ES8703885A1 - Un procedimiento para preparar nuevos derivados de cefem. - Google Patents

Un procedimiento para preparar nuevos derivados de cefem.

Info

Publication number
ES8703885A1
ES8703885A1 ES550819A ES550819A ES8703885A1 ES 8703885 A1 ES8703885 A1 ES 8703885A1 ES 550819 A ES550819 A ES 550819A ES 550819 A ES550819 A ES 550819A ES 8703885 A1 ES8703885 A1 ES 8703885A1
Authority
ES
Spain
Prior art keywords
derivative
substituted
lower alkyl
alkyl group
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550819A
Other languages
English (en)
Other versions
ES550819A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ES550819A0 publication Critical patent/ES550819A0/es
Publication of ES8703885A1 publication Critical patent/ES8703885A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CEFEM, DE FORMULA (I) Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II), CUYOS GRUPOS AMINO Y CARBOXILO HAN SIDO PROTEHIDOS, O SIN PROTEGER, O UNA DE SUS SALES, CON UN COMPUESTO DE FORMULA (III) O UNA DE SUS SALES, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LAS QUE N VALE 1 O 2, X REPRESENTA HALOGENO, Y ES NITROGENO O CH, Y R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO ANHIDRO, A UNA TEMPERATURA COMPRENDIDA ENTRE C10JC Y 60JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA.
ES550819A 1985-01-14 1986-01-13 Un procedimiento para preparar nuevos derivados de cefem. Expired ES8703885A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP318185 1985-01-14
JP7533385 1985-04-11
JP17432685 1985-08-09

Publications (2)

Publication Number Publication Date
ES550819A0 ES550819A0 (es) 1987-03-01
ES8703885A1 true ES8703885A1 (es) 1987-03-01

Family

ID=27275690

Family Applications (1)

Application Number Title Priority Date Filing Date
ES550819A Expired ES8703885A1 (es) 1985-01-14 1986-01-13 Un procedimiento para preparar nuevos derivados de cefem.

Country Status (18)

Country Link
US (3) US4748171A (es)
EP (1) EP0188255B1 (es)
KR (1) KR930004016B1 (es)
CN (1) CN1019494B (es)
AU (1) AU595495B2 (es)
CA (1) CA1281318C (es)
DE (1) DE3678453D1 (es)
DK (2) DK13686A (es)
ES (1) ES8703885A1 (es)
FI (1) FI85489C (es)
HU (1) HU195664B (es)
IL (1) IL77458A (es)
MX (1) MX164766B (es)
NO (1) NO166326C (es)
NZ (1) NZ214759A (es)
PH (1) PH23045A (es)
PT (1) PT81840B (es)
YU (1) YU45303B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77458A (en) * 1985-01-14 1990-07-26 Eisai Co Ltd Cephem derivatives,their production and antibacterial compositions containing them and certain novel intermediates therefor
GB8611823D0 (en) * 1986-05-15 1986-06-25 Ici Plc Process
JP2690009B2 (ja) * 1986-07-10 1997-12-10 エーザイ 株式会社 セフアロスポリン注射剤
DE3711343A1 (de) * 1987-04-03 1988-10-20 Bayer Ag Cephalosporinderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US4929612A (en) * 1987-04-17 1990-05-29 Eisai Co., Ltd. Thiadiazolylacetamide cephem derivatives
KR910004335B1 (ko) * 1987-07-09 1991-06-26 에이자이 가부시기가이샤 세펨 유도체 결정
IE61679B1 (en) * 1987-08-10 1994-11-16 Fujisawa Pharmaceutical Co Water-soluble antibiotic composition and water-soluble salts of new cephem compounds
US5210080A (en) * 1987-09-07 1993-05-11 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
KR0174535B1 (ko) * 1989-09-04 1999-02-01 알렌 제이 스피글 베타-락탐 함유 화합물 및 그의 제조방법
US5143910A (en) * 1989-09-07 1992-09-01 Shionogi & Co., Ltd. Piperaziniocephalosporins
KR960008761B1 (ko) * 1993-06-09 1996-07-03 이영길 교체가 가능한 온열치료기용 적외선치료약제 에너지판
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
AT412214B (de) * 1999-05-05 2004-11-25 Sandoz Ag Verfahren zur herstellung des dinatrium-hemiheptahydratsalzes von ceftriaxon
US20060122082A1 (en) * 2000-02-17 2006-06-08 Leonard Paul Foam/spray producing compositions and dispensing system therefor
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
US9751894B2 (en) * 2015-12-10 2017-09-05 Naeja-Rgm Pharmaceuticals Inc. Cephem compounds, their production and use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0062321B1 (en) * 1981-04-03 1989-03-01 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
DE3409431A1 (de) * 1983-10-08 1985-04-18 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
NZ211223A (en) * 1984-03-05 1988-02-12 Teijin Ltd Cephalosporins and pharmaceutical compositions
JPS60197693A (ja) * 1984-03-19 1985-10-07 Eisai Co Ltd ３−（キヌクリジニウム）メチル−３−セフエム誘導体
JPS60231683A (ja) * 1984-05-02 1985-11-18 Teijin Ltd セフアロスポリン誘導体その製造法及びそれを有効成分とする抗菌剤
IL77458A (en) * 1985-01-14 1990-07-26 Eisai Co Ltd Cephem derivatives,their production and antibacterial compositions containing them and certain novel intermediates therefor
US4698336A (en) * 1985-01-30 1987-10-06 Eisai Co., Ltd. 3-(pyrrolidinio)methyl-3-cephem derivatives
US4929612A (en) * 1987-04-17 1990-05-29 Eisai Co., Ltd. Thiadiazolylacetamide cephem derivatives

Also Published As

Publication number Publication date
DK64795A (da) 1995-06-08
EP0188255B1 (en) 1991-04-03
EP0188255A3 (en) 1987-08-26
FI85489C (fi) 1992-04-27
AU5224086A (en) 1986-07-17
ES550819A0 (es) 1987-03-01
YU45303B (en) 1992-05-28
CN86100852A (zh) 1986-07-09
NZ214759A (en) 1989-01-27
FI860154A0 (fi) 1986-01-13
AU595495B2 (en) 1990-04-05
CN1019494B (zh) 1992-12-16
YU20886A (en) 1988-04-30
KR860005826A (ko) 1986-08-13
EP0188255A2 (en) 1986-07-23
US4748171A (en) 1988-05-31
FI85489B (fi) 1992-01-15
PT81840B (pt) 1987-11-30
HUT41035A (en) 1987-03-30
PT81840A (en) 1986-02-01
DE3678453D1 (de) 1991-05-08
HU195664B (en) 1988-06-28
KR930004016B1 (ko) 1993-05-19
US5008260A (en) 1991-04-16
CA1281318C (en) 1991-03-12
FI860154A (fi) 1986-07-15
DK13686A (da) 1986-10-03
NO166326C (no) 1991-07-03
PH23045A (en) 1989-03-10
DK13686D0 (da) 1986-01-13
US5010188A (en) 1991-04-23
NO855356L (no) 1986-07-15
NO166326B (no) 1991-03-25
MX164766B (es) 1992-09-23
IL77458A (en) 1990-07-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20011110