KR970064597A - 위장장애 또는 위산분해가 있는 약물의 직장투여용 조성물 - Google Patents
위장장애 또는 위산분해가 있는 약물의 직장투여용 조성물 Download PDFInfo
- Publication number
- KR970064597A KR970064597A KR1019970009499A KR19970009499A KR970064597A KR 970064597 A KR970064597 A KR 970064597A KR 1019970009499 A KR1019970009499 A KR 1019970009499A KR 19970009499 A KR19970009499 A KR 19970009499A KR 970064597 A KR970064597 A KR 970064597A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- rectal administration
- drug
- gastric acid
- gastrointestinal disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
본 발명은 위장장애 또는 위산분해가 있는 약물, 폴록사머 및 친수성 천연 고분자을 함유하는 직장투여용 조성물에 관한 것이다.
본 발명의 직장투여용 조성물은 겔화온도가 30-36℃이고, 겔강도와 생체부착력이 우수하여 투여전 상온에서 액체상태이고, 투여후에는 즉시 겔화되어 직장점막에 부착되어 지속적으로 머무르면서 약물을 방출하여 체외로 빠져나오거나 대장말단으로 이행되지 않으며 위장장애 또는 위산분해없이 흡수된다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 위장장애 또는 위산분해가 있는 약물 0.1-10중량부, 폴록사머 25-40중량부 및 친수성 천연 고분자 0.1-1중량부를 함유하는 직장투여용 조성물.
- 제1항에 있어서, 위장장애가 있는 약물이 아스피린, 아세트아미노펜, 케토르로펜, 인도메타신, 나프록센, 철분 화합물, 케토코나졸, 이트라코나졸, 에코나졸 및 세파-항생제에서 선택됨을 특징으로 하는 직장투여용 조성물.
- 제1항에 있어서, 위산분해가 있는 약물이 프로폭시펜, 메페리딘, 메타돈, 펜타조산, 덱사메타존, p-아미노안식향, 설폰아미드, p-아미노히푸르산, 에스트로겐, 오메프라졸, 판크레아틴, 세라티오펩티다아제, 1-도파, α-메틸도마, 하이ㅡ로코티손, 코티손, 알도스테론, 프로게스테론 및 인슐린에서 선택됨을 특징으로 하는 직장투여용 조성물.
- 제1항에 있어서, 플록사머가 고상타입, 액상타입 및 페이스트 타입에서 1종 또는 2종이상 선택됨을 특징으로 하는 직장투여용 조성물.
- 제1항에 있어서, 친수성 천연고분자가 키토산 및 알긴산 나트륨염의 천연고분자에서 단독으로 또는 혼합하여 선택됨을 특징으로 하는 직장투여용 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR19960007637 | 1996-03-21 | ||
KR96-7637 | 1996-03-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR970064597A true KR970064597A (ko) | 1997-10-13 |
Family
ID=19453575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019970009499A KR970064597A (ko) | 1996-03-21 | 1997-03-20 | 위장장애 또는 위산분해가 있는 약물의 직장투여용 조성물 |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR970064597A (ko) |
WO (1) | WO1997034580A1 (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1158957A4 (en) | 1999-02-24 | 2004-12-15 | Dong Wha Pharm Ind Co Ltd | LIQUID SUPPOSITORY COMPOSITION FOR DICLOFENAC SODIUM |
US20030204180A1 (en) * | 2002-04-30 | 2003-10-30 | Kimberly-Clark Worldwide, Inc. | Temperature responsive delivery systems |
US20060078616A1 (en) * | 2004-08-30 | 2006-04-13 | Georgewill Dawaye A | Thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol |
EP2338477A1 (en) | 2009-12-15 | 2011-06-29 | bene-Arzneimittel GmbH | Suppository comprising pantoprazole |
KR101003890B1 (ko) * | 2010-04-14 | 2010-12-30 | 영남대학교 산학협력단 | 직장투여용 도세탁셀 함유 온도감응성 액상좌제 조성물 |
WO2012171540A1 (en) | 2011-06-15 | 2012-12-20 | Bene-Arzneimittel Gmbh | Suppository comprising pantoprazole comprised in pellets with a cellulose core |
DE102015112875A1 (de) * | 2015-08-05 | 2017-02-09 | Dr. Armah-Biomedica Gmbh & Co. Kg | Suppositorium auf Basis einer wärme-unempfindlichen Fettmasse |
EP3538132B1 (en) | 2016-11-14 | 2020-12-30 | University of Copenhagen | Rectal insulin for treatment of inflammatory bowel diseases |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1207231A (en) * | 1982-08-24 | 1986-07-08 | Hans W. Zulliger | Medicated suppository |
US4946870A (en) * | 1986-06-06 | 1990-08-07 | Union Carbide Chemicals And Plastics Company Inc. | Delivery systems for pharmaceutical or therapeutic actives |
US5292516A (en) * | 1990-05-01 | 1994-03-08 | Mediventures, Inc. | Body cavity drug delivery with thermoreversible gels containing polyoxyalkylene copolymers |
US5346703A (en) * | 1990-08-07 | 1994-09-13 | Mediventures, Inc. | Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels |
EP0551626A1 (en) * | 1991-12-19 | 1993-07-21 | LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. | Thermoreversible gel as a liquid pharmaceutical carrier for a galenic formulation |
IT1255460B (it) * | 1992-07-28 | 1995-11-02 | Poli Ind Chimica Spa | Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive |
FR2694194B1 (fr) * | 1992-07-31 | 1994-11-04 | Health Business Dev | Gel hydratant, médicament et composition cosmétique le contenant, procédé de préparation dudit gel. |
-
1997
- 1997-03-20 WO PCT/KR1997/000042 patent/WO1997034580A1/en active Application Filing
- 1997-03-20 KR KR1019970009499A patent/KR970064597A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1997034580A1 (en) | 1997-09-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Liu et al. | A moldable nanocomposite hydrogel composed of a mussel‐inspired polymer and a nanosilicate as a fit‐to‐shape tissue sealant | |
Khanlari et al. | Bioadhesives: a review | |
KR970064597A (ko) | 위장장애 또는 위산분해가 있는 약물의 직장투여용 조성물 | |
Chonkar et al. | Smart polymers in nasal drug delivery | |
BR9903345A (pt) | Emplastro cosmético, farmacêutico ou dermatológico e conjunto | |
HUP9904174A2 (hu) | Bőrön át történő adagoláshoz szánt gyógyszerkészítmények | |
DE69803940D1 (de) | Ophthalmische zusammensetzungen mit verlängerte freisetzung enthaltend im wasser lösliche arzneistoffe | |
CA2149362A1 (en) | Pharmaceutical composition based on guar gum coated with simethicone, inassociation with a neutralizing antacid | |
IL149572A0 (en) | Film preparation for biphasic release of pharmacologically active or other substances | |
KR960700670A (ko) | 거대분자 약물의 경점막 수송용 제형 | |
ATE300286T1 (de) | Gastroretentive pharmazeutische dosierungsformen mit gesteuerten abgaben | |
ATE17189T1 (de) | 5-asa enthaltende orale verabreichungsform mit verzoegerter wirkstofffreigabe. | |
KR910007518A (ko) | 서방성 제제 | |
BRPI0414017A8 (pt) | pró-fármacos poliméricos de múltiplos braços | |
NO993195L (no) | Blanding for administrasjon av medikamenter | |
BG102438A (en) | Medicamentous form | |
EP0966966A3 (en) | Nefazodone dosage form | |
NO20025759L (no) | Formulering basert på heparin, glykosaminoglykan eller heparinoid, anvendelse av formuleringen og formuleringsbasen | |
EA200100118A1 (ru) | Препарат в виде порошка для введения через слизистую оболочку, содержащий лекарственное средство с высокой молекулярной массой | |
EP1992336A3 (fr) | Forme galénique pour la délivrance colique de principes actifs | |
DE69226950T2 (de) | Kapsel mit Langzeitwirkung fuer die Adhäsion im Gastrointestinaltrakt | |
EP2108378A3 (en) | Non-covalent bioconjugates useful for diagnosis and therapy | |
BR9914841A (pt) | Sistema de terapia gastrorretentivo, expansìvel, com tempo de permanência no estÈmago prolongado | |
HUP0103543A2 (hu) | Nyálkahártyán megtapadó hatóanyag bejuttató rendszerek és ezek alkalmazása állatok kezelésére | |
WO2003074086A1 (fr) | Matrice liquide a transfert de phase in vivo, et preparations liquides orales |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |