KR920700288A - 펲티드 및 dna배열 - Google Patents
펲티드 및 dna배열Info
- Publication number
- KR920700288A KR920700288A KR1019900700595A KR900700595A KR920700288A KR 920700288 A KR920700288 A KR 920700288A KR 1019900700595 A KR1019900700595 A KR 1019900700595A KR 900700595 A KR900700595 A KR 900700595A KR 920700288 A KR920700288 A KR 920700288A
- Authority
- KR
- South Korea
- Prior art keywords
- leu
- ser
- phe
- acid sequence
- polypeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 폴리스미드 pEK113의 제한효소지도이다,
제2도는 폴리스미드 pEK25의 제한효소지도이다,
제3도는 폴리스미드 pAYE230의 제한효소지도이다.
Claims (12)
- 하기와 같은 아미노산 배열:(a)H N-Met-Lys-Trp-Val-Ser-Phe-lle-Ser-Leu-Leu-Phe-Leu-Phe-Ser-Ser-Ala-Tyr-Ser-Arg-Ser-Leu-Asp-Lys-Arg-COOH 또는 (b)H N-Met-Asn-lle-Phe-tyr-lle-Phe-Leu-Phe-Leu-Leu-Ser-Phe-Val-Gln-Gly-Ser-Leu-Asp-Lys-Arg-COOH 또는 상기 어느 배열의 보전적 수식 변이형.
- 카르복실 말단에서 폴리펩티드의 N-말단 잔기에 연결된 제1항의 아미노산 배열을 포함하고 있는 융합체.
- 제2항에 있어서, 상기 아미노산 배열이 상기 폴립펩티드에 직접 연결되어 있는 융합체.
- 제3항에 있어서, 폴리펩티드가 자연발생 인체혈청 알부민, 수식된 인체형청 알부민 또는 상기 둘중 어느 것의 단편인 융합체.
- 제1항의 아미노산 배열 또는 제2항의 융합체에 대한 암호화 핵산배열.
- 제5항에 있어서, 표2 또는 표3에 제시된 배열로부터 선택된 핵산배열.
- 적절한 조절영역 또는 영역들 및, 조절영역의 조절하에 있는 제5항 또는 제6항의 핵산배열을 포함하는 DNA 구조.
- 제7항의 DNA구조로 형질전환된 숙주.
- 제8항의 사카로미세스 세레비지에(Saccharomyces cerevisiae) 또는 시조사카로미세스 폼베(Schizosaccharomyces pombe).
- 제8항 또는 제9항의 숙주를 배양하고 그들로부터 상기 핵산배열 또는 그 수식 변역체에 의하여 발현된 폴리펩티드를 얻는 것을 포함하는 폴리펩티드의 제조방법.
- 제10항의 방법으로 제조된 폴리펩티드.
- 제10항의 방법으로 제조된 인체혈청 알부빈 또는 그 변이형.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888817598A GB8817598D0 (en) | 1988-07-23 | 1988-07-23 | Dna & peptide sequences |
GB8817598.9 | 1988-07-23 | ||
GB898906920A GB8906920D0 (en) | 1989-03-28 | 1989-03-28 | Peptide and dna sequences |
GB8906920.7 | 1989-03-28 | ||
GB896920.7 | 1989-03-28 | ||
PCT/GB1989/000816 WO1990001063A1 (en) | 1988-07-23 | 1989-07-14 | New secretory leader sequences |
GBPGB89/00816 | 1989-07-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR920700288A true KR920700288A (ko) | 1992-02-19 |
KR100195632B1 KR100195632B1 (ko) | 1999-06-15 |
Family
ID=26294196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900700595A KR100195632B1 (ko) | 1988-07-23 | 1989-07-14 | 펩티드 및 dna 배열 |
Country Status (15)
Country | Link |
---|---|
US (1) | US5302697A (ko) |
EP (1) | EP0387319B1 (ko) |
JP (1) | JP3092811B2 (ko) |
KR (1) | KR100195632B1 (ko) |
AT (1) | ATE135045T1 (ko) |
AU (1) | AU633020B2 (ko) |
CA (1) | CA1340547C (ko) |
DE (1) | DE68925893T2 (ko) |
DK (1) | DK175853B1 (ko) |
FI (1) | FI104564B (ko) |
GB (1) | GB2230268B (ko) |
HU (1) | HU213571B (ko) |
IE (1) | IE62266B1 (ko) |
IL (1) | IL91024A (ko) |
WO (1) | WO1990001063A1 (ko) |
Families Citing this family (68)
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CA1340772C (en) * | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
US5759802A (en) * | 1988-10-26 | 1998-06-02 | Tonen Corporation | Production of human serum alubumin A |
DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
US5766883A (en) * | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
FR2650598B1 (fr) * | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
DK300090D0 (da) * | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US5521086A (en) * | 1993-09-16 | 1996-05-28 | Cephalon, Inc. | Secretion sequence for the production of a heterologous protein in yeast |
DE69636536T2 (de) * | 1995-02-03 | 2007-10-25 | Asahi Glass Co., Ltd. | Sekretionssignal-Gen und dieses enthaltender Expressionsvektor |
US5712114A (en) * | 1995-06-06 | 1998-01-27 | Basf Aktiengesellschaft | Compositions for expression of proteins in host cells using a preprocollagen signal sequence |
GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
GB9712370D0 (en) | 1997-06-14 | 1997-08-13 | Aepact Ltd | Therapeutic systems |
ATE218892T1 (de) * | 1997-11-07 | 2002-06-15 | Conjuchem Inc | Affinitätsmarkierer für menschliches serum albumin |
GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
CA2405701A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20050054051A1 (en) * | 2001-04-12 | 2005-03-10 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20050244931A1 (en) * | 2001-04-12 | 2005-11-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7507413B2 (en) | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20060084794A1 (en) * | 2001-04-12 | 2006-04-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
AU2002332041A1 (en) * | 2001-10-05 | 2003-04-22 | Human Genome Sciences, Inc. | Albumin fusion proteins |
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AU2002364587A1 (en) * | 2001-12-21 | 2003-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
CA2475382A1 (en) | 2002-02-07 | 2003-08-14 | Delta Biotechnology Limited | Albumin-fused anti-angiogenesis peptides |
GB0217033D0 (en) * | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
EP1594530A4 (en) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | HYBRID PROTEINS OF ALBUMIN |
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GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
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JP5631533B2 (ja) | 2004-12-23 | 2014-11-26 | ノボザイムス バイオファーマ デーコー アクティーゼルスカブ | 遺伝子発現技術 |
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US7803769B2 (en) * | 2006-10-25 | 2010-09-28 | Amgen Inc. | OSK1 peptide analogs and pharmaceutical compositions |
AU2008262490B2 (en) * | 2007-05-22 | 2011-11-17 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
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DK2393834T3 (da) | 2009-02-06 | 2013-06-24 | Novozymes Biopharma Dk As | Fremgangsmåde til oprensning |
JP5936112B2 (ja) | 2009-02-11 | 2016-06-15 | アルブミディクス アクティーゼルスカブ | アルブミン変異体及び複合体 |
JP2012521197A (ja) | 2009-03-20 | 2012-09-13 | アムジエン・インコーポレーテツド | 担体免疫グロブリンおよびその使用 |
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JP2013535692A (ja) | 2010-08-10 | 2013-09-12 | アムジエン・インコーポレーテツド | 標的抗体に対する中和抗体検出用インビトロ二重機能標的結合アッセイ |
KR20130110169A (ko) | 2010-09-22 | 2013-10-08 | 암젠 인크 | 담체 면역글로뷸린 및 이것의 용도 |
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JP6937309B2 (ja) | 2016-01-27 | 2021-09-22 | ジャスト−エヴォテック バイオロジックス、インコーポレイテッド | ハイブリッドプロモーターおよびその使用 |
CN116327963A (zh) | 2016-11-21 | 2023-06-27 | 济世-伊沃泰克生物制品有限公司 | 一种眼科制剂及其用途 |
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-
1989
- 1989-07-14 DE DE68925893T patent/DE68925893T2/de not_active Expired - Lifetime
- 1989-07-14 AT AT89909015T patent/ATE135045T1/de not_active IP Right Cessation
- 1989-07-14 EP EP89909015A patent/EP0387319B1/en not_active Expired - Lifetime
- 1989-07-14 JP JP01508293A patent/JP3092811B2/ja not_active Expired - Lifetime
- 1989-07-14 AU AU40427/89A patent/AU633020B2/en not_active Expired
- 1989-07-14 WO PCT/GB1989/000816 patent/WO1990001063A1/en active IP Right Grant
- 1989-07-14 KR KR1019900700595A patent/KR100195632B1/ko not_active IP Right Cessation
- 1989-07-14 HU HU894572A patent/HU213571B/hu unknown
- 1989-07-17 CA CA000605832A patent/CA1340547C/en not_active Expired - Fee Related
- 1989-07-18 IL IL9102489A patent/IL91024A/en unknown
- 1989-07-20 IE IE236189A patent/IE62266B1/en not_active IP Right Cessation
- 1989-12-21 GB GB8928849A patent/GB2230268B/en not_active Expired
-
1990
- 1990-03-21 DK DK199000729A patent/DK175853B1/da not_active IP Right Cessation
- 1990-03-21 FI FI901428A patent/FI104564B/fi active IP Right Grant
-
1993
- 1993-05-21 US US08/067,243 patent/US5302697A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU633020B2 (en) | 1993-01-21 |
DE68925893D1 (de) | 1996-04-11 |
JP3092811B2 (ja) | 2000-09-25 |
CA1340547C (en) | 1999-05-18 |
KR100195632B1 (ko) | 1999-06-15 |
GB8928849D0 (en) | 1990-07-18 |
US5302697A (en) | 1994-04-12 |
EP0387319B1 (en) | 1996-03-06 |
ATE135045T1 (de) | 1996-03-15 |
IE62266B1 (en) | 1995-01-11 |
GB2230268B (en) | 1992-01-29 |
EP0387319A1 (en) | 1990-09-19 |
IL91024A (en) | 1995-08-31 |
HU213571B (en) | 1997-08-28 |
FI901428A0 (fi) | 1990-03-21 |
FI104564B (fi) | 2000-02-29 |
HU894572D0 (en) | 1991-05-28 |
GB2230268A (en) | 1990-10-17 |
DK175853B1 (da) | 2005-04-04 |
HUT57829A (en) | 1991-12-30 |
AU4042789A (en) | 1990-02-19 |
DE68925893T2 (de) | 1996-08-08 |
IE892361L (en) | 1990-01-23 |
DK72990D0 (da) | 1990-03-21 |
WO1990001063A1 (en) | 1990-02-08 |
JPH03500370A (ja) | 1991-01-31 |
DK72990A (da) | 1990-03-21 |
IL91024A0 (en) | 1990-02-09 |
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