DK81583D0 - Derivater af 3-hydroxysmoersyre og fremgangsmade til fremstilling deraf - Google Patents
Derivater af 3-hydroxysmoersyre og fremgangsmade til fremstilling derafInfo
- Publication number
- DK81583D0 DK81583D0 DK0815/83A DK81583A DK81583D0 DK 81583 D0 DK81583 D0 DK 81583D0 DK 0815/83 A DK0815/83 A DK 0815/83A DK 81583 A DK81583 A DK 81583A DK 81583 D0 DK81583 D0 DK 81583D0
- Authority
- DK
- Denmark
- Prior art keywords
- acid
- hydroxyloic
- procedures
- derivatives
- preparing
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 230000000302 ischemic effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 208000031229 Cardiomyopathies Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000009109 curative therapy Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001477 organic nitrogen group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8203100 | 1982-02-23 | ||
| FR8203100A FR2521857B1 (fr) | 1982-02-23 | 1982-02-23 | Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK81583D0 true DK81583D0 (da) | 1983-02-23 |
| DK81583A DK81583A (da) | 1983-08-24 |
| DK163235B DK163235B (da) | 1992-02-10 |
| DK163235C DK163235C (da) | 1992-06-29 |
Family
ID=9271331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK081583A DK163235C (da) | 1982-02-23 | 1983-02-23 | Analogifremgangsmaade til fremstilling af farmaceutisk aktive 3-hydroxysmoersyresalte |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US4579955A (da) |
| EP (1) | EP0087192B1 (da) |
| JP (1) | JPS58201746A (da) |
| KR (1) | KR910000143B1 (da) |
| AT (1) | ATE24478T1 (da) |
| AU (2) | AU560757B2 (da) |
| CA (1) | CA1203242A (da) |
| DE (1) | DE3368601D1 (da) |
| DK (1) | DK163235C (da) |
| ES (2) | ES519991A0 (da) |
| FI (1) | FI79523C (da) |
| FR (1) | FR2521857B1 (da) |
| GR (1) | GR77934B (da) |
| IE (1) | IE54561B1 (da) |
| IL (1) | IL67965A0 (da) |
| MX (1) | MX156855A (da) |
| NO (1) | NO161909C (da) |
| NZ (1) | NZ203279A (da) |
| PH (1) | PH21561A (da) |
| PT (1) | PT76267A (da) |
| ZA (1) | ZA831019B (da) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2521857B1 (fr) * | 1982-02-23 | 1985-10-31 | Solvay | Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee |
| USRE38604E1 (en) | 1984-06-22 | 2004-09-28 | Btg International Limited | Fluid therapy with L-lactate and/or pyruvate anions |
| US6020007A (en) * | 1984-06-22 | 2000-02-01 | Btg International Limited | Fluid therapy with l-lactate and/or pyruvate anions |
| US4777288A (en) * | 1987-06-11 | 1988-10-11 | Pfizer Inc. | Process for preparing a 4,4-diphenylbutanoic acid derivative |
| BE1001209A3 (fr) * | 1987-11-19 | 1989-08-22 | Solvay | Compositions pharmaceutiques contenant un derive de l'acide 3-hydroxybutanoique choisi parmi les oligomeres de cet acide et les esters de cet acide ou de ces oligomeres avec du 1,3-butanediol. |
| US5292774A (en) * | 1988-07-26 | 1994-03-08 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Substitution fluid preparation comprising 3-hydroxy-butyric acid (β-hydroxybutric acid) and its salts |
| DE4113984C2 (de) * | 1991-04-29 | 2002-05-08 | Koehler Chemie Dr Franz | Salze der 4-Hydroxy-Buttersäure |
| ES2051222B1 (es) * | 1992-03-12 | 1995-02-16 | Sanmiguel Gabriel Serrano | Procedimiento de neutralizacion de acido alfa-hidroxietanoico. |
| JP4598203B2 (ja) | 1995-12-01 | 2010-12-15 | ビーティージー・インターナショナル・リミテッド | 脳機能改善剤 |
| US20090253781A1 (en) * | 2002-05-24 | 2009-10-08 | Btg International Limited | Therapeutic compositions |
| EP1017379B1 (en) * | 1997-03-17 | 2014-12-10 | BTG International Limited | Therapeutic compositions comprising ketone bodies and precursors thereof |
| US6323237B1 (en) | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
| US6316038B1 (en) | 1997-03-17 | 2001-11-13 | Btg International Limited | Therapeutic compositions |
| US6613356B1 (en) | 2000-10-10 | 2003-09-02 | Victor Vlahakos | Weight loss medication and method |
| GB0420856D0 (en) * | 2004-09-20 | 2004-10-20 | Ketocytonyx Inc | Cns modulators |
| US7947736B2 (en) * | 2004-07-16 | 2011-05-24 | Btg International Limited | Oligomeric compounds |
| US7485743B2 (en) * | 2004-07-20 | 2009-02-03 | Btg International Limited | Oligomeric ketone compounds |
| WO2006012490A2 (en) * | 2004-07-23 | 2006-02-02 | Ketocytonyx Inc. | Ketogenic saccharides |
| WO2006034361A2 (en) * | 2004-09-21 | 2006-03-30 | Ketocytonyx Inc. | Dopaminergic mimetics |
| WO2006098767A2 (en) * | 2004-09-21 | 2006-09-21 | Ketocytonyx Inc. | Treatment of adhd |
| RU2302239C1 (ru) * | 2006-07-14 | 2007-07-10 | Михаил Владимирович Покровский | Способ фармакологической коррекции ишемии конечности |
| JPWO2008053982A1 (ja) | 2006-10-30 | 2010-02-25 | 株式会社オフテクス | アレルギー治療用組成物 |
| EP3659595A1 (en) | 2012-11-05 | 2020-06-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Ketone bodies to protect tissues from damage by ionizing radiation |
| JP6875288B2 (ja) | 2015-11-19 | 2021-05-19 | 協和発酵バイオ株式会社 | ３−ヒドロキシイソ吉草酸の一価カチオン塩の結晶および該結晶の製造方法 |
| US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
| US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US11806324B2 (en) | 2018-04-18 | 2023-11-07 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies |
| US11202769B2 (en) | 2017-11-22 | 2021-12-21 | Axcess Global Sciences, Llc | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| JP6710098B2 (ja) * | 2016-05-10 | 2020-06-17 | 大阪瓦斯株式会社 | 栄養剤組成物及び栄養補助食品 |
| AU2017282515A1 (en) * | 2016-06-24 | 2019-01-17 | Otsuka Pharmaceutical Factory, Inc. | Crystal of β-hydroxy β-methylbutyric acid amino acid salt and production method therefor |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| CN112341331B (zh) * | 2019-08-07 | 2023-04-07 | 辽宁科硕营养科技股份有限公司 | 一种3-羟基丁酸盐及其制备方法与应用 |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| WO2024192165A1 (en) * | 2023-03-14 | 2024-09-19 | The Board Of Trustees Of The Leland Stanford Junior University | N-beta-hydroxybutyryl-amino acids and related compositions and methods |
| WO2025056246A1 (en) * | 2023-09-11 | 2025-03-20 | Societe Des Produits Nestle S.A. | Polymorphs and compositions comprising same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2101097A (en) * | 1934-07-26 | 1937-12-07 | Wm S Merrell Co | Products for rendering the urine bacteriostatic |
| US2799684A (en) * | 1954-06-18 | 1957-07-16 | Food Chemical And Res Lab Inc | Crystalline compounds of tryptophane and methods of manufacturing them |
| NL279760A (da) * | 1961-06-17 | |||
| US3830931A (en) * | 1972-11-06 | 1974-08-20 | Felice S De | Carnitine and its use in the treatment of arrhythmia and impaired cardiac function |
| US3879537A (en) * | 1973-09-04 | 1975-04-22 | Scott Eugene J Van | Treatment of ichthyosiform dermatoses |
| DE2733202A1 (de) * | 1976-08-04 | 1978-02-09 | Agroferm Ag | Verfahren zur herstellung der d(-)-3-hydroxybuttersaeure |
| US4412943A (en) * | 1981-02-23 | 1983-11-01 | Kao Soap Co., Ltd. | Liquid detergent composition |
| FR2521857B1 (fr) * | 1982-02-23 | 1985-10-31 | Solvay | Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee |
-
1982
- 1982-02-23 FR FR8203100A patent/FR2521857B1/fr not_active Expired
-
1983
- 1983-02-15 EP EP83200228A patent/EP0087192B1/fr not_active Expired
- 1983-02-15 DE DE8383200228T patent/DE3368601D1/de not_active Expired
- 1983-02-15 ZA ZA831019A patent/ZA831019B/xx unknown
- 1983-02-15 AT AT83200228T patent/ATE24478T1/de active
- 1983-02-15 NZ NZ203279A patent/NZ203279A/en unknown
- 1983-02-17 AU AU11624/83A patent/AU560757B2/en not_active Ceased
- 1983-02-21 GR GR70556A patent/GR77934B/el unknown
- 1983-02-21 PH PH28545A patent/PH21561A/en unknown
- 1983-02-21 IL IL67965A patent/IL67965A0/xx not_active IP Right Cessation
- 1983-02-21 PT PT76267A patent/PT76267A/pt not_active IP Right Cessation
- 1983-02-22 MX MX196357A patent/MX156855A/es unknown
- 1983-02-22 IE IE366/83A patent/IE54561B1/en not_active IP Right Cessation
- 1983-02-22 US US06/468,385 patent/US4579955A/en not_active Expired - Fee Related
- 1983-02-22 NO NO830618A patent/NO161909C/no unknown
- 1983-02-22 ES ES519991A patent/ES519991A0/es active Granted
- 1983-02-23 CA CA000422215A patent/CA1203242A/fr not_active Expired
- 1983-02-23 KR KR1019830000728A patent/KR910000143B1/ko not_active Expired
- 1983-02-23 DK DK081583A patent/DK163235C/da not_active IP Right Cessation
- 1983-02-23 JP JP58029197A patent/JPS58201746A/ja active Pending
- 1983-02-23 FI FI830603A patent/FI79523C/fi not_active IP Right Cessation
-
1984
- 1984-05-28 ES ES532880A patent/ES8506283A1/es not_active Expired
-
1985
- 1985-10-23 US US06/790,391 patent/US4771074A/en not_active Expired - Fee Related
-
1987
- 1987-02-23 AU AU69161/87A patent/AU602329B2/en not_active Ceased
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |