DE4028119C1 - - Google Patents

Info

Publication number
DE4028119C1
DE4028119C1 DE4028119A DE4028119A DE4028119C1 DE 4028119 C1 DE4028119 C1 DE 4028119C1 DE 4028119 A DE4028119 A DE 4028119A DE 4028119 A DE4028119 A DE 4028119A DE 4028119 C1 DE4028119 C1 DE 4028119C1
Authority
DE
Germany
Prior art keywords
reaction
dao
amino acid
acid oxidase
cephalosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE4028119A
Other languages
German (de)
English (en)
Inventor
Thomas Dr. Bayer
Klaus Dr. 6232 Bad Soden De Sauber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz GmbH
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE4028119A priority Critical patent/DE4028119C1/de
Priority to IL9938291A priority patent/IL99382A/en
Priority to US07/754,000 priority patent/US5284754A/en
Priority to FI914149A priority patent/FI103806B1/fi
Priority to NZ239651A priority patent/NZ239651A/en
Priority to KR1019910015315A priority patent/KR920006509A/ko
Priority to ES91114933T priority patent/ES2083495T3/es
Priority to NO913475A priority patent/NO180594C/no
Priority to ZA917004A priority patent/ZA917004B/xx
Priority to IE311691A priority patent/IE70755B1/en
Priority to AT91114933T priority patent/ATE133204T1/de
Priority to AU83566/91A priority patent/AU646285B2/en
Priority to EP91114933A priority patent/EP0474211B1/de
Priority to DK91114933.4T priority patent/DK0474211T3/da
Priority to DE59107275T priority patent/DE59107275D1/de
Priority to CA002050615A priority patent/CA2050615A1/en
Priority to PT98863A priority patent/PT98863B/pt
Priority to JP03226000A priority patent/JP3117092B2/ja
Application granted granted Critical
Publication of DE4028119C1 publication Critical patent/DE4028119C1/de
Priority to GR950403689T priority patent/GR3018713T3/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungi isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/03—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12Y104/03003—D-Amino-acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE4028119A 1990-09-05 1990-09-05 Expired - Lifetime DE4028119C1 (enExample)

Priority Applications (19)

Application Number Priority Date Filing Date Title
DE4028119A DE4028119C1 (enExample) 1990-09-05 1990-09-05
US07/754,000 US5284754A (en) 1990-09-05 1991-09-03 Process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives
FI914149A FI103806B1 (fi) 1990-09-05 1991-09-03 Menetelmä kefalosporiinijohdannaisten saattamiseksi jatkuvatoimisesti reagoimaan glutaryyli-7-aminokefalosporiinihappojohdannaisiksi
NZ239651A NZ239651A (en) 1990-09-05 1991-09-03 Process for converting cephalosporin derivatives into corresponding
KR1019910015315A KR920006509A (ko) 1990-09-05 1991-09-03 세팔로스포린 유도체의 글루타릴-7-아미노세팔로스포란산 유도체로의 연속적 전환 방법
IL9938291A IL99382A (en) 1990-09-05 1991-09-03 Process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives
AT91114933T ATE133204T1 (de) 1990-09-05 1991-09-04 Verfahren zur kontinuierlichen umsetzung von cephalosporinderivaten zu glutaryl-7-amino- cephalosporansäurederivaten
NO913475A NO180594C (no) 1990-09-05 1991-09-04 Fremgangsmåte for kontinuerlig omsetning av cefalosporinderivater til glutaryl-7-aminocefalosporansyrederivater
ZA917004A ZA917004B (en) 1990-09-05 1991-09-04 A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives
IE311691A IE70755B1 (en) 1990-09-05 1991-09-04 Process for the continuous transformation of cephalosporin derivatives into glutaryl-7-amino-cephalosporin derivatives
ES91114933T ES2083495T3 (es) 1990-09-05 1991-09-04 Procedimiento para la reaccion continua de derivados de cefalosporina para dar derivados del acido glutaril-7-amino-cefalosporanico.
AU83566/91A AU646285B2 (en) 1990-09-05 1991-09-04 A process for the continuous conversion of cephalosporin derivatives into gluytaryl-7-aminocephalosporanic acid derivatives
EP91114933A EP0474211B1 (de) 1990-09-05 1991-09-04 Verfahren zur kontinuierlichen Umsetzung von Cephalosporinderivaten zu Glutaryl-7-amino-cephalosporansäurederivaten
DK91114933.4T DK0474211T3 (da) 1990-09-05 1991-09-04 Fremgangsmåde til kontinuerlig omsætning af cephalosporinderivater til glutaryl-7-aminocephalosporansyrederivater
DE59107275T DE59107275D1 (de) 1990-09-05 1991-09-04 Verfahren zur kontinuierlichen Umsetzung von Cephalosporinderivaten zu Glutaryl-7-amino-cephalosporansäurederivaten
CA002050615A CA2050615A1 (en) 1990-09-05 1991-09-04 Process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives
PT98863A PT98863B (pt) 1990-09-05 1991-09-04 Processo para a transformacao continua de derivados de cefalosporinas em derivados do acido glutaril-7-aminocefalosporanico
JP03226000A JP3117092B2 (ja) 1990-09-05 1991-09-05 セファロスポリン誘導体をグルタリル−７−アミノセファロスポラン酸誘導体に連続転化する方法
GR950403689T GR3018713T3 (en) 1990-09-05 1996-01-18 Process for the continuous transformation of cephalosporin derivatives in glutaryl-7-amino-cephalosporin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4028119A DE4028119C1 (enExample) 1990-09-05 1990-09-05

Publications (1)

Publication Number Publication Date
DE4028119C1 true DE4028119C1 (enExample) 1991-12-05

Family

ID=6413630

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4028119A Expired - Lifetime DE4028119C1 (enExample) 1990-09-05 1990-09-05
DE59107275T Expired - Fee Related DE59107275D1 (de) 1990-09-05 1991-09-04 Verfahren zur kontinuierlichen Umsetzung von Cephalosporinderivaten zu Glutaryl-7-amino-cephalosporansäurederivaten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59107275T Expired - Fee Related DE59107275D1 (de) 1990-09-05 1991-09-04 Verfahren zur kontinuierlichen Umsetzung von Cephalosporinderivaten zu Glutaryl-7-amino-cephalosporansäurederivaten

Country Status (18)

Country Link
US (1) US5284754A (enExample)
EP (1) EP0474211B1 (enExample)
JP (1) JP3117092B2 (enExample)
KR (1) KR920006509A (enExample)
AT (1) ATE133204T1 (enExample)
AU (1) AU646285B2 (enExample)
CA (1) CA2050615A1 (enExample)
DE (2) DE4028119C1 (enExample)
DK (1) DK0474211T3 (enExample)
ES (1) ES2083495T3 (enExample)
FI (1) FI103806B1 (enExample)
GR (1) GR3018713T3 (enExample)
IE (1) IE70755B1 (enExample)
IL (1) IL99382A (enExample)
NO (1) NO180594C (enExample)
NZ (1) NZ239651A (enExample)
PT (1) PT98863B (enExample)
ZA (1) ZA917004B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401269B (de) * 1993-03-08 1996-07-25 Asahi Chemical Ind Enzymatisches oxidationsverfahren zur umsetzung von cephalosporin c in glutaryl-7- aminocephalosporansäure

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW198064B (enExample) * 1990-12-24 1993-01-11 Hoechst Ag
IT1247964B (it) * 1991-06-03 1995-01-05 Ministero Dell Uni E Della Processo per la preparazione enzimatica di derivati cefalosporanici
CA2100987C (en) * 1992-07-27 1999-06-15 Kaoru Furuya A transformant capable of producing d-amino acid oxidase
US5597704A (en) * 1995-05-01 1997-01-28 Food Industry Research And Development Institute Bioconversion of cephalosporin C to glutaryl-7-aminocephalosporanic acid
CA2216322C (en) * 1996-09-20 2004-06-29 Boris Tartakovsky Immobilization of bacterial cells or sludge using chitosan crosslinked with lignosulphonate
KR100481138B1 (ko) * 1997-09-09 2005-04-11 바이오케미 게젤샤프트 엠베하 효소 활성을 갖는 미생물을 함유하는 구형 입자 및 구형 입자의 제조방법
EP1375649B1 (en) * 2002-06-19 2012-03-07 Evonik Degussa GmbH D-amino acid oxidase from Arthrobacter protophormiae
KR100650207B1 (ko) * 2005-07-29 2006-11-27 종근당바이오 주식회사 글루타릴 7-아미노-3-비닐-세팔로스포란산 유도체와 이의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1272769A (en) * 1968-08-02 1972-05-03 Glaxo Lab Ltd Improvements in or relating to cephalosporin derivatives
GB1385685A (en) * 1971-04-21 1975-02-26 Glaxo Lab Ltd Cephalosporin derivatives
DE2215687C3 (de) * 1972-03-30 1980-12-11 Bayer Ag, 5090 Leverkusen Neue wasserunlösliche Proteinpräparate
US4579818A (en) * 1983-06-27 1986-04-01 Queen's University At Kingston Biosynthesis of unnatural cephalosporins
DE3344912A1 (de) * 1983-12-13 1985-06-20 Hoechst Ag, 6230 Frankfurt Vernetzte polymerisate, verfahren zu ihrer herstellung und ihre anwendung
WO1990012110A1 (en) * 1989-04-04 1990-10-18 Biopure Corporation Enzymatic production of 7-amino cephalosporanic acid
ATE129012T1 (de) * 1989-07-19 1995-10-15 Lilly Co Eli Enzymatische oxidation von ceph c zu glutaryl-7- aminocephalosporansäure.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS ERMITTELT *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401269B (de) * 1993-03-08 1996-07-25 Asahi Chemical Ind Enzymatisches oxidationsverfahren zur umsetzung von cephalosporin c in glutaryl-7- aminocephalosporansäure

Also Published As

Publication number Publication date
AU8356691A (en) 1992-03-12
GR3018713T3 (en) 1996-04-30
NO180594B (no) 1997-02-03
NZ239651A (en) 1994-01-26
PT98863B (pt) 1999-02-26
EP0474211B1 (de) 1996-01-17
JP3117092B2 (ja) 2000-12-11
FI103806B (fi) 1999-09-30
CA2050615A1 (en) 1992-03-06
KR920006509A (ko) 1992-04-27
IE70755B1 (en) 1996-12-30
IE913116A1 (en) 1992-03-11
IL99382A0 (en) 1992-08-18
EP0474211A3 (en) 1992-08-12
ES2083495T3 (es) 1996-04-16
DE59107275D1 (de) 1996-02-29
EP0474211A2 (de) 1992-03-11
ZA917004B (en) 1992-04-29
US5284754A (en) 1994-02-08
ATE133204T1 (de) 1996-02-15
IL99382A (en) 1995-03-30
PT98863A (pt) 1992-07-31
JPH04229190A (ja) 1992-08-18
FI914149L (fi) 1992-03-06
AU646285B2 (en) 1994-02-17
FI103806B1 (fi) 1999-09-30
DK0474211T3 (da) 1996-05-20
FI914149A0 (fi) 1991-09-03
NO913475L (no) 1992-03-06
NO180594C (no) 1997-05-14
NO913475D0 (no) 1991-09-04

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Legal Events

Date Code Title Description
8100 Publication of patent without earlier publication of application
D1 Grant (no unexamined application published) patent law 81
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIOCHEMIE GESELLSCHAFT M.B.H., KUNDL, AT

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

8339 Ceased/non-payment of the annual fee