KR910009240A - 약제학적 또는 치료학적 활성제의 수송 시스템 - Google Patents

약제학적 또는 치료학적 활성제의 수송 시스템 Download PDF

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KR910009240A
KR910009240A KR1019890016073A KR890016073A KR910009240A KR 910009240 A KR910009240 A KR 910009240A KR 1019890016073 A KR1019890016073 A KR 1019890016073A KR 890016073 A KR890016073 A KR 890016073A KR 910009240 A KR910009240 A KR 910009240A
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transport system
composition
chitosan derivative
chitosonium
pharmaceutically
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KR1019890016073A
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KR940002657B1 (ko
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맬론 파테인 3세 엠미트
브로드 2세 루이스
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티모시 엔·비숍
유니온 카바이드 케미칼스 앤드 플라스틱스 캄파니 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0076—Sprayable compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/08—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54—Polymers characterized by specific structures/properties
    • A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
    • A61K2800/5426—Polymers characterized by specific structures/properties characterized by the charge cationic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S261/00—Gas and liquid contact apparatus
    • Y10S261/88—Aroma dispensers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/15—Suppositories

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  • Dermatology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Cosmetics (AREA)
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Abstract

내용 없음

Description

약학적 또는 치료학적 활성제의 수송 시스템
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (27)

  1. (1) 키토소늄 중합체, 및 (2) 공유 결합성 키토산 유도체로 이루어진 그룹중에서 선택된 적어도 하나의 아미노폴리삭카라이드 시스템을 약 0.1 내지 약 99.99중량% 함유하고, 환자의 목적하는 국부에 수송된 후 활성제가 환자의 목적 부위 치료에 이용될 수 있도록하는 비자극성, 비자각성, 실재성, 기체 투과성 필름을 제공함을 특징으로 하는, 약학적 또는 치료학적 활성제를 환자의 목적하는 국부에 수송하기 위한 생물학적으로 허용되는 실재성 필름 형성 수송 시스템.
  2. 제 1항에 있어서, 키토산 유도체가 키토소늄 중합체인 수송 시스템.
  3. 제 1항에 있어서, 키토산이 공유결합성 키토산 유도체인 수송 시스템.
  4. 제 1항에 있어서, 키토산 유도체가 키토소늄 피롤리돈 카복실레이트인 수송 시스템.
  5. 제 1항에 있어서, 키토산 유도체가 키토소늄 니아시네이트인 수송 시스템.
  6. 제 1항에 있어서, 키토산 유도체가 키토소늄 이타코네이트인 수송 시스템.
  7. 제 1항에 있어서, 키토산 유도체가 키토소늄 살리실레이트인 수송 시스템.
  8. 제 1항에 있어서, 키토산 유도체가 키토소늄 락테이트인 수송 시스템.
  9. 제 1항에 있어서, 키토산 유도체가 키토소늄 글리콜레이트인 수송 시스템.
  10. 제 1항에 있어서, 키토산 유도체를 히알투론산과 혼합시킨 수송 시스템.
  11. 제 1항에 있어서, 약학적으로 허용되는 희석제를 함유하는 수송 시스템.
  12. 제 1항에 있어서, 필름 형태인 조성물.
  13. 제 1항에 있어서, 겔 형태인 조성물.
  14. 제 1항에 있어서, 팻치 형태인 조성물.
  15. 제 1항에 있어서, 에어로졸 형태인 조성물.
  16. 제 1항에 있어서, 좌제 형태인 조성물.
  17. 제 1항에 있어서, 섬유 형태인 조성물.
  18. 제 1항에 있어서, 막대 형태인 조성물.
  19. 제 1항에 있어서, 마이크로스피 형태인 조성물.
  20. 제 1항에 있어서, 지혈장치 또는 지혈 용액 형태인 조성물.
  21. 제 1항에 있어서 패드, 스폰지 및 봉합선으로 이루어진 그룹중에서 선택된 장치인 조성물.
  22. 제 1항에 있어서, 봉합선 형태인 조성물.
  23. 적어도 하나의 약학적 또는 치료학적 활성 성분을 키토산 유도체 및 희석제와 혼합시킴을 특징으로 하여, a) 적어도 하나의 약학적 또는 치료학적 활성성분, 및 b) (1) 키토소늄 중합체 및 (2) 키토산 유도체로 이루어진 그룹중에서 선택된 적어도 하나의 키토산 유도체로 이루어지고 약학적 및 치료학적 활성제를 환자의 국부 또는 점막 부위에 투여하는데 사용하기 위한 수송 시스템의 제조방법.
  24. 제 23항에 있어서, 희석제를 포함하는 방법.
  25. 제 23항에 있어서, 키토산 유도체를 혼합하기 전에 용매중에 용해시키는 방법.
  26. 제 23항에 있어서, 활성성분을 혼합하기전에 용매중에 용해시키는 방법.
  27. 약학적 또는 치료학적 유효량의 제1항에 따른 수송 시스템을 환자의 선정된 부위에 투여함을 특징으로 하여, 약학적 또는 치료학적 활성제를 환자에 국부 투여하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890016073A 1988-11-08 1989-11-07 약제학적 또는 치료학적 활성물질의 수송 시스템 KR940002657B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US268.871 1988-11-08
US07/268,871 US4946870A (en) 1986-06-06 1988-11-08 Delivery systems for pharmaceutical or therapeutic actives

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KR910009240A true KR910009240A (ko) 1991-06-28
KR940002657B1 KR940002657B1 (ko) 1994-03-28

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US (1) US4946870A (ko)
EP (1) EP0368253A3 (ko)
JP (1) JPH02196728A (ko)
KR (1) KR940002657B1 (ko)
AU (1) AU625075B2 (ko)
CA (1) CA2002404A1 (ko)
IL (1) IL92225A0 (ko)

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