиеся тем, что в качестве глюкокортикостероидов они содержат бетаметазон, будесонид, метилпреднизолон, дексаметазон и/или циклесонид.
3. Композиции по п. 1, отличающиеся тем, что в качестве легочного ПАВ они содержат смеси фосфолипидов.
4. Композиции по п. 3, отличающиеся тем, что они содержат фосфолипиды, встречающиеся в природных легочных ПАВ.
5. Композиции по п. 3, отличающиеся тем, что они дополнительно содержат белки легочных ПАВ.
6. Композиции по п. 5, отличающиеся тем, что они содержат белки SP-B и/или SP-C и/или их модифицированные производные.
7. Композиции по п. 4, отличающиеся тем, что они содержат легочные ПАВ, полученные путем лаважа легких.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4434629A DE4434629C1 (de) | 1994-09-28 | 1994-09-28 | Zusammensetzungen zur Behandlung von IRDS und ARDS |
| DEP4434629.8 | 1994-09-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU97106790A true RU97106790A (ru) | 1999-05-10 |
| RU2157222C2 RU2157222C2 (ru) | 2000-10-10 |
Family
ID=6529394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97106790/14A RU2157222C2 (ru) | 1994-09-28 | 1995-09-27 | Композиции для лечения респираторного дистресс-синдрома новорожденных и острого респираторного дистресс-синдрома, содержащие по крайней мере, один глюкокортикостероид в сочетании с легочным поверхностно-активным веществом |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5891844A (ru) |
| EP (1) | EP0783314B1 (ru) |
| JP (1) | JP4425991B2 (ru) |
| KR (1) | KR100365030B1 (ru) |
| CN (1) | CN1100542C (ru) |
| AT (1) | ATE241372T1 (ru) |
| AU (1) | AU705099B2 (ru) |
| BG (1) | BG62556B1 (ru) |
| CA (1) | CA2201377C (ru) |
| CZ (1) | CZ292846B6 (ru) |
| DE (2) | DE4434629C1 (ru) |
| DK (1) | DK0783314T3 (ru) |
| EE (1) | EE03422B1 (ru) |
| ES (1) | ES2201120T3 (ru) |
| FI (1) | FI118886B (ru) |
| HK (1) | HK1003869A1 (ru) |
| HU (1) | HU226958B1 (ru) |
| MX (1) | MX9702303A (ru) |
| NO (1) | NO313405B1 (ru) |
| NZ (1) | NZ294587A (ru) |
| PL (1) | PL187496B1 (ru) |
| PT (1) | PT783314E (ru) |
| RU (1) | RU2157222C2 (ru) |
| SK (1) | SK284446B6 (ru) |
| UA (1) | UA43378C2 (ru) |
| WO (1) | WO1996009831A2 (ru) |
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| US6039932A (en) * | 1996-09-27 | 2000-03-21 | 3M Innovative Properties Company | Medicinal inhalation aerosol formulations containing budesonide |
| ES2271990T3 (es) * | 1997-02-17 | 2007-04-16 | Altana Pharma Ag | Composiciones para el tratamiento de ards o irds que contienen 3- (ciclopropilmetoxi) -n- (3,5-dicloro-4-piridinil) -4- (difluorometoxi) benzamina y un tensioactivo pulmonar. |
| US20060281681A1 (en) | 1997-05-28 | 2006-12-14 | Pilon Aprile L | Methods and compositions for the reduction of neutrophil influx and for the treatment of bronchpulmonary dysplasia, respiratory distress syndrome, chronic lung disease, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease |
| US7122344B2 (en) | 1997-05-28 | 2006-10-17 | Claragen, Inc. | Methods for the production of purified recombinant human uteroglobin for the treatment of inflammatory and fibrotic conditions |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US20020017295A1 (en) * | 2000-07-07 | 2002-02-14 | Weers Jeffry G. | Phospholipid-based powders for inhalation |
| US6433040B1 (en) | 1997-09-29 | 2002-08-13 | Inhale Therapeutic Systems, Inc. | Stabilized bioactive preparations and methods of use |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6946117B1 (en) | 1997-09-29 | 2005-09-20 | Nektar Therapeutics | Stabilized preparations for use in nebulizers |
| CN1194833A (zh) * | 1997-10-08 | 1998-10-07 | 刘柏宏 | 肺活素 |
| US6858223B2 (en) | 1998-06-23 | 2005-02-22 | Altana Pharma Ag | Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS) |
| JP2003501481A (ja) * | 1999-06-11 | 2003-01-14 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | サーファクタントタンパク質ｂ（ｓｐ−ｂ）改変体およびサーファクタントタンパク質ｃ（ｓｐ−ｃ）改変体を含有する医薬品製剤 |
| AU6083899A (en) | 1999-09-16 | 2001-04-17 | Aventis Behring Gmbh | Combination of c1-inh and lung surfactant for the treatment of respiratory disorders |
| DE19957898A1 (de) * | 1999-12-01 | 2001-06-07 | Byk Gulden Lomberg Chem Fab | Neue Verwendung von Lungensurfactant |
| DE10018022A1 (de) * | 2000-04-12 | 2001-10-31 | Byk Gulden Lomberg Chem Fab | Neue Verwendung von Lungensurfactant zur Prophylaxe oder Frühbehandlung von akuten Lungenerkrankungen |
| JP2003530356A (ja) * | 2000-04-12 | 2003-10-14 | アルタナ ファルマ アクチエンゲゼルシャフト | 急性肺疾患の予防又は早期治療のための肺表面活性物質の新規使用 |
| US20040254112A1 (en) * | 2000-04-12 | 2004-12-16 | Dietrich Hafner | Use of pulmonary surfactant for the early treatment of acute pulmonary diseases |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US7442388B2 (en) * | 2000-05-10 | 2008-10-28 | Weers Jeffry G | Phospholipid-based powders for drug delivery |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| DE10132307A1 (de) * | 2001-07-06 | 2003-01-30 | Aventis Behring Gmbh | Arzneizubereitung zur Inhalation von Antithrombin bei entzündlichen Lungenerkrankungen und ARDS |
| US20030099601A1 (en) * | 2001-11-27 | 2003-05-29 | Gordon Marc S. | Inhalation lung surfactant therapy |
| US6998384B2 (en) * | 2001-12-12 | 2006-02-14 | The Penn State Research Foundation | Surfactant prevention of lung complications from cancer chemotherapy |
| CA2468958C (en) | 2001-12-19 | 2012-07-03 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
| US20040023935A1 (en) * | 2002-08-02 | 2004-02-05 | Dey, L.P. | Inhalation compositions, methods of use thereof, and process for preparation of same |
| US20040109826A1 (en) * | 2002-12-06 | 2004-06-10 | Dey, L.P. | Stabilized albuterol compositions and method of preparation thereof |
| ATE547104T1 (de) | 2003-06-16 | 2012-03-15 | Nycomed Gmbh | Zusammensetzung enthaltend einen lungensurfactant und sildenafil zur behandlung von lungenerkrankungen |
| PL1670482T5 (pl) * | 2003-09-16 | 2022-10-03 | Covis Pharma Gmbh | Zastosowanie cyklezonidu w leczeniu chorób układu oddechowego |
| US7464012B2 (en) * | 2004-12-10 | 2008-12-09 | L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude | Simplified process simulator |
| US7582312B2 (en) | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
| JP2008526868A (ja) | 2005-01-06 | 2008-07-24 | ディスカバリー ラボラトリーズ，インコーポレイテッド | 表面活性剤処置療法 |
| KR100891595B1 (ko) | 2005-02-28 | 2009-04-03 | 주식회사 케이티앤지 | 혈액 단백질의 삼출을 감소시키는 조성물 |
| RU2455021C2 (ru) * | 2006-09-19 | 2012-07-10 | Дискавери Лабораториз, Инк. | Композиции легочных сурфактантов и способы их применения, содействующие очищению от слизи |
| EP2022798A1 (en) * | 2007-08-09 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | Synthetic pulmonary surfactant peptides |
| US9345716B2 (en) * | 2010-12-10 | 2016-05-24 | Indian Institute Of Technology, Bombay | Protein free surfactant composition for pulmonary diseases and a process for preparing the same |
| WO2013188016A2 (en) | 2012-05-04 | 2013-12-19 | Discovery Laboratories, Inc. | Surfactant therapy for exposure to ionizing radiation |
| CN106310280A (zh) * | 2016-08-18 | 2017-01-11 | 滨州医学院 | 地瑞那韦增强糖皮质激素抗炎作用的医药新用途 |
| RU2757902C2 (ru) * | 2016-12-22 | 2021-10-22 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Терапевтическая комбинация для лечения развивающейся bpd, содержащая легочный сурфактант и стероид |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4944941A (en) * | 1987-08-07 | 1990-07-31 | Genentech, Inc. | Methods and compositions for the treatment of lung conditions |
| US5006343A (en) * | 1988-12-29 | 1991-04-09 | Benson Bradley J | Pulmonary administration of pharmaceutically active substances |
-
1994
- 1994-09-28 DE DE4434629A patent/DE4434629C1/de not_active Expired - Lifetime
-
1995
- 1995-09-27 EE EE9700084A patent/EE03422B1/xx unknown
- 1995-09-27 JP JP51137796A patent/JP4425991B2/ja not_active Expired - Fee Related
- 1995-09-27 SK SK401-97A patent/SK284446B6/sk not_active IP Right Cessation
- 1995-09-27 EP EP95935387A patent/EP0783314B1/de not_active Expired - Lifetime
- 1995-09-27 UA UA97042034A patent/UA43378C2/ru unknown
- 1995-09-27 DK DK95935387T patent/DK0783314T3/da active
- 1995-09-27 CN CN95196265A patent/CN1100542C/zh not_active Expired - Fee Related
- 1995-09-27 ES ES95935387T patent/ES2201120T3/es not_active Expired - Lifetime
- 1995-09-27 WO PCT/EP1995/003816 patent/WO1996009831A2/de active IP Right Grant
- 1995-09-27 DE DE59510705T patent/DE59510705D1/de not_active Expired - Lifetime
- 1995-09-27 KR KR1019970701971A patent/KR100365030B1/ko not_active IP Right Cessation
- 1995-09-27 MX MX9702303A patent/MX9702303A/es unknown
- 1995-09-27 PL PL95319608A patent/PL187496B1/pl not_active IP Right Cessation
- 1995-09-27 AU AU37428/95A patent/AU705099B2/en not_active Ceased
- 1995-09-27 CZ CZ1997940A patent/CZ292846B6/cs not_active IP Right Cessation
- 1995-09-27 NZ NZ294587A patent/NZ294587A/en not_active IP Right Cessation
- 1995-09-27 RU RU97106790/14A patent/RU2157222C2/ru not_active IP Right Cessation
- 1995-09-27 AT AT95935387T patent/ATE241372T1/de active
- 1995-09-27 CA CA002201377A patent/CA2201377C/en not_active Expired - Fee Related
- 1995-09-27 PT PT95935387T patent/PT783314E/pt unknown
- 1995-09-27 HU HU9801664A patent/HU226958B1/hu not_active IP Right Cessation
-
1997
- 1997-03-25 NO NO19971403A patent/NO313405B1/no not_active IP Right Cessation
- 1997-03-26 FI FI971277A patent/FI118886B/fi not_active IP Right Cessation
- 1997-04-25 BG BG101441A patent/BG62556B1/bg unknown
- 1997-06-19 US US08/809,687 patent/US5891844A/en not_active Expired - Lifetime
-
1998
- 1998-04-15 HK HK98103100A patent/HK1003869A1/xx not_active IP Right Cessation
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