GB2011410A - Pyrido[1,2-a]Pyrimidine Derivatives, Their Preparation and Pharmaceutical Compositions Containing Them - Google Patents

Pyrido[1,2-a]Pyrimidine Derivatives, Their Preparation and Pharmaceutical Compositions Containing Them

Info

Publication number
GB2011410A
GB2011410A GB7850108A GB7850108A GB2011410A GB 2011410 A GB2011410 A GB 2011410A GB 7850108 A GB7850108 A GB 7850108A GB 7850108 A GB7850108 A GB 7850108A GB 2011410 A GB2011410 A GB 2011410A
Authority
GB
United Kingdom
Prior art keywords
pyrido
pyrimidine derivatives
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7850108A
Other versions
GB2011410B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of GB2011410A publication Critical patent/GB2011410A/en
Application granted granted Critical
Publication of GB2011410B publication Critical patent/GB2011410B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Pyrido[1,2-a]pyrimidine derivatives of the general formula I <IMAGE> wherein R-R<3> are hydrogen or various organic groups, may be made by cyclising suitably substituted 2- aminopyridine starting materials. The compounds are of interest as chemical intermediates. Some also exhibit a variety of pharmacological activities.
GB7850108A 1977-12-29 1978-12-28 Pyrido pyrimidine derivatives their preparation and pharmaceutical compositions contgaining them Expired GB2011410B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77CI1796A HU180701B (en) 1977-12-29 1977-12-29 Process for preparing pyrido-/1,2-a/pyrimidines containing a carboxylic or ester group on the pirimidimering

Publications (2)

Publication Number Publication Date
GB2011410A true GB2011410A (en) 1979-07-11
GB2011410B GB2011410B (en) 1982-09-22

Family

ID=10994685

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7850108A Expired GB2011410B (en) 1977-12-29 1978-12-28 Pyrido pyrimidine derivatives their preparation and pharmaceutical compositions contgaining them

Country Status (8)

Country Link
JP (1) JPS5498797A (en)
BE (1) BE873195A (en)
CH (1) CH642368A5 (en)
DE (1) DE2853273A1 (en)
FR (1) FR2413375A1 (en)
GB (1) GB2011410B (en)
HU (1) HU180701B (en)
SU (1) SU1022659A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110218196A1 (en) * 2008-07-18 2011-09-08 Ke Ding Compounds of estrogen-related receptor modulators and the uses thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59802A (en) 1979-05-08 1983-07-31 Erba Farmitalia Substituted pyrido(1,2-a)pyrimidine carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU168014B (en) * 1973-03-30 1976-02-28
US3898224A (en) * 1974-09-09 1975-08-05 Squibb & Sons Inc 1,6,7,8-Tetrahydro-4-oxo-4H-pyrido {8 1,2-A{9 pyrimidine-9-carboalkoxy compounds
HU173438B (en) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 4-oxo-1,6,7,8-tetrahydro-4h-pyrido-/1,2-a/pyrimidine derivatives with antiinflammatory and anticoagulant activity
HU174693B (en) * 1976-02-12 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing condensed pyrimidine derivatives
HU178910B (en) * 1977-08-19 1982-07-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 2,3-disubstituted-4-oxo-4h-pyrido/1,2-a/-pyrimidines

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110218196A1 (en) * 2008-07-18 2011-09-08 Ke Ding Compounds of estrogen-related receptor modulators and the uses thereof
US8853221B2 (en) * 2008-07-18 2014-10-07 Guangzhou Institute Of Biomedicine & Health, Chinese Academy Of Sciences Compounds of estrogen-related receptor modulators and the uses thereof

Also Published As

Publication number Publication date
JPS5498797A (en) 1979-08-03
SU1022659A3 (en) 1983-06-07
FR2413375B1 (en) 1983-08-05
HU180701B (en) 1983-04-29
CH642368A5 (en) 1984-04-13
BE873195A (en) 1979-04-17
FR2413375A1 (en) 1979-07-27
DE2853273A1 (en) 1979-07-12
GB2011410B (en) 1982-09-22

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Legal Events

Date Code Title Description
746 Register noted 'licences of right' (sect. 46/1977)
PCNP Patent ceased through non-payment of renewal fee