NO971332L - Fremstilling av krystallinsk penem - Google Patents
Fremstilling av krystallinsk penemInfo
- Publication number
- NO971332L NO971332L NO971332A NO971332A NO971332L NO 971332 L NO971332 L NO 971332L NO 971332 A NO971332 A NO 971332A NO 971332 A NO971332 A NO 971332A NO 971332 L NO971332 L NO 971332L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- crystallization
- accomplished
- maintaining
- smaller
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Fremgangsmåte for krystallisering av (lR,5S,6S)-2- [(6 ,7-dlhydro-5H-pyrazolo[l,2-a] [1, 2 ,4]t^iazolluIn-6- yl )]tlo-6-C(R)-l-hydroksyetyl]-l-metyl-karbapenem-3- karboksylat (heretter forkortet som L-627), og er kjennetegnet ved at man opprettholder en vandig oppløsning med L-627 ved temperaturer 1 oppløsningen 1 området fra eutektlsk temperatur til temperaturer lavere enn 0*C. Fremgangsmåten medfører noen fordeler ved at tap av L- 627 som følge av krystallisasjon er mindre, antall trinn i fremstillingen av beholderformuleringene er mindre og opprettholdelse av disse trinnene under sterile og støvfrie betingelser kan enkelt bil gjennomfart, dlspenserlng av medikamentet kan bli gjennomført med kvantitativ nøyaktighet, og krystallene oppløses i et oppløsningsmiddel øyeblikkelig på anvendelsestidspunktet.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24164891 | 1991-09-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO971332L true NO971332L (no) | 1993-03-22 |
NO971332D0 NO971332D0 (no) | 1997-03-21 |
Family
ID=17077445
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO92923619A NO923619L (no) | 1991-09-20 | 1992-09-17 | Fremstilling av krystallinsk penem |
NO971332A NO971332D0 (no) | 1991-09-20 | 1997-03-21 | Fremstilling av krystallinsk penem |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO92923619A NO923619L (no) | 1991-09-20 | 1992-09-17 | Fremstilling av krystallinsk penem |
Country Status (9)
Country | Link |
---|---|
US (2) | US5286856A (no) |
EP (1) | EP0533149A1 (no) |
JP (1) | JP2767171B2 (no) |
KR (1) | KR930006022A (no) |
FI (1) | FI924210A (no) |
IL (1) | IL103218A0 (no) |
NO (2) | NO923619L (no) |
TW (1) | TW264475B (no) |
ZA (1) | ZA927164B (no) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW264475B (no) * | 1991-09-20 | 1995-12-01 | Takeda Pharm Industry Co Ltd | |
US6111098A (en) * | 1994-05-02 | 2000-08-29 | Shionogi & Co., Ltd. | Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same |
AU749234B2 (en) * | 1998-03-02 | 2002-06-20 | Merck Sharp & Dohme Corp. | Process for synthesizing carbapenem antibiotics |
DE10300620B4 (de) * | 2002-05-18 | 2017-04-13 | Carl Zeiss Meditec Ag | Trägervorrichtung für ein medizinisch-optisches Gerät |
KR101013535B1 (ko) * | 2004-10-21 | 2011-02-14 | 주식회사 만도 | 자동차의 파워 스티어링 장치용 실린더 튜브와 피드튜브의 조립 구조물 |
BRPI0717107A2 (pt) | 2006-09-25 | 2013-10-15 | Ptc Therapeutics Inc | FORMA DE CRISTAL, FORMA DE DOSAGEM FARMACÊUTICA, E, MÉTODO PARA MODULAR TERMINAÇÃO DE TRANSLAÇÃO PREMATURA OU DETERIORAÇÃO DE mRNA |
US8293924B2 (en) * | 2007-10-08 | 2012-10-23 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of carbapenem antibiotic |
DE102008043318A1 (de) | 2008-10-30 | 2010-05-12 | Mvg Metallverarbeitungsgesellschaft Mbh | Anhängekupplung |
WO2013132422A1 (en) * | 2012-03-05 | 2013-09-12 | Orchid Chemicals & Pharmaceuticals Ltd | An improved process for the preparation of carbapenem antibiotic |
ES2758507T3 (es) | 2012-05-30 | 2020-05-05 | Meiji Seika Pharma Co Ltd | Nuevo inhibidor de B-lactamasa y método para producir el mismo |
WO2014097221A1 (en) | 2012-12-21 | 2014-06-26 | Ranbaxy Laboratories Limited | Process for the purification of biapenem |
RU2719480C2 (ru) | 2013-09-24 | 2020-04-17 | Мейдзи Сейка Фарма Ко., Лтд. | Способ получения производного диазабициклооктана и его промежуточного соединения |
ES2901198T3 (es) | 2013-10-08 | 2022-03-21 | Meiji Seika Pharma Co Ltd | Formas cristalinas de derivado de diazabiciclooctano y procedimiento de producción de las mismas |
KR102555657B1 (ko) | 2014-12-05 | 2023-07-18 | 메이지 세이카 파루마 가부시키가이샤 | 디아자비시클로옥탄 유도체의 결정 및 안정된 동결 건조 제제의 제조법 |
CN114349772B (zh) * | 2020-10-13 | 2022-11-25 | 珠海联邦制药股份有限公司 | 一种比阿培南粗品的精制方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4029655A (en) * | 1975-04-11 | 1977-06-14 | Eli Lilly And Company | Method of preparing stable sterile crystalline cephalosporins for parenteral administration |
IL53427A0 (en) * | 1976-11-24 | 1978-01-31 | Lilly Co Eli | Method of preparing a rapidly dissolving powder of sterile crystalline cefozolin sodium for parenteral administration |
JPS6024080B2 (ja) * | 1977-06-01 | 1985-06-11 | 武田薬品工業株式会社 | 結晶の製造法 |
GB1589317A (en) * | 1977-11-24 | 1981-05-13 | Lilly Co Eli | Freeze drying cephalothin sodium |
JPS56120615A (en) * | 1980-02-27 | 1981-09-22 | Nippon Chemiphar Co Ltd | Preparation of lyophilized powder of cephalothin |
US4713451A (en) * | 1984-04-09 | 1987-12-15 | Merck & Co., Inc. | Crystalline dimethyliminothienamycin |
IE60588B1 (en) * | 1986-07-30 | 1994-07-27 | Sumitomo Pharma | Carbapenem compound in crystalline form, and its production and use |
US4866171A (en) * | 1987-04-11 | 1989-09-12 | Lederle (Japan), Ltd. | (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate |
JPS6425779A (en) * | 1987-04-11 | 1989-01-27 | Lederle Japan Ltd | (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative |
DK168047B1 (da) * | 1987-12-07 | 1994-01-24 | Lederle Japan Ltd | (1r,5s,6s)-2-substitueret thio-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater, fremgangsmaade til remstilling deraf, midler og praeparater indeholdende den krystallinske forbindelse samt dens anvendelse. |
US5082661A (en) * | 1990-09-26 | 1992-01-21 | Elizabeth Arden Co., Division Of Conopco, Inc. | Odorless cosmetic compositions in gelatin capsules |
GB9021061D0 (en) * | 1990-09-27 | 1990-11-07 | Unilever Plc | Encapsulating method and products containing encapsulated material |
TW264475B (no) * | 1991-09-20 | 1995-12-01 | Takeda Pharm Industry Co Ltd | |
ATE201877T1 (de) * | 1993-01-29 | 2001-06-15 | Agouron Pharma | Kondensierte heterocyclische glutaminsäurederivate als antiproliferative mittel |
-
1992
- 1992-09-16 TW TW081107287A patent/TW264475B/zh active
- 1992-09-17 EP EP92115869A patent/EP0533149A1/en not_active Withdrawn
- 1992-09-17 NO NO92923619A patent/NO923619L/no unknown
- 1992-09-18 KR KR1019920017057A patent/KR930006022A/ko not_active Application Discontinuation
- 1992-09-18 JP JP4249767A patent/JP2767171B2/ja not_active Expired - Lifetime
- 1992-09-18 FI FI924210A patent/FI924210A/fi not_active Application Discontinuation
- 1992-09-18 ZA ZA927164A patent/ZA927164B/xx unknown
- 1992-09-18 IL IL103218A patent/IL103218A0/xx unknown
- 1992-09-18 US US07/946,614 patent/US5286856A/en not_active Expired - Fee Related
-
1993
- 1993-11-30 US US08/159,252 patent/US5424069A/en not_active Expired - Fee Related
-
1997
- 1997-03-21 NO NO971332A patent/NO971332D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO923619D0 (no) | 1992-09-17 |
IL103218A0 (en) | 1993-02-21 |
US5286856A (en) | 1994-02-15 |
ZA927164B (en) | 1994-03-18 |
FI924210A (fi) | 1993-03-21 |
JP2767171B2 (ja) | 1998-06-18 |
NO971332D0 (no) | 1997-03-21 |
AU2459792A (en) | 1993-03-25 |
KR930006022A (ko) | 1993-04-20 |
US5424069A (en) | 1995-06-13 |
JPH05271241A (ja) | 1993-10-19 |
AU645442B2 (en) | 1994-01-13 |
FI924210A0 (fi) | 1992-09-18 |
EP0533149A1 (en) | 1993-03-24 |
TW264475B (no) | 1995-12-01 |
NO923619L (no) | 1993-03-22 |
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