KR950014113A - 이환 아미딘, 그의 제조방법, 및 그의 촉매로서의 용도 - Google Patents

이환 아미딘, 그의 제조방법, 및 그의 촉매로서의 용도 Download PDF

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KR950014113A
KR950014113A KR1019940029661A KR19940029661A KR950014113A KR 950014113 A KR950014113 A KR 950014113A KR 1019940029661 A KR1019940029661 A KR 1019940029661A KR 19940029661 A KR19940029661 A KR 19940029661A KR 950014113 A KR950014113 A KR 950014113A
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amino
alkyl
general formula
aminomethyl
iii
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KR1019940029661A
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KR100362543B1 (ko
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페어비쯔키 올레크
다움 울리히
브레기 라헬
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크리스티안 슈바이쩌, 모니카 풀데
론자 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Adhesives Or Adhesive Processes (AREA)

Abstract

락톤 및 아민으로부터 이환 아미딘의 제조에 대하여 기재된 신규의 일-단계 공정이다. 또는 관능기로서, 특히 아미노 또는 아미노알킬기를 갖는 신규의 이환 아미딘에 관한 것이다. 본 발명에 따른 아미딘은 특히 폴리우레탄의 제조시에 적당하고 폴리우레탄내에 견고하게 결합되는 공지된 이환 아미딘과 비교되는 장점을 가지고 있다.

Description

이환 아미딘, 그의 제조방법 및 그의 촉매로서의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기 일반식(Ⅱ)의 락톤을 150℃이상으로 동몰량 이상의 하기 일반식(Ⅲ)의 아민과 함께 가열하고, 생성된 반응 혼합물을, 중간체를 단리시키지 않으면서, 분별 증류하는 것을 특징으로하는 하기 일반식( I )의 이환 아미딘의 제조방법:
    [상기식에서, A는 -CR1R2-CR3R4-CR5R6- , -CR1R2-CR3R4-CR5R6-CR7R8-및 -CR1R2-CR3R4-CR5R6_CR7R8_CR9R10-으로 구성된 군으로부터 선택되고 (A에서 치환기는, 각 경우에 질소 원자로부터 출발하여 번호가 붙여진다), B는 -CR11R12-CR13R14-및- CR11R12-CR15R16-CR13R14- 및 -CR11R12-CR15R16_CR17R18_CR13R14-으로 구성된 군으로부터 선택되고, R1, R2및 R11∼R12는 각 경우에, 서로 독립적으로, 수소, C1-C4-알킬, 아릴이거나, 히드록실, 아미노, C1-C4-알킬아미노 또는 메르캅토로 치환된 C1-C4-알킬이고, R3∼R10및 R15∼R18은 각 경우에, 서로 독립적으로, 수소, C1-C4-알킬, 아릴, 히드록실, 아미노, C1-C4-알킬아미노 또는 메르캅톤이거나, 히드록실, 아미노, C1-C4-알킬아미노 또는 메르캅토로 치환된 C1-C4-알킬이다].
  2. 제1항에 있어서, 락톤(Ⅱ)와 아민(Ⅲ)의 반응이 산성 촉매의 존재하에서 수행되는 것을 특징으로 하는 방법.
  3. 제1또는 2항에 있어서, 아민(Ⅲ)을 락톤(Ⅱ)1몰당 2∼20몰의 양으로 사용하는 것을 특징으로 하는 방법.
  4. 제1또는 2항에 있어서, 사용된 락톨(Ⅱ)가 γ-부티로락톤, γ-발레로락론, δ-발레로락톤, ε-카프로락톤 및 판토락톤으로 구성된 군으로 부터 선택된 화합물인 것을 특징으로 하는 방법.
  5. 제1또는 2항에 있어서, 사용된 아민(Ⅲ)이 1, 2-디아미노에탄, 1, 2-디아미노프로판, 1, 3-디아미노프로판, 1, 2, 3-트리아모노프로판, 1, 1, 1-트리스(아미노메틸)에탄 및 데트라키스(아미노메틸)메탄으로 구성된 군으로부터 선택된 화합물인 것을 특징으로 하는 방법.
  6. 하기 일반식( I )의 이환 아민 및 그의 혼합물:
    (상기식에서, A, B및 A및 B에 존재할 수 있는 임의의 치환기 R1∼R18은 제1항의 정의와 동일하고, 단, 치환기 R1∼R18의 1개 이상은 히드록실, 아미노, C1-C4-알킬아미노 또는 메르캅토이고/거나 히드록실,아미노, C1-C4-알킬아미노 또는 메르캅토로 치환된 C1-C4-알킬이다. ).
  7. 제6항에 있어서, 하나 이상의 치환기 R11∼R18은 아미노 또는 아미노메틸인 것을 특징으로하는 이환 아미딘.
  8. 하기 일반식의 3-아미노-2, 3, 4, 6, 7, 8-헥사히드로피롤로(1, 2-a)피리미딘:
  9. 하기 일반식의 3-(아미노메틸)-2, 5, 6, 7-데트라히드로-3H-피롤로(1, 2-a)이미다졸:
  10. 하기 일반식의 3-(아미노메틸)-3-메틸-2, 3, 4, 6, 7, 8-헥사히드로피롤로(1, 2-a)피리미딘:
  11. 폴리우레탄 제조 촉매용 제6내지 10항에 따른 이환 아미딘.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940029661A 1993-11-11 1994-11-11 이환아미딘,그의제조방법,및그의촉매로서의용도 KR100362543B1 (ko)

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CH338593 1993-11-11
CH93-3385 1993-11-11

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KR950014113A true KR950014113A (ko) 1995-06-15
KR100362543B1 KR100362543B1 (ko) 2003-02-05

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US (4) US5723605A (ko)
EP (2) EP0662476B2 (ko)
JP (1) JP4348747B2 (ko)
KR (1) KR100362543B1 (ko)
CN (2) CN1042227C (ko)
AT (2) ATE175969T1 (ko)
BR (1) BR9404410A (ko)
CA (1) CA2134009C (ko)
CZ (1) CZ286335B6 (ko)
DE (2) DE59409907D1 (ko)
DK (2) DK0662476T4 (ko)
ES (2) ES2165114T3 (ko)
PT (1) PT869127E (ko)
RU (1) RU2132850C1 (ko)
SI (2) SI0869127T1 (ko)

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WO2006037802A2 (en) 2004-10-07 2006-04-13 Novo Nordisk A/S Method and system for self- management of a disease
CN101636119A (zh) * 2007-03-22 2010-01-27 诺瓦利恩整形公司 分节髓内结构
RU2480449C2 (ru) * 2007-08-29 2013-04-27 Басф Се Способ получения аминов из глицерина
US10383580B2 (en) 2012-12-31 2019-08-20 Abbott Diabetes Care Inc. Analysis of glucose median, variability, and hypoglycemia risk for therapy guidance
US9085712B2 (en) 2013-03-14 2015-07-21 Bayer Materialscience Llc Fast cure aspartate polysiloxane hybrid coating
EP3543270A1 (de) 2018-03-23 2019-09-25 Covestro Deutschland AG Katalysatorsystem für uretdiondispersionen
EP3768748A1 (de) 2018-03-23 2021-01-27 Covestro Deutschland AG Katalysatorsystem für uretdiondispersionen
EP3572446A1 (de) 2018-05-24 2019-11-27 Evonik Degussa GmbH Reaktive mischung von uretdionen und katalysatoren
EP3916032A1 (de) 2020-05-29 2021-12-01 Covestro Deutschland AG Bei niedrigen temperaturen vernetzende uretdiongruppen enthaltende zusammensetzungen
TW202244046A (zh) 2021-03-08 2022-11-16 義大利商佛沙里斯股份有限公司 製備脒類的方法
IT202100005336A1 (it) 2021-03-08 2022-09-08 Versalis Spa Metodo per la preparazione di amidine.

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EP0869127B1 (de) 2001-10-10
ES2165114T3 (es) 2002-03-01
CZ286335B6 (cs) 2000-03-15
ATE206711T1 (de) 2001-10-15
RU2132850C1 (ru) 1999-07-10
SI0869127T1 (ko) 2001-12-31
JP4348747B2 (ja) 2009-10-21
DK0662476T3 (da) 1999-09-13
ATE175969T1 (de) 1999-02-15
US5922869A (en) 1999-07-13
CN1106406A (zh) 1995-08-09
EP0869127A1 (de) 1998-10-07
DE59409907D1 (de) 2001-11-15
CN1042227C (zh) 1999-02-24
EP0662476B1 (de) 1999-01-20
US20020028939A1 (en) 2002-03-07
ES2128490T3 (es) 1999-05-16
JPH07188235A (ja) 1995-07-25
DE59407697D1 (de) 1999-03-04
ES2128490T5 (es) 2003-02-01
CZ276894A3 (en) 1995-07-12
RU94040173A (ru) 1996-10-10
SI0662476T1 (en) 1999-04-30
CN1070861C (zh) 2001-09-12
CA2134009A1 (en) 1995-05-12
EP0662476B2 (de) 2002-08-14
EP0662476A1 (de) 1995-07-12
PT869127E (pt) 2002-03-28
KR100362543B1 (ko) 2003-02-05
BR9404410A (pt) 1995-06-20
CN1215727A (zh) 1999-05-05
US6476175B2 (en) 2002-11-05
US5723605A (en) 1998-03-03
CA2134009C (en) 2005-03-08
DK0869127T3 (da) 2001-12-03
US6255488B1 (en) 2001-07-03
DK0662476T4 (da) 2002-10-07

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