KR940703923A - 4,5-디히드로겔다나마이신 및 그의 하이드로퀴논의 제조 방법 및 용도(Process and Uses for 4,5-Dihydrogeldanamycin and Its Hydroquinone) - Google Patents

4,5-디히드로겔다나마이신 및 그의 하이드로퀴논의 제조 방법 및 용도(Process and Uses for 4,5-Dihydrogeldanamycin and Its Hydroquinone)

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Publication number
KR940703923A
KR940703923A KR1019940702334A KR19940702334A KR940703923A KR 940703923 A KR940703923 A KR 940703923A KR 1019940702334 A KR1019940702334 A KR 1019940702334A KR 19940702334 A KR19940702334 A KR 19940702334A KR 940703923 A KR940703923 A KR 940703923A
Authority
KR
South Korea
Prior art keywords
compound
mammalian subject
amount
treating
formula
Prior art date
Application number
KR1019940702334A
Other languages
English (en)
Korean (ko)
Inventor
윌터 피. 콜렌
마크 티. 제퍼슨
마이클 피. 모이에르
Original Assignee
알렌 제이. 스피겔
화이자 인크
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 알렌 제이. 스피겔, 화이자 인크 filed Critical 알렌 제이. 스피겔
Publication of KR940703923A publication Critical patent/KR940703923A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
KR1019940702334A 1992-01-06 1992-12-03 4,5-디히드로겔다나마이신 및 그의 하이드로퀴논의 제조 방법 및 용도(Process and Uses for 4,5-Dihydrogeldanamycin and Its Hydroquinone) KR940703923A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81723592A 1992-01-06 1992-01-06
US817,235 1992-01-06
PCT/US1992/010189 WO1993014215A1 (fr) 1992-01-06 1992-12-03 Procede et utilisations de la 4,5-dihydrogeldanamycine et de son hydroquinone

Publications (1)

Publication Number Publication Date
KR940703923A true KR940703923A (ko) 1994-12-12

Family

ID=25222638

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702334A KR940703923A (ko) 1992-01-06 1992-12-03 4,5-디히드로겔다나마이신 및 그의 하이드로퀴논의 제조 방법 및 용도(Process and Uses for 4,5-Dihydrogeldanamycin and Its Hydroquinone)

Country Status (15)

Country Link
JP (1) JPH06510913A (fr)
KR (1) KR940703923A (fr)
CN (1) CN1074937A (fr)
AU (1) AU3225693A (fr)
BR (1) BR9207024A (fr)
CA (1) CA2127457A1 (fr)
CZ (1) CZ390592A3 (fr)
FI (1) FI943207A (fr)
HU (1) HU9401936D0 (fr)
IL (1) IL104289A0 (fr)
MX (1) MX9300011A (fr)
NO (1) NO942532L (fr)
PT (1) PT101169A (fr)
WO (1) WO1993014215A1 (fr)
ZA (1) ZA9333B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2794342B2 (ja) * 1993-06-29 1998-09-03 ファイザー・インク． 抗癌遺伝子剤および抗癌剤としてのアンサマイシン誘導体
US5932566A (en) * 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US6852496B1 (en) 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
US6872715B2 (en) * 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
KR20040054692A (ko) 2001-09-24 2004-06-25 콘포마 세러퓨틱스 코포레이션 17-알릴 아미노 겔다나마이신 (17-ａａｇ) 및 기타안사마이신의 제조 방법
EP1923061A1 (fr) 2001-09-24 2008-05-21 Conforma Therapeutic Corporation Procédé pour la préparation de 17-allyl amino geldanamycine (17-AAG) et autres ansamycines
US7465718B2 (en) 2002-02-08 2008-12-16 Conforma Therapeutics Corporation Ansamycins having improved pharmacological and biological properties
TW200303363A (en) * 2002-02-25 2003-09-01 Upjohn Co Process to prepare and isolate geldanamycin
WO2005009345A2 (fr) 2003-06-13 2005-02-03 Kosan Biosciences, Inc. Composes de 2-desmethyl ansamycine
US6887993B1 (en) 2003-11-12 2005-05-03 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6875863B1 (en) 2003-11-12 2005-04-05 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6855705B1 (en) 2003-11-12 2005-02-15 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
EP1682514A4 (fr) 2003-11-12 2008-07-16 Kosan Biosciences Inc Composes 11-o-methylgeldanamycine
EP1689436A1 (fr) * 2003-11-26 2006-08-16 Entelos, Inc. TRAITEMENT DE LA POLYARTHRITE RHUMATOIDE AU MOYEN D'ANTAGONISTES DU FACTEUR a INDUCTIBLE PAR HYPOXIE
US7282493B2 (en) * 2003-12-23 2007-10-16 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins and methods of use thereof
ZA200604863B (en) * 2003-12-23 2007-12-27 Infinity Pharmaceuticals Inc Analogs of benzoquinone-containing ansamycins for the treatment of cancer
US20060019941A1 (en) * 2003-12-23 2006-01-26 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins and methods of use thereof
NZ561939A (en) 2005-03-30 2011-03-31 Conforma Therapeutics Corp Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors
ES2389740T3 (es) * 2006-11-09 2012-10-31 Bristol-Myers Squibb Company Nuevos compuestos y procedimientos para su producción
PE20081506A1 (es) 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
CN100500668C (zh) * 2006-12-19 2009-06-17 中国人民解放军军事医学科学院毒物药物研究所 格尔德霉素衍生物及其制备方法和制备药物的用途
EP2121957A4 (fr) 2007-01-26 2010-11-10 Kosan Biosciences Inc Macrolactames obtenus par biosynthèse modifiée
US20110034686A1 (en) * 2008-04-21 2011-02-10 Nitin Sopanrao Patil Process for Isolation and Purification of Geldanamycin
CN102245021B (zh) 2008-10-15 2014-09-17 无限药品公司 安莎霉素氢醌组合物
CN102030764B (zh) * 2010-11-12 2012-07-04 中国医学科学院医药生物技术研究所 4，5双氢噻嗪酮格尔德霉素及其制备方法
CN103305563B (zh) * 2013-06-14 2014-12-03 湖南农业大学 一种以链霉菌提制阿里沙霉素的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595955A (en) * 1969-03-26 1971-07-27 Upjohn Co Geldanamycin and process for producing same

Also Published As

Publication number Publication date
FI943207A0 (fi) 1994-07-05
PT101169A (pt) 1994-03-31
MX9300011A (es) 1993-12-01
FI943207A (fi) 1994-07-05
NO942532D0 (no) 1994-07-05
CA2127457A1 (fr) 1993-07-22
HU9401936D0 (en) 1994-09-28
BR9207024A (pt) 1995-12-05
CN1074937A (zh) 1993-08-04
JPH06510913A (ja) 1994-12-08
ZA9333B (en) 1994-07-05
CZ390592A3 (en) 1993-08-11
IL104289A0 (en) 1993-05-13
NO942532L (no) 1994-07-05
WO1993014215A1 (fr) 1993-07-22
AU3225693A (en) 1993-08-03

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