KR930001410B1 - 치환된 벤즈이미다졸 유도체의 제조방법 - Google Patents
치환된 벤즈이미다졸 유도체의 제조방법 Download PDFInfo
- Publication number
- KR930001410B1 KR930001410B1 KR1019850008129A KR850008129A KR930001410B1 KR 930001410 B1 KR930001410 B1 KR 930001410B1 KR 1019850008129 A KR1019850008129 A KR 1019850008129A KR 850008129 A KR850008129 A KR 850008129A KR 930001410 B1 KR930001410 B1 KR 930001410B1
- Authority
- KR
- South Korea
- Prior art keywords
- chloro
- formula
- benzimidazole
- piperidino
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8427836 | 1984-11-02 | ||
| GB848427836A GB8427836D0 (en) | 1984-11-02 | 1984-11-02 | Chemical compounds |
| GB8432515 | 1984-12-21 | ||
| GB848432515A GB8432515D0 (en) | 1984-12-21 | 1984-12-21 | Heterocyclic compounds |
| GB858518043A GB8518043D0 (en) | 1985-07-17 | 1985-07-17 | Heterocyclic compounds |
| GB8518043 | 1985-07-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR860004050A KR860004050A (ko) | 1986-06-16 |
| KR930001410B1 true KR930001410B1 (ko) | 1993-02-27 |
Family
ID=27262502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850008129A Expired - Fee Related KR930001410B1 (ko) | 1984-11-02 | 1985-11-01 | 치환된 벤즈이미다졸 유도체의 제조방법 |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0184322B1 (enExample) |
| KR (1) | KR930001410B1 (enExample) |
| CN (1) | CN1013445B (enExample) |
| AR (1) | AR241592A1 (enExample) |
| AU (1) | AU576634B2 (enExample) |
| CA (1) | CA1253150A (enExample) |
| DE (1) | DE3574873D1 (enExample) |
| DK (1) | DK501085A (enExample) |
| ES (1) | ES8701752A1 (enExample) |
| FI (1) | FI84718C (enExample) |
| GR (1) | GR852643B (enExample) |
| HU (1) | HU200763B (enExample) |
| IE (1) | IE58587B1 (enExample) |
| JO (1) | JO1406B1 (enExample) |
| NO (1) | NO164541C (enExample) |
| NZ (1) | NZ214024A (enExample) |
| PH (1) | PH22303A (enExample) |
| PT (1) | PT81420B (enExample) |
| ZW (1) | ZW19185A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2161160B (en) * | 1984-07-06 | 1989-05-24 | Fisons Plc | Heterocyclic sulphinyl compounds |
| CA1341314C (en) * | 1984-07-06 | 2001-11-06 | David Cox | Derivatives of benzimidazole, benzothiazole and benzoxazole |
| GB8610607D0 (en) * | 1986-04-30 | 1986-06-04 | Smith Kline French Lab | Chemical compounds |
| GB8621425D0 (en) * | 1986-09-05 | 1986-10-15 | Smith Kline French Lab | Compounds |
| DE3722810A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung |
| HU217298B (hu) | 1993-12-01 | 1999-12-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | (Helyettesített amino)-alkil-amino-piridil-metil-tio-benzimidazol- és -imidazo [5,4-b]piridin-származékok, előállításuk és alkalmazásuk, valamint a vegyületeket tartalmazó gyógyászati készítmények |
| SI1187601T1 (sl) | 1999-06-07 | 2005-12-31 | Altana Pharma Ag | Novi pripravek in dajalna oblika, ki obsega kislinsko labilen inhibitor protonske crpalke |
| CA2464031A1 (en) | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
| US7138402B2 (en) | 2003-09-18 | 2006-11-21 | Conforma Therapeutics Corporation | Pyrrolopyrimidines and related analogs as HSP90-inhibitors |
| US8802139B2 (en) | 2003-06-26 | 2014-08-12 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
| US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
| US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
| JP2008534609A (ja) * | 2005-03-30 | 2008-08-28 | コンフォーマ・セラピューティクス・コーポレイション | Ｈｓｐ９０阻害剤としてのアルキニルピロロピリミジンおよび関連類似体 |
| US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
| US9561188B2 (en) | 2006-04-03 | 2017-02-07 | Intellipharmaceutics Corporation | Controlled release delivery device comprising an organosol coat |
| US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA825106B (en) * | 1981-08-13 | 1983-04-27 | Haessle Ab | Novel pharmaceutical compositions |
| US4575554A (en) * | 1983-12-05 | 1986-03-11 | The Upjohn Company | Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents |
| CA1341314C (en) * | 1984-07-06 | 2001-11-06 | David Cox | Derivatives of benzimidazole, benzothiazole and benzoxazole |
| EP0178438A1 (en) * | 1984-09-19 | 1986-04-23 | Beecham Group Plc | Novel compounds |
| AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
| IL76837A0 (en) * | 1984-10-31 | 1986-02-28 | Byk Gulden Lomberg Chem Fab | Benzimidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them |
| US4851419A (en) * | 1985-10-16 | 1989-07-25 | Fisons Plc | Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity |
| EP0806002A1 (en) * | 1995-11-24 | 1997-11-12 | Koninklijke Philips Electronics N.V. | A method for presenting virtual reality enhanced with tactile stimuli, and a system for executing the method |
-
1985
- 1985-10-24 JO JO19851406A patent/JO1406B1/en active
- 1985-10-28 CA CA000493978A patent/CA1253150A/en not_active Expired
- 1985-10-28 PH PH32987A patent/PH22303A/en unknown
- 1985-10-30 AR AR85302116A patent/AR241592A1/es active
- 1985-10-30 ZW ZW191/85A patent/ZW19185A1/xx unknown
- 1985-10-30 AU AU49207/85A patent/AU576634B2/en not_active Ceased
- 1985-10-30 FI FI854267A patent/FI84718C/fi not_active IP Right Cessation
- 1985-10-31 DK DK501085A patent/DK501085A/da not_active Application Discontinuation
- 1985-10-31 PT PT81420A patent/PT81420B/pt not_active IP Right Cessation
- 1985-10-31 DE DE8585307928T patent/DE3574873D1/de not_active Expired - Lifetime
- 1985-10-31 NZ NZ214024A patent/NZ214024A/xx unknown
- 1985-10-31 EP EP85307928A patent/EP0184322B1/en not_active Expired
- 1985-10-31 ES ES548409A patent/ES8701752A1/es not_active Expired
- 1985-11-01 KR KR1019850008129A patent/KR930001410B1/ko not_active Expired - Fee Related
- 1985-11-01 HU HU854204A patent/HU200763B/hu not_active IP Right Cessation
- 1985-11-01 IE IE268485A patent/IE58587B1/en not_active IP Right Cessation
- 1985-11-01 NO NO854369A patent/NO164541C/no unknown
- 1985-11-02 CN CN85108133A patent/CN1013445B/zh not_active Expired
- 1985-11-04 GR GR852643A patent/GR852643B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0184322A1 (en) | 1986-06-11 |
| GR852643B (enExample) | 1986-03-05 |
| KR860004050A (ko) | 1986-06-16 |
| ZW19185A1 (en) | 1986-05-21 |
| NO164541C (no) | 1990-10-17 |
| ES8701752A1 (es) | 1986-12-01 |
| IE852684L (en) | 1986-05-02 |
| HUT39176A (en) | 1986-08-28 |
| PT81420B (pt) | 1988-05-27 |
| EP0184322B1 (en) | 1989-12-20 |
| FI84718C (fi) | 1992-01-10 |
| DK501085A (da) | 1986-05-03 |
| DK501085D0 (da) | 1985-10-31 |
| IE58587B1 (en) | 1993-10-06 |
| NZ214024A (en) | 1989-08-29 |
| DE3574873D1 (en) | 1990-01-25 |
| CA1253150A (en) | 1989-04-25 |
| AR241592A1 (es) | 1992-09-30 |
| CN1013445B (zh) | 1991-08-07 |
| NO854369L (no) | 1986-05-05 |
| FI854267A0 (fi) | 1985-10-30 |
| HU200763B (en) | 1990-08-28 |
| PH22303A (en) | 1988-07-22 |
| NO164541B (no) | 1990-07-09 |
| AU4920785A (en) | 1986-05-08 |
| PT81420A (en) | 1985-11-01 |
| CN85108133A (zh) | 1986-04-10 |
| FI84718B (fi) | 1991-09-30 |
| JO1406B1 (en) | 1986-11-30 |
| FI854267L (fi) | 1986-05-03 |
| ES548409A0 (es) | 1986-12-01 |
| AU576634B2 (en) | 1988-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
St.27 status event code: A-0-1-A10-A12-nap-PA0109 |
|
| R17-X000 | Change to representative recorded |
St.27 status event code: A-3-3-R10-R17-oth-X000 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| A201 | Request for examination | ||
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| G160 | Decision to publish patent application | ||
| PG1605 | Publication of application before grant of patent |
St.27 status event code: A-2-2-Q10-Q13-nap-PG1605 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U11-oth-PR1002 Fee payment year number: 1 |
|
| LAPS | Lapse due to unpaid annual fee | ||
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 19960228 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 19960228 |