FR2413375A1 - NEW DERIVATIVES OF (1,2-A) PYRIMIDINE AND PROCESS FOR THEIR PREPARATION - Google Patents

NEW DERIVATIVES OF (1,2-A) PYRIMIDINE AND PROCESS FOR THEIR PREPARATION

Info

Publication number
FR2413375A1
FR2413375A1 FR7836463A FR7836463A FR2413375A1 FR 2413375 A1 FR2413375 A1 FR 2413375A1 FR 7836463 A FR7836463 A FR 7836463A FR 7836463 A FR7836463 A FR 7836463A FR 2413375 A1 FR2413375 A1 FR 2413375A1
Authority
FR
France
Prior art keywords
preparation
pyrimidine
new derivatives
derivatives
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7836463A
Other languages
French (fr)
Other versions
FR2413375B1 (en
Inventor
Istvan Hermecz
Zoltan Meszaros
Lelle Vasvari
Agnes Horvath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of FR2413375A1 publication Critical patent/FR2413375A1/en
Application granted granted Critical
Publication of FR2413375B1 publication Critical patent/FR2413375B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

NOUVEAUX DERIVES DE 1,2-APYRIMIDINE ET PROCEDE POUR LEUR PREPARATION. CES DERIVES REPONDENT A LA FORMULE: (CF DESSIN DANS BOPI) APPLICATION COMME COMPOSES INTERMEDIAIRES POUR LA PREPARATION DE COMPOSES PHARMACEUTIQUES, AGISSANT NOTAMMENT SUR LE SYSTEME NERVEUX CENTRAL.NEW DERIVATIVES OF 1,2-APYRIMIDINE AND PROCESS FOR THEIR PREPARATION. THESE DERIVATIVES MEET THE FORMULA: (CF DRAWING IN BOPI) APPLICATION AS INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PHARMACEUTICAL COMPOUNDS, ACTING IN PARTICULAR ON THE CENTRAL NERVOUS SYSTEM.

FR7836463A 1977-12-29 1978-12-27 NEW DERIVATIVES OF (1,2-A) PYRIMIDINE AND PROCESS FOR THEIR PREPARATION Granted FR2413375A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77CI1796A HU180701B (en) 1977-12-29 1977-12-29 Process for preparing pyrido-/1,2-a/pyrimidines containing a carboxylic or ester group on the pirimidimering

Publications (2)

Publication Number Publication Date
FR2413375A1 true FR2413375A1 (en) 1979-07-27
FR2413375B1 FR2413375B1 (en) 1983-08-05

Family

ID=10994685

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7836463A Granted FR2413375A1 (en) 1977-12-29 1978-12-27 NEW DERIVATIVES OF (1,2-A) PYRIMIDINE AND PROCESS FOR THEIR PREPARATION

Country Status (8)

Country Link
JP (1) JPS5498797A (en)
BE (1) BE873195A (en)
CH (1) CH642368A5 (en)
DE (1) DE2853273A1 (en)
FR (1) FR2413375A1 (en)
GB (1) GB2011410B (en)
HU (1) HU180701B (en)
SU (1) SU1022659A3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59802A (en) 1979-05-08 1983-07-31 Erba Farmitalia Substituted pyrido(1,2-a)pyrimidine carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
CN101628913B (en) * 2008-07-18 2013-01-23 中国科学院广州生物医药与健康研究院 Compound as estrogen-related receptor modulator and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3898224A (en) * 1974-09-09 1975-08-05 Squibb & Sons Inc 1,6,7,8-Tetrahydro-4-oxo-4H-pyrido {8 1,2-A{9 pyrimidine-9-carboalkoxy compounds
BE869832A (en) * 1977-08-19 1978-12-18 Chinoin Gyogyszer Es Vegyeszet PYRIDO (1,2-A) DERIVATIVES PYRIMIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU168014B (en) * 1973-03-30 1976-02-28
HU173438B (en) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new 4-oxo-1,6,7,8-tetrahydro-4h-pyrido-/1,2-a/pyrimidine derivatives with antiinflammatory and anticoagulant activity
HU174693B (en) * 1976-02-12 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing condensed pyrimidine derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3898224A (en) * 1974-09-09 1975-08-05 Squibb & Sons Inc 1,6,7,8-Tetrahydro-4-oxo-4H-pyrido {8 1,2-A{9 pyrimidine-9-carboalkoxy compounds
BE869832A (en) * 1977-08-19 1978-12-18 Chinoin Gyogyszer Es Vegyeszet PYRIDO (1,2-A) DERIVATIVES PYRIMIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2416892A1 (en) * 1977-08-19 1979-09-07 Chinoin Gyogyszer Es Vegyeszet PYRIDO (1,2-A) DERIVATIVES PYRIMIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/76 *
EXBK/78 *

Also Published As

Publication number Publication date
SU1022659A3 (en) 1983-06-07
FR2413375B1 (en) 1983-08-05
CH642368A5 (en) 1984-04-13
JPS5498797A (en) 1979-08-03
BE873195A (en) 1979-04-17
GB2011410B (en) 1982-09-22
GB2011410A (en) 1979-07-11
HU180701B (en) 1983-04-29
DE2853273A1 (en) 1979-07-12

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