KR930004304A - 신규한 티아졸릴벤조푸란 유도체, 그의 제조방법 및 이 화합물을 함유하는 약제학적 조성물 - Google Patents

신규한 티아졸릴벤조푸란 유도체, 그의 제조방법 및 이 화합물을 함유하는 약제학적 조성물 Download PDF

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Publication number
KR930004304A
KR930004304A KR1019920014712A KR920014712A KR930004304A KR 930004304 A KR930004304 A KR 930004304A KR 1019920014712 A KR1019920014712 A KR 1019920014712A KR 920014712 A KR920014712 A KR 920014712A KR 930004304 A KR930004304 A KR 930004304A
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KR
South Korea
Prior art keywords
alkyl
compound
formula
salt
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019920014712A
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English (en)
Korean (ko)
Inventor
마사아끼 마쭈오
가쭈오 오꾸무라
신찌 신게나가
히로시 마쭈다
Original Assignee
후지야마 아끼라
후지사와 야꾸힝 고교 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919117733A external-priority patent/GB9117733D0/en
Priority claimed from GB929201057A external-priority patent/GB9201057D0/en
Application filed by 후지야마 아끼라, 후지사와 야꾸힝 고교 가부시끼가이샤 filed Critical 후지야마 아끼라
Publication of KR930004304A publication Critical patent/KR930004304A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019920014712A 1991-08-16 1992-08-14 신규한 티아졸릴벤조푸란 유도체, 그의 제조방법 및 이 화합물을 함유하는 약제학적 조성물 Ceased KR930004304A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB919117733A GB9117733D0 (en) 1991-08-16 1991-08-16 New thiazolylbenzofuran derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
GB9117733.7 1991-08-16
GB9201057.8 1992-01-17
GB929201057A GB9201057D0 (en) 1992-01-17 1992-01-17 New thiazolylbenzofuran derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same

Publications (1)

Publication Number Publication Date
KR930004304A true KR930004304A (ko) 1993-03-22

Family

ID=26299417

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920014712A Ceased KR930004304A (ko) 1991-08-16 1992-08-14 신규한 티아졸릴벤조푸란 유도체, 그의 제조방법 및 이 화합물을 함유하는 약제학적 조성물

Country Status (16)

Country Link
US (1) US5296495A (https=)
EP (1) EP0528337B1 (https=)
JP (1) JP2600644B2 (https=)
KR (1) KR930004304A (https=)
CN (1) CN1033088C (https=)
AT (1) ATE185807T1 (https=)
AU (1) AU665007B2 (https=)
CA (1) CA2076192A1 (https=)
DE (1) DE69230163T2 (https=)
DK (1) DK0528337T3 (https=)
ES (1) ES2137169T3 (https=)
GR (1) GR3032425T3 (https=)
HU (2) HUT64336A (https=)
MX (1) MX9204746A (https=)
SG (1) SG45259A1 (https=)
TW (1) TW224464B (https=)

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DE69728581D1 (de) * 1996-01-22 2004-05-13 Fujisawa Pharmaceutical Co Thiazolylbenzofuranderivate und ihre Verwendung als SRS-A- und Leukotrien-Antagonisten
DE69821132T2 (de) * 1997-10-27 2004-10-21 Takeda Chemical Industries Ltd 1,3-thiazole als adenosine a3 rezeptor antagonisten zur behandlung von asthma, allergien und diabetes
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
WO2003048140A1 (en) 2001-12-03 2003-06-12 Japan Tobacco Inc. Azole compound and medicinal use thereof
EP1424101A3 (en) * 2002-11-29 2004-08-18 NOZAKI, Masako Use of a leukotriene C4 and D4 receptor antagonist for the preparation of a medicament for treating or preventing brain inflammation and sepsis
US7148248B2 (en) 2002-11-29 2006-12-12 Masako Nozaki Method of treating or inhibiting the development of brain inflammation and sepsis
MXPA05010945A (es) * 2003-04-09 2005-11-25 Japan Tobacco Inc Compuesto pentaciclico heteroaromatico y uso medicinal del mismo.
JP2005008631A (ja) * 2003-05-29 2005-01-13 New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
US7638540B2 (en) * 2003-05-29 2009-12-29 The New Industry Research Organization Benzofuran compound and medicinal composition containing the same
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
DE602005023797D1 (de) 2004-07-14 2010-11-04 Inflammation Res Ct Co Ltd Verfahren zur Hemmung von Tumormetastasierung
EP1819329A2 (en) * 2004-08-04 2007-08-22 Schering Corporation Pharmaceutical formulations comprising pleconaril for the treatment of airway diseases
WO2006046683A1 (en) * 2004-10-25 2006-05-04 Astellas Pharma Inc. Thiazolylbenzofuran derivatives as leukotriene and prostaglandin d2 receptor antagonists
JP2008517938A (ja) 2004-10-25 2008-05-29 シェーリング コーポレイション 呼吸器障害を処置するために他の活性剤と組み合わせたｍ１レセプターアンタゴニストおよび／またはｍ３レセプターアンタゴニスト
JPWO2006054793A1 (ja) * 2004-11-19 2008-06-05 財団法人新産業創造研究機構 ベンゾフラン化合物、およびそれを含有してなる医薬組成物
KR20090026217A (ko) * 2006-07-11 2009-03-11 쉐링 코포레이션 치환된 5-옥사졸-2-일-퀴놀린 화합물의 크시나포에이트 염
CA2669704A1 (en) * 2006-11-16 2008-05-22 Allergan, Inc. Sulfoximines as kinase inhibitors
JP2012530140A (ja) 2009-06-16 2012-11-29 メルク・シャープ・アンド・ドーム・コーポレーション グルココルチコイド受容体アゴニストとしての新規［３，２−ｃ］ヘテロアリールステロイド、組成物およびこの使用
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
US8710043B2 (en) 2011-06-24 2014-04-29 Amgen Inc. TRPM8 antagonists and their use in treatments
ES2643403T3 (es) * 2011-12-28 2017-11-22 Global Blood Therapeutics, Inc. Compuestos de benzaldehído sustituidos y métodos para su uso en el aumento de la oxigenación tisular
HK1203412A1 (en) 2011-12-28 2015-10-30 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
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US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014150258A1 (en) 2013-03-15 2014-09-25 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
CN114181195A (zh) 2014-02-07 2022-03-15 全球血液疗法股份有限公司 一种化合物的结晶多晶型物
HUE056957T2 (hu) * 2014-08-29 2022-04-28 Chdi Foundation Inc Próbák huntingtin fehérjét megjelenítõ képalkotásra
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Also Published As

Publication number Publication date
MX9204746A (es) 1994-04-29
JP2600644B2 (ja) 1997-04-16
ES2137169T3 (es) 1999-12-16
CN1033088C (zh) 1996-10-23
CA2076192A1 (en) 1993-02-17
HU211630A9 (en) 1995-12-28
DE69230163T2 (de) 2000-03-23
DE69230163D1 (de) 1999-11-25
SG45259A1 (en) 1998-01-16
CN1070910A (zh) 1993-04-14
AU2102992A (en) 1993-02-18
HUT64336A (en) 1993-12-28
GR3032425T3 (en) 2000-05-31
ATE185807T1 (de) 1999-11-15
EP0528337B1 (en) 1999-10-20
EP0528337A1 (en) 1993-02-24
JPH05202040A (ja) 1993-08-10
US5296495A (en) 1994-03-22
HU9202656D0 (en) 1992-10-28
DK0528337T3 (da) 2000-03-27
AU665007B2 (en) 1995-12-14
TW224464B (https=) 1994-06-01

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