KR940703923A - Process and Uses for 4,5-Dihydrogeldanamycin and Its Hydroquinone - Google Patents

Abstract

Also disclosed herein are chemical synthesis of compound (II) from compound (I) as well as methods of fermentation and isolation of compounds (I) and (II), which are one of ansamycin benzoquinone antibiotics. The compounds of the present invention are useful for proliferative diseases including, but not limited to, cancers of mammals, particularly humans. The compounds of the present invention are also expected to be useful against certain microorganisms and have utility as immunosuppressive agents against autoimmune diseases.

Description

Process and Uses for 4, 5-Dihydrogeldanamycin and Its Hydroquinone

Since this is an open matter, no full text was included.

Claims (23)

Propagating the microorganism Streptomyces hygroscopicus (ATCC 55256) in an aqueous nutrient medium consisting of an inorganic salt containing a carbohydrate source, an organic nitrogen source, a growth substrate and trace elements under immersion aerobic conditions, and (b) A process for producing the compound of formula (I), which comprises the step of isolating the compound of (I). A method of treating a proliferative disorder in a mammalian subject, comprising administering an amount of a compound of formula (I) below to treat the proliferative disorder in the mammalian subject. The method of claim 2, wherein the compound is administered orally. The method of claim 2, wherein the compound is parenterally administered. The method of claim 2, wherein the proliferative disease is human breast cancer, uterine cancer or gastric cancer. A method of treating an autoimmune disease in a mammalian subject, comprising administering to the mammalian subject an amount of a compound of formula (I): 7. The method of claim 6, wherein the autoimmune disease is rheumatoid arthritis or graft versus host disease. A method of treating an infection by a bacterium, virus, fungus and protozoa of a mammalian subject comprising administering to the mammalian subject an amount of a compound of the formula (I) below to treat the infection by bacteria, virus, fungus and protozoa . A pharmaceutical composition useful for the treatment of a proliferative disorder in a mammalian subject, comprising a pharmaceutically acceptable carrier or diluent and an amount of a compound of formula (I) below to treat the proliferative disorder. A pharmaceutical composition useful for the treatment of autoimmune diseases of a mammalian subject, comprising a pharmaceutically acceptable carrier or diluent and an amount of a compound of formula (I) below to treat the autoimmune disease. Infection of infection by bacteria, viruses, fungi and protozoa of a mammalian subject consisting of a pharmaceutically acceptable carrier or diluent and a compound of formula (I) in an amount capable of treating infection by bacteria, viruses, fungi and protozoa Pharmaceutical compositions useful for the treatment. The compound of formula (II). (a) propagating microorganism Streptomyces hygroscopicus (ATCC 55256) in an aqueous nutrient medium consisting of inorganic salts containing carbohydrate sources, organic nitrogen sources, growth substrates and trace elements under soaking aerobic conditions, and (b) A process for preparing the compound of formula (II) according to claim 12, comprising the step of isolating the compound of formula (II). A method of treating a proliferative disorder in a mammalian subject, comprising administering an amount of the compound of claim 12 to treat the proliferative disorder in the mammalian subject. The method of claim 14, wherein said compound is administered parenterally. The method of claim 14, wherein the compound is administered orally. The method of claim 14, wherein the proliferative disease is human breast cancer, uterine cancer or gastric cancer. A method of treating an autoimmune disease in a mammalian subject, comprising administering an amount of the compound of claim 12 to treat the autoimmune disease in the mammalian subject. The method of claim 18, wherein the autoimmune disease is rheumatoid arthritis or graft versus host disease. A method of treating an infection by a bacterium, virus, fungus and protozoa of a mammalian subject comprising administering to the mammalian subject an amount of the compound of claim 12 that is capable of treating the infection by bacteria, virus, fungus and protozoa. A pharmaceutical composition useful for the treatment of a proliferative disorder in a mammalian subject, comprising a pharmaceutically acceptable carrier or diluent and an amount of the compound of claim 12 capable of treating the proliferative disorder. A pharmaceutical composition useful for the treatment of an autoimmune disease in a mammalian subject, comprising a pharmaceutically acceptable carrier or diluent and an amount of the compound of claim 12 capable of treating the autoimmune disease. Useful for the treatment of infection by bacteria, viruses, fungi and protozoa of a mammalian subject comprising a pharmaceutically acceptable carrier or diluent and an amount of the compound of claim 12 which is capable of treating infection by bacteria, viruses, fungi and protozoa. Pharmaceutical compositions. ※ Note: The disclosure is based on the initial application.