IT1395957B1 - Uso di una combinazione di d-aspartato e l-aspartato per il trattamento della infertilita' maschile. - Google Patents

Uso di una combinazione di d-aspartato e l-aspartato per il trattamento della infertilita' maschile.

Info

Publication number
IT1395957B1
IT1395957B1 ITRM2009A000253A ITRM20090253A IT1395957B1 IT 1395957 B1 IT1395957 B1 IT 1395957B1 IT RM2009A000253 A ITRM2009A000253 A IT RM2009A000253A IT RM20090253 A ITRM20090253 A IT RM20090253A IT 1395957 B1 IT1395957 B1 IT 1395957B1
Authority
IT
Italy
Prior art keywords
aspartate
treatment
combination
male infertility
infertility
Prior art date
Application number
ITRM2009A000253A
Other languages
English (en)
Inventor
Aniello Salvatore D
Aniello Enrico D
Original Assignee
Pharmaguida S R L
Aniello D
Ronsini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITRM2009A000253A priority Critical patent/IT1395957B1/it
Application filed by Pharmaguida S R L, Aniello D, Ronsini filed Critical Pharmaguida S R L
Priority to ES10736818.5T priority patent/ES2555387T3/es
Priority to KR1020167031463A priority patent/KR20160132500A/ko
Priority to JP2012511414A priority patent/JP5833545B2/ja
Priority to EP10736818.5A priority patent/EP2432463B1/en
Priority to KR1020117030391A priority patent/KR20120038408A/ko
Priority to AU2010250747A priority patent/AU2010250747B2/en
Priority to BRPI1011103A priority patent/BRPI1011103B8/pt
Priority to ITRM2010A000255A priority patent/IT1400312B1/it
Priority to US13/320,780 priority patent/US20120095100A1/en
Priority to CA2759674A priority patent/CA2759674C/en
Priority to PCT/IT2010/000222 priority patent/WO2010134117A1/en
Priority to MX2011012323A priority patent/MX2011012323A/es
Priority to SG2011077302A priority patent/SG175304A1/en
Priority to CN2010800223090A priority patent/CN102438611A/zh
Priority to KR1020187036782A priority patent/KR102054942B1/ko
Priority to EA201171431A priority patent/EA021832B1/ru
Publication of ITRM20090253A1 publication Critical patent/ITRM20090253A1/it
Priority to ZA2011/07764A priority patent/ZA201107764B/en
Priority to IL216112A priority patent/IL216112A/en
Publication of IT1395957B1 publication Critical patent/IT1395957B1/it
Application granted granted Critical
Priority to US14/288,439 priority patent/US10342826B2/en
Priority to US16/504,372 priority patent/US11524031B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Fodder In General (AREA)
ITRM2009A000253A 2009-05-19 2009-05-19 Uso di una combinazione di d-aspartato e l-aspartato per il trattamento della infertilita' maschile. IT1395957B1 (it)

Priority Applications (21)

Application Number Priority Date Filing Date Title
ITRM2009A000253A IT1395957B1 (it) 2009-05-19 2009-05-19 Uso di una combinazione di d-aspartato e l-aspartato per il trattamento della infertilita' maschile.
MX2011012323A MX2011012323A (es) 2009-05-19 2010-05-19 Uso de una combinacion de acidos d-aspartico y l-aspartico o sus sales para el tratamiento de infertilidad masculina.
PCT/IT2010/000222 WO2010134117A1 (en) 2009-05-19 2010-05-19 Use of a combination of d-aspartic and l-aspartic acids or salts thereof for the treatment of male infertility
EP10736818.5A EP2432463B1 (en) 2009-05-19 2010-05-19 Use of a combination of d-aspartic and l-aspartic acids or salts thereof for the treatment of male infertility
KR1020117030391A KR20120038408A (ko) 2009-05-19 2010-05-19 남성 불임을 치료하기 위한 ｄ－아스파르트산 및 ｌ－아스파르트산 또는 이들 염의 조합체의 용도
AU2010250747A AU2010250747B2 (en) 2009-05-19 2010-05-19 Use of a combination of D-aspartic and L-aspartic acids or salts thereof for the treatment of male infertility
BRPI1011103A BRPI1011103B8 (pt) 2009-05-19 2010-05-19 composição para tratar infertilidade masculina e usos de ácido d-aspártico e de ácido l-aspártico
ITRM2010A000255A IT1400312B1 (it) 2009-05-19 2010-05-19 Uso di una combinazione di acido d-aspartico e l-aspartico o di loro sali per il trattamento della infertilita' maschile.
US13/320,780 US20120095100A1 (en) 2009-05-19 2010-05-19 Use of a combination of d-aspartic and l-aspartic acids or salts thereof for the treatment of male infertility
SG2011077302A SG175304A1 (en) 2009-05-19 2010-05-19 Use of a combination of d-aspartic and l-aspartic acids or salts thereof for the treatment of male infertility
ES10736818.5T ES2555387T3 (es) 2009-05-19 2010-05-19 Uso de una combinación de ácidos D-aspártico y L-aspártico o sus sales para el tratamiento de la esterilidad masculina
JP2012511414A JP5833545B2 (ja) 2009-05-19 2010-05-19 男性不妊の治療のための、ｄ−アスパラギン酸とｌ−アスパラギン酸またはこれら酸の塩の組み合わせの使用
CA2759674A CA2759674C (en) 2009-05-19 2010-05-19 Use of a combination of d-aspartic and l-aspartic acids or salts thereof for the treatment of male infertility
CN2010800223090A CN102438611A (zh) 2009-05-19 2010-05-19 D-天冬氨酸和l-天冬氨酸或其盐联用治疗男性不育的应用
KR1020187036782A KR102054942B1 (ko) 2009-05-19 2010-05-19 남성 불임을 치료하기 위한 ｄ－아스파르트산 및 ｌ－아스파르트산 또는 이들 염의 조합체의 용도
EA201171431A EA021832B1 (ru) 2009-05-19 2010-05-19 Применение комбинации d-аспарагиновой и l-аспарагиновой кислот или их солей для лечения мужского бесплодия
KR1020167031463A KR20160132500A (ko) 2009-05-19 2010-05-19 남성 불임을 치료하기 위한 ｄ－아스파르트산 및 ｌ－아스파르트산 또는 이들 염의 조합체의 용도
ZA2011/07764A ZA201107764B (en) 2009-05-19 2011-10-24 Use of a combination of d-aspartic and l-aspartic acids or salts thereof for the treatment of male infertility
IL216112A IL216112A (en) 2009-05-19 2011-11-03 Preparations that are a combination of d-aspartic acid and l-aspartic acid or their salts for the treatment of male infertility
US14/288,439 US10342826B2 (en) 2009-05-19 2014-05-28 Use of a combination of D-aspartic and L-aspartic acids or salts thereof for the treatment of male infertility
US16/504,372 US11524031B2 (en) 2009-05-19 2019-07-08 Use of a combination of D-aspartic and L-aspartic acids or salts thereof for the treatment of male infertility

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM2009A000253A IT1395957B1 (it) 2009-05-19 2009-05-19 Uso di una combinazione di d-aspartato e l-aspartato per il trattamento della infertilita' maschile.

Publications (2)

Publication Number Publication Date
ITRM20090253A1 ITRM20090253A1 (it) 2010-11-20
IT1395957B1 true IT1395957B1 (it) 2012-11-02

Family

ID=41262507

Family Applications (2)

Application Number Title Priority Date Filing Date
ITRM2009A000253A IT1395957B1 (it) 2009-05-19 2009-05-19 Uso di una combinazione di d-aspartato e l-aspartato per il trattamento della infertilita' maschile.
ITRM2010A000255A IT1400312B1 (it) 2009-05-19 2010-05-19 Uso di una combinazione di acido d-aspartico e l-aspartico o di loro sali per il trattamento della infertilita' maschile.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ITRM2010A000255A IT1400312B1 (it) 2009-05-19 2010-05-19 Uso di una combinazione di acido d-aspartico e l-aspartico o di loro sali per il trattamento della infertilita' maschile.

Country Status (16)

Country Link
US (3) US20120095100A1 (it)
EP (1) EP2432463B1 (it)
JP (1) JP5833545B2 (it)
KR (3) KR102054942B1 (it)
CN (1) CN102438611A (it)
AU (1) AU2010250747B2 (it)
BR (1) BRPI1011103B8 (it)
CA (1) CA2759674C (it)
EA (1) EA021832B1 (it)
ES (1) ES2555387T3 (it)
IL (1) IL216112A (it)
IT (2) IT1395957B1 (it)
MX (1) MX2011012323A (it)
SG (1) SG175304A1 (it)
WO (1) WO2010134117A1 (it)
ZA (1) ZA201107764B (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1395957B1 (it) 2009-05-19 2012-11-02 Pharmaguida S R L Uso di una combinazione di d-aspartato e l-aspartato per il trattamento della infertilita' maschile.
CN102603551A (zh) * 2011-12-20 2012-07-25 安徽华恒生物工程有限公司 一种d-天冬氨酸二价盐及其制备方法
CN102631663B (zh) * 2012-05-02 2014-08-20 张风帆 一种治疗男性不育、阳痿早泄的制剂及其应用
MX356383B (es) * 2013-11-12 2018-05-24 Cadila Healthcare Ltd Formulación líquida de gonadotropina estabilizada con polietilenglicol.
CN106563124A (zh) * 2016-10-19 2017-04-19 广西大学 硫辛酸作为疫苗佐剂的应用
FR3070263B1 (fr) * 2017-08-28 2020-07-24 Serelys Pharma S A M Composition pour son utilisation dans le traitement et/ou la prevention de l’infertilite

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607570D0 (en) * 1986-03-26 1986-04-30 Euro Celtique Sa Vaginal pharmaceutical preparation
US5397786A (en) * 1993-01-08 1995-03-14 Simone; Charles B. Rehydration drink
KR970008105B1 (ko) * 1993-06-28 1997-05-21 주식회사 미원 L-아스파테이트 또는 아스파라긴을 유효성분으로 함유하는 알콜성 장해 보호제 및 그의 제조방법
US5863940A (en) * 1997-12-01 1999-01-26 Sigma-Tau Healthscience S.P.A. Medicament and therapeutical method for treating idiopathic asthenozoospermia
US6632449B2 (en) * 2001-11-20 2003-10-14 The Procter & Gamble Co. Compositions and kits comprising a defined boron compound and methods of their preparation
WO2005120488A1 (en) * 2004-06-10 2005-12-22 Sara Sarig Aspartic acid for the regeneration of bone matter
CN101115477A (zh) * 2005-02-04 2008-01-30 雷普罗斯治疗公司 用反式氯米芬治疗男性不育症的方法和物质
US20060210692A1 (en) * 2005-03-18 2006-09-21 Mower Thomas E Baby food composition
ITRM20050468A1 (it) * 2005-09-14 2007-03-15 Marzocchella Teresa Uso dell'acido d-aspartico o dei suoi sali per il trattamento della infertilita' maschile.
US8202908B1 (en) * 2008-03-28 2012-06-19 Thermolife International, Llc D-aspartic acid supplement
IT1395957B1 (it) 2009-05-19 2012-11-02 Pharmaguida S R L Uso di una combinazione di d-aspartato e l-aspartato per il trattamento della infertilita' maschile.

Also Published As

Publication number Publication date
MX2011012323A (es) 2012-03-07
ZA201107764B (en) 2012-12-27
CA2759674C (en) 2017-02-14
KR20120038408A (ko) 2012-04-23
BRPI1011103B8 (pt) 2021-05-25
AU2010250747B2 (en) 2014-10-23
IL216112A (en) 2016-02-29
EP2432463B1 (en) 2015-09-30
SG175304A1 (en) 2011-12-29
JP5833545B2 (ja) 2015-12-16
EP2432463A1 (en) 2012-03-28
AU2010250747A2 (en) 2012-01-12
KR102054942B1 (ko) 2019-12-11
IT1400312B1 (it) 2013-05-24
KR20180137605A (ko) 2018-12-27
ITRM20100255A1 (it) 2010-11-20
US20140271595A1 (en) 2014-09-18
EA201171431A1 (ru) 2012-05-30
JP2012527448A (ja) 2012-11-08
CN102438611A (zh) 2012-05-02
BRPI1011103A2 (pt) 2017-05-09
EA021832B1 (ru) 2015-09-30
ITRM20090253A1 (it) 2010-11-20
CA2759674A1 (en) 2010-11-25
US20120095100A1 (en) 2012-04-19
BRPI1011103B1 (pt) 2021-04-13
US10342826B2 (en) 2019-07-09
AU2010250747A1 (en) 2011-11-10
IL216112A0 (en) 2012-01-31
US20190328778A1 (en) 2019-10-31
KR20160132500A (ko) 2016-11-18
ES2555387T3 (es) 2015-12-30
US11524031B2 (en) 2022-12-13
WO2010134117A1 (en) 2010-11-25

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