KR940003956A - 이미다조피리딘류의 제조방법 - Google Patents

이미다조피리딘류의 제조방법 Download PDF

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Publication number
KR940003956A
KR940003956A KR1019930014922A KR930014922A KR940003956A KR 940003956 A KR940003956 A KR 940003956A KR 1019930014922 A KR1019930014922 A KR 1019930014922A KR 930014922 A KR930014922 A KR 930014922A KR 940003956 A KR940003956 A KR 940003956A
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South Korea
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chloro
amino
producing
represented
cyanobiphenyl
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KR1019930014922A
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English (en)
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메더스키 베르너
보켈 하인쯔-헤르만
Original Assignee
호이만, 쉬틀러
메르크 파텐트 게젤샤프트 미트 배슈랭크터 하프퉁
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Publication of KR940003956A publication Critical patent/KR940003956A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 하기 구조식(I)으로 표시되는 이미다조피리딘류의 신규한 제조방법에 관한 것이다.
(상기식에서 R은 탄소수 1∼6의 알킬임.) 본 발명의 방법은, 3, 4-디아미노-2-클로로피리딘(Ⅱ)을 R-CO-0-COR'의 구조식(여기에서 R은 상기에서 정의된 바와 같고, R'는 R이거나 또는 기타 지방족 혹은 방향족 리디칼일 수 있다)으로 표시되는 산무수물(Ⅲ)과 반응시켜 4-아미노-2-클로로-3-R-CO-아미노피리딘(Ⅳ)을 얻고 이 화합물을 불활성 용매중에서 알킬리금속 알콜레이트 존재하에 4'-브로모메틸-2-시아노비페닐(Ⅴ)과 반응시켜 4-아미노-2-클로로-3-R-CO-[N-(2'-시아노비페닐-4-일메틸)아미노]피리딘(Ⅵ)으로 전환시킨 후, 이 화합물을 강산으로 처리하여 2-R-4-클로로-3-(2'-시아노-비페닐-4-일메틸)-3H-이미다조[4,5-C]피리딘(Ⅶ)을 중간체로 형성시키는 것을 특징으로 한다.

Description

이미다조피리딘류의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 하기 구조식(I)으로 표시되는 이미다조피리딘류의 제조방법.
    (단, 상기 구조식에서 R은 탄소수 1∼6의 알킬임).
    3,4-디아미노-2-클로로피리딘(7)을 R-CO-0-COR'의 구조식 (이때, R은 상기에서 정의된 바와 같으며, R'는 R이거나 또는 기타 지방족 혹은 방향족 리디탈임)의 산무수물(Ⅲ)과 반응시켜 4-아미노-2-클로로-3-R-CO-아미노피리딘(Ⅳ)을 얻고 이 화합물(Ⅵ)을 불활성 용매중에서 알킬리금속 알콜레이트 존재하에 4'-브로모메틸-2-시아노비페닐(V)과 반응시켜 4-아미노-2-클로로-3-R-CO-[N-(2'-시아노비페닐-4-일메틸)아미노]피리딘(Ⅵ)으로 전환시킨 후, 이 화합물을 강산으로 처리하여 2-R-4-클로로-3-(2'-시아노-비페닐-4-일메틸)-3H-이미다조(4,5-C)피리딘(Ⅶ)을 중간체로 형성시키는 것을 특징으로 하는 이미다조피리딘류의 제조방법.
    ※ 참고사항 :최초출원 내용에 의하여 공개하는 것임
KR1019930014922A 1992-08-05 1993-08-02 이미다조피리딘류의 제조방법 KR940003956A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4225835.9 1992-08-05
DE4225835A DE4225835A1 (de) 1992-08-05 1992-08-05 Verfahren zur Herstellung von Imidazopyridinen

Publications (1)

Publication Number Publication Date
KR940003956A true KR940003956A (ko) 1994-03-14

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Application Number Title Priority Date Filing Date
KR1019930014922A KR940003956A (ko) 1992-08-05 1993-08-02 이미다조피리딘류의 제조방법

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Country Link
US (1) US5321137A (ko)
EP (1) EP0582146A3 (ko)
JP (1) JPH06157526A (ko)
KR (1) KR940003956A (ko)
CN (1) CN1089265A (ko)
AU (1) AU4434593A (ko)
CA (1) CA2101789A1 (ko)
CZ (1) CZ150893A3 (ko)
DE (1) DE4225835A1 (ko)
HU (1) HUT64956A (ko)
MX (1) MX9304722A (ko)
NO (1) NO932783L (ko)
PL (1) PL299917A1 (ko)
SK (1) SK77893A3 (ko)
TW (1) TW232693B (ko)
ZA (1) ZA935657B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2708612B1 (fr) * 1993-08-05 1996-03-01 Roussel Uclaf Nouveaux dérivés bicycliques de l'imidazole, leur procédé de préparation, les nouveaux intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant.
DE4341453A1 (de) * 1993-12-06 1995-06-08 Merck Patent Gmbh Imidazopyridine
DE4432860A1 (de) * 1994-09-15 1996-03-21 Merck Patent Gmbh Imidazopyridine
KR100707602B1 (ko) 2005-10-20 2007-04-13 삼성에스디아이 주식회사 유기 전계 발광 표시장치 및 그의 제조방법
TWI324493B (en) 2006-05-19 2010-05-01 Au Optronics Corp Lectro-luminescence panel, el panel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
DE4110019C2 (de) * 1991-03-27 2000-04-13 Merck Patent Gmbh Imidazopyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

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SK77893A3 (en) 1994-06-08
AU4434593A (en) 1994-02-10
NO932783L (no) 1994-02-07
CA2101789A1 (en) 1994-02-06
MX9304722A (es) 1994-02-28
HU9302277D0 (en) 1993-10-28
US5321137A (en) 1994-06-14
DE4225835A1 (de) 1994-02-10
CN1089265A (zh) 1994-07-13
CZ150893A3 (en) 1994-03-16
NO932783D0 (no) 1993-08-04
TW232693B (ko) 1994-10-21
ZA935657B (en) 1994-03-07
EP0582146A2 (de) 1994-02-09
HUT64956A (en) 1994-03-28
PL299917A1 (en) 1994-04-18
JPH06157526A (ja) 1994-06-03
EP0582146A3 (en) 1994-06-15

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