KR910000143B1 - 3-히드록시부탄산 또는 이 산으로 부터 유도된 염의 제조방법 - Google Patents

3-히드록시부탄산 또는 이 산으로 부터 유도된 염의 제조방법 Download PDF

Info

Publication number
KR910000143B1
KR910000143B1 KR1019830000728A KR830000728A KR910000143B1 KR 910000143 B1 KR910000143 B1 KR 910000143B1 KR 1019830000728 A KR1019830000728 A KR 1019830000728A KR 830000728 A KR830000728 A KR 830000728A KR 910000143 B1 KR910000143 B1 KR 910000143B1
Authority
KR
South Korea
Prior art keywords
hydroxybutanoic acid
experiment
salts derived
salts
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019830000728A
Other languages
English (en)
Korean (ko)
Other versions
KR840003414A (ko
Inventor
라머란트 자케스
클라노브스키 자로슬라브
Original Assignee
솔베이 앤드 시에 (소시에떼 아노님)
클라우디 라우트렐
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 솔베이 앤드 시에 (소시에떼 아노님), 클라우디 라우트렐 filed Critical 솔베이 앤드 시에 (소시에떼 아노님)
Publication of KR840003414A publication Critical patent/KR840003414A/ko
Application granted granted Critical
Publication of KR910000143B1 publication Critical patent/KR910000143B1/ko
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1019830000728A 1982-02-23 1983-02-23 3-히드록시부탄산 또는 이 산으로 부터 유도된 염의 제조방법 Expired KR910000143B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR82-03100 1982-02-23
FR82.03100 1982-02-23
FR8203100A FR2521857B1 (fr) 1982-02-23 1982-02-23 Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee

Publications (2)

Publication Number Publication Date
KR840003414A KR840003414A (ko) 1984-09-08
KR910000143B1 true KR910000143B1 (ko) 1991-01-21

Family

ID=9271331

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830000728A Expired KR910000143B1 (ko) 1982-02-23 1983-02-23 3-히드록시부탄산 또는 이 산으로 부터 유도된 염의 제조방법

Country Status (21)

Country Link
US (2) US4579955A (enExample)
EP (1) EP0087192B1 (enExample)
JP (1) JPS58201746A (enExample)
KR (1) KR910000143B1 (enExample)
AT (1) ATE24478T1 (enExample)
AU (2) AU560757B2 (enExample)
CA (1) CA1203242A (enExample)
DE (1) DE3368601D1 (enExample)
DK (1) DK163235C (enExample)
ES (2) ES519991A0 (enExample)
FI (1) FI79523C (enExample)
FR (1) FR2521857B1 (enExample)
GR (1) GR77934B (enExample)
IE (1) IE54561B1 (enExample)
IL (1) IL67965A0 (enExample)
MX (1) MX156855A (enExample)
NO (1) NO161909C (enExample)
NZ (1) NZ203279A (enExample)
PH (1) PH21561A (enExample)
PT (1) PT76267A (enExample)
ZA (1) ZA831019B (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2521857B1 (fr) * 1982-02-23 1985-10-31 Solvay Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee
USRE38604E1 (en) 1984-06-22 2004-09-28 Btg International Limited Fluid therapy with L-lactate and/or pyruvate anions
US6020007A (en) * 1984-06-22 2000-02-01 Btg International Limited Fluid therapy with l-lactate and/or pyruvate anions
US4777288A (en) * 1987-06-11 1988-10-11 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
BE1001209A3 (fr) * 1987-11-19 1989-08-22 Solvay Compositions pharmaceutiques contenant un derive de l'acide 3-hydroxybutanoique choisi parmi les oligomeres de cet acide et les esters de cet acide ou de ces oligomeres avec du 1,3-butanediol.
US5292774A (en) * 1988-07-26 1994-03-08 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Substitution fluid preparation comprising 3-hydroxy-butyric acid (β-hydroxybutric acid) and its salts
DE4113984C2 (de) * 1991-04-29 2002-05-08 Koehler Chemie Dr Franz Salze der 4-Hydroxy-Buttersäure
ES2051222B1 (es) * 1992-03-12 1995-02-16 Sanmiguel Gabriel Serrano Procedimiento de neutralizacion de acido alfa-hidroxietanoico.
JP4598203B2 (ja) 1995-12-01 2010-12-15 ビーティージー・インターナショナル・リミテッド 脳機能改善剤
US20090253781A1 (en) * 2002-05-24 2009-10-08 Btg International Limited Therapeutic compositions
EP1017379B1 (en) * 1997-03-17 2014-12-10 BTG International Limited Therapeutic compositions comprising ketone bodies and precursors thereof
US6323237B1 (en) 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
US6316038B1 (en) 1997-03-17 2001-11-13 Btg International Limited Therapeutic compositions
US6613356B1 (en) 2000-10-10 2003-09-02 Victor Vlahakos Weight loss medication and method
GB0420856D0 (en) * 2004-09-20 2004-10-20 Ketocytonyx Inc Cns modulators
US7947736B2 (en) * 2004-07-16 2011-05-24 Btg International Limited Oligomeric compounds
US7485743B2 (en) * 2004-07-20 2009-02-03 Btg International Limited Oligomeric ketone compounds
WO2006012490A2 (en) * 2004-07-23 2006-02-02 Ketocytonyx Inc. Ketogenic saccharides
WO2006034361A2 (en) * 2004-09-21 2006-03-30 Ketocytonyx Inc. Dopaminergic mimetics
WO2006098767A2 (en) * 2004-09-21 2006-09-21 Ketocytonyx Inc. Treatment of adhd
RU2302239C1 (ru) * 2006-07-14 2007-07-10 Михаил Владимирович Покровский Способ фармакологической коррекции ишемии конечности
JPWO2008053982A1 (ja) 2006-10-30 2010-02-25 株式会社オフテクス アレルギー治療用組成物
EP3659595A1 (en) 2012-11-05 2020-06-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Ketone bodies to protect tissues from damage by ionizing radiation
JP6875288B2 (ja) 2015-11-19 2021-05-19 協和発酵バイオ株式会社 ３−ヒドロキシイソ吉草酸の一価カチオン塩の結晶および該結晶の製造方法
US11241403B2 (en) 2016-03-11 2022-02-08 Axcess Global Sciences, Llc Beta-hydroxybutyrate mixed salt compositions and methods of use
US11103470B2 (en) 2017-11-22 2021-08-31 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US11806324B2 (en) 2018-04-18 2023-11-07 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies
US11202769B2 (en) 2017-11-22 2021-12-21 Axcess Global Sciences, Llc Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function
US11944598B2 (en) 2017-12-19 2024-04-02 Axcess Global Sciences, Llc Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer
US12109182B2 (en) 2016-04-19 2024-10-08 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate and related compounds in humans
US12496283B2 (en) 2016-04-19 2025-12-16 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate and related compounds in humans
US12329734B2 (en) 2017-12-19 2025-06-17 Axcess Global Sciences, Llc Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow
US10925843B2 (en) 2018-04-18 2021-02-23 Axcess Global Sciences, Llc Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate
JP6710098B2 (ja) * 2016-05-10 2020-06-17 大阪瓦斯株式会社 栄養剤組成物及び栄養補助食品
AU2017282515A1 (en) * 2016-06-24 2019-01-17 Otsuka Pharmaceutical Factory, Inc. Crystal of β-hydroxy β-methylbutyric acid amino acid salt and production method therefor
US12090129B2 (en) 2017-11-22 2024-09-17 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US12472200B2 (en) 2019-05-15 2025-11-18 Axcess Global Sciences, Llc Autobiotic compositions and method for promoting healthy gut microbiome
US11950616B2 (en) 2019-06-21 2024-04-09 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
US11969430B1 (en) 2023-03-10 2024-04-30 Axcess Global Sciences, Llc Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance
US12167993B2 (en) 2019-06-21 2024-12-17 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
CN112341331B (zh) * 2019-08-07 2023-04-07 辽宁科硕营养科技股份有限公司 一种3-羟基丁酸盐及其制备方法与应用
US12186297B2 (en) 2020-08-26 2025-01-07 Axcess Global Sciences, Llc Compositions and methods for increasing lean-to-fat mass ratio
WO2024192165A1 (en) * 2023-03-14 2024-09-19 The Board Of Trustees Of The Leland Stanford Junior University N-beta-hydroxybutyryl-amino acids and related compositions and methods
WO2025056246A1 (en) * 2023-09-11 2025-03-20 Societe Des Produits Nestle S.A. Polymorphs and compositions comprising same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2101097A (en) * 1934-07-26 1937-12-07 Wm S Merrell Co Products for rendering the urine bacteriostatic
US2799684A (en) * 1954-06-18 1957-07-16 Food Chemical And Res Lab Inc Crystalline compounds of tryptophane and methods of manufacturing them
NL279760A (enExample) * 1961-06-17
US3830931A (en) * 1972-11-06 1974-08-20 Felice S De Carnitine and its use in the treatment of arrhythmia and impaired cardiac function
US3879537A (en) * 1973-09-04 1975-04-22 Scott Eugene J Van Treatment of ichthyosiform dermatoses
DE2733202A1 (de) * 1976-08-04 1978-02-09 Agroferm Ag Verfahren zur herstellung der d(-)-3-hydroxybuttersaeure
US4412943A (en) * 1981-02-23 1983-11-01 Kao Soap Co., Ltd. Liquid detergent composition
FR2521857B1 (fr) * 1982-02-23 1985-10-31 Solvay Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee

Also Published As

Publication number Publication date
NZ203279A (en) 1985-04-30
DK163235B (da) 1992-02-10
ATE24478T1 (de) 1987-01-15
DK81583D0 (da) 1983-02-23
EP0087192A1 (fr) 1983-08-31
DK81583A (da) 1983-08-24
ES8500240A1 (es) 1984-10-01
IL67965A0 (en) 1983-06-15
CA1203242A (fr) 1986-04-15
NO830618L (no) 1983-08-24
NO161909B (no) 1989-07-03
AU1162483A (en) 1983-09-01
IE54561B1 (en) 1989-11-22
AU602329B2 (en) 1990-10-11
US4579955A (en) 1986-04-01
FR2521857B1 (fr) 1985-10-31
FI79523C (fi) 1990-01-10
ES532880A0 (es) 1985-07-01
AU560757B2 (en) 1987-04-16
IE830366L (en) 1983-08-23
AU6916187A (en) 1987-05-21
PH21561A (en) 1987-12-11
MX156855A (es) 1988-10-07
FI79523B (fi) 1989-09-29
PT76267A (fr) 1983-03-01
DK163235C (da) 1992-06-29
JPS58201746A (ja) 1983-11-24
US4771074A (en) 1988-09-13
DE3368601D1 (en) 1987-02-05
FI830603L (fi) 1983-08-24
ES8506283A1 (es) 1985-07-01
EP0087192B1 (fr) 1986-12-30
KR840003414A (ko) 1984-09-08
NO161909C (no) 1989-10-11
FR2521857A1 (fr) 1983-08-26
FI830603A0 (fi) 1983-02-23
ES519991A0 (es) 1984-10-01
GR77934B (enExample) 1984-09-25
ZA831019B (en) 1983-11-30

Similar Documents

Publication Publication Date Title
KR910000143B1 (ko) 3-히드록시부탄산 또는 이 산으로 부터 유도된 염의 제조방법
US3658966A (en) Methods of treating hypertension
EP0186252B1 (en) use of thiophene compounds for the manufacture of a medicament against tumours
RU2007148709A (ru) Стабильный биологически активный комплекс солей о-ацетилсалициловой кислоты с основными аминокислотами и глицина
FR2584405A1 (fr) Sels de furosemide, composition pharmaceutique les contenant et leur procede de preparation
JPH04505760A (ja) Ａｚｔの副作用および毒性からの保護方法
US3065133A (en) Imidazoles for the control of histomoniasis
US4423043A (en) Aqueous liquid formulations for control of bacterial and protozoal diseases
US4973553A (en) Salt or organogermanium compound and medicine containing the same
US4137326A (en) Use of magnesium monospartate hydrochloride complex
CA1036618A (en) Process for the manufacture of tris (2-hydroxyethyl) ammonium-ortho-cresosyacetate
JPS6348217A (ja) 麻酔薬組成物
JPS58500526A (ja) 非経口栄養供給のための改良溶液
US4618618A (en) Compounds and compositions
FR2472387A1 (fr) Compositions pharmaceutiques pour le traitement de l'oedeme pulmonaire aigu, de certains etats de choc et de l'hyperfibrinolyse
US3542929A (en) Chemotherapeutic compositions useful in animal detoxification
EP0059057A1 (en) Treatment of diarrhoea
Gray The treatment of diabetes mellitus with insoluble insulin compounds
SU1766910A1 (ru) Литиева соль N- @ -изобутоксибензоил- @ -аминомасл ной кислоты, обладающа активностью улучшать микроциркул цию мозга
KR850000210B1 (ko) 옥사졸린의 제조방법
US3639606A (en) Method for the prevention or cure of oxalic lithiasis and pharmaceutical compositions therefor
KR930004647B1 (ko) 신장 질환 치료제
DE2324535A1 (de) Phenylalaninderivate
CA1118353A (en) Pharmaceutical compositions comprising phenylglyoxylic acids
JPS63225343A (ja) ドブタミン塩の改良

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

FPAY Annual fee payment

Payment date: 19931223

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19950122

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19950122