PT101169A - Processo para a preparacao de 4,5-di-hidrogeldanamicina e sua hidroquinona, hidroquinona obtida e composicao contendo um destes compostos - Google Patents

Processo para a preparacao de 4,5-di-hidrogeldanamicina e sua hidroquinona, hidroquinona obtida e composicao contendo um destes compostos

Info

Publication number
PT101169A
PT101169A PT101169A PT10116993A PT101169A PT 101169 A PT101169 A PT 101169A PT 101169 A PT101169 A PT 101169A PT 10116993 A PT10116993 A PT 10116993A PT 101169 A PT101169 A PT 101169A
Authority
PT
Portugal
Prior art keywords
hydroquinone
dihydrogeldanamicin
compounds
preparation
composition containing
Prior art date
Application number
PT101169A
Other languages
English (en)
Inventor
Walter P Cullen
Mikel P Moyer
Mark T Jefferson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT101169A publication Critical patent/PT101169A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
PT101169A 1992-01-06 1993-01-04 Processo para a preparacao de 4,5-di-hidrogeldanamicina e sua hidroquinona, hidroquinona obtida e composicao contendo um destes compostos PT101169A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81723592A 1992-01-06 1992-01-06

Publications (1)

Publication Number Publication Date
PT101169A true PT101169A (pt) 1994-03-31

Family

ID=25222638

Family Applications (1)

Application Number Title Priority Date Filing Date
PT101169A PT101169A (pt) 1992-01-06 1993-01-04 Processo para a preparacao de 4,5-di-hidrogeldanamicina e sua hidroquinona, hidroquinona obtida e composicao contendo um destes compostos

Country Status (15)

Country Link
JP (1) JPH06510913A (pt)
KR (1) KR940703923A (pt)
CN (1) CN1074937A (pt)
AU (1) AU3225693A (pt)
BR (1) BR9207024A (pt)
CA (1) CA2127457A1 (pt)
CZ (1) CZ390592A3 (pt)
FI (1) FI943207A0 (pt)
HU (1) HU9401936D0 (pt)
IL (1) IL104289A0 (pt)
MX (1) MX9300011A (pt)
NO (1) NO942532L (pt)
PT (1) PT101169A (pt)
WO (1) WO1993014215A1 (pt)
ZA (1) ZA9333B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0706516A1 (en) * 1993-06-29 1996-04-17 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5932566A (en) * 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US6852496B1 (en) 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
KR20040054692A (ko) 2001-09-24 2004-06-25 콘포마 세러퓨틱스 코포레이션 17-알릴 아미노 겔다나마이신 (17-ａａｇ) 및 기타안사마이신의 제조 방법
EP1923061A1 (en) 2001-09-24 2008-05-21 Conforma Therapeutic Corporation Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins
JP2005530689A (ja) 2002-02-08 2005-10-13 コンフォーマ・セラピューティクス・コーポレイション 改良された薬理学的および生物学的特性を有するアンサマイシン
TW200303363A (en) * 2002-02-25 2003-09-01 Upjohn Co Process to prepare and isolate geldanamycin
US7241754B2 (en) 2003-06-13 2007-07-10 Kosan Biosciences, Inc. 2-Desmethyl ansamycin compounds
US6870049B1 (en) 2003-11-12 2005-03-22 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6875863B1 (en) 2003-11-12 2005-04-05 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6887993B1 (en) 2003-11-12 2005-05-03 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6855705B1 (en) 2003-11-12 2005-02-15 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
EP1689436A1 (en) * 2003-11-26 2006-08-16 Entelos, Inc. TREATMENT OF RHEUMATOID ARTHRITIS WITH HYPOXIA-INDUCIBLE FACTOR a ANTAGONISTS
US20060019941A1 (en) * 2003-12-23 2006-01-26 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins and methods of use thereof
CN1898212B (zh) * 2003-12-23 2012-06-13 无限发现公司 用于治疗癌症的包含苯醌的安沙霉素类似物
EP2492261B1 (en) 2003-12-23 2015-02-18 Infinity Discovery, Inc. Analogs of benzoquinone-containing ansamycins for the treatment of cancer
BRPI0609509A2 (pt) 2005-03-30 2010-04-13 Conforma Therapeutics Corp composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável
WO2008056188A2 (en) * 2006-11-09 2008-05-15 Biotica Technology Limited Novel compounds and methods for their production
PE20081506A1 (es) 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
CN100500668C (zh) * 2006-12-19 2009-06-17 中国人民解放军军事医学科学院毒物药物研究所 格尔德霉素衍生物及其制备方法和制备药物的用途
US7855192B2 (en) 2007-01-26 2010-12-21 Kosan Biosciences, Inc. Macrolactams by engineered biosynthesis
WO2009130706A1 (en) * 2008-04-21 2009-10-29 Biocon Limited A process for isolation and purification of geldanamycin
AU2009305755B2 (en) 2008-10-15 2014-09-18 Infinity Pharmaceuticals, Inc. Ansamycin hydroquinone compositions
CN102030764B (zh) * 2010-11-12 2012-07-04 中国医学科学院医药生物技术研究所 4，5双氢噻嗪酮格尔德霉素及其制备方法
CN103305563B (zh) * 2013-06-14 2014-12-03 湖南农业大学 一种以链霉菌提制阿里沙霉素的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595955A (en) * 1969-03-26 1971-07-27 Upjohn Co Geldanamycin and process for producing same

Also Published As

Publication number Publication date
KR940703923A (ko) 1994-12-12
ZA9333B (en) 1994-07-05
CZ390592A3 (en) 1993-08-11
BR9207024A (pt) 1995-12-05
NO942532D0 (no) 1994-07-05
CN1074937A (zh) 1993-08-04
FI943207L (fi) 1994-07-05
MX9300011A (es) 1993-12-01
FI943207A7 (fi) 1994-07-05
HU9401936D0 (en) 1994-09-28
AU3225693A (en) 1993-08-03
FI943207A0 (fi) 1994-07-05
IL104289A0 (en) 1993-05-13
WO1993014215A1 (en) 1993-07-22
JPH06510913A (ja) 1994-12-08
NO942532L (no) 1994-07-05
CA2127457A1 (en) 1993-07-22

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19930818

FC3A Refusal

Effective date: 19990505