ATE300286T1 - Gastroretentive pharmazeutische dosierungsformen mit gesteuerten abgaben - Google Patents

Gastroretentive pharmazeutische dosierungsformen mit gesteuerten abgaben

Info

Publication number
ATE300286T1
ATE300286T1 AT00978993T AT00978993T ATE300286T1 AT E300286 T1 ATE300286 T1 AT E300286T1 AT 00978993 T AT00978993 T AT 00978993T AT 00978993 T AT00978993 T AT 00978993T AT E300286 T1 ATE300286 T1 AT E300286T1
Authority
AT
Austria
Prior art keywords
polymers
dosage forms
pharmaceutical dosage
stomach
mixtures
Prior art date
Application number
AT00978993T
Other languages
English (en)
Inventor
Michael Friedman
Eytan Klausner
Eran Lavy
Amnon Hoffman
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Application granted granted Critical
Publication of ATE300286T1 publication Critical patent/ATE300286T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT00978993T 1999-11-29 2000-11-20 Gastroretentive pharmazeutische dosierungsformen mit gesteuerten abgaben ATE300286T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13319699A IL133196A0 (en) 1999-11-29 1999-11-29 Gastroretentive controlled release pharmaceutical dosage forms
PCT/IL2000/000774 WO2001037812A2 (en) 1999-11-29 2000-11-20 Gastroretentive controlled release pharmaceutical dosage forms

Publications (1)

Publication Number Publication Date
ATE300286T1 true ATE300286T1 (de) 2005-08-15

Family

ID=11073546

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00978993T ATE300286T1 (de) 1999-11-29 2000-11-20 Gastroretentive pharmazeutische dosierungsformen mit gesteuerten abgaben

Country Status (12)

Country Link
US (1) US6685962B2 (de)
EP (1) EP1235557B1 (de)
JP (1) JP4679020B2 (de)
AT (1) ATE300286T1 (de)
AU (1) AU783062B2 (de)
CA (1) CA2392361C (de)
DE (1) DE60021604T2 (de)
ES (1) ES2243327T3 (de)
IL (2) IL133196A0 (de)
RU (1) RU2002114348A (de)
WO (1) WO2001037812A2 (de)
ZA (1) ZA200204268B (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040219186A1 (en) * 2001-08-16 2004-11-04 Ayres James W. Expandable gastric retention device
TWI312285B (en) * 2001-10-25 2009-07-21 Depomed Inc Methods of treatment using a gastric retained gabapentin dosage
AUPR951501A0 (en) * 2001-12-14 2002-01-24 Smart Drug Systems Inc Modified sustained release pharmaceutical system
AU2003299838A1 (en) * 2002-12-19 2004-07-14 Polymorfix, Inc. Ingestible formulations for transient, noninvasive reduction of gastric volume
US7554452B2 (en) * 2003-07-18 2009-06-30 Cary Cole Ingestible tracking and locating device
JP4988345B2 (ja) * 2003-09-04 2012-08-01 ザ・ユナイテッド・ステイツ・オブ・アメリカ・アズ・リプレゼンティッド・バイ・ザ・デパートメント・オブ・ヴェテランズ・アフェアーズ 眼用ハイドロゲルナノコンポジット
WO2005030179A1 (en) * 2003-09-29 2005-04-07 Cj Corporation Sustained-release formulations
CA2549195A1 (en) * 2003-12-09 2005-06-23 Spherics, Inc. Bioadhesive polymers with catechol functionality
US20080089933A1 (en) * 2006-10-16 2008-04-17 Amir Alon Device and method for reducing calorie intake
US20050196355A1 (en) * 2004-03-03 2005-09-08 Constantine Georgiades Film products having controlled disintegration properties
US8007827B2 (en) * 2004-04-02 2011-08-30 Impax Laboratories, Inc. Pharmaceutical dosage forms having immediate release and/or controlled release properties
CA2568640C (en) 2004-06-04 2011-08-09 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
US20080311191A1 (en) * 2004-08-27 2008-12-18 Avinash Nangia Multi-Layer Tablets and Bioadhesive Dosage Forms
US20070129402A1 (en) * 2004-12-27 2007-06-07 Eisai Research Institute Sustained release formulations
US20060246003A1 (en) * 2004-12-27 2006-11-02 Eisai Co. Ltd. Composition containing anti-dementia drug
US20060280789A1 (en) * 2004-12-27 2006-12-14 Eisai Research Institute Sustained release formulations
AU2005320547B2 (en) * 2004-12-27 2009-02-05 Eisai R & D Management Co., Ltd. Method for stabilizing anti-dementia drug
IL166183A0 (en) * 2005-01-06 2006-01-15 Yissum Res Dev Co Novel diagnostic and imaging techniques of the gi tract
WO2006088305A1 (en) * 2005-02-15 2006-08-24 Chong Kun Dang Pharmaceutical Corp. Gastric-retentive controlled release mono-matrix tablet
US20070077309A1 (en) * 2005-09-30 2007-04-05 Wong Patrick S Banded controlled release nanoparticle active agent formulation dosage forms and methods
US20070092565A1 (en) * 2005-10-25 2007-04-26 Pharmascience Inc. Gastric retention drug delivery system
DK1981465T3 (en) 2006-01-18 2016-02-01 Intec Pharma Ltd METHOD FOR PRODUCING delivery devices FOR ORAL USE OF A MEANS
US20090304768A1 (en) * 2006-02-15 2009-12-10 Intec Pharma Ltd Gastro-Retentive System for the Delivery of Macromolecules
WO2007103286A2 (en) * 2006-03-02 2007-09-13 Spherics, Inc. Rate-controlled bioadhesive oral dosage formulations
WO2008030830A2 (en) * 2006-09-08 2008-03-13 Drugtech Corporation Sustained-release composition and method of use thereof
ZA200904573B (en) 2006-12-22 2010-09-29 Ironwood Pharmaceuticals Inc Compositions comprising bile acid sequestrants for treating esophageal disorders
WO2008115597A2 (en) * 2007-03-21 2008-09-25 Cytologic, Inc. Cytokine muteins and methods for enhancing immune responses in mammals
DK2192946T3 (da) 2007-09-25 2022-11-21 Otsuka Pharma Co Ltd Kropsintern anordning med virtuel dipol signalforstærkning
US20090253808A1 (en) 2007-11-12 2009-10-08 Pharmaceutics International, Inc. Tri-molecular complexes and their use in drug delivery systems
CA2721493C (en) 2008-04-18 2017-11-28 Intec Pharma Ltd. Carbidopa/levodopa gastroretentive drug delivery
CN101796640A (zh) * 2008-05-08 2010-08-04 松下电器产业株式会社 非易失性存储元件、非易失性存储装置、以及其制造方法
US8287902B2 (en) * 2008-07-23 2012-10-16 Rainbow Medical Ltd. Enhanced-diffusion capsule
PL2378883T3 (pl) * 2008-12-04 2016-06-30 Intec Pharma Ltd SYSTEM DOSTARCZANIA LEKU ZATRZYMYWANEGO W ŻOŁĄDKU dLA ZALEPLONU
US9901551B2 (en) 2009-04-20 2018-02-27 Ambra Bioscience Llc Chemosensory receptor ligand-based therapies
US8828953B2 (en) * 2009-04-20 2014-09-09 NaZura BioHealth, Inc. Chemosensory receptor ligand-based therapies
BRPI1013856A2 (pt) 2009-04-20 2016-04-05 Elcelyx Therapeutics Inc terapias à base de ligantes de receptores quimiossensíveis
US20100286628A1 (en) * 2009-05-07 2010-11-11 Rainbow Medical Ltd Gastric anchor
US8414559B2 (en) * 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
US20110066175A1 (en) * 2009-05-07 2011-03-17 Rainbow Medical Ltd. Gastric anchor
WO2011048494A2 (en) * 2009-10-19 2011-04-28 Intec Pharma Ltd. Novel gastroretentive dosage forms of poorly soluble drugs
EP2498764B1 (de) 2009-11-09 2017-09-06 Spotlight Technology Partners LLC Fragmentierte hydrogele
JP5864429B2 (ja) 2009-11-09 2016-02-17 スポットライト テクノロジー パートナーズ エルエルシーＳｐｏｔｌｉｇｈｔ Ｔｅｃｈｎｏｌｏｇｙ Ｐａｒｔｎｅｒｓ Ｌｌｃ 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット
EP2513200B1 (de) 2009-12-18 2018-03-07 Coloplast A/S Biomaterial
WO2011073968A1 (en) * 2009-12-18 2011-06-23 Vysera Biomedical Limited A drug delivery system
EP2544666A2 (de) 2010-03-09 2013-01-16 Council of Scientific and Industrial Research Gastroretentive retard-zusammensetzung eines therapeutikums
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
KR20140114736A (ko) 2010-10-19 2014-09-29 엘셀릭스 테라퓨틱스 인코포레이티드 화학감각 수용체 리간드-기반 요법
WO2012094636A2 (en) 2011-01-07 2012-07-12 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
US8722066B2 (en) 2011-03-29 2014-05-13 Primigenia, LLC Devices and methods for weight control and weight loss
US20130143867A1 (en) 2011-12-02 2013-06-06 Sychroneuron Inc. Acamprosate formulations, methods of using the same, and combinations comprising the same
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
WO2014039951A1 (en) 2012-09-10 2014-03-13 Novartis Ag Enteral pharmaceutical compositions
WO2014174496A1 (en) * 2013-04-25 2014-10-30 Ranbaxy Laboratories Limited Pharmaceutical gastro-retentive solid oral dosage form of nilotinib
CN105431144A (zh) 2013-06-05 2016-03-23 思康脑侒股份有限公司 阿坎酸制剂、使用阿坎酸制剂的方法以及包含阿坎酸制剂的组合
CN105828809B (zh) 2013-12-20 2019-10-29 费森尤斯卡比德国有限公司 包含脂质和活性药剂的具有聚合物涂层的微胶囊
CA2949372C (en) 2014-06-02 2023-08-22 Teva Pharmaceutical Industries Ltd. Expandable gastroretentive dosage form
CA2951884A1 (en) 2014-06-11 2015-12-17 Massachusetts Institute Of Technology Residence structures and related methods
US20170266112A1 (en) 2014-06-11 2017-09-21 Massachusetts Institute Of Technology Residence structures and related methods
US9492396B2 (en) 2014-07-15 2016-11-15 Yossi Gross Enhanced drug delivery pill
CA2987114A1 (en) 2015-06-03 2016-12-08 Triastek, Inc. Method of 3d printing oral dosage forms having a drug in a compartment sealed by an erodible plug
CN106236715B (zh) * 2015-06-03 2021-05-07 南京三迭纪医药科技有限公司 药品剂型及其使用
KR20180018711A (ko) 2015-06-17 2018-02-21 바이오젠 엠에이 인코포레이티드 디메틸 푸마레이트 입자 및 이들의 약제학적 조성물
JP7085473B2 (ja) 2015-10-23 2022-06-16 リンドラ セラピューティクス， インコーポレイティド 治療薬の持続放出用の胃内滞留システム及びその使用方法
WO2017075096A1 (en) * 2015-10-26 2017-05-04 Blaesi Aron H Solid dosage form immediate drug release and apparatus and method for manufacture thereof
US11129798B2 (en) 2016-08-19 2021-09-28 Aron H. Blaesi Fibrous dosage form
US11478427B2 (en) * 2015-10-26 2022-10-25 Aron H. Blaesi Dosage form comprising structural framework of two-dimensional elements
AU2016365321A1 (en) * 2015-12-01 2018-06-21 Clexio Biosciences Ltd. Gastric retentive devices
CA3007165A1 (en) * 2015-12-02 2017-06-08 Clexio Biosciences Ltd. Device for preparing gastroretentive dosage forms
EP4302817A3 (de) 2015-12-08 2024-02-21 Lyndra Therapeutics, Inc. Geometrische konfigurationen für magenverweilsysteme
CN109310653A (zh) 2016-03-17 2019-02-05 硫创治疗公司 用于控制释放半胱胺和系统治疗半胱胺敏感性病症的组合物
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
KR20190026799A (ko) * 2016-07-11 2019-03-13 인텍 파마 리미티드 경구 위체류 제형 및 이의 용도
AU2017336154B2 (en) 2016-09-30 2023-11-09 Lyndra Therapeutics, Inc. Gastric residence systems for sustained delivery of adamantane-class drugs
IL266377B2 (en) 2016-12-02 2023-10-01 Clexio Biosciences Ltd Stomach retention system
WO2019060634A1 (en) 2017-09-20 2019-03-28 Thiogenesis Therapeutics, Inc. METHODS OF TREATING CYSTEAMINE SENSITIVE DISORDERS
EP3720537A1 (de) 2017-12-04 2020-10-14 Clexio Biosciences Ltd. Langwirkendes magenverweilsystem
US11571391B2 (en) 2018-01-09 2023-02-07 Triastek, Inc. Oral drug dosage forms compromising a fixed-dose of an ADHD non-stimulant and an ADHD stimulant
US11911513B2 (en) 2018-05-23 2024-02-27 Shanghai Wd Pharmaceutical Co., Ltd Controlled-release system of active pharmaceutical ingredient and preparation method therefor
CN114191307A (zh) 2020-09-17 2022-03-18 上海汉都医药科技有限公司 一种口腔滞留装置及其制备方法
JP7125791B2 (ja) 2018-05-23 2022-08-25 シャンハイ ダブリュディー ファーマシューティカル カンパニー，リミティド 活性薬物成分の放出制御システムおよびその製造方法
US10675248B2 (en) 2018-08-14 2020-06-09 Alma Therapeutics Ltd. Expandable pill
AU2021396978A1 (en) 2020-12-08 2023-02-23 Ruminant Biotech Corp Limited Improvements to devices and methods for delivery of substances to animals

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3574820A (en) 1968-01-08 1971-04-13 Upjohn Co Medicinal dosage forms of unpolymerized thiolated gelatin with a cross-linking accelerating agent providing slowly released medication from a swollen matrix
US4207890A (en) 1977-01-04 1980-06-17 Mcneilab, Inc. Drug-dispensing device and method
US4434153A (en) 1982-03-22 1984-02-28 Alza Corporation Drug delivery system comprising a reservoir containing a plurality of tiny pills
US4735804A (en) 1985-05-10 1988-04-05 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4758436A (en) 1985-05-29 1988-07-19 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4767627A (en) 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
US5217712A (en) 1989-09-20 1993-06-08 Merck & Co., Inc. Bioerodible thermoset elastomers
US5047464A (en) 1989-09-20 1991-09-10 Merck & Co., Inc. Bioerodible thermoset elastomers
IT1265240B1 (it) * 1993-11-30 1996-10-31 Ekita Investments Nv Compressa farmaceutica a rilascio controllato, di forma lenticolare
DE4406424A1 (de) 1994-02-28 1995-08-31 Bayer Ag Expandierbare Arzneiformen
US5840332A (en) * 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system

Also Published As

Publication number Publication date
CA2392361A1 (en) 2001-05-31
AU783062B2 (en) 2005-09-22
US6685962B2 (en) 2004-02-03
ZA200204268B (en) 2003-08-28
IL133196A0 (en) 2001-03-19
DE60021604D1 (de) 2005-09-01
EP1235557B1 (de) 2005-07-27
RU2002114348A (ru) 2004-01-10
US20030021845A1 (en) 2003-01-30
ES2243327T3 (es) 2005-12-01
AU1647701A (en) 2001-06-04
JP4679020B2 (ja) 2011-04-27
CA2392361C (en) 2010-01-19
IL149853A (en) 2006-12-31
WO2001037812A3 (en) 2002-02-21
JP2003514845A (ja) 2003-04-22
WO2001037812A2 (en) 2001-05-31
DE60021604T2 (de) 2006-06-01
EP1235557A2 (de) 2002-09-04

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