NO923619L - Fremstilling av krystallinsk penem - Google Patents

Fremstilling av krystallinsk penem

Info

Publication number
NO923619L
NO923619L NO92923619A NO923619A NO923619L NO 923619 L NO923619 L NO 923619L NO 92923619 A NO92923619 A NO 92923619A NO 923619 A NO923619 A NO 923619A NO 923619 L NO923619 L NO 923619L
Authority
NO
Norway
Prior art keywords
preparation
crystallization
smaller
carried out
temperatures
Prior art date
Application number
NO92923619A
Other languages
English (en)
Other versions
NO923619D0 (no
Inventor
Masayoshi Kaneko
Shigeo Yabuno
Original Assignee
Lederle Japan Ltd
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lederle Japan Ltd, Takeda Chemical Industries Ltd filed Critical Lederle Japan Ltd
Publication of NO923619D0 publication Critical patent/NO923619D0/no
Publication of NO923619L publication Critical patent/NO923619L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Fremgangsmåte for krystalllsering av (lR,5S,6S)-2- [ ( 6 ,7-dihydro-5E-pyrazolo[l ,2-a] [l ,2 , 4]triazolium-6- yl)]tio-6-[(R )-l-hydroksyetyl]-l-metyl-karbapenem-3- karboksylat (heretter forkortet som L-627), og er kjennetegnet ved at man opprettholder en vandig oppløsning med L-627 ved temperaturer l oppløsningen l området fra eutektisk temperatur til temperaturer lavere enn O'C. Fremgangsmåten medfører noen fordeler ved at tap av L- 627 som følge av krystallisasjon er mindre, antall trinn l fremstillingen av beholderformuleringene er mindre og opprettholdelse av disse trinnene under sterile og støvfrie betingelser kan enkelt bli . gjennomført, dlspensering av medikamentet kan bli gjennomført med kvantitativ nøyaktighet, og krystallene oppløses i et oppløsningsmlddel øyeblikkelig på anvendelsestldspunktet.
NO92923619A 1991-09-20 1992-09-17 Fremstilling av krystallinsk penem NO923619L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP24164891 1991-09-20

Publications (2)

Publication Number Publication Date
NO923619D0 NO923619D0 (no) 1992-09-17
NO923619L true NO923619L (no) 1993-03-22

Family

ID=17077445

Family Applications (2)

Application Number Title Priority Date Filing Date
NO92923619A NO923619L (no) 1991-09-20 1992-09-17 Fremstilling av krystallinsk penem
NO971332A NO971332D0 (no) 1991-09-20 1997-03-21 Fremstilling av krystallinsk penem

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO971332A NO971332D0 (no) 1991-09-20 1997-03-21 Fremstilling av krystallinsk penem

Country Status (9)

Country Link
US (2) US5286856A (no)
EP (1) EP0533149A1 (no)
JP (1) JP2767171B2 (no)
KR (1) KR930006022A (no)
FI (1) FI924210A (no)
IL (1) IL103218A0 (no)
NO (2) NO923619L (no)
TW (1) TW264475B (no)
ZA (1) ZA927164B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW264475B (no) * 1991-09-20 1995-12-01 Takeda Pharm Industry Co Ltd
DE69528166T2 (de) * 1994-05-02 2003-04-30 Shionogi & Co., Ltd. Kristalline pyrrolidylthiocarbapenem derivate, lyophilisierste präparationen dieser kristalle und verfahren zu deren herstellung
DE69930616T2 (de) * 1998-03-02 2006-11-23 Merck & Co., Inc. Verfahren zur synthese von carbapenem-antibiotika
DE10300620B4 (de) * 2002-05-18 2017-04-13 Carl Zeiss Meditec Ag Trägervorrichtung für ein medizinisch-optisches Gerät
KR101013535B1 (ko) * 2004-10-21 2011-02-14 주식회사 만도 자동차의 파워 스티어링 장치용 실린더 튜브와 피드튜브의 조립 구조물
ZA200901949B (en) 2006-09-25 2010-07-28 Ptc Therapeutics Inc Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid
WO2009047604A1 (en) * 2007-10-08 2009-04-16 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
DE102008043318A1 (de) 2008-10-30 2010-05-12 Mvg Metallverarbeitungsgesellschaft Mbh Anhängekupplung
WO2013132422A1 (en) * 2012-03-05 2013-09-12 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of carbapenem antibiotic
TWI565707B (zh) 2012-05-30 2017-01-11 明治製菓藥業股份有限公司 新穎β－內醯胺酶抑制劑及其製造方法
WO2014097221A1 (en) 2012-12-21 2014-06-26 Ranbaxy Laboratories Limited Process for the purification of biapenem
JP6453222B2 (ja) 2013-09-24 2019-01-16 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ジアザビシクロオクタン誘導体の製造法とその中間体
AR097971A1 (es) 2013-10-08 2016-04-20 Meiji Seika Pharma Co Ltd Formas cristalinas de derivado de diazabiciclooctano y proceso de producción de ellas
BR112017010445B8 (pt) 2014-12-05 2024-02-27 Meiji Seika Pharma Co Ltd Processo de produção de cristais de derivado de diazabiciclo-octano e preparação liofilizada estável
CN114349772B (zh) * 2020-10-13 2022-11-25 珠海联邦制药股份有限公司 一种比阿培南粗品的精制方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
IL53427A0 (en) * 1976-11-24 1978-01-31 Lilly Co Eli Method of preparing a rapidly dissolving powder of sterile crystalline cefozolin sodium for parenteral administration
JPS6024080B2 (ja) * 1977-06-01 1985-06-11 武田薬品工業株式会社 結晶の製造法
GB1589317A (en) * 1977-11-24 1981-05-13 Lilly Co Eli Freeze drying cephalothin sodium
JPS56120615A (en) * 1980-02-27 1981-09-22 Nippon Chemiphar Co Ltd Preparation of lyophilized powder of cephalothin
US4713451A (en) * 1984-04-09 1987-12-15 Merck & Co., Inc. Crystalline dimethyliminothienamycin
IE60588B1 (en) * 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
US4866171A (en) * 1987-04-11 1989-09-12 Lederle (Japan), Ltd. (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
DK168047B1 (da) * 1987-12-07 1994-01-24 Lederle Japan Ltd (1r,5s,6s)-2-substitueret thio-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater, fremgangsmaade til remstilling deraf, midler og praeparater indeholdende den krystallinske forbindelse samt dens anvendelse.
US5082661A (en) * 1990-09-26 1992-01-21 Elizabeth Arden Co., Division Of Conopco, Inc. Odorless cosmetic compositions in gelatin capsules
GB9021061D0 (en) * 1990-09-27 1990-11-07 Unilever Plc Encapsulating method and products containing encapsulated material
TW264475B (no) * 1991-09-20 1995-12-01 Takeda Pharm Industry Co Ltd
NZ261497A (en) * 1993-01-29 1997-06-24 Agouron Pharma 2-[4-[2-(2-amino-4-oxo-3h-pyrido[5,4-b]n-hetring)-ring containing hydrocarbyl chain]-amido]-pentanedioic acid

Also Published As

Publication number Publication date
US5424069A (en) 1995-06-13
NO971332D0 (no) 1997-03-21
FI924210A0 (fi) 1992-09-18
NO923619D0 (no) 1992-09-17
AU645442B2 (en) 1994-01-13
EP0533149A1 (en) 1993-03-24
FI924210A (fi) 1993-03-21
US5286856A (en) 1994-02-15
NO971332L (no) 1993-03-22
AU2459792A (en) 1993-03-25
JPH05271241A (ja) 1993-10-19
JP2767171B2 (ja) 1998-06-18
ZA927164B (en) 1994-03-18
IL103218A0 (en) 1993-02-21
TW264475B (no) 1995-12-01
KR930006022A (ko) 1993-04-20

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