KR840007398A - 디벤조사이클로헵테닐리덴의 제조방법 - Google Patents

디벤조사이클로헵테닐리덴의 제조방법 Download PDF

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Publication number
KR840007398A
KR840007398A KR1019830006313A KR830006313A KR840007398A KR 840007398 A KR840007398 A KR 840007398A KR 1019830006313 A KR1019830006313 A KR 1019830006313A KR 830006313 A KR830006313 A KR 830006313A KR 840007398 A KR840007398 A KR 840007398A
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South Korea
Prior art keywords
compound
formula
hydrogen
tetrazolyl
preparing
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KR1019830006313A
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English (en)
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볼프 밀튼
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원본미기재
아메리칸 홈 프로덕츠 코포레이션
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Publication of KR840007398A publication Critical patent/KR840007398A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
    • C07C63/72—Polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음.

Description

디벤조사이클로헵테닐리덴의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. 일반식(D) 화합물에 R4-C-R3그룹을 도입시키고, 경우에 따라 생성물을 그의 약학적으로 무독한 염으로 전환시킴을 특징으로 하여 일반식(B) 화합물, 그의 입체이성체, 및 그의 약학적으로 무독한 염을 제조하는 방법.
  3. 상기 식에서,
  4. R4는 수소 또는 클로로이고, R5는 카복시, 그의 에스테르 또는 테트라졸릴이며,
  5. R2는 수소, 할로 또는 탄소수 1 내지 4의 알콕시이고, R3는 수소 또는 브로모인데,
  6. 단, R4가 수소이고, R5가 카복시이면, R2또는 R3는 수소가 아니며, R4, R2및 R3가 모두 수소이면, R5는 테트라졸릴이다.
  7. R5가 카복실산 에스테르인 일반식(B) 화합물을 가수분해시킴을 특징으로 하여 다음 일반식(B) 화합물 또는 그의 약학적으로 무독한 염을 제조하는 방법.
  9. 상기 식에서, R5는 카복시이고, R2, R3및 R4는 제1항에서 정의한 바와 같다.
  10. 일반식(C) 화합물을 테트라졸 환구조를 이룰 수 있는 알카리금속 아지드 또는 암모늄 아지드와 반응시켜 R5가 테트라졸릴인 생성물 B를 수독하고, 경우에 따라 그 생성물을 약학적으로 무독한 염으로 전환시킴을 특징으로 하여 다음 일반식(B) 화합물 또는 그의 약학적으로 무독한 염을 제조하는 방법.
  12. 〔상기 식에서, R2, R3및 R4는 전술한 바와 같고, R5는 테트라졸릴이고, Q는 불포화 -C-N 결합을 함유하는 그룹이다.〕
  13. 제3항에 있어서, Q가 -C≡N 또는(이때 G는 할로겐원자 또는 알콕시라디칼이다)인 일반식(C) 화합물을 알칼리금속 아지드 또는 암모늄아지드와 반응시켜 R5가 테트라졸릴인 일반식(B)의 화합물을 수득하고, 경우에 따라 생성물을 약학적으로 무독한 염으로 전환시킴을 특징으로 하여 일반식(B) 화합물을 제조하는 방법.
  14. 제2항에 있어서, R2가 할로 또는 탄소수 1 내지 4의 알콕시이고, R5가 카복실산 에스테르인 일반식(B) 화합물의 E-이성체를 가수분해하는 방법.
  15. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830006313A 1983-01-03 1983-12-30 디벤조사이클로헵테닐리덴의 제조방법 KR840007398A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45494183A 1983-01-03 1983-01-03
US454941 1983-01-03

Publications (1)

Publication Number Publication Date
KR840007398A true KR840007398A (ko) 1984-12-07

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ID=23806706

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Application Number Title Priority Date Filing Date
KR1019830006313A KR840007398A (ko) 1983-01-03 1983-12-30 디벤조사이클로헵테닐리덴의 제조방법

Country Status (9)

Country Link
EP (1) EP0115690A1 (ko)
JP (1) JPS59176230A (ko)
KR (1) KR840007398A (ko)
AU (1) AU2258683A (ko)
DK (1) DK1384A (ko)
GB (1) GB2132618A (ko)
GR (1) GR81689B (ko)
PT (1) PT77911B (ko)
ZA (1) ZA839509B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195800B (en) * 1983-10-13 1988-07-28 Sandoz Ltd Process for producing 4h-benzo/4,5/cylopenta/1,2-b/ thiofene derivatives and pharmaceutical compositions containing them
DE19941211A1 (de) 1999-08-30 2001-03-08 Haarmann & Reimer Gmbh Herstellung von Dibenzosuberenon-Derivaten durch katralytische Dehydrierung
DE102005022020A1 (de) * 2005-05-12 2006-11-23 Merckle Gmbh Dibenzocycloheptanverbindungen und pharmazeutische Mittel, welche diese Verbindungen enthalten

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633316A (ko) *
GB1053844A (ko) * 1963-09-16 1900-01-01
US4267192A (en) * 1980-03-11 1981-05-12 American Home Products Corporation Method for treating inflammation

Also Published As

Publication number Publication date
DK1384A (da) 1984-07-04
ZA839509B (en) 1985-08-28
JPS59176230A (ja) 1984-10-05
EP0115690A1 (en) 1984-08-15
GR81689B (ko) 1984-12-12
GB2132618A (en) 1984-07-11
AU2258683A (en) 1984-07-05
PT77911B (en) 1986-04-11
PT77911A (en) 1984-01-01
DK1384D0 (da) 1984-01-02
GB8334019D0 (en) 1984-02-01

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