FR2375231A1 - DERIVATIVES OF DI- AND TETRAHYDROBENZO- (5.6) CYCLOHEPTA (1,2-B) PYRAZOLO (4.3-A) PYRIDINE, AND THEIR USE AS MEDICINAL PRODUCTS - Google Patents

DERIVATIVES OF DI- AND TETRAHYDROBENZO- (5.6) CYCLOHEPTA (1,2-B) PYRAZOLO (4.3-A) PYRIDINE, AND THEIR USE AS MEDICINAL PRODUCTS

Info

Publication number
FR2375231A1
FR2375231A1 FR7738900A FR7738900A FR2375231A1 FR 2375231 A1 FR2375231 A1 FR 2375231A1 FR 7738900 A FR7738900 A FR 7738900A FR 7738900 A FR7738900 A FR 7738900A FR 2375231 A1 FR2375231 A1 FR 2375231A1
Authority
FR
France
Prior art keywords
derivatives
cyclohepta
tetrahydrobenzo
pyrazolo
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7738900A
Other languages
French (fr)
Inventor
Hans Hoehn
Jack Bernstein
Berthold R Vogt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/753,116 external-priority patent/US4062858A/en
Priority claimed from US05/785,398 external-priority patent/US4111940A/en
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2375231A1 publication Critical patent/FR2375231A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux dérivés de 5,6-dihydrobenzo-Ø5,7õcycloheptaØ1,2-bõpyrazoloØ4,3-eõpyridin- 11 (1H) ones et imines de formule générale :The invention relates to novel derivatives of 5,6-dihydrobenzo-Ø5,7õcycloheptaØ1,2-bõpyrazoloØ4,3-eõpyridin-11 (1H) ones and imines of general formula:

FR7738900A 1976-12-22 1977-12-22 DERIVATIVES OF DI- AND TETRAHYDROBENZO- (5.6) CYCLOHEPTA (1,2-B) PYRAZOLO (4.3-A) PYRIDINE, AND THEIR USE AS MEDICINAL PRODUCTS Withdrawn FR2375231A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/753,116 US4062858A (en) 1976-12-22 1976-12-22 Derivatives of 5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridin-11(1H)-ones and 11(1H)-imines
US05/785,398 US4111940A (en) 1977-04-07 1977-04-07 1,5,6,11-Tetrahydro[5,6]cyclohepta-[1,2,-b]pyrazolo[4,3-e]pyridine derivatives

Publications (1)

Publication Number Publication Date
FR2375231A1 true FR2375231A1 (en) 1978-07-21

Family

ID=27115698

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7738900A Withdrawn FR2375231A1 (en) 1976-12-22 1977-12-22 DERIVATIVES OF DI- AND TETRAHYDROBENZO- (5.6) CYCLOHEPTA (1,2-B) PYRAZOLO (4.3-A) PYRIDINE, AND THEIR USE AS MEDICINAL PRODUCTS

Country Status (4)

Country Link
JP (1) JPS5387399A (en)
DE (1) DE2757503A1 (en)
FR (1) FR2375231A1 (en)
GB (1) GB1593417A (en)

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Publication number Priority date Publication date Assignee Title
US5177099A (en) * 1989-04-10 1993-01-05 Sociedad Espanola De Especialidades Farmaco-Terapeuticas S.A. Dichloro-substituted imidazole derivatives as antifungal agents
ES2012297A6 (en) * 1989-04-10 1990-03-01 Espnola De Especialidades Farm Dichloro-substituted imidazole derivatives as antifungal agents.
US5965570A (en) * 1996-09-13 1999-10-12 Schering Corporation Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase
EP0931077B1 (en) * 1996-09-13 2005-04-27 Schering Corporation Substituted benzocycloheptapyridine useful as inhibitors of farnesyl-protein transferase
ID21218A (en) * 1996-09-13 1999-05-06 Schering Corp A NEW PYRICIDIC TRICICLIC COMPOUNDS USING AS A RESERVE FARNESIL PROTEIN TRANSFERASE
US5958940A (en) * 1997-09-11 1999-09-28 Schering Corporation Tricyclic compounds useful as inhibitors of farnesyl-protein transferase
EP3141542B1 (en) 2011-12-28 2020-05-27 Global Blood Therapeutics, Inc. Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
ES2790358T3 (en) 2011-12-28 2020-10-27 Global Blood Therapeutics Inc Substituted Heteroaryl Aldehyde Compounds and Methods for Their Use in Increasing Tissue Oxygenation
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
ES2852054T3 (en) 2013-03-15 2021-09-10 Global Blood Therapeutics Inc Compounds and their uses for modulation of hemoglobin
SG11201507453VA (en) 2013-03-15 2015-10-29 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
MX2015011448A (en) 2013-03-15 2016-06-06 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin.
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA202092627A1 (en) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. COMPOUNDS AND THEIR APPLICATIONS FOR HEMOGLOBIN MODULATION
EP3868745A1 (en) 2014-02-07 2021-08-25 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
MA41841A (en) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc ALDEHYDE COMPOUNDS FOR THE TREATMENT OF PULMONARY FIBROSIS, HYPOXIA, AND AUTOIMMUNE AND CONNECTIVE TISSUE DISEASES
WO2017096230A1 (en) 2015-12-04 2017-06-08 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI663160B (en) 2016-05-12 2019-06-21 全球血液治療公司 Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
TWI778983B (en) 2016-10-12 2022-10-01 美商全球血液治療公司 Tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
EP3860975B1 (en) 2018-10-01 2023-10-18 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2139035A1 (en) * 1971-05-25 1973-01-05 Squibb & Sons Inc
US4018779A (en) * 1976-03-25 1977-04-19 E. R. Squibb & Sons, Inc. Derivatives of 10,11-dihydrobenzo[4,5]cyclohepta[1,2-b]-pyrazolo[4,3-e]pyridine-5(1H)ones

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2139035A1 (en) * 1971-05-25 1973-01-05 Squibb & Sons Inc
US4018779A (en) * 1976-03-25 1977-04-19 E. R. Squibb & Sons, Inc. Derivatives of 10,11-dihydrobenzo[4,5]cyclohepta[1,2-b]-pyrazolo[4,3-e]pyridine-5(1H)ones

Also Published As

Publication number Publication date
GB1593417A (en) 1981-07-15
JPS5387399A (en) 1978-08-01
DE2757503A1 (en) 1978-06-29

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