KR950704007A - 감광제의 활성화 방법(method of activating photosensitive agents) - Google Patents

감광제의 활성화 방법(method of activating photosensitive agents) Download PDF

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KR950704007A
KR950704007A KR1019950702052A KR19950702052A KR950704007A KR 950704007 A KR950704007 A KR 950704007A KR 1019950702052 A KR1019950702052 A KR 1019950702052A KR 19950702052 A KR19950702052 A KR 19950702052A KR 950704007 A KR950704007 A KR 950704007A
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엠. 리쳐 안나
워터필드 엘리자베스
지.레비 줄리아
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윌리암 팜
유니버스티 오브 브리티스 콜롬비아
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Adhesives Or Adhesive Processes (AREA)
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Abstract

광역학적 요법을 행하는 방법은 감광제에 대해 보통의 임상적 투여량의 약 절반 미만인 감광제 유효량을 동물에 투여하는 것으로 시작된다. 그 다음 보통의 주사후 간격의 약 1/4 미만인 주사후 간격후 감광제와 관련하여 사용되는 보통의 임상적 투사량의 약 절반 미만인 유효 광투사량을 동물에 투여한다.

Description

감광제의 활성화 방법(METHOD OF ACTIVATING PHOTOSENSITIVE AGENTS)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제3도는 BPD-MA 2㎎/㎏의 주사와 BPO-MA주사 3시간 후 시작하여 100Joules/㎠의 노광후 총 4일후의 마우스를 나타내며,
제4도는 0.5, 1.0, 1.5, 및 2.0㎎/㎏(리포좀성 제제)의 투여량에 대한 BPD-MA 투여량 반응곡선을 나타내는 그래프이며, 노광은 주사 3시간 후 일어났다,
제5도는 50, 75, 100, 125 및 150J/㎠ 690nm에서)의 투사량에 대한 광투사량 반응 곡선을 나타내는 그래프이며, 노광은 2㎎/㎏ BPD-MA의 주사 3시간 후 일어났다.

Claims (5)

  1. 광역학적 요법을 환자에게 행하는 방법에 있어서, (a)감광제에 대해 보통의 임상적 투여량의 약 절반 미만인 상기 감광제 유효량을 상기 환자에 투여하는 단계와 (b)상기 감광제와 관련하여 사용되는 보통의 임상적 광투사량의 약 절반 미만인 유효광투사량을 상기 환자에게 투여하되, 상기 광투사량은 보통의 주사후 간격의 약 1/4 미만인 주사후 간격에서 시작하는 단계로 이루어지는 것을 특징으로 하는 방법.
  2. 제1항에 있어서, 상기 감광제는 클로린, 박테리오클로린, 프탈로시아닌, 포르피린, 퓨르푸린, 메로시아닌, 페오포르바이드 또는 소랄렌으로 구성되는 군으로 부터 선택되는 것을 특징으로 하는 방법.
  3. 제2항에 있어서, 상기 포르피린은 벤조포르피린 유도체 1-산 (BPD-MA)포르피머 나트륨 또는 테트라히드록시 테트라페닐 포르피린인 것을 특징으로 하는 방법.
  4. 제1항에 있어서, 상기 광투사량이 약 75Joules/㎠ 미만이거나 또는 상기 간격이 약 2시간 미만인 것을 특징으로 하는 방법.
  5. 광역학적 요법을 환자에게 행하는 방법에 있어서, (a)약 0. 125㎎/㎏미만인 양으로 벤조포리피린 유도체 1-산을 상기 환자에 투여하는 단계와 (b)상기 벤조포르피린 유도체 1-산과 관련하여 사용되는 보통의 임상적 광투사량의 약 절반 미만인 유효 광투사량을 상기 환자에게 투여하되, 상기 광투사량은 약 반시간 미만인 주사 후 간격후 시작하는 단계로 이루어지는 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950702052A 1992-11-20 1993-11-17 감광제함유 광역학적 요법제 KR100230588B1 (ko)

Applications Claiming Priority (4)

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US97954692A 1992-11-20 1992-11-20
US07/979546 1992-11-20
US7/979546 1992-11-20
PCT/CA1993/000490 WO1994012239A1 (en) 1992-11-20 1993-11-17 Method of activating photosensitive agents

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EP (2) EP0947222B1 (ko)
JP (1) JP3146008B2 (ko)
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AT (2) ATE322932T1 (ko)
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DE (3) DE69327972T2 (ko)
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FI (1) FI952436A (ko)
GR (1) GR3033362T3 (ko)
HK (1) HK1025059A1 (ko)
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IL (1) IL107676A (ko)
NO (1) NO323107B1 (ko)
PH (1) PH31688A (ko)
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PT (2) PT680365E (ko)
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JP3146008B2 (ja) 2001-03-12
EP0680365B1 (en) 2000-03-01
EP0947222B1 (en) 2006-04-12
ES2148132T3 (es) 2006-12-01
PL309033A1 (en) 1995-09-18
HU9501489D0 (en) 1995-07-28
US5770619A (en) 1998-06-23
IL107676A0 (en) 1994-02-27
JPH08505069A (ja) 1996-06-04
PT947222E (pt) 2006-09-29
NO952004D0 (no) 1995-05-19
EP0947222A3 (en) 1999-10-27
DK0947222T3 (da) 2006-09-04
ES2143539T3 (es) 2000-05-16
HU224722B1 (en) 2006-01-30
HK1025059A1 (en) 2000-11-03
ATE322932T1 (de) 2006-04-15
ATE189966T1 (de) 2000-03-15
PH31688A (en) 1999-01-18
ZA938710B (en) 1994-06-30
EP0947222A2 (en) 1999-10-06
ES2148132T1 (es) 2000-10-16
GR3033362T3 (en) 2000-09-29
FI952436A0 (fi) 1995-05-19
EP0680365A1 (en) 1995-11-08
NO323107B1 (no) 2007-01-02
KR100230588B1 (ko) 1999-12-01
HUT72037A (en) 1996-03-28
AU5460094A (en) 1994-06-22
DE69334009T2 (de) 2006-11-23
IL107676A (en) 1999-11-30
DK0680365T3 (da) 2000-06-05
FI952436A (fi) 1995-07-05
CA2149636C (en) 2001-04-03
AU679016B2 (en) 1997-06-19
CA2149636A1 (en) 1994-06-09
PL172480B1 (pl) 1997-09-30
NO952004L (no) 1995-07-11
DE69327972T2 (de) 2000-11-02
WO1994012239A1 (en) 1994-06-09
US5705518A (en) 1998-01-06
DE947222T1 (de) 2000-05-04
DE69327972D1 (de) 2000-04-06
PT680365E (pt) 2000-07-31
DE69334009D1 (de) 2006-05-24

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