KR950007872A - 안정화된 약제학적 조성물 및 안정화용매 - Google Patents

안정화된 약제학적 조성물 및 안정화용매 Download PDF

Info

Publication number
KR950007872A
KR950007872A KR1019940025248A KR19940025248A KR950007872A KR 950007872 A KR950007872 A KR 950007872A KR 1019940025248 A KR1019940025248 A KR 1019940025248A KR 19940025248 A KR19940025248 A KR 19940025248A KR 950007872 A KR950007872 A KR 950007872A
Authority
KR
South Korea
Prior art keywords
solvent
composition
pharmaceutical
acid
castor oil
Prior art date
Application number
KR1019940025248A
Other languages
English (en)
Other versions
KR100515631B1 (ko
Inventor
나라하리 아그하카르 쉬레르함
에스. 고게이트 우데이
카바나크 토마스
Original Assignee
니콜라스 피. 말라테스티닉
브리스톨-마이어스 스퀴브 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22433231&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR950007872(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 니콜라스 피. 말라테스티닉, 브리스톨-마이어스 스퀴브 캄파니 filed Critical 니콜라스 피. 말라테스티닉
Publication of KR950007872A publication Critical patent/KR950007872A/ko
Application granted granted Critical
Publication of KR100515631B1 publication Critical patent/KR100515631B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

1. 청구범위에 기재된 발명이 속하는 기술분야
카르복실레이트 음이온 함량을 감소시킨 용매계
2. 발명이 해결하려고 하는 기술적 과제
약제학적 물질의 분해를 억제
3. 발명의 해결방법의 요지
폴리옥시에틸화된 피마자유를 산으로 처리 또는 알루미나와 접촉
4. 발명의 중요한 용도
안정화된 약제학적 조성물

Description

안정화된 약제학적 조성물 및 안정화용매
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (42)

  1. 알킬렌 옥사이드의 축합생성물을 함유하고, 약제학적 물질의 분해를 실질적으로 방지하기에 충분히 낮은 카르복실레이트 음이온 함량을 갖는 용매.
  2. 제1항에 있어서, 용매의 카르복실레이트 음이온 함량이 mL당 카르복실레이트 음이은의 0.6×10-6g당량 미만 또는 이와 동일량인 용매.
  3. 제1항에 있어서, 축합생성물이 알킬렌옥사이드와 지질의 축합생성물인 용매.
  4. 제3항에 있어서, 축합생성물이 폴리옥시에틸화 피마자유인 용매.
  5. 제3항에 있어서, 용매가 폴리에톡실화 12-하이드록시 스테아린산인 용매.
  6. 제1항에 있어서, 용매가 추가로 알콜을 함유하는 용매.
  7. 제6항에 있어서, 알콜이 에탄올 및 폴리에틸렌 글리콜로 이루어진 그룹중에서 선택되는 용매.
  8. 하나 이상의 약제학적 화합물 : 및 이 약제학적 화합물을 분산시키거나 용해시킬 수 있고 약제학적 화합물의 촉매화 분해를 방지하기에 충분히 낮은 카르복실레이트 음이온 함량을 갖는 유효량의 가용화제를 함유하는 용매를 함유한 안정화된 조성물.
  9. 제8항에 있어서, 가용화제가 알킬렌옥사이드 변형지질인 조성물.
  10. 제8항에 있어서, 용매가 알콜과 폴리옥시에틸화 피마자유의 혼합물인 조성물.
  11. 제10항에 있어서, 용매가 에틸알콜과 폴리옥시에틸화 피마자유가 약 50 : 50용량비로 이루어진 혼합물인 조성물.
  12. 제8항에 있어서, 약제학적 화합물이 테니포시드, 파클리텍셀, 캠프토테신 및 이들의 유도체로 이루어진 그룹중에서 선택된 항종양화합물인 조성물.
  13. 제8항에 있어서, 약제학적 화합물이 카르복실레이트 옴이온의 존재하에서 분해에 민감한 화합물인 조성물.
  14. 제8항에 있어서, 용매가 용매 mL당 약 0.6×10-6g당량의 카르복실레이트 음이온 함량을 갖는 조성물.
  15. 제8항에 있어서, 용매가 용매 mL당 약 0.6×10-6g당량 미만 또는 이와 동일량의 카르복실레이트 음이온 항량을 유지하기에 효과적인 양의 산을 함유하는 조성물.
  16. 제15항에 있어서, 산이 무기산인 조성물.
  17. 제15항에 있어서, 산이 HCl, HBr, HI, HF, H2SO4, HNO3로 이루어진 그룹중에서 선택되는 조성물.
  18. 제8항에 있어서, 가용화제가 피마자유와 피마자유 1몰당 20내지 40몰의 에틸렌옥사이드의 폴리옥시에틸화 피마자유 축합생성물인 조성물.
  19. 제8항에 있어서, 용매가 용매 mL당 약 5.6×10-6g 내지 8.4×10-6g의 H+를 제공하는 양으로 무기산을 함유하는 조성물.
  20. 제8항에 있어서, 가용화제가 폴리옥시에틸화 지질, 폴리옥시에틸화 12-하이드록시 스테아린산 및 폴리에틸렌 글리콜로 이루어진 그룹중에서 선택되는 조성물.
  21. 폴리옥시에틸화 피마자유를 함유한 용매를 카르복실레이트 음이온 함량이 감소되도록 처리하여 항종양화합물의 촉매화 분해를 방지하기에 충분히 낮은 카르복실레이트 음이온 함량을 갖는 용매를 제조하고, 항종양화합물을 용매중에 분산시켜 안정화된 조성물을 제조하는 방법.
  22. 제21항에 있어서, 용매가 에탄올 및 폴리에털렌 글리콜로 이루어진 그룹중에서 선택된 알콜을 함유하는 방법.
  23. 제21항에 있어서, 용매가 에탄올과 폴리옥시에틸화 피마자유가 약 50 : 50용량이로 이루어진 혼합물인 방법.
  24. 제21항에 있어서, 항종양화합물이 테니포시드, 파클리텍셀, 캠프로테신 및 이들의 유도체로 이루어진 그룹중에서 선택되는 방법.
  25. 제21항에 있어서, 처리단계가 폴릭옥시에틸화 피마자유를 알루미늄 옥사이드와 접촉시켜 용매의 카르복실레이트 음이온 함량을 감소시키는 방법.
  26. 제21항에 있어서, 용매가 용매 mL당 약 0.6×10-6g당량 이하의 카르복실레이트 음이온 함량을 갖는 방법.
  27. 제21항에 있어서, 처리단계가 용매 mL당 5.6×10-6g이상의 H+을 제공하는 양으로 산을 첨가하는 방법.
  28. 제21항에 있어서, 처리단계가 용매 mL당 5.6×10-6내지 8.6×10-6g의 H+을 제공하는 양으로 첨가하는 방법.
  29. 제28항에 있어서, 산이 무기산인 방법.
  30. 제28항에 있어서, 산이 HCl, HBr, HF, HI, H2SO4및 HNO3로 이루어진 그룹중에서 선택되는 조성물인 방법.
  31. 카르복실레이트 음이온의 존재하에 분해될 수 있는 하나이상의 약제학적 물질과 알킬렌옥사이드의 축합생성물을 함유하는 약제학적 조성물을 정제하여 카르복실레이트 음이온 함량을 약제학적 물질의 촉매화 분해를 실질적으로 방지하기에 충분한 양으로 감소시켜, 언급된 약제학적 조성물을 안정화하는 방법.
  32. 제31항에 있어서, 약제학적 조성물이 에탄올과 폴리옥시에틸화 피마자유를 약 50 : 50용적의 양으로 함유하는 방법.
  33. 제31항에 있어서, 약제학적 물질이 파클리텍셀, 테니포시드. 캠프토테신 및 이들의 유도체로 이루어진 그룹중에서 선택되는 방법.
  34. 제32항에 있어서, 정제단계가 산을 폴리옥시에틸화 피마자유에 카르복실화 음이온의 양을 감소시켜 약제학적 물질의 분해를 방지하는 양으로 첨가하는 방법.
  35. 제34항에 있어서, 산이 약제학적 조성물 mL당 5.6×10-6g 내지 8.4×10-6g의 H+을 제공하는 양으로 첨가되는 방법.
  36. 제34항에 있어서, 정제단계가 카르복실레이트 음이온 함량을 약제학적 조성물 mL당 0.6×10-6g당량 미만으로 낮쳐주는 방법.
  37. 에탄올과 용해량의 가용화제 하나이상을 함유한 용매를 처리하여 카르복실레이트 음이온 함량을 파크릴텍셀, 테니포시드, 캠프토테신 및 이들의 유도체로 이루어진 그룹중에서 선택된 약제학적 물질의 분해를 실질적으로 방지하기에 충분히 낮은 수준으로 감소시켜, 언급된 약제학적 물질과 용매를 함유한 약제학적 조성물을 안정화시키는 방법.
  38. 제37항에 있어서, 가용화재가 폴리옥시에틸화 지질, 폴리에톡실화 12-하이드록시 스테아린산 및 폴리에틸렌 글리콜로 이루어진 그룹중에서 선택되는 방법.
  39. 제37항에 있어서, 가용화제가 폴리옥시에틸화 피마자유인 방법.
  40. 제37항에 있어서, 폴리옥시에틸화 피마자유가 피마자유와 피마자유 1몰당 약 20 내지 40몰의 에틸렌옥사이드의 축합생성물인 방법.
  41. 제37항에 있어서, 처리단계가 용매를 산과 혼합함을 포함하고, 산이 약제학적 조성몰 mL당 5.6×10-6내피 8.4×10-6g의 H+을 제공하는 양인 방법.
  42. 제38항에 있어서, 처리단계가 용매를 알루미늄 옥사이드와 접촉시켜 카르복실레이트 함량을 감소시켜 약제학적 물질의 분해를 방지하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940025248A 1993-09-29 1994-09-29 안정화된약제학적조성물및안정화용매 KR100515631B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12802693A 1993-09-29 1993-09-29
US08/128.026 1993-09-29

Publications (2)

Publication Number Publication Date
KR950007872A true KR950007872A (ko) 1995-04-15
KR100515631B1 KR100515631B1 (ko) 2005-12-08

Family

ID=22433231

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940025248A KR100515631B1 (ko) 1993-09-29 1994-09-29 안정화된약제학적조성물및안정화용매

Country Status (28)

Country Link
US (1) US5504102A (ko)
EP (1) EP0645145B1 (ko)
JP (1) JP3447386B2 (ko)
KR (1) KR100515631B1 (ko)
CN (1) CN1140297C (ko)
AT (1) ATE149843T1 (ko)
AU (1) AU686651B2 (ko)
BE (1) BE1007987A5 (ko)
BR (1) BR1100361A (ko)
CA (1) CA2132936C (ko)
CY (1) CY2035A (ko)
CZ (2) CZ287358B6 (ko)
DE (1) DE69402022T2 (ko)
DK (1) DK0645145T3 (ko)
ES (2) ES2098842T3 (ko)
FI (1) FI115825B (ko)
GR (1) GR3023583T3 (ko)
HK (1) HK96797A (ko)
HU (1) HU217962B (ko)
IL (1) IL111065A (ko)
IT (1) IT1279383B1 (ko)
NO (1) NO308447B1 (ko)
NZ (1) NZ264526A (ko)
PL (1) PL176826B1 (ko)
RU (1) RU2107500C1 (ko)
SG (1) SG50479A1 (ko)
TW (1) TW406020B (ko)
ZA (1) ZA947482B (ko)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69320206T2 (de) * 1992-11-27 1999-02-11 Napro Biotherapeutics Inc Paclitaxel enthaltende injizierbare zusammensetzung
US20030068362A1 (en) * 1993-02-22 2003-04-10 American Bioscience, Inc. Methods and formulations for the delivery of pharmacologically active agents
US6753006B1 (en) * 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US6096331A (en) 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US20030133955A1 (en) * 1993-02-22 2003-07-17 American Bioscience, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5610173A (en) * 1994-01-07 1997-03-11 Sugen, Inc. Formulations for lipophilic compounds
US6335356B1 (en) 1994-01-07 2002-01-01 Sugen, Inc. Method of treating a patient by parenteral administration of a lipophilic compound
US5631287A (en) * 1994-12-22 1997-05-20 Alcon Laboratories, Inc. Storage-stable prostaglandin compositions
US6011062A (en) * 1994-12-22 2000-01-04 Alcon Laboratories, Inc. Storage-stable prostaglandin compositions
NL9500340A (nl) * 1995-02-22 1996-10-01 Yew Tree Pharmaceuticals B V Gestabiliseerde paclitaxel-oplossing en farmaceutisch preparaat dat deze oplossing bevat.
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
DE19536165A1 (de) * 1995-09-28 1997-04-03 Basf Ag Verfahren zur Reinigung von alkoxylierten Fetten
US6964946B1 (en) 1995-10-26 2005-11-15 Baker Norton Pharmaceuticals, Inc. Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same
US6245805B1 (en) * 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
CN1209059A (zh) * 1995-12-21 1999-02-24 基因实验室技术有限公司 紫杉烷类组合物及方法
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
KR100358934B1 (ko) * 1996-09-13 2003-01-29 주식회사한국신약 탁솔을함유한주사용약제조성물
EP0954283B1 (en) 1996-12-30 2007-03-21 Battelle Memorial Institute Use of a non-encapsulated anticancer drug for the preparation of a formulation for treating neoplasms by inhalation
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US6316479B1 (en) 1997-05-19 2001-11-13 Sugen, Inc. Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders
BE1011216A3 (fr) * 1997-06-13 1999-06-01 Thissen En Abrege L T B Lab Forme pharmaceutique pour l'administration de paclitaxel, procede de preparation d'une composition de paclitaxel prete a l'emploi et utilisation de cette composition.
US5925776A (en) * 1997-12-24 1999-07-20 Schein Pharmacetical, Inc. Polyethoxylated castor oil, process of making the same and formulations thereof
US7030155B2 (en) * 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US5922754A (en) * 1998-10-02 1999-07-13 Abbott Laboratories Pharmaceutical compositions containing paclitaxel
WO2000023070A1 (en) * 1998-10-20 2000-04-27 Ben Venue Laboratories, Inc. Process for purification of solvents useful in the preparation of pharmaceutical compositions
US6017948A (en) * 1998-10-30 2000-01-25 Supergen, Inc. Water-miscible pharmaceutical compositions
US6071952A (en) * 1998-12-02 2000-06-06 Mylan Pharmaceuticals, Inc. Stabilized injectable pharmaceutical compositions containing taxoid anti-neoplastic agents
US6040330A (en) * 1999-01-08 2000-03-21 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of taxanes
US7235583B1 (en) * 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
US6828346B2 (en) * 1999-10-25 2004-12-07 Supergen, Inc. Methods for administration of paclitaxel
US6136846A (en) * 1999-10-25 2000-10-24 Supergen, Inc. Formulation for paclitaxel
WO2001072300A1 (en) * 2000-03-24 2001-10-04 Baker Norton Pharmaceuticals, Inc. Uses of metal salts to stabilize taxane-based compositions
WO2001076559A1 (en) 2000-04-10 2001-10-18 Teva Pharmaceutical Industries Ltd. Method 0f administration of paclitaxel-plasma protein formulation
EP1280557B1 (en) 2000-05-12 2012-06-20 Samyang Corporation Method for the preparation of polymeric micelle via phase separation of block copolymer
US7217770B2 (en) 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
WO2002009695A1 (en) * 2000-08-02 2002-02-07 Atossa Healthcare, Inc. Bimodal emulsions of taxanes and butyrate polyalcohol esters
US6410059B1 (en) * 2000-10-20 2002-06-25 Council Of Scientific And Industrial Research Pharmaceutical composition containing cow urine distillate and an antibiotic
PL203300B1 (pl) 2000-10-31 2009-09-30 Akad Medyczna Stabilna postać farmaceutyczna leku przeciwnowotworowego oraz sposób wytwarzania stabilnej postaci farmaceutycznej leku przeciwnowotworowego
ATE413164T1 (de) 2000-11-09 2008-11-15 Neopharm Inc Sn-38-lipidkomplexe und verfahren zu ihrer verwendung
WO2002043765A2 (en) * 2000-11-28 2002-06-06 Transform Pharmaceuticals, Inc. Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof
ATE414511T1 (de) 2000-12-05 2008-12-15 Los Angeles Childrens Hospital Pharmazeutische zusammensetzungen von fenretinid mit erhöhter bioverfügbarkeit und verfahren zu deren verwendung
US7115565B2 (en) 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
PL207720B1 (pl) * 2001-01-25 2011-01-31 Bristol Myers Squibb Co Sposób przygotowania preparatu farmaceutycznego i jego zastosowanie, farmaceutyczny produkt oraz sposób wytwarzania kompozycji farmaceutycznej
WO2002076402A2 (en) 2001-03-23 2002-10-03 Protarga, Inc. Fatty amine drug conjugates
AU2002305099A1 (en) * 2001-03-23 2002-10-08 Protarga, Inc. Fatty alcohol drug conjugates
DE10115740A1 (de) * 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
EP1379231A2 (en) 2001-04-06 2004-01-14 Cytorex Biosciences, Inc. Pharmacologically active strong acid solutions
WO2003030864A1 (en) * 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
KR100774366B1 (ko) 2001-09-10 2007-11-08 주식회사 중외제약 파클리탁셀 주사제 조성물
KR20030023369A (ko) * 2001-09-13 2003-03-19 한국과학기술연구원 화학색전용 파클리탁셀 유성 조성물, 그의 제형 및 제조방법
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
EP1461056A4 (en) * 2001-11-26 2006-01-25 Supergen Inc PROCESS FOR THE PREPARATION AND USE OF POLYOXYETHYLATED CICRIC OIL IN PHARMACEUTICAL COMPOSITIONS
AU2002357012A1 (en) * 2001-11-27 2003-06-10 Transform Pharmaceuticals, Inc. Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
US20080220075A1 (en) * 2002-03-20 2008-09-11 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
DE60309300T3 (de) * 2002-03-20 2011-02-24 Elan Pharma International Ltd. Nanopartikelzusammensetzungen von angiogeneseinhibitoren
CZ294371B6 (cs) * 2002-06-10 2004-12-15 Pliva - Lachema, A. S. Stabilizovaná farmaceutická kompozice na bázi polyoxyethylovaného ricinového oleje a způsob její přípravy
AU2003247671B2 (en) * 2002-07-15 2008-02-14 Alcon, Inc. Bioerodible film for ophthalmic drug delivery
US20060030578A1 (en) * 2002-08-20 2006-02-09 Neopharm, Inc. Pharmaceutically active lipid based formulation of irinotecan
AU2003296897A1 (en) * 2002-08-20 2004-05-04 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
EP1560577A2 (en) * 2002-11-08 2005-08-10 Bristol-Myers Squibb Company Pharmaceutical compositions and methods of using taxane derivatives
EP1558241A2 (en) * 2002-11-08 2005-08-03 Bristol-Myers Squibb Company Pharmaceutical compositions and methods of using taxane derivatives
ATE437654T1 (de) * 2003-05-19 2009-08-15 Ebewe Pharma Gmbh Nfg Kg Verfahren zur herstellung einer stabilen injizierbaren formulierung von paclitaxel
RU2236852C1 (ru) * 2003-06-23 2004-09-27 Закрытое акционерное общество "ДЕСКО" Средство для ингибирования репродукции оболоченных вирусов, способ его получения, фармацевтическая композиция и способ ингибирования вирусных инфекций
US20050016926A1 (en) * 2003-07-24 2005-01-27 Dabur Research Foundation Stabilized formulation
EP1648988A1 (en) * 2003-07-24 2006-04-26 Dabur Research Foundation Process for the purification of non-ionic solvents for stabilized injectable pharmaceutical formulations
US7311901B2 (en) 2003-10-10 2007-12-25 Samyang Corporation Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
EP1947094A3 (en) 2003-12-12 2009-02-18 Quiral Quimica Do Brasil Process for the preparation of taxane derivatives
CN1893892B (zh) * 2003-12-17 2012-03-28 比奥纽默里克药物公司 喜树碱的药物制剂和制备它们的方法
JP4433918B2 (ja) * 2004-07-15 2010-03-17 コニカミノルタエムジー株式会社 画像形成方法
KR100651728B1 (ko) * 2004-11-10 2006-12-06 한국전자통신연구원 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법
GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos
US7361683B2 (en) * 2004-11-24 2008-04-22 Yung Shin Pharm. Ind., Co., Ltd Paclitaxel aqueous injection solution and methods for preparing the same
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
WO2008105852A2 (en) * 2006-10-26 2008-09-04 Creighton University Mucoadhesive nanoparticles for cancer treatment
US8449886B2 (en) 2008-01-08 2013-05-28 Bristol-Myers Squibb Company Combination of anti-CTLA4 antibody with tubulin modulating agents for the treatment of proliferative diseases
DK2254570T3 (da) * 2008-02-20 2014-02-03 Actelion Pharmaceuticals Ltd Kombination omfattende paclitaxel til behandling af ovariecancer
DE102008059201A1 (de) * 2008-11-27 2010-06-02 GÖPFERICH, Achim, Prof. Dr. In situ präzipitierende Arzneistofflösungen
EP2204167A1 (en) 2009-01-05 2010-07-07 Azad Pharma AG Pharmaceutical microemulsion for preventing supramolecular aggregation of amphiphilic molecules
HUE033312T2 (en) 2009-07-20 2017-11-28 Bristol Myers Squibb Co Combination of anti CTLA4 antibody with etoposide for synergistic treatment of proliferative diseases
AR093275A1 (es) 2010-03-17 2015-05-27 Centro De Excelencia En Productos Y Procesos De Cordoba (Ceprocor) Una composicion farmaceutica soluble en agua que comprende al menos una sustancia terapeuticamente activa de caracteristicas hidrofobicas y al menos un compuesto seleccionado entre los sialoglicoesfingolipidos, los glicoesfingolipidos o una mezcla de sialoglicoesfingolipidos y glicoesfingolipidos
US9345683B2 (en) * 2010-11-08 2016-05-24 Cadila Pharmaceuticals Limited Pharmaceutical composition of taxoids
US9198969B2 (en) * 2012-08-15 2015-12-01 Yung Shin Pharm. Ind. Co., Ltd. Stable pharmaceutical formulation of cabazitaxel
SG11201506116XA (en) * 2013-02-05 2015-09-29 1Globe Health Inst Llc Biodegradable and clinically-compatible nanop articles as drug delivery carriers
EP2777691A1 (en) 2013-03-14 2014-09-17 Pharmachemie B.V. Taxoid - Purification of Liquid Excipients
US10849916B2 (en) 2014-07-11 2020-12-01 Dr. Reddys Laboratories Limited Stable liquid formulations of cyclophosphamide and its impurities
WO2016005962A2 (en) 2014-07-11 2016-01-14 Dr. Reddy’S Laboratories Limited Stable liquid formulations of cyclophosphamide and processes
AR100034A1 (es) 2015-01-30 2016-09-07 Consejo Nac De Investig Científicas Y Técnicas (Conicet) Una composición farmacéutica soluble en agua que comprende, al menos, una sustancia terapéuticamente activa y, al menos, una sustancia con capacidad para formar micelas

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR830002614B1 (ko) * 1980-04-14 1983-05-30 후로인도 산교오 가부시끼 가이샤 활성화된 의약조성물의 제법
JPS61152621A (ja) * 1984-12-27 1986-07-11 Lion Corp 液状透明口腔用組成物
RO92831B1 (ro) * 1985-07-29 1988-01-01 Viorica Dobrescu Procedeu de purificare a polietilenglicolilor
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
JPH02196789A (ja) * 1989-01-25 1990-08-03 Sankyo Co Ltd リゾキシン類化合物の安定化法
JP2598206B2 (ja) * 1992-07-17 1997-04-09 ツヤック株式会社 蛋白繊維品のハイグラル・エクスパンションの安定化法
DE69320206T2 (de) * 1992-11-27 1999-02-11 Napro Biotherapeutics Inc Paclitaxel enthaltende injizierbare zusammensetzung
AU5553894A (en) * 1992-11-27 1994-06-22 F.H. Faulding & Co. Limited Injectable taxol composition

Also Published As

Publication number Publication date
BR1100361A (pt) 2000-07-18
JP3447386B2 (ja) 2003-09-16
ES2098842T3 (es) 1997-05-01
ZA947482B (en) 1995-05-15
HK96797A (en) 1997-08-08
PL176826B1 (pl) 1999-07-30
RU2107500C1 (ru) 1998-03-27
AU686651B2 (en) 1998-02-12
AU7427394A (en) 1995-04-13
SG50479A1 (en) 1998-07-20
IL111065A (en) 2003-03-12
ITRM940621A0 (it) 1994-09-28
CY2035A (en) 1998-02-20
NO943583L (no) 1995-03-30
CZ234994A3 (en) 1995-04-12
CZ287358B6 (en) 2000-11-15
NZ264526A (en) 1996-10-28
NO308447B1 (no) 2000-09-18
HUT68687A (en) 1995-07-28
ES2095802A1 (es) 1997-02-16
KR100515631B1 (ko) 2005-12-08
EP0645145A3 (en) 1995-05-24
FI944448A (fi) 1995-03-30
US5504102A (en) 1996-04-02
HU9402776D0 (en) 1994-12-28
CA2132936C (en) 1999-06-29
HU217962B (hu) 2000-05-28
DK0645145T3 (da) 1997-04-07
JPH07179362A (ja) 1995-07-18
PL305240A1 (en) 1995-04-03
CZ287485B6 (cs) 2000-12-13
CA2132936A1 (en) 1995-03-30
CN1140297C (zh) 2004-03-03
FI944448A0 (fi) 1994-09-26
BE1007987A5 (fr) 1995-12-05
DE69402022T2 (de) 1997-07-17
IL111065A0 (en) 1994-12-29
EP0645145A2 (en) 1995-03-29
CN1107367A (zh) 1995-08-30
ATE149843T1 (de) 1997-03-15
ITRM940621A1 (it) 1996-03-28
EP0645145B1 (en) 1997-03-12
DE69402022D1 (de) 1997-04-17
IT1279383B1 (it) 1997-12-10
NO943583D0 (no) 1994-09-27
FI115825B (fi) 2005-07-29
TW406020B (en) 2000-09-21
GR3023583T3 (en) 1997-08-29
RU94037231A (ru) 1996-09-27

Similar Documents

Publication Publication Date Title
KR950007872A (ko) 안정화된 약제학적 조성물 및 안정화용매
AU771577B2 (en) Stabilized injectable pharmaceutical compositions containing taxoid anti-neoplastic agents
KR100330316B1 (ko) 탁산유도체를기재로한주사용조성물
KR960028918A (ko) 국소용 약제학적 조성물
BR0206511A (pt) Formulação parenteral para análogos de epotilona
KR950703932A (ko) 안정화된 의학용 에어로졸 용액 제제(Stabilized medicinal aerosol solution formulations)
IL151311A0 (en) Pharmaceutical compositions containing propofol
US7699987B2 (en) Stabilized formulation
JP3199475B2 (ja) ビタミンａ類可溶化水溶液の安定化法
KR930702965A (ko) 생체이용성이 개선된 프로부콜 함유 제약 조성물
IE873348L (en) Compositions for topical application
AU2003256786B2 (en) Process for the purification of non-ionic solvents for stabilized injectable pharmaceutical formulations
Whitworth et al. Stability of aspirin in liquid and semisolid bases IV: Polyethylene glycol 400 diacetate and triethylene glycol diacetate
Ghosh et al. Product development studies for the selection of an ideal solvent system for diazepam in injectable formulations
NL9500340A (nl) Gestabiliseerde paclitaxel-oplossing en farmaceutisch preparaat dat deze oplossing bevat.

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
AMND Amendment
E902 Notification of reason for refusal
AMND Amendment
E601 Decision to refuse application
E601 Decision to refuse application
J201 Request for trial against refusal decision
AMND Amendment
E902 Notification of reason for refusal
E902 Notification of reason for refusal
B701 Decision to grant
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20080825

Year of fee payment: 4

LAPS Lapse due to unpaid annual fee