KR940703923A - 4,5-디히드로겔다나마이신 및 그의 하이드로퀴논의 제조 방법 및 용도(Process and Uses for 4,5-Dihydrogeldanamycin and Its Hydroquinone) - Google Patents

4,5-디히드로겔다나마이신 및 그의 하이드로퀴논의 제조 방법 및 용도(Process and Uses for 4,5-Dihydrogeldanamycin and Its Hydroquinone)

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Publication number
KR940703923A
KR940703923A KR1019940702334A KR19940702334A KR940703923A KR 940703923 A KR940703923 A KR 940703923A KR 1019940702334 A KR1019940702334 A KR 1019940702334A KR 19940702334 A KR19940702334 A KR 19940702334A KR 940703923 A KR940703923 A KR 940703923A
Authority
KR
South Korea
Prior art keywords
compound
mammalian subject
amount
treating
formula
Prior art date
Application number
KR1019940702334A
Other languages
English (en)
Korean (ko)
Inventor
윌터 피. 콜렌
마크 티. 제퍼슨
마이클 피. 모이에르
Original Assignee
알렌 제이. 스피겔
화이자 인크
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 알렌 제이. 스피겔, 화이자 인크 filed Critical 알렌 제이. 스피겔
Publication of KR940703923A publication Critical patent/KR940703923A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1019940702334A 1992-01-06 1992-12-03 4,5-디히드로겔다나마이신 및 그의 하이드로퀴논의 제조 방법 및 용도(Process and Uses for 4,5-Dihydrogeldanamycin and Its Hydroquinone) KR940703923A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81723592A 1992-01-06 1992-01-06
US817,235 1992-01-06
PCT/US1992/010189 WO1993014215A1 (en) 1992-01-06 1992-12-03 Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone

Publications (1)

Publication Number Publication Date
KR940703923A true KR940703923A (ko) 1994-12-12

Family

ID=25222638

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702334A KR940703923A (ko) 1992-01-06 1992-12-03 4,5-디히드로겔다나마이신 및 그의 하이드로퀴논의 제조 방법 및 용도(Process and Uses for 4,5-Dihydrogeldanamycin and Its Hydroquinone)

Country Status (15)

Country Link
JP (1) JPH06510913A (fi)
KR (1) KR940703923A (fi)
CN (1) CN1074937A (fi)
AU (1) AU3225693A (fi)
BR (1) BR9207024A (fi)
CA (1) CA2127457A1 (fi)
CZ (1) CZ390592A3 (fi)
FI (1) FI943207A0 (fi)
HU (1) HU9401936D0 (fi)
IL (1) IL104289A0 (fi)
MX (1) MX9300011A (fi)
NO (1) NO942532D0 (fi)
PT (1) PT101169A (fi)
WO (1) WO1993014215A1 (fi)
ZA (1) ZA9333B (fi)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0706516A1 (en) * 1993-06-29 1996-04-17 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5932566A (en) * 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US6852496B1 (en) 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
US6872715B2 (en) * 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
EP1923061A1 (en) 2001-09-24 2008-05-21 Conforma Therapeutic Corporation Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins
WO2003026571A2 (en) 2001-09-24 2003-04-03 Conforma Therapeutics Corporation Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins
DE60327994D1 (de) 2002-02-08 2009-07-30 Conforma Therapeutics Corp Ansamycine mit verbesserten pharmakologischen und biologischen eigenschaften
TW200303363A (en) * 2002-02-25 2003-09-01 Upjohn Co Process to prepare and isolate geldanamycin
WO2005009345A2 (en) 2003-06-13 2005-02-03 Kosan Biosciences, Inc. 2-desmethyl ansamycin compounds
US6875863B1 (en) 2003-11-12 2005-04-05 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6887993B1 (en) 2003-11-12 2005-05-03 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6855705B1 (en) 2003-11-12 2005-02-15 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
WO2005056531A1 (en) 2003-11-12 2005-06-23 Kosan Biosciences, Inc. 11-o-methylgeldanamycin compounds
US20050148496A1 (en) * 2003-11-26 2005-07-07 Entelos, Inc. Treatment of rheumatoid arthritis with hypoxia inducible factor-1alpha antagonists
CA2547343C (en) 2003-12-23 2013-05-14 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins for the treatment of cancer
US20060019941A1 (en) * 2003-12-23 2006-01-26 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins and methods of use thereof
CN1898212B (zh) * 2003-12-23 2012-06-13 无限发现公司 用于治疗癌症的包含苯醌的安沙霉素类似物
US7544672B2 (en) 2005-03-30 2009-06-09 Conforma Therapeutics Corporation Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs as HSP90-inhibitors
ES2389740T3 (es) * 2006-11-09 2012-10-31 Bristol-Myers Squibb Company Nuevos compuestos y procedimientos para su producción
PE20081506A1 (es) 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
CN100500668C (zh) * 2006-12-19 2009-06-17 中国人民解放军军事医学科学院毒物药物研究所 格尔德霉素衍生物及其制备方法和制备药物的用途
WO2008094438A1 (en) 2007-01-26 2008-08-07 Kosan Biosciences Incorporated Macrolactams by engineered biosynthesis
US20110034686A1 (en) * 2008-04-21 2011-02-10 Nitin Sopanrao Patil Process for Isolation and Purification of Geldanamycin
WO2010045442A1 (en) 2008-10-15 2010-04-22 Infinity Discovery, Inc. Ansamycin hydroquinone compositions
CN102030764B (zh) * 2010-11-12 2012-07-04 中国医学科学院医药生物技术研究所 4，5双氢噻嗪酮格尔德霉素及其制备方法
CN103305563B (zh) * 2013-06-14 2014-12-03 湖南农业大学 一种以链霉菌提制阿里沙霉素的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595955A (en) * 1969-03-26 1971-07-27 Upjohn Co Geldanamycin and process for producing same

Also Published As

Publication number Publication date
NO942532L (no) 1994-07-05
WO1993014215A1 (en) 1993-07-22
CN1074937A (zh) 1993-08-04
JPH06510913A (ja) 1994-12-08
FI943207A (fi) 1994-07-05
IL104289A0 (en) 1993-05-13
NO942532D0 (no) 1994-07-05
PT101169A (pt) 1994-03-31
BR9207024A (pt) 1995-12-05
CZ390592A3 (en) 1993-08-11
AU3225693A (en) 1993-08-03
FI943207A0 (fi) 1994-07-05
HU9401936D0 (en) 1994-09-28
CA2127457A1 (en) 1993-07-22
MX9300011A (es) 1993-12-01
ZA9333B (en) 1994-07-05

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