IT1255460B - Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive - Google Patents

Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive

Info

Publication number
IT1255460B
IT1255460B ITMI921831A ITMI921831A IT1255460B IT 1255460 B IT1255460 B IT 1255460B IT MI921831 A ITMI921831 A IT MI921831A IT MI921831 A ITMI921831 A IT MI921831A IT 1255460 B IT1255460 B IT 1255460B
Authority
IT
Italy
Prior art keywords
substances
liposomial
peptidal
bioadhesive
microemulsions
Prior art date
Application number
ITMI921831A
Other languages
English (en)
Inventor
Stefano Poli
Federico Mailland
Luigi Moro
Original Assignee
Poli Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poli Ind Chimica Spa filed Critical Poli Ind Chimica Spa
Publication of ITMI921831A0 publication Critical patent/ITMI921831A0/it
Priority to ITMI921831A priority Critical patent/IT1255460B/it
Priority to PCT/EP1993/001965 priority patent/WO1994003157A1/en
Priority to CA002141026A priority patent/CA2141026C/en
Priority to EP93917634A priority patent/EP0652744B1/en
Priority to AT93917634T priority patent/ATE135566T1/de
Priority to DE69301920T priority patent/DE69301920T2/de
Priority to DK93917634.3T priority patent/DK0652744T3/da
Priority to ES93917634T priority patent/ES2085166T3/es
Publication of ITMI921831A1 publication Critical patent/ITMI921831A1/it
Application granted granted Critical
Publication of IT1255460B publication Critical patent/IT1255460B/it
Priority to GR960400866T priority patent/GR3019479T3/el
Priority to US08/664,852 priority patent/US5759566A/en
Priority to US08/693,620 priority patent/US5654000A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Vengono descritte alcune formulazioni contenenti sostanze proteiche, in particolare calcitonina, che rendono concreta la possibilità di somministrare per via transmucosale farmaci destinati ad una azione sistemica oltre che locale o topica. A questo tipo di somministrazione sono associati alcuni vantaggi non trascurabili di attività, tollerabilità, individualizzazione della dose e stabilità del farmaco.
ITMI921831A 1992-07-28 1992-07-28 Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive IT1255460B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ITMI921831A IT1255460B (it) 1992-07-28 1992-07-28 Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive
DK93917634.3T DK0652744T3 (da) 1992-07-28 1993-07-23 Farmaceutiske midler til afgivelse af peptider gennem slimhinden
CA002141026A CA2141026C (en) 1992-07-28 1993-07-23 Pharmaceutical compositions for transmucosal delivery of peptides
EP93917634A EP0652744B1 (en) 1992-07-28 1993-07-23 Pharmaceutical compositions for transmucosal delivery of peptides
AT93917634T ATE135566T1 (de) 1992-07-28 1993-07-23 Arzneimittel zur transmucosalen verabreichung von peptiden
DE69301920T DE69301920T2 (de) 1992-07-28 1993-07-23 Arzneimittel zur transmucosalen verabreichung von peptiden
PCT/EP1993/001965 WO1994003157A1 (en) 1992-07-28 1993-07-23 Pharmaceutical compositions for transmucosal delivery of peptides
ES93917634T ES2085166T3 (es) 1992-07-28 1993-07-23 Composiciones farmaceuticas para la administracion de peptidos a traves de las mucosas.
GR960400866T GR3019479T3 (en) 1992-07-28 1996-04-02 Pharmaceutical compositions for transmucosal delivery of peptides.
US08/664,852 US5759566A (en) 1992-07-28 1996-06-17 Microemulsion pharmaceutical compositions for the delivery of pharmaceutically active agents
US08/693,620 US5654000A (en) 1992-07-28 1996-07-17 Pharmaceutical compositions for transmucosal delivery of peptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI921831A IT1255460B (it) 1992-07-28 1992-07-28 Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive

Publications (3)

Publication Number Publication Date
ITMI921831A0 ITMI921831A0 (it) 1992-07-28
ITMI921831A1 ITMI921831A1 (it) 1994-01-28
IT1255460B true IT1255460B (it) 1995-11-02

Family

ID=11363760

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI921831A IT1255460B (it) 1992-07-28 1992-07-28 Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive

Country Status (9)

Country Link
EP (1) EP0652744B1 (it)
AT (1) ATE135566T1 (it)
CA (1) CA2141026C (it)
DE (1) DE69301920T2 (it)
DK (1) DK0652744T3 (it)
ES (1) ES2085166T3 (it)
GR (1) GR3019479T3 (it)
IT (1) IT1255460B (it)
WO (1) WO1994003157A1 (it)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436425B1 (en) 1988-11-16 2002-08-20 Mdv Technologies, Inc. Method and non-gelling composition for inhibiting post-surgical adhesions
US5346703A (en) 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5744155A (en) * 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
US5514670A (en) * 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
IT1277338B1 (it) * 1995-07-25 1997-11-10 Poli Ind Chimicia S P A Composizioni farmaceutiche di ciclosporina o altre sostanze peptidiche
US5843470A (en) 1995-10-06 1998-12-01 Mdv Technologies, Inc. Method and composition for inhibiting post-surgical adhesions
KR970061240A (ko) * 1996-02-26 1997-09-12 이우용 간에서 초회통과 효과를 받는 약물의 직장투여용 조성물
KR970064596A (ko) * 1996-03-21 1997-10-13 이우용 직장투여용 치질치료제 조성물
WO1997034580A1 (en) * 1996-03-21 1997-09-25 Dong Wha Pharmaceutical Industrial Co., Ltd. Suppository composition of the drug which has gastro-intestinal disturbances or undergoes the decomposition by gastric acid
CN1177594C (zh) * 1996-05-09 2004-12-01 传染病研究股份有限公司 预防治疗粘膜皮肤各种感染 (特别是包括人类免疫缺陷病毒的性传播性疾病 )、炎症、赘生物或其他类型疾病的方法和制剂
US5861174A (en) * 1996-07-12 1999-01-19 University Technology Corporation Temperature sensitive gel for sustained delivery of protein drugs
AU753206B2 (en) * 1997-12-23 2002-10-10 Alliance Pharmaceutical Corporation Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
BR9815708B1 (pt) 1998-03-07 2010-10-19 composição tópica para tratar lesões cutáneas.
WO2000050005A1 (en) 1999-02-24 2000-08-31 Dong Wha Pharm. Ind. Co., Ltd Liquid suppository composition of diclofenac sodium
CA2367266A1 (en) * 1999-03-19 2000-09-28 Mingshu Li Gel-microemulsion formulations
US7064114B2 (en) 1999-03-19 2006-06-20 Parker Hughes Institute Gel-microemulsion formulations
WO2002041837A2 (en) * 2000-11-22 2002-05-30 Rxkinetix, Inc. Treatment of mucositis
EP1598074B1 (en) 2003-02-28 2019-01-02 Chugai Seiyaku Kabushiki Kaisha Stabilized protein-containing formulations
PT1965787E (pt) 2005-11-30 2013-07-05 Endo Pharmaceuticals Inc Tratamento de xerostomia com um antioxidante que contém enxofre
ES2319054B1 (es) 2007-08-06 2010-02-12 Gp Pharm S.A. Composicion farmaceutica oral de desmopresina.
GB201116248D0 (en) * 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3576117D1 (de) * 1984-09-24 1990-04-05 Michael Mezei Mehrphasige pharmazeutische zusammensetzung.
US4917892A (en) * 1988-06-28 1990-04-17 Temple University Encapsulated topical delivery system
US4944948A (en) * 1989-02-24 1990-07-31 Liposome Technology, Inc. EGF/Liposome gel composition and method
EP0386960A3 (en) * 1989-03-07 1991-10-23 American Cyanamid Company Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings
IT1240354B (it) * 1990-03-30 1993-12-07 Poli Ind Chimica Spa Formulazioni liposomiali di farmaci antimicotici,antibatterici e/o antantiflogistici per applicazione locale e vaginale

Also Published As

Publication number Publication date
EP0652744B1 (en) 1996-03-20
ATE135566T1 (de) 1996-04-15
ITMI921831A1 (it) 1994-01-28
ITMI921831A0 (it) 1992-07-28
ES2085166T3 (es) 1996-05-16
WO1994003157A1 (en) 1994-02-17
DK0652744T3 (da) 1996-07-08
DE69301920D1 (de) 1996-04-25
CA2141026A1 (en) 1994-02-17
GR3019479T3 (en) 1996-07-31
EP0652744A1 (en) 1995-05-17
DE69301920T2 (de) 1996-08-08
CA2141026C (en) 2000-04-18

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960725