KR920700288A - 펲티드 및 dna배열 - Google Patents
펲티드 및 dna배열Info
- Publication number
- KR920700288A KR920700288A KR1019900700595A KR900700595A KR920700288A KR 920700288 A KR920700288 A KR 920700288A KR 1019900700595 A KR1019900700595 A KR 1019900700595A KR 900700595 A KR900700595 A KR 900700595A KR 920700288 A KR920700288 A KR 920700288A
- Authority
- KR
- South Korea
- Prior art keywords
- leu
- ser
- phe
- acid sequence
- polypeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 폴리스미드 pEK113의 제한효소지도이다,
제2도는 폴리스미드 pEK25의 제한효소지도이다,
제3도는 폴리스미드 pAYE230의 제한효소지도이다.
Claims (12)
- 하기와 같은 아미노산 배열:(a)H N-Met-Lys-Trp-Val-Ser-Phe-lle-Ser-Leu-Leu-Phe-Leu-Phe-Ser-Ser-Ala-Tyr-Ser-Arg-Ser-Leu-Asp-Lys-Arg-COOH 또는 (b)H N-Met-Asn-lle-Phe-tyr-lle-Phe-Leu-Phe-Leu-Leu-Ser-Phe-Val-Gln-Gly-Ser-Leu-Asp-Lys-Arg-COOH 또는 상기 어느 배열의 보전적 수식 변이형.
- 카르복실 말단에서 폴리펩티드의 N-말단 잔기에 연결된 제1항의 아미노산 배열을 포함하고 있는 융합체.
- 제2항에 있어서, 상기 아미노산 배열이 상기 폴립펩티드에 직접 연결되어 있는 융합체.
- 제3항에 있어서, 폴리펩티드가 자연발생 인체혈청 알부민, 수식된 인체형청 알부민 또는 상기 둘중 어느 것의 단편인 융합체.
- 제1항의 아미노산 배열 또는 제2항의 융합체에 대한 암호화 핵산배열.
- 제5항에 있어서, 표2 또는 표3에 제시된 배열로부터 선택된 핵산배열.
- 적절한 조절영역 또는 영역들 및, 조절영역의 조절하에 있는 제5항 또는 제6항의 핵산배열을 포함하는 DNA 구조.
- 제7항의 DNA구조로 형질전환된 숙주.
- 제8항의 사카로미세스 세레비지에(Saccharomyces cerevisiae) 또는 시조사카로미세스 폼베(Schizosaccharomyces pombe).
- 제8항 또는 제9항의 숙주를 배양하고 그들로부터 상기 핵산배열 또는 그 수식 변역체에 의하여 발현된 폴리펩티드를 얻는 것을 포함하는 폴리펩티드의 제조방법.
- 제10항의 방법으로 제조된 폴리펩티드.
- 제10항의 방법으로 제조된 인체혈청 알부빈 또는 그 변이형.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8817598.9 | 1988-07-23 | ||
GB888817598A GB8817598D0 (en) | 1988-07-23 | 1988-07-23 | Dna & peptide sequences |
GB898906920A GB8906920D0 (en) | 1989-03-28 | 1989-03-28 | Peptide and dna sequences |
GB896920.7 | 1989-03-28 | ||
GB8906920.7 | 1989-03-28 | ||
GBPGB89/00816 | 1989-07-14 | ||
PCT/GB1989/000816 WO1990001063A1 (en) | 1988-07-23 | 1989-07-14 | New secretory leader sequences |
Publications (2)
Publication Number | Publication Date |
---|---|
KR920700288A true KR920700288A (ko) | 1992-02-19 |
KR100195632B1 KR100195632B1 (ko) | 1999-06-15 |
Family
ID=26294196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900700595A KR100195632B1 (ko) | 1988-07-23 | 1989-07-14 | 펩티드 및 dna 배열 |
Country Status (15)
Country | Link |
---|---|
US (1) | US5302697A (ko) |
EP (1) | EP0387319B1 (ko) |
JP (1) | JP3092811B2 (ko) |
KR (1) | KR100195632B1 (ko) |
AT (1) | ATE135045T1 (ko) |
AU (1) | AU633020B2 (ko) |
CA (1) | CA1340547C (ko) |
DE (1) | DE68925893T2 (ko) |
DK (1) | DK175853B1 (ko) |
FI (1) | FI104564B (ko) |
GB (1) | GB2230268B (ko) |
HU (1) | HU213571B (ko) |
IE (1) | IE62266B1 (ko) |
IL (1) | IL91024A (ko) |
WO (1) | WO1990001063A1 (ko) |
Families Citing this family (68)
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CA1340772C (en) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
US5759802A (en) * | 1988-10-26 | 1998-06-02 | Tonen Corporation | Production of human serum alubumin A |
DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
US5766883A (en) * | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
FR2650598B1 (fr) * | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
DK300090D0 (da) * | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US5521086A (en) * | 1993-09-16 | 1996-05-28 | Cephalon, Inc. | Secretion sequence for the production of a heterologous protein in yeast |
EP0773296B1 (en) * | 1995-02-03 | 2006-09-13 | Asahi Glass Company Ltd. | Secretory signal gene and expression vector having the same |
US5712114A (en) * | 1995-06-06 | 1998-01-27 | Basf Aktiengesellschaft | Compositions for expression of proteins in host cells using a preprocollagen signal sequence |
GB9526733D0 (en) * | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
GB9712370D0 (en) | 1997-06-14 | 1997-08-13 | Aepact Ltd | Therapeutic systems |
EP1056474B1 (en) * | 1997-11-07 | 2002-06-12 | ConjuChem, Inc. | Affinity markers for human serum albumin |
GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
EP1274720A4 (en) | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | ALBUMIN FUSED PROTEINS |
US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20050244931A1 (en) * | 2001-04-12 | 2005-11-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20060084794A1 (en) * | 2001-04-12 | 2006-04-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7507413B2 (en) | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20050054051A1 (en) * | 2001-04-12 | 2005-03-10 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
AU2002332041A1 (en) * | 2001-10-05 | 2003-04-22 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2277888A3 (en) | 2001-12-21 | 2011-04-27 | Human Genome Sciences, Inc. | Fusion proteins of albumin and erythropoietin |
US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
EP1463752A4 (en) * | 2001-12-21 | 2005-07-13 | Human Genome Sciences Inc | ALBUMIN FUSION PROTEINS |
JP2005538932A (ja) | 2002-02-07 | 2005-12-22 | アベンティス、ベーリング、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング | アルブミン融合クニッツドメインペプチド |
GB0217033D0 (en) * | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
WO2005055944A2 (en) | 2003-12-05 | 2005-06-23 | Cincinnati Children's Hospital Medical Center | Oligosaccharide compositions and use thereof in the treatment of infection |
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GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
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KR101193722B1 (ko) | 2006-07-24 | 2013-01-11 | 바이오렉시스 파마슈티칼 코포레이션 | 엑센딘 융합 단백질 |
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CN103314296A (zh) | 2010-08-10 | 2013-09-18 | 安姆根有限公司 | 用于检测针对靶抗体的中和抗体的双功能体外靶结合测定 |
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JP6101638B2 (ja) | 2011-03-03 | 2017-03-22 | ザイムワークス,インコーポレイテッド | 多価ヘテロマルチマー足場設計及び構築物 |
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EP3039129B1 (en) | 2013-08-30 | 2018-06-27 | Amgen Inc. | High titer recombinant aav vector production in adherent and suspension cells |
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CA2874083C (en) | 2014-12-05 | 2024-01-02 | Universite Laval | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
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JP6937309B2 (ja) | 2016-01-27 | 2021-09-22 | ジャスト−エヴォテック バイオロジックス、インコーポレイテッド | ハイブリッドプロモーターおよびその使用 |
JP7116059B2 (ja) | 2016-11-21 | 2022-08-09 | ジャスト-エヴォテック バイオロジックス、インコーポレイテッド | アフリベルセプト製剤及びその使用 |
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NZ207925A (en) * | 1983-04-25 | 1988-05-30 | Genentech Inc | Yeast expression vehicle consisting of a yeast promoter and signal peptide encoding region linked to a heterologus peptide coding region; expression and culture |
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-
1989
- 1989-07-14 KR KR1019900700595A patent/KR100195632B1/ko not_active IP Right Cessation
- 1989-07-14 AU AU40427/89A patent/AU633020B2/en not_active Expired
- 1989-07-14 HU HU894572A patent/HU213571B/hu unknown
- 1989-07-14 AT AT89909015T patent/ATE135045T1/de not_active IP Right Cessation
- 1989-07-14 WO PCT/GB1989/000816 patent/WO1990001063A1/en active IP Right Grant
- 1989-07-14 DE DE68925893T patent/DE68925893T2/de not_active Expired - Lifetime
- 1989-07-14 JP JP01508293A patent/JP3092811B2/ja not_active Expired - Lifetime
- 1989-07-14 EP EP89909015A patent/EP0387319B1/en not_active Expired - Lifetime
- 1989-07-17 CA CA000605832A patent/CA1340547C/en not_active Expired - Fee Related
- 1989-07-18 IL IL9102489A patent/IL91024A/en unknown
- 1989-07-20 IE IE236189A patent/IE62266B1/en not_active IP Right Cessation
- 1989-12-21 GB GB8928849A patent/GB2230268B/en not_active Expired
-
1990
- 1990-03-21 DK DK199000729A patent/DK175853B1/da not_active IP Right Cessation
- 1990-03-21 FI FI901428A patent/FI104564B/fi active IP Right Grant
-
1993
- 1993-05-21 US US08/067,243 patent/US5302697A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK175853B1 (da) | 2005-04-04 |
HUT57829A (en) | 1991-12-30 |
GB8928849D0 (en) | 1990-07-18 |
EP0387319B1 (en) | 1996-03-06 |
ATE135045T1 (de) | 1996-03-15 |
DE68925893T2 (de) | 1996-08-08 |
GB2230268A (en) | 1990-10-17 |
KR100195632B1 (ko) | 1999-06-15 |
FI901428A0 (fi) | 1990-03-21 |
JP3092811B2 (ja) | 2000-09-25 |
DK72990D0 (da) | 1990-03-21 |
CA1340547C (en) | 1999-05-18 |
HU213571B (en) | 1997-08-28 |
WO1990001063A1 (en) | 1990-02-08 |
IL91024A (en) | 1995-08-31 |
EP0387319A1 (en) | 1990-09-19 |
DK72990A (da) | 1990-03-21 |
HU894572D0 (en) | 1991-05-28 |
US5302697A (en) | 1994-04-12 |
IE892361L (en) | 1990-01-23 |
AU4042789A (en) | 1990-02-19 |
JPH03500370A (ja) | 1991-01-31 |
IL91024A0 (en) | 1990-02-09 |
FI104564B (fi) | 2000-02-29 |
DE68925893D1 (de) | 1996-04-11 |
GB2230268B (en) | 1992-01-29 |
IE62266B1 (en) | 1995-01-11 |
AU633020B2 (en) | 1993-01-21 |
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