FR2375231A1 - DERIVATIVES OF DI- AND TETRAHYDROBENZO- (5.6) CYCLOHEPTA (1,2-B) PYRAZOLO (4.3-A) PYRIDINE, AND THEIR USE AS MEDICINAL PRODUCTS - Google Patents
DERIVATIVES OF DI- AND TETRAHYDROBENZO- (5.6) CYCLOHEPTA (1,2-B) PYRAZOLO (4.3-A) PYRIDINE, AND THEIR USE AS MEDICINAL PRODUCTSInfo
- Publication number
- FR2375231A1 FR2375231A1 FR7738900A FR7738900A FR2375231A1 FR 2375231 A1 FR2375231 A1 FR 2375231A1 FR 7738900 A FR7738900 A FR 7738900A FR 7738900 A FR7738900 A FR 7738900A FR 2375231 A1 FR2375231 A1 FR 2375231A1
- Authority
- FR
- France
- Prior art keywords
- derivatives
- cyclohepta
- tetrahydrobenzo
- pyrazolo
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne de nouveaux dérivés de 5,6-dihydrobenzo-Ø5,7õcycloheptaØ1,2-bõpyrazoloØ4,3-eõpyridin- 11 (1H) ones et imines de formule générale :The invention relates to novel derivatives of 5,6-dihydrobenzo-Ø5,7õcycloheptaØ1,2-bõpyrazoloØ4,3-eõpyridin-11 (1H) ones and imines of general formula:
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/753,116 US4062858A (en) | 1976-12-22 | 1976-12-22 | Derivatives of 5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridin-11(1H)-ones and 11(1H)-imines |
US05/785,398 US4111940A (en) | 1977-04-07 | 1977-04-07 | 1,5,6,11-Tetrahydro[5,6]cyclohepta-[1,2,-b]pyrazolo[4,3-e]pyridine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2375231A1 true FR2375231A1 (en) | 1978-07-21 |
Family
ID=27115698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7738900A Withdrawn FR2375231A1 (en) | 1976-12-22 | 1977-12-22 | DERIVATIVES OF DI- AND TETRAHYDROBENZO- (5.6) CYCLOHEPTA (1,2-B) PYRAZOLO (4.3-A) PYRIDINE, AND THEIR USE AS MEDICINAL PRODUCTS |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS5387399A (en) |
DE (1) | DE2757503A1 (en) |
FR (1) | FR2375231A1 (en) |
GB (1) | GB1593417A (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5177099A (en) * | 1989-04-10 | 1993-01-05 | Sociedad Espanola De Especialidades Farmaco-Terapeuticas S.A. | Dichloro-substituted imidazole derivatives as antifungal agents |
ES2012297A6 (en) * | 1989-04-10 | 1990-03-01 | Espnola De Especialidades Farm | Dichloro-substituted imidazole derivatives as antifungal agents. |
US5965570A (en) * | 1996-09-13 | 1999-10-12 | Schering Corporation | Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase |
EP0931077B1 (en) * | 1996-09-13 | 2005-04-27 | Schering Corporation | Substituted benzocycloheptapyridine useful as inhibitors of farnesyl-protein transferase |
ID21218A (en) * | 1996-09-13 | 1999-05-06 | Schering Corp | A NEW PYRICIDIC TRICICLIC COMPOUNDS USING AS A RESERVE FARNESIL PROTEIN TRANSFERASE |
US5958940A (en) * | 1997-09-11 | 1999-09-28 | Schering Corporation | Tricyclic compounds useful as inhibitors of farnesyl-protein transferase |
EP3141542B1 (en) | 2011-12-28 | 2020-05-27 | Global Blood Therapeutics, Inc. | Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation |
ES2790358T3 (en) | 2011-12-28 | 2020-10-27 | Global Blood Therapeutics Inc | Substituted Heteroaryl Aldehyde Compounds and Methods for Their Use in Increasing Tissue Oxygenation |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
ES2852054T3 (en) | 2013-03-15 | 2021-09-10 | Global Blood Therapeutics Inc | Compounds and their uses for modulation of hemoglobin |
SG11201507453VA (en) | 2013-03-15 | 2015-10-29 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
MX2015011448A (en) | 2013-03-15 | 2016-06-06 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin. |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
EA202092627A1 (en) | 2013-11-18 | 2021-09-30 | Глобал Блад Терапьютикс, Инк. | COMPOUNDS AND THEIR APPLICATIONS FOR HEMOGLOBIN MODULATION |
EP3868745A1 (en) | 2014-02-07 | 2021-08-25 | Global Blood Therapeutics, Inc. | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
MA41841A (en) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | ALDEHYDE COMPOUNDS FOR THE TREATMENT OF PULMONARY FIBROSIS, HYPOXIA, AND AUTOIMMUNE AND CONNECTIVE TISSUE DISEASES |
WO2017096230A1 (en) | 2015-12-04 | 2017-06-08 | Global Blood Therapeutics, Inc. | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
TWI663160B (en) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde |
TWI778983B (en) | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | Tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
EP3860975B1 (en) | 2018-10-01 | 2023-10-18 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2139035A1 (en) * | 1971-05-25 | 1973-01-05 | Squibb & Sons Inc | |
US4018779A (en) * | 1976-03-25 | 1977-04-19 | E. R. Squibb & Sons, Inc. | Derivatives of 10,11-dihydrobenzo[4,5]cyclohepta[1,2-b]-pyrazolo[4,3-e]pyridine-5(1H)ones |
-
1977
- 1977-12-13 GB GB51812/77A patent/GB1593417A/en not_active Expired
- 1977-12-22 FR FR7738900A patent/FR2375231A1/en not_active Withdrawn
- 1977-12-22 JP JP16098677A patent/JPS5387399A/en active Pending
- 1977-12-22 DE DE19772757503 patent/DE2757503A1/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2139035A1 (en) * | 1971-05-25 | 1973-01-05 | Squibb & Sons Inc | |
US4018779A (en) * | 1976-03-25 | 1977-04-19 | E. R. Squibb & Sons, Inc. | Derivatives of 10,11-dihydrobenzo[4,5]cyclohepta[1,2-b]-pyrazolo[4,3-e]pyridine-5(1H)ones |
Also Published As
Publication number | Publication date |
---|---|
GB1593417A (en) | 1981-07-15 |
JPS5387399A (en) | 1978-08-01 |
DE2757503A1 (en) | 1978-06-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |