KR930006022A - 페넴의 결정화법 - Google Patents

페넴의 결정화법 Download PDF

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Publication number
KR930006022A
KR930006022A KR1019920017057A KR920017057A KR930006022A KR 930006022 A KR930006022 A KR 930006022A KR 1019920017057 A KR1019920017057 A KR 1019920017057A KR 920017057 A KR920017057 A KR 920017057A KR 930006022 A KR930006022 A KR 930006022A
Authority
KR
South Korea
Prior art keywords
crystallization method
aqueous solution
temperature
solution
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019920017057A
Other languages
English (en)
Korean (ko)
Inventor
마사요시 가네꼬
시게오 야부노
Original Assignee
고니시 신베이.히사나가 가쓰이찌로
니혼레다리 가부시끼가이샤
모리따 가쓰라
다께다야꾸힝고오교 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 고니시 신베이.히사나가 가쓰이찌로, 니혼레다리 가부시끼가이샤, 모리따 가쓰라, 다께다야꾸힝고오교 가부시끼가이샤 filed Critical 고니시 신베이.히사나가 가쓰이찌로
Publication of KR930006022A publication Critical patent/KR930006022A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019920017057A 1991-09-20 1992-09-18 페넴의 결정화법 Withdrawn KR930006022A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP91-241648 1991-09-20
JP24164891 1991-09-20

Publications (1)

Publication Number Publication Date
KR930006022A true KR930006022A (ko) 1993-04-20

Family

ID=17077445

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920017057A Withdrawn KR930006022A (ko) 1991-09-20 1992-09-18 페넴의 결정화법

Country Status (9)

Country Link
US (2) US5286856A (enExample)
EP (1) EP0533149A1 (enExample)
JP (1) JP2767171B2 (enExample)
KR (1) KR930006022A (enExample)
FI (1) FI924210A7 (enExample)
IL (1) IL103218A0 (enExample)
NO (2) NO923619L (enExample)
TW (1) TW264475B (enExample)
ZA (1) ZA927164B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101013535B1 (ko) * 2004-10-21 2011-02-14 주식회사 만도 자동차의 파워 스티어링 장치용 실린더 튜브와 피드튜브의 조립 구조물

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW264475B (enExample) * 1991-09-20 1995-12-01 Takeda Pharm Industry Co Ltd
PT758651E (pt) * 1994-05-02 2002-12-31 Shionogi & Co Cristal de derivado de pirrolidiltiocarbapenem formulacao liofilizada contendo o citado cristal e processo para a producao do mesmo
ATE321762T1 (de) * 1998-03-02 2006-04-15 Merck & Co Inc Verfahren zur synthese von carbapenem-antibiotika
DE10300620B4 (de) * 2002-05-18 2017-04-13 Carl Zeiss Meditec Ag Trägervorrichtung für ein medizinisch-optisches Gerät
PL2076501T3 (pl) 2006-09-25 2016-06-30 Ptc Therapeutics Inc Postacie krystaliczne kwasu 3-[5-(2-fluorofenylo)[1,2,4]oksadiazol-3-ilo]-benzoesowego
US8293924B2 (en) * 2007-10-08 2012-10-23 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
DE102008043318A1 (de) 2008-10-30 2010-05-12 Mvg Metallverarbeitungsgesellschaft Mbh Anhängekupplung
WO2013132422A1 (en) * 2012-03-05 2013-09-12 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of carbapenem antibiotic
CN104334559B (zh) 2012-05-30 2017-03-22 明治制果药业株式会社 β‑内酰胺酶抑制剂及其制备方法
WO2014097221A1 (en) 2012-12-21 2014-06-26 Ranbaxy Laboratories Limited Process for the purification of biapenem
MY176278A (en) 2013-09-24 2020-07-27 Meiji Seika Pharma Co Ltd Process for producing diazabicyclooctane derivative and intermediate thereof
EP3067355B1 (en) 2013-10-08 2020-12-16 Meiji Seika Pharma Co., Ltd. Crystals of diazabicyclooctane derivative and production method for crystals of diazabicyclooctane derivative
RU2732129C2 (ru) 2014-12-05 2020-09-11 Мейдзи Сейка Фарма Ко., Лтд. Способ производства кристаллов производного диазабициклооктана и стабильного лиофилизированного препарата
CN114349772B (zh) * 2020-10-13 2022-11-25 珠海联邦制药股份有限公司 一种比阿培南粗品的精制方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
IL53427A0 (en) * 1976-11-24 1978-01-31 Lilly Co Eli Method of preparing a rapidly dissolving powder of sterile crystalline cefozolin sodium for parenteral administration
JPS6024080B2 (ja) * 1977-06-01 1985-06-11 武田薬品工業株式会社 結晶の製造法
GB1589317A (en) * 1977-11-24 1981-05-13 Lilly Co Eli Freeze drying cephalothin sodium
JPS56120615A (en) * 1980-02-27 1981-09-22 Nippon Chemiphar Co Ltd Preparation of lyophilized powder of cephalothin
US4713451A (en) * 1984-04-09 1987-12-15 Merck & Co., Inc. Crystalline dimethyliminothienamycin
IE60588B1 (en) * 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
US4866171A (en) * 1987-04-11 1989-09-12 Lederle (Japan), Ltd. (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
DK168047B1 (da) * 1987-12-07 1994-01-24 Lederle Japan Ltd (1r,5s,6s)-2-substitueret thio-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater, fremgangsmaade til remstilling deraf, midler og praeparater indeholdende den krystallinske forbindelse samt dens anvendelse.
US5082661A (en) * 1990-09-26 1992-01-21 Elizabeth Arden Co., Division Of Conopco, Inc. Odorless cosmetic compositions in gelatin capsules
GB9021061D0 (en) * 1990-09-27 1990-11-07 Unilever Plc Encapsulating method and products containing encapsulated material
TW264475B (enExample) * 1991-09-20 1995-12-01 Takeda Pharm Industry Co Ltd
ATE201877T1 (de) * 1993-01-29 2001-06-15 Agouron Pharma Kondensierte heterocyclische glutaminsäurederivate als antiproliferative mittel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101013535B1 (ko) * 2004-10-21 2011-02-14 주식회사 만도 자동차의 파워 스티어링 장치용 실린더 튜브와 피드튜브의 조립 구조물

Also Published As

Publication number Publication date
JPH05271241A (ja) 1993-10-19
JP2767171B2 (ja) 1998-06-18
US5286856A (en) 1994-02-15
FI924210A0 (fi) 1992-09-18
US5424069A (en) 1995-06-13
NO971332D0 (no) 1997-03-21
TW264475B (enExample) 1995-12-01
FI924210L (fi) 1993-03-21
IL103218A0 (en) 1993-02-21
NO923619D0 (no) 1992-09-17
AU2459792A (en) 1993-03-25
EP0533149A1 (en) 1993-03-24
ZA927164B (en) 1994-03-18
AU645442B2 (en) 1994-01-13
NO923619L (no) 1993-03-22
NO971332L (no) 1993-03-22
FI924210A7 (fi) 1993-03-21

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Legal Events

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PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PC1203 Withdrawal of no request for examination

St.27 status event code: N-1-6-B10-B12-nap-PC1203

WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000