KR920702217A - 말라리아 치료 조성물 - Google Patents

말라리아 치료 조성물

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Publication number
KR920702217A
KR920702217A KR1019920700800A KR920700800A KR920702217A KR 920702217 A KR920702217 A KR 920702217A KR 1019920700800 A KR1019920700800 A KR 1019920700800A KR 920700800 A KR920700800 A KR 920700800A KR 920702217 A KR920702217 A KR 920702217A
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KR
South Korea
Prior art keywords
effective amount
pharmaceutical composition
synergistically effective
compound
mixed
Prior art date
Application number
KR1019920700800A
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English (en)
Other versions
KR100221689B1 (ko
Inventor
쪼우 이큉
닝 단시
왕 슈펜
딩 디벤
리 꿔우푸
샨 쳉키
류 광유
Original Assignee
베르너 발데그
시바-가이기 에이지
샤오산 왕
인스티튜트 오브 마이크로바이 알러지 앤드 에피더미알러지, 아카데미 오브 밀리터리 메디칼 사이언시즈
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25742651&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR920702217(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 베르너 발데그, 시바-가이기 에이지, 샤오산 왕, 인스티튜트 오브 마이크로바이 알러지 앤드 에피더미알러지, 아카데미 오브 밀리터리 메디칼 사이언시즈 filed Critical 베르너 발데그
Publication of KR920702217A publication Critical patent/KR920702217A/ko
Application granted granted Critical
Publication of KR100221689B1 publication Critical patent/KR100221689B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

말라리아 치료 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 상승작용적 유효량의 하나 이상의 일반식(Ⅱ)의 화합물 및 약제학적으로 허용되는 이의 염과 상승작용적 유효량의 구조식(Ⅰ)의 화합물을 포함함을 특징으로 하는, 말라리아에 대해 활성 성분을 상승적으로 작용시키기에 적합한 약제학적 조성물.
    상기식에서, R및 R1은 함께 산소를 나타내거나, 또는 R 및 R1중의 하나는 각각 하이드록시, C1-C6-알콕시, C1-C6-알케닐옥시, C1-C|5-알카노일옥시, 카복시-C1-C6-알카노일옥시, 사이클로헥산카보닐옥시, 벤조일옥시, 또는 나프토일옥시를 나타내고, 나머지 하나는 수소를 나타낸다.
  2. 제1항에 있어서, 상승작용적 유효량의, 아테미시닌, 디하이드로아테미시닌, 아테에테르, 아테메테르 및 아테수네이트로 이루어진 그룹으로 부터 하나 이상의 일반식(Ⅱ)의 화합물과 혼합된 상승작용적 유효량의 벤플루메톨(Ⅰ)을 포함하는 약제학적 조성물.
  3. 제1항에 있어서, 상승작용적 유효량의 아테메테르(Ⅱ)와 혼합된 상승작용적 유효량의 벤플루메톨(Ⅰ)을 포함하는 약제학적 조성물.
  4. 상승작용적 유효량의 아테메테르(Ⅱ)와 혼합된 상승작용적 유효량의 벤플루메톨(Ⅰ)을 포함하는, 말라리아에 대해 활성 성분을 상승적으로 적용시키기에 적합한 약제학적 조성물.
  5. 제1항에 있어서, 일반식(Ⅱ)의 화합물 1중량을 혼합된 벤플루메톨(Ⅰ) 1 내지 10중량을 포함하는 약제학적 조성물.
  6. 제1항에 있어서, 일반식(Ⅱ)의 화합물 1중량을 혼합된 벤플루메톨(Ⅰ) 3 내지 7중량을 포함하는 약제학적 조성물.
  7. 제4항에 있어서, 아테메테르(Ⅱ) 5 내지 6중량과 혼합된 벤플루메톨(Ⅰ)1중량을 포함하는 약제학적 조성물.
  8. 제5항 또는 제6항에 있어서, 아테메테르(Ⅱ) 5 내지 6중량과 혼합된 벤플루메톨(Ⅰ)1중량을 포함하는 약제학적 조성물.
  9. 상승작용적 유효량의 제1항에 따른 화합물(Ⅰ)을 상승작용적 유효량의 하나 이상의 일반식(Ⅱ)의 화합물 또는 약제학적으로 허용되는 이의 염과 혼합한 다음, 임의로 약제학적으로 허용되는 첨가제를 가하면서 활성성분의 혼합물을 적합한 투여 형태로 제형화시킴을 특징으로 하여, 말라리아에 대해 활성 성분을 상승적으로 작용시키기에 적합한 약제학적 조성물을 제조하는 방법.
  10. 인간 또는 동물의 신체를 치료하는 방법에 있어서의, 제1항에 따른 약제학적 조성물의 용도.
  11. 환자에게 유효량의 제1항에 따른 약제학적 조성물을 투여함을 특징으로 하여, 말라리아를 치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920700800A 1990-08-08 1991-06-05 항말라리아조성물 KR100221689B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN90106722.9 1990-08-08
CN901067229 1990-08-08
CN90106722A CN1058717A (zh) 1990-08-08 1990-08-08 抗疟新药—复方蒿甲醚及其制备方法
CN911025758 1991-04-24
CN91102575A CN1085527C (zh) 1990-08-08 1991-04-24 增效复方抗疟药本芴醇的制备方法
CN91102575.8 1991-04-24
PCT/EP1991/001033 WO1992002217A1 (en) 1990-08-08 1991-06-05 Antimalarial compositions

Publications (2)

Publication Number Publication Date
KR920702217A true KR920702217A (ko) 1992-09-03
KR100221689B1 KR100221689B1 (ko) 1999-09-15

Family

ID=25742651

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920700800A KR100221689B1 (ko) 1990-08-08 1991-06-05 항말라리아조성물

Country Status (27)

Country Link
US (1) US5677331A (ko)
EP (1) EP0500823B1 (ko)
JP (1) JP2562857B2 (ko)
KR (1) KR100221689B1 (ko)
CN (2) CN1058717A (ko)
AP (1) AP231A (ko)
AT (1) ATE135209T1 (ko)
AU (1) AU642747B2 (ko)
CA (1) CA2065285C (ko)
DE (2) DE10199038I2 (ko)
DK (1) DK0500823T3 (ko)
EG (1) EG19905A (ko)
ES (1) ES2084168T3 (ko)
FI (1) FI921491A (ko)
GR (1) GR3019313T3 (ko)
HK (1) HK1000312A1 (ko)
HU (1) HU227345B1 (ko)
IE (1) IE72095B1 (ko)
IL (1) IL98463A (ko)
LU (1) LU90844I2 (ko)
MA (1) MA22176A1 (ko)
NL (1) NL300048I2 (ko)
NZ (1) NZ238477A (ko)
PT (1) PT97945B (ko)
SA (1) SA91120263B1 (ko)
WO (1) WO1992002217A1 (ko)
ZA (1) ZA914490B (ko)

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US5637594A (en) * 1991-04-11 1997-06-10 Ciba Geigy Corporation Antimalarial synergistic compositions containing benflumetol
NZ246606A (en) * 1992-02-07 1995-09-26 Ciba Geigy Ag Antimalarial compostions containing a synergistic combination of benflumetol and quinine or a derivative thereof
AU2291195A (en) * 1994-04-12 1995-10-30 Qualcomm Incorporated Method and apparatus for freight transportation using a satellite navigation system
US5657088A (en) * 1995-12-22 1997-08-12 Cirrus Logic, Inc. System and method for extracting caption teletext information from a video signal
US6136847A (en) * 1996-12-02 2000-10-24 Johns Hopkins University Water-soluble trioxanes as potent and safe antimalarial agents
CH692321A5 (de) 1997-11-03 2002-05-15 Mepha Ag Pharmazeutisch wirksame Zusammensetzung, welche eine gegen Malariaparasiten wirksame Substanz enthält.
CO5040050A1 (es) * 1998-06-25 2001-05-29 Novartis Ag Compuestos de 2-amino-1-(9-arilmetilidina-2,7-dicloro-9h- fluoren-4-ilo)-etanoles n-sustituidos, procedimientos para su obtencion y preparados farmaceuticos que los contienen .
IN191696B (ko) 1999-02-12 2003-12-20 Council Scient Ind Res
EP1267864A1 (en) * 2000-03-31 2003-01-02 Council Of Scientific & Industrial Research A synergistic anti-malarial formulation
AU2001295979A1 (en) * 2000-10-20 2002-04-29 Ajinomoto Co., Inc. Medicinal compositions, dose and method for treating malaria
US7842719B2 (en) * 2002-10-31 2010-11-30 Kemin Foods, L.C. Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus
WO2004075817A2 (en) * 2003-02-26 2004-09-10 Vrije Universiteit Brussel Suspendable pharmaceutical composition
ZA200602031B (en) * 2003-09-04 2007-05-30 Cipla Ltd Antimalarial compositions and process thereof
US20110206636A1 (en) * 2003-09-16 2011-08-25 Kemin Foods, LLC Use of Endoperoxides for the Treatment of Infections Caused by Flaviviridae, Including Hepatitis C, Bovine Viral Diarrhea and Classical Swine Fever Virus
WO2007017646A2 (en) * 2005-08-05 2007-02-15 Cipla Limited Anti-malarial composition comprising artesunate and lumefantrine
WO2007036947A1 (en) * 2005-09-30 2007-04-05 Ipca Laboratories Limited Delayed release anti-malarial composition
CN101478965A (zh) * 2006-06-26 2009-07-08 兰贝克赛实验室有限公司 蒿甲醚和本芴醇的高剂量口服药物组合物
CN100463669C (zh) * 2006-08-31 2009-02-25 广州市医药工业研究所 复方蒿甲醚自乳化剂
WO2008098586A1 (en) * 2007-02-13 2008-08-21 Dafra Pharma N.V. Pharmaceutical carrier composition and pharmaceutical composition
CH700941B1 (de) * 2007-12-04 2010-11-15 Mepha Ag Pharmazeutische Zusammensetzung zur Behandlung von Malaria.
FR2926993B1 (fr) * 2008-02-06 2011-03-11 Sanofi Aventis Association entre un sel de bis-thiazolium ou l'un de ses precurseurs et l'artemisinine ou l'un de ses derives pour le traitement du paludisme
WO2010004573A1 (en) * 2008-07-07 2010-01-14 Ipca Laboratories Limited Synergistic antimalarial pharmaceutical composition
CN104202996A (zh) * 2012-03-30 2014-12-10 甜糖（曼海姆/奥克森富特）股份公司 用于涂覆在口香糖芯材料的表面上的改进的轧制化合物粉末
CN103251584A (zh) * 2013-05-09 2013-08-21 西安力邦制药有限公司 注射用蒿甲醚/本芴醇复方脂肪乳的制备及其在疟疾治疗中的应用
WO2015140709A1 (en) * 2014-03-19 2015-09-24 Novartis Ag Solid pharmaceutical dosage forms
TWI791515B (zh) * 2017-04-24 2023-02-11 瑞士商諾華公司 治療療法
CN113599382B (zh) * 2021-08-20 2023-01-03 兰州大学 喹啉类衍生物在制备治疗糖尿病及其并发症药物中的应用
CN116747218B (zh) * 2023-08-21 2023-10-31 山东省中医药研究院 百秋李醇、百秋李醇复合抗疟组合物及制备抗疟原虫药物中的应用

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CN85100978A (zh) * 1985-04-01 1986-08-13 中医研究院中药研究所 还原青蒿素的生产工艺
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Also Published As

Publication number Publication date
SA91120263B1 (ar) 2004-08-31
WO1992002217A1 (en) 1992-02-20
AU7954991A (en) 1992-03-02
IE911989A1 (en) 1992-02-12
US5677331A (en) 1997-10-14
NL300048I2 (nl) 2002-03-01
NL300048I1 (nl) 2001-10-01
GR3019313T3 (en) 1996-06-30
CN1058717A (zh) 1992-02-19
CN1085527C (zh) 2002-05-29
DE69117922T2 (de) 1996-09-05
FI921491A0 (fi) 1992-04-03
KR100221689B1 (ko) 1999-09-15
NZ238477A (en) 1992-12-23
JPH05501568A (ja) 1993-03-25
AP231A (en) 1993-01-31
DE10199038I2 (de) 2007-01-04
IE72095B1 (en) 1997-03-12
CN1065993A (zh) 1992-11-11
MA22176A1 (fr) 1991-12-31
DE69117922D1 (de) 1996-04-18
IL98463A0 (en) 1992-07-15
AP9100275A0 (en) 1991-07-31
JP2562857B2 (ja) 1996-12-11
CA2065285A1 (en) 1992-02-09
DK0500823T3 (da) 1996-04-01
FI921491A (fi) 1992-04-03
ES2084168T3 (es) 1996-05-01
HUT61664A (en) 1993-03-01
PT97945A (pt) 1992-04-30
LU90844I2 (fr) 2002-01-24
DE10199038I1 (de) 2001-11-22
PT97945B (pt) 1998-11-30
HU227345B1 (en) 2011-04-28
CA2065285C (en) 2000-05-09
ZA914490B (en) 1992-03-25
EP0500823B1 (en) 1996-03-13
EG19905A (en) 1996-05-31
ATE135209T1 (de) 1996-03-15
EP0500823A1 (en) 1992-09-02
HK1000312A1 (en) 1998-02-27
HU9201528D0 (en) 1992-08-28
IL98463A (en) 1995-10-31
AU642747B2 (en) 1993-10-28

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