Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Sekisui Chemical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Sekisui Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd, Sekisui Chemical Co LtdfiledCriticalChugai Pharmaceutical Co Ltd
Priority to JP8108388ApriorityCriticalpatent/JPS6425720A/en
Publication of JPS6425720ApublicationCriticalpatent/JPS6425720A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
PURPOSE:To obtain a percutaneous absorption pharmaceutical, by using a specific absorbefacient consisting of combination of a fatty acid ester with a specific N-acylsarcosine, etc., and capable of improving percutaneous absorbability and stability of nicorandils useful as a remedy for angina pectoris. CONSTITUTION:A percutaneous absorption pharmaceutical, obtained by blending nicorandil useful as the above-mentioned medicine and/or salts thereof with an absorbefacient consisting of combination of (A) a fatty acid ester, preferably an ester synthesized from a 10-18C fatty acid and a 1-20C alcohol, especially isopropyl myristate, etc., with (B) an N-acylsarcosine, fatty acid mono- or diethanolamides or alkylene oxide adducts thereof, preferably N-lauroylsarcosine, lauroylmono- or diethanolamide, etc., in a base and having excellent absorbability and stability of the aforementioned medicine.
1-Substituted-2- (3-amino-1-propynyl) pyrrolidine derivatives, thereby methods for treating central cholinergic dysfunction and pharmaceutical compositions thereof