KR930702965A - 생체이용성이 개선된 프로부콜 함유 제약 조성물 - Google Patents
생체이용성이 개선된 프로부콜 함유 제약 조성물Info
- Publication number
- KR930702965A KR930702965A KR1019930701836A KR930701836A KR930702965A KR 930702965 A KR930702965 A KR 930702965A KR 1019930701836 A KR1019930701836 A KR 1019930701836A KR 930701836 A KR930701836 A KR 930701836A KR 930702965 A KR930702965 A KR 930702965A
- Authority
- KR
- South Korea
- Prior art keywords
- probucol
- pharmaceutical composition
- fatty acids
- group
- containing pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Polyesters Or Polycarbonates (AREA)
Abstract
본 발명은 일반식 CXH2XO2(식중, x는 4,6,8,10,12,14,16임)로 표시되는 지방산으로 이루어진 군에서 선택된 지방산의 프로필렌 글리콜 에스테르 중에 용해된 치료적 유효량의 프로부콜로 이루어진, 환자에 있어서 약제의 생체이용성을 개선시키고 혈장 약제 농도의 가변성을 감소시키는 프로부콜의 제약 조성물에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 일반식 CXH2XO2(식중, x는 4,6,8,10,12,14,16임)로 표시되는 지방산으로 이루어진 군에서 선택된 지방산의 프로필렌 글리콜 에스테르 중에 용해된 치료적 유효량의 프로부콜로 이루어진 것이 특징인, 환자의 혈장 프로부콜 농도의 가변성을 감소시키면서 프로부콜의 생체이용성을 개선시키는 프로부콜의 제약 조성물.
- 제1항에 있어서, 지방산이 일반식 CXH2XO2(식중, x는 4,8,10,12임)로 표시되는 지방산으로 이루어진 군에서 선택되는 제약 조성물.
- 제1항에 있어서, 지방산이 카프린산 및 카프릴산으로 이루어진 군에서 선택되는 제약 조성물.
- 혈청 콜레스테롤 농도를 저하시키기 위한 제1항 내지 3항중 어느 한 항에 따른 제약 조성물의 용도.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62954090A | 1990-12-18 | 1990-12-18 | |
US629,540 | 1990-12-18 | ||
PCT/US1991/008565 WO1992010996A1 (en) | 1990-12-18 | 1991-11-15 | Enhanced bioavailability pharmaceutical composition containing probucol |
Publications (2)
Publication Number | Publication Date |
---|---|
KR930702965A true KR930702965A (ko) | 1993-11-29 |
KR0177845B1 KR0177845B1 (ko) | 1999-03-20 |
Family
ID=24523438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019930701836A KR0177845B1 (ko) | 1990-12-18 | 1991-11-15 | 생체이용성이 개선된 프로부콜 함유 제약 조성물 |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0563112B1 (ko) |
JP (1) | JP3127998B2 (ko) |
KR (1) | KR0177845B1 (ko) |
AT (1) | ATE117200T1 (ko) |
AU (1) | AU647563B2 (ko) |
CA (1) | CA2097827C (ko) |
DE (1) | DE69106892T2 (ko) |
DK (1) | DK0563112T3 (ko) |
ES (1) | ES2069987T3 (ko) |
FI (1) | FI102457B1 (ko) |
GR (1) | GR3015837T3 (ko) |
HU (1) | HU210565B (ko) |
IE (1) | IE65578B1 (ko) |
IL (1) | IL100390A (ko) |
NO (1) | NO303526B1 (ko) |
NZ (1) | NZ240961A (ko) |
WO (1) | WO1992010996A1 (ko) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2517095A (en) * | 1994-05-19 | 1995-12-18 | R.P. Scherer International Corporation | Solutions of aryl or heteroaryl substituted alkanoic acids in lipophilic solvents and soft gelatin capsules containing such solutions |
US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
US6838091B2 (en) | 1998-12-18 | 2005-01-04 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US6814977B1 (en) | 1998-12-18 | 2004-11-09 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US7014864B1 (en) | 1998-12-18 | 2006-03-21 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
WO2000037057A2 (en) * | 1998-12-18 | 2000-06-29 | Abbott Laboratories | Novel formulations comprising lipid-regulating agents |
AU2571400A (en) * | 1999-02-23 | 2000-09-14 | Chugai Seiyaku Kabushiki Kaisha | Seam soft capsule preparations containing dihydrobenzofuran derivative |
US6719999B2 (en) | 1999-03-31 | 2004-04-13 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US6372251B2 (en) | 1999-06-11 | 2002-04-16 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
WO2005037251A1 (en) * | 2003-10-17 | 2005-04-28 | Amylin Pharmaceuticals, Inc. | Self-emulsifying drug delivery systems for hydrophobic therapeutic compounds |
US12016830B2 (en) | 2022-07-01 | 2024-06-25 | Acrotech Biopharma, LLC | Pharmaceutical compositions comprising isotretinoin and processes for preparation and uses thereof |
CN116617179B (zh) * | 2023-05-19 | 2024-03-29 | 齐鲁制药有限公司 | 一种普罗布考软胶囊及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3862332A (en) * | 1967-05-11 | 1975-01-21 | Dow Chemical Co | Method of lowering serum cholesterol |
US4902513A (en) * | 1987-07-31 | 1990-02-20 | Jean Carvais | Oral sustained release medicament |
-
1991
- 1991-11-15 AU AU90678/91A patent/AU647563B2/en not_active Expired
- 1991-11-15 DE DE69106892T patent/DE69106892T2/de not_active Expired - Lifetime
- 1991-11-15 WO PCT/US1991/008565 patent/WO1992010996A1/en active IP Right Grant
- 1991-11-15 HU HU9301769A patent/HU210565B/hu unknown
- 1991-11-15 DK DK92900932.2T patent/DK0563112T3/da active
- 1991-11-15 EP EP92900932A patent/EP0563112B1/en not_active Expired - Lifetime
- 1991-11-15 CA CA002097827A patent/CA2097827C/en not_active Expired - Lifetime
- 1991-11-15 JP JP04501952A patent/JP3127998B2/ja not_active Expired - Lifetime
- 1991-11-15 KR KR1019930701836A patent/KR0177845B1/ko not_active IP Right Cessation
- 1991-11-15 ES ES92900932T patent/ES2069987T3/es not_active Expired - Lifetime
- 1991-11-15 AT AT92900932T patent/ATE117200T1/de not_active IP Right Cessation
- 1991-12-12 NZ NZ240961A patent/NZ240961A/en not_active IP Right Cessation
- 1991-12-16 IL IL10039091A patent/IL100390A/en not_active IP Right Cessation
- 1991-12-17 IE IE440191A patent/IE65578B1/en not_active IP Right Cessation
-
1993
- 1993-06-16 FI FI932769A patent/FI102457B1/fi not_active IP Right Cessation
- 1993-06-17 NO NO932236A patent/NO303526B1/no not_active IP Right Cessation
-
1995
- 1995-04-17 GR GR950400967T patent/GR3015837T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK0563112T3 (da) | 1995-04-10 |
AU9067891A (en) | 1992-07-22 |
FI102457B (fi) | 1998-12-15 |
IE914401A1 (en) | 1992-07-01 |
NO932236D0 (no) | 1993-06-17 |
JPH06503340A (ja) | 1994-04-14 |
FI932769A (fi) | 1993-06-16 |
EP0563112B1 (en) | 1995-01-18 |
NZ240961A (en) | 1994-03-25 |
NO932236L (no) | 1993-06-17 |
HU210565B (en) | 1995-05-29 |
EP0563112A1 (en) | 1993-10-06 |
NO303526B1 (no) | 1998-07-27 |
ES2069987T3 (es) | 1995-05-16 |
CA2097827A1 (en) | 1992-06-19 |
AU647563B2 (en) | 1994-03-24 |
DE69106892T2 (de) | 1995-05-18 |
IL100390A0 (en) | 1992-09-06 |
KR0177845B1 (ko) | 1999-03-20 |
FI102457B1 (fi) | 1998-12-15 |
IE65578B1 (en) | 1995-11-01 |
DE69106892D1 (de) | 1995-03-02 |
ATE117200T1 (de) | 1995-02-15 |
HU9301769D0 (en) | 1993-09-28 |
HUT64218A (en) | 1993-12-28 |
IL100390A (en) | 1996-12-05 |
WO1992010996A1 (en) | 1992-07-09 |
GR3015837T3 (en) | 1995-07-31 |
FI932769A0 (fi) | 1993-06-16 |
JP3127998B2 (ja) | 2001-01-29 |
CA2097827C (en) | 2002-07-23 |
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Legal Events
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A201 | Request for examination | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20101118 Year of fee payment: 13 |
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EXPY | Expiration of term |