KR920006509A - 세팔로스포린 유도체의 글루타릴-7-아미노세팔로스포란산 유도체로의 연속적 전환 방법 - Google Patents

세팔로스포린 유도체의 글루타릴-7-아미노세팔로스포란산 유도체로의 연속적 전환 방법 Download PDF

Info

Publication number
KR920006509A
KR920006509A KR1019910015315A KR910015315A KR920006509A KR 920006509 A KR920006509 A KR 920006509A KR 1019910015315 A KR1019910015315 A KR 1019910015315A KR 910015315 A KR910015315 A KR 910015315A KR 920006509 A KR920006509 A KR 920006509A
Authority
KR
South Korea
Prior art keywords
amino acid
acid oxidase
cephalosporin
derivatives
cephalosporin derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019910015315A
Other languages
English (en)
Korean (ko)
Inventor
바이어 토마스
사우버 클라우스
Original Assignee
이센브룩 라피세
훽스트 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이센브룩 라피세, 훽스트 아크티엔게젤샤프트 filed Critical 이센브룩 라피세
Publication of KR920006509A publication Critical patent/KR920006509A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungi isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/03—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12Y104/03003—D-Amino-acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
KR1019910015315A 1990-09-05 1991-09-03 세팔로스포린 유도체의 글루타릴-7-아미노세팔로스포란산 유도체로의 연속적 전환 방법 Ceased KR920006509A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4028119.1 1990-09-05
DE4028119A DE4028119C1 (enExample) 1990-09-05 1990-09-05

Publications (1)

Publication Number Publication Date
KR920006509A true KR920006509A (ko) 1992-04-27

Family

ID=6413630

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910015315A Ceased KR920006509A (ko) 1990-09-05 1991-09-03 세팔로스포린 유도체의 글루타릴-7-아미노세팔로스포란산 유도체로의 연속적 전환 방법

Country Status (18)

Country Link
US (1) US5284754A (enExample)
EP (1) EP0474211B1 (enExample)
JP (1) JP3117092B2 (enExample)
KR (1) KR920006509A (enExample)
AT (1) ATE133204T1 (enExample)
AU (1) AU646285B2 (enExample)
CA (1) CA2050615A1 (enExample)
DE (2) DE4028119C1 (enExample)
DK (1) DK0474211T3 (enExample)
ES (1) ES2083495T3 (enExample)
FI (1) FI103806B1 (enExample)
GR (1) GR3018713T3 (enExample)
IE (1) IE70755B1 (enExample)
IL (1) IL99382A (enExample)
NO (1) NO180594C (enExample)
NZ (1) NZ239651A (enExample)
PT (1) PT98863B (enExample)
ZA (1) ZA917004B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100650207B1 (ko) * 2005-07-29 2006-11-27 종근당바이오 주식회사 글루타릴 7-아미노-3-비닐-세팔로스포란산 유도체와 이의 제조방법

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW198064B (enExample) * 1990-12-24 1993-01-11 Hoechst Ag
IT1247964B (it) * 1991-06-03 1995-01-05 Ministero Dell Uni E Della Processo per la preparazione enzimatica di derivati cefalosporanici
CA2100987C (en) * 1992-07-27 1999-06-15 Kaoru Furuya A transformant capable of producing d-amino acid oxidase
ES2097080B1 (es) * 1993-03-08 1997-11-16 Asahi Chemical Ind Procedimiento para la conversion de cefalosporina c en acido glutaril-7-aminocefalosporanico.
US5597704A (en) * 1995-05-01 1997-01-28 Food Industry Research And Development Institute Bioconversion of cephalosporin C to glutaryl-7-aminocephalosporanic acid
CA2216322C (en) * 1996-09-20 2004-06-29 Boris Tartakovsky Immobilization of bacterial cells or sludge using chitosan crosslinked with lignosulphonate
KR100481138B1 (ko) * 1997-09-09 2005-04-11 바이오케미 게젤샤프트 엠베하 효소 활성을 갖는 미생물을 함유하는 구형 입자 및 구형 입자의 제조방법
EP1375649B1 (en) * 2002-06-19 2012-03-07 Evonik Degussa GmbH D-amino acid oxidase from Arthrobacter protophormiae

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1272769A (en) * 1968-08-02 1972-05-03 Glaxo Lab Ltd Improvements in or relating to cephalosporin derivatives
GB1385685A (en) * 1971-04-21 1975-02-26 Glaxo Lab Ltd Cephalosporin derivatives
DE2215687C3 (de) * 1972-03-30 1980-12-11 Bayer Ag, 5090 Leverkusen Neue wasserunlösliche Proteinpräparate
US4579818A (en) * 1983-06-27 1986-04-01 Queen's University At Kingston Biosynthesis of unnatural cephalosporins
DE3344912A1 (de) * 1983-12-13 1985-06-20 Hoechst Ag, 6230 Frankfurt Vernetzte polymerisate, verfahren zu ihrer herstellung und ihre anwendung
WO1990012110A1 (en) * 1989-04-04 1990-10-18 Biopure Corporation Enzymatic production of 7-amino cephalosporanic acid
ATE129012T1 (de) * 1989-07-19 1995-10-15 Lilly Co Eli Enzymatische oxidation von ceph c zu glutaryl-7- aminocephalosporansäure.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100650207B1 (ko) * 2005-07-29 2006-11-27 종근당바이오 주식회사 글루타릴 7-아미노-3-비닐-세팔로스포란산 유도체와 이의 제조방법

Also Published As

Publication number Publication date
AU8356691A (en) 1992-03-12
GR3018713T3 (en) 1996-04-30
NO180594B (no) 1997-02-03
NZ239651A (en) 1994-01-26
PT98863B (pt) 1999-02-26
EP0474211B1 (de) 1996-01-17
JP3117092B2 (ja) 2000-12-11
FI103806B (fi) 1999-09-30
CA2050615A1 (en) 1992-03-06
IE70755B1 (en) 1996-12-30
IE913116A1 (en) 1992-03-11
IL99382A0 (en) 1992-08-18
EP0474211A3 (en) 1992-08-12
ES2083495T3 (es) 1996-04-16
DE59107275D1 (de) 1996-02-29
EP0474211A2 (de) 1992-03-11
ZA917004B (en) 1992-04-29
US5284754A (en) 1994-02-08
ATE133204T1 (de) 1996-02-15
IL99382A (en) 1995-03-30
PT98863A (pt) 1992-07-31
DE4028119C1 (enExample) 1991-12-05
JPH04229190A (ja) 1992-08-18
FI914149L (fi) 1992-03-06
AU646285B2 (en) 1994-02-17
FI103806B1 (fi) 1999-09-30
DK0474211T3 (da) 1996-05-20
FI914149A0 (fi) 1991-09-03
NO913475L (no) 1992-03-06
NO180594C (no) 1997-05-14
NO913475D0 (no) 1991-09-04

Similar Documents

Publication Publication Date Title
Hale et al. A new class of amperometric biosensor incorporating a polymeric electron-transfer mediator
KR920006509A (ko) 세팔로스포린 유도체의 글루타릴-7-아미노세팔로스포란산 유도체로의 연속적 전환 방법
Watanabe et al. Formation of hydrogen peroxide by a polyvinyl alcohol degrading enzyme
KR860006986A (ko) 수화 부착식 겔의 제조방법
KR940014440A (ko) 수용액에서의 치환도가 중간인 전분에스테르 및 그 제조방법
KR910001065A (ko) 하이드록시산의 제조방법
KR870007097A (ko) 말단 카르복실지니는 반응성 비닐단량체의 및 그 제조방법
JPH04504362A (ja) 酵素による７―アミノセフアロスポラン酸の製造
EP0042221B1 (en) Production of 2-keto-d-gluconic acid and hydrogen peroxide
Clifton The utilization of amino acids and of glucose by Clostridium botulinum
KR940014813A (ko) 타닝제 및 이를 사용하는 방법
KR880009937A (ko) 치환된 3-알킬퀴놀린-8-카르복실산의 제조방법
KR910000818A (ko) 카르복시기를 함유하는 옥시알킬화된 중합체의 제법
Mateescu et al. Ready to use p-Benzoquinone activated supports for biochemical coupling, with special applications for laccase immobilization
Issartel et al. Binding of [14C] aurovertin D to Escherichia coli F1-ATPase and the isolated. beta. subunit. Correlation with inhibition of the ATPase activity
Ottolina et al. Coenzymatic properties of low molecular-weight and macromolecular N6-derivatives of NAD+ and NADP+ with dehydrogenases of interest for organic synthesis
Goldman et al. Changes in terminal respiratory pathways of intact cells of Bacillus cereus at various stages of development
KR920012449A (ko) 고정화된 d-아미노산 옥시다제 및 약물 제조를 위한 이의 용도
GB1453484A (en) Purification of a-amylase
SE463921B (sv) Foerfarande foer immobilisering av foereningar,som innefattar nukleofila grupper
GB1469042A (en) Collector for dissolved uranium
Fukusaki et al. Preparation of carboxyalkyl acrylate by lipase-catalyzed regioselective hydrolysis of corresponding methyl ester
Kato et al. Regeneration of NAD (H) covalently bound to formate dehydrogenase with several second enzymes
ITMI940418A1 (it) Procedimento per la conversione della cefalosporina c in acido glutaril - 7 amminocefalosporanico
TW459048B (en) Catalytic method for the desacetylation of cephalosporin intermediates

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19910903

PG1501 Laying open of application
A201 Request for examination
AMND Amendment
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19960902

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19910903

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19981020

Patent event code: PE09021S01D

AMND Amendment
E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19990428

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19981020

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

J201 Request for trial against refusal decision
PJ0201 Trial against decision of rejection

Patent event date: 19990728

Comment text: Request for Trial against Decision on Refusal

Patent event code: PJ02012R01D

Patent event date: 19990428

Comment text: Decision to Refuse Application

Patent event code: PJ02011S01I

Appeal kind category: Appeal against decision to decline refusal

Decision date: 20000630

Appeal identifier: 1999101002647

Request date: 19990728

A107 Divisional application of patent
PA0107 Divisional application

Comment text: Divisional Application of Patent

Patent event date: 19990827

Patent event code: PA01071R01D

PB0901 Examination by re-examination before a trial

Comment text: Request for Trial against Decision on Refusal

Patent event date: 19990728

Patent event code: PB09011R01I

Comment text: Amendment to Specification, etc.

Patent event date: 19990319

Patent event code: PB09011R02I

Comment text: Amendment to Specification, etc.

Patent event date: 19960902

Patent event code: PB09011R02I

B601 Maintenance of original decision after re-examination before a trial
PB0601 Maintenance of original decision after re-examination before a trial
J301 Trial decision

Free format text: TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 19990728

Effective date: 20000630

PJ1301 Trial decision

Patent event code: PJ13011S01D

Patent event date: 20000713

Comment text: Trial Decision on Objection to Decision on Refusal

Appeal kind category: Appeal against decision to decline refusal

Request date: 19990728

Decision date: 20000630

Appeal identifier: 1999101002647