KR950000143A - 아스파테이트 또는 아스파라긴을 유효성분으로 함유하는 알콜성 장해보호제 및 그의 제조방법 - Google Patents
아스파테이트 또는 아스파라긴을 유효성분으로 함유하는 알콜성 장해보호제 및 그의 제조방법 Download PDFInfo
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- KR950000143A KR950000143A KR1019930026324A KR930026324A KR950000143A KR 950000143 A KR950000143 A KR 950000143A KR 1019930026324 A KR1019930026324 A KR 1019930026324A KR 930026324 A KR930026324 A KR 930026324A KR 950000143 A KR950000143 A KR 950000143A
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- A—HUMAN NECESSITIES
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Abstract
알콜의 여러가지 대사 경로 중에서 가장 중요한 과정은 알콜디히드로케나제(alcohol dehydrogenase, ADH)와 아세트알데히드디드로게나제(acetaldehyed dehydrogenase, ALDH)를 이용하는 방법이다.
종래 대부분의 알콜관련 연구는 이러한 효소들의 활성을 부활 또는 저해하는 물질의 구멍에 제한되어 왔고, 이들이 작용하는데 필요한 조효소인 니콘틴산아미드 아데닌 디뉴클레오티드(Nicotinamide Adenine Dinucleotide; NAD)에 대한 방안은 전혀 강구되어 있지 못하였다.
NAD는 옥살로아세테이트가 말레이트로 변하는 과정에서 생성되어 알콜대사에 이용될 수 있는데 이 과정에 필요한 옥살로아세테이트는 세포막 투과가 어렵기 때문에 L-아스파테이트 또는 아스파라긴을 투여하여 세포내에 흡수된 다음, 대부분 조직세포들에 대량 존재하는 아미노트랜스퍼라제에 의하여 2차적으로 옥살로 아세테이트가 생성되도록 유도하였다.
그 결과 실제로 정상인들을 대상으로 120ml의 위스키(43%)를 음용시 1시간뒤 혈중농도가 0.055g/dl이었고, 3시간뒤 0.024g/dl이었으나, 동양의 알콜과 5g의 L-아스파테이트 또는 아스파라긴을 함께 복용시에는 혈중 알콜 농도가 1시간 뒤 0.025g/dl, 3시간 뒤에는 0.018g/dl로 알콜단독 투여군에 비하여 55%이상 혈중 농도를 저하시키는 효과를 보였다. 뿐만 아니라, 간략한 신체 균형 검사에서도 아스파트산염 또는 아스파라긴 공동투여는 오류 발생율을 50%정도 저하시키는 유의한 효과를 보였다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 알콜의 체내 산화대사경로, 제2도는 말레이트/아스파테이트 샤틀을 이용한 세포질 NAD 재생기작, 제3도는 MSA 투여에 의한 알콜음용에 따른 혈중 농도변화이다.
Claims (20)
- L-아스파테이트(L-Aspartare) 또는 아스파라긴(Asparagine)의 각각 또는 그들의 혼합물을 유효성분으로 함유함을 특징으로 하는 알콜성 장해 보호제.
- 제1항에 있어서, L-아스파테이트 또는 아스파라긴으로 환산하여 하루에 0.01-0.4g/Kg 체중의 양으로 사용됨을 특징으로 하는 알콜성 장해 보호제.
- 제1항에 있어서, 알콜성 장해는 알콜성 간기능 저해방지 또는 알콜성 간조직 손상보호 또는 알콜성 정신 및 행동장해 임을 특징으로 하는 알콜성 장해 보호제.
- 제1항에 있어서, 아스파테이트 또는 아스파라긴을 각각 또는 혼합하여 물, 탄산수, 비타민, 당류, 소금, 스프류, 육류, 아미노산, 과실류, 곡류, 채소류, 어류, 해조류 또는 유기산으로부터 선택된 1종 또는 2종 이상과 함께 함유함을 특징으로 하는 알콜성 장해 보호제.
- 제4항에 있어서, 당류는 단당류, 이당류, 다당류 임을 특징으로 하는 알콜성 장해 보호제.
- 제4항에 있어서, 스프류는 콩나물 스프, 아스파라거스 스프 또는 생선육(fish soup)임을 특징으로 하는 알콜성 장해 보호제.
- 제4항에 있어서, 육류는 쇠고기, 돼지고기, 양고기 또는 닭고기임을 특징으로 하는 알콜성 장해 보호제.
- 제4항에 있어서, 아미노산은 이소루이신, 루이신, 발린 또는 타우린임을 특징으로 하는 알콜성 장해보호제.
- 제4항에 있어서, 과실류는 배, 복숭아, 사과, 무화과, 딸기, 파인애플, 오렌지 또는 자두임을 특징으로 하는 알콜성 장해 보호제.
- 제4항에 있어서, 곡류 및 채소류는 콩, 숙주, 강남콩, 땅콩, 아스파라거스, 박, 호박, 연근, 근대, 고구마 또는 감자임을 특징으로 하는 알콜성 장해 보호제.
- 제4항에 있어서, 어류 및 해조류는 김, 미역, 다시마, 오징어 또는 북어임을 특징으로 하는 알콜성 장해 보호제.
- 제4항에 있어서, 유기산은 구연산, 사과산, 호박산 또는 주석산임을 특징으로 하는 알콜성 장해 보호제.
- 제1항에 있어서, L-아스파테이트 또는 아스파라긴을 각각 또는 혼합하여 0.1-90중량%의 양으로 함유함을 특징으로 하는 알콜성 장해 보호제.
- 제13항에 있어서, L-아스파테이트 또는 아스파라긴을 각각 또는 혼합하여 0.1-10중량%의 양으로 함유함을 특징으로 하는 알콜성 장해 보호제.
- 제13항에 있어서, L-아스파테이트 또는 아스파라긴을 각각 또는 혼합하여 0.2-90중량%의 양으로 함유함을 특징으로 하는 고체 또는 분말형 알콜성 장해 보호제.
- 제1항에 있어서, 상기 보호제를 알콜 음용전 1시간 이내 또는 알콜 음용시 또는 알콜 음용후 1시간내에 투여함을 특징으로 하는 알콜성 장해 보호제.
- 제1항에 있어서, 상기 보호제를 사람의 근육, 피하 또는 정맥에 주사함을 특징으로 하는 알콜성 장해 보호제.
- L-아스파테이트 또는 아스파라긴을 각각 또는 혼합하여 물 , 탄산수, 비타민, 당류, 소금, 스프류, 육류, 아미노산, 과실류, 곡류, 채소류, 어류, 해조류 또는 유기산으로부터 선택된 1종 또는 2종 이상과 함께 함유함을 특징으로 하는 알콜성 장해 보호제를 제조하는 방법.
- 제18항에 있어서, L-아스파테이트 또는 아스파라긴을 각각 또는 혼합하여 0.1-10중량%의 양으로 함유함을 특징으로 하는 액체형 알콜성 장해 보호제를 제조하는 방법.
- 제18항에 있어서, L-아스파테이트 또는 아스파라긴을 각각 또는 혼합하여 0.2-90중량%의 양으로 함유함을 특징으로 하는 고체 또는 분말형 알콜성 장해 보호제를 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019930026324A KR970008105B1 (ko) | 1993-06-28 | 1993-12-03 | L-아스파테이트 또는 아스파라긴을 유효성분으로 함유하는 알콜성 장해 보호제 및 그의 제조방법 |
| US08/182,506 US5389359A (en) | 1993-06-28 | 1994-01-18 | Pharmaceutical preparation containing L-aspartate or L-asparagine for preventing ethanol toxicity, and process for preparation thereof |
| EP94101990A EP0631778A1 (en) | 1993-06-28 | 1994-02-09 | Use of L-aspartate or L-asparagine to prevent alcohol toxicity |
| JP6021537A JPH0753366A (ja) | 1993-06-28 | 1994-02-18 | エタノール毒性を防止するためのｌ−アスパラギン酸、ｌ−アスパラギンまたはその塩を含む医薬製剤、その製造方法及び食品組成物 |
| TW083101619A TW278035B (ko) | 1993-06-28 | 1994-02-25 | |
| BR9401354A BR9401354A (pt) | 1993-06-28 | 1994-03-30 | Preparo farmacêutico contendo L-aspartato ou L-aspargina para evitar a toxidade do etanol, e processo para o seu preparo |
| CN94104765A CN1098624A (zh) | 1993-06-28 | 1994-05-02 | 用于预防酒精中毒的药物制剂及其制备方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR93-11849 | 1993-06-28 | ||
| KR930011849 | 1993-06-28 | ||
| KR?93-11849? | 1993-06-28 | ||
| KR1019930026324A KR970008105B1 (ko) | 1993-06-28 | 1993-12-03 | L-아스파테이트 또는 아스파라긴을 유효성분으로 함유하는 알콜성 장해 보호제 및 그의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR950000143A true KR950000143A (ko) | 1995-01-03 |
| KR970008105B1 KR970008105B1 (ko) | 1997-05-21 |
Family
ID=26629748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930026324A KR970008105B1 (ko) | 1993-06-28 | 1993-12-03 | L-아스파테이트 또는 아스파라긴을 유효성분으로 함유하는 알콜성 장해 보호제 및 그의 제조방법 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5389359A (ko) |
| EP (1) | EP0631778A1 (ko) |
| JP (1) | JPH0753366A (ko) |
| KR (1) | KR970008105B1 (ko) |
| CN (1) | CN1098624A (ko) |
| BR (1) | BR9401354A (ko) |
| TW (1) | TW278035B (ko) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020088734A (ko) * | 2001-05-21 | 2002-11-29 | 엄경용 | 숙취 해소용 조성물 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006061992A1 (ja) * | 2004-12-10 | 2006-06-15 | Ajinomoto Co., Inc. | 肝疾患予防・治療用組成物 |
| JP2007020432A (ja) * | 2005-07-13 | 2007-02-01 | Asahi Breweries Ltd | アルコール代謝促進飲料 |
| US7565555B2 (en) * | 2005-11-23 | 2009-07-21 | Cisco Technology, Inc. | Uninterruptible power supply resource sharing for multiple power sourcing equipment network devices |
| JPWO2007142297A1 (ja) * | 2006-06-09 | 2009-10-29 | 味の素株式会社 | 肝疾患予防・治療用組成物 |
| IT1395957B1 (it) * | 2009-05-19 | 2012-11-02 | Pharmaguida S R L | Uso di una combinazione di d-aspartato e l-aspartato per il trattamento della infertilita' maschile. |
| WO2013168694A1 (ja) * | 2012-05-07 | 2013-11-14 | 株式会社明治 | 非糖質性エネルギー産生増強剤 |
| US9161957B2 (en) | 2012-08-03 | 2015-10-20 | Life Well Lived, Llc | Compositions and methods for reducing blood alcohol content |
| WO2015008101A1 (en) | 2013-07-15 | 2015-01-22 | Schaumlöffel Rolf A | Composition of a drink for enhanced reduction of blood alcohol level |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3009859A (en) * | 1958-07-22 | 1961-11-21 | Laborit Henri | Potassium aspartate and magnesium aspartate fatigue-recovery promoting process and compositions |
| GB949076A (en) * | 1961-08-10 | 1964-02-12 | Wesley Gale Irons | Preparation of polypeptide derivatives |
| GB1066084A (en) * | 1963-05-08 | 1967-04-19 | Kyowa Hakko Kogyo Kk | Improved alcoholic beverages |
| GB1068478A (en) * | 1963-07-30 | 1967-05-10 | Kyowa Hakko Kogyo Kk | Increasing amino-acid content of food |
| RO55542A2 (ko) * | 1971-02-27 | 1973-09-20 | ||
| CA1057568A (en) * | 1974-06-10 | 1979-07-03 | General Foods Corporation | Soluble sweetening composition and method |
| FR2310708A1 (fr) * | 1975-05-16 | 1976-12-10 | Sopharga Lab | Nouvelles boissons sans alcools |
| US4479974A (en) * | 1982-10-19 | 1984-10-30 | General Foods Corporation | Amino acids as dry beverage mix ingredients |
| GB8325627D0 (en) * | 1983-09-24 | 1983-10-26 | Scras | Therapeutic compositions |
| US4913923A (en) * | 1984-09-12 | 1990-04-03 | Firmenich Sa | Process for improving or modifying the taste and aroma of citrus fruit compositions |
| US4738856A (en) * | 1985-05-13 | 1988-04-19 | Nutrition Technologies, Inc. | Beverage and method for making a beverage for the nutritional supplementation of calcium in humans |
| US4997672A (en) * | 1987-03-10 | 1991-03-05 | Virginia Commonwealth University | Salt taste enhancer |
| EP0336960A4 (en) * | 1987-10-19 | 1990-02-20 | Joseph A Haklitch | DETOXIDATION ADDITIVES FOR FOODSTUFFS. |
| IT1219919B (it) * | 1988-04-11 | 1990-05-24 | Foscama Biomed Chim Farma | Impiego del fruttosio-1,6-difosfato nel trattamento della intossicazione alcolica acuta e dell' etilismo cronico e composizioni farmaceutiche relative |
| US4992282A (en) * | 1989-05-08 | 1991-02-12 | The Procter & Gamble Company | Stable nutritional vitamin and mineral supplemented beverage |
| AT394493B (de) * | 1989-05-11 | 1992-04-10 | Homosan Ag | Pharmazeutisches praeparat zur behandlung von lebererkrankungen |
| HU207800B (en) * | 1990-05-10 | 1993-06-28 | Andras Sikter | Process for producing composition for improving condition and for treating different illnesses |
| US5145707A (en) * | 1991-12-12 | 1992-09-08 | Kraft General Foods, Inc. | Salt enhancer |
| US5176934A (en) * | 1991-12-12 | 1993-01-05 | Kraft General Foods, Inc. | Seasoned food product with a salt enhancer |
| KR930012028A (ko) * | 1991-12-19 | 1993-07-20 | 박용성 | 생약제제 |
-
1993
- 1993-12-03 KR KR1019930026324A patent/KR970008105B1/ko not_active IP Right Cessation
-
1994
- 1994-01-18 US US08/182,506 patent/US5389359A/en not_active Expired - Lifetime
- 1994-02-09 EP EP94101990A patent/EP0631778A1/en not_active Withdrawn
- 1994-02-18 JP JP6021537A patent/JPH0753366A/ja active Pending
- 1994-02-25 TW TW083101619A patent/TW278035B/zh active
- 1994-03-30 BR BR9401354A patent/BR9401354A/pt not_active Application Discontinuation
- 1994-05-02 CN CN94104765A patent/CN1098624A/zh active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020088734A (ko) * | 2001-05-21 | 2002-11-29 | 엄경용 | 숙취 해소용 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR970008105B1 (ko) | 1997-05-21 |
| BR9401354A (pt) | 1995-03-07 |
| CN1098624A (zh) | 1995-02-15 |
| JPH0753366A (ja) | 1995-02-28 |
| TW278035B (ko) | 1996-06-11 |
| EP0631778A1 (en) | 1995-01-04 |
| US5389359A (en) | 1995-02-14 |
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