FR2521857B1 - Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee - Google Patents

Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee

Info

Publication number
FR2521857B1
FR2521857B1 FR8203100A FR8203100A FR2521857B1 FR 2521857 B1 FR2521857 B1 FR 2521857B1 FR 8203100 A FR8203100 A FR 8203100A FR 8203100 A FR8203100 A FR 8203100A FR 2521857 B1 FR2521857 B1 FR 2521857B1
Authority
FR
France
Prior art keywords
hydroxybutanoic acid
pharmaceutical compositions
compositions containing
organic nitrogen
nitrogen base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8203100A
Other languages
English (en)
French (fr)
Other versions
FR2521857A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Solvay SA
Original Assignee
Solvay SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay SA filed Critical Solvay SA
Priority to FR8203100A priority Critical patent/FR2521857B1/fr
Priority to NZ203279A priority patent/NZ203279A/en
Priority to AT83200228T priority patent/ATE24478T1/de
Priority to EP83200228A priority patent/EP0087192B1/fr
Priority to ZA831019A priority patent/ZA831019B/xx
Priority to DE8383200228T priority patent/DE3368601D1/de
Priority to AU11624/83A priority patent/AU560757B2/en
Priority to PT76267A priority patent/PT76267A/pt
Priority to PH28545A priority patent/PH21561A/en
Priority to IL67965A priority patent/IL67965A0/xx
Priority to GR70556A priority patent/GR77934B/el
Priority to US06/468,385 priority patent/US4579955A/en
Priority to MX196357A priority patent/MX156855A/es
Priority to IE366/83A priority patent/IE54561B1/en
Priority to ES519991A priority patent/ES519991A0/es
Priority to NO830618A priority patent/NO161909C/no
Priority to DK081583A priority patent/DK163235C/da
Priority to KR1019830000728A priority patent/KR910000143B1/ko
Priority to CA000422215A priority patent/CA1203242A/fr
Priority to JP58029197A priority patent/JPS58201746A/ja
Priority to FI830603A priority patent/FI79523C/fi
Publication of FR2521857A1 publication Critical patent/FR2521857A1/fr
Priority to ES532880A priority patent/ES8506283A1/es
Priority to US06/790,391 priority patent/US4771074A/en
Application granted granted Critical
Publication of FR2521857B1 publication Critical patent/FR2521857B1/fr
Priority to AU69161/87A priority patent/AU602329B2/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
FR8203100A 1982-02-23 1982-02-23 Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee Expired FR2521857B1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FR8203100A FR2521857B1 (fr) 1982-02-23 1982-02-23 Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee
NZ203279A NZ203279A (en) 1982-02-23 1983-02-15 3-hydroxybutanoic acid salts and pharmaceutical compositions
AT83200228T ATE24478T1 (de) 1982-02-23 1983-02-15 3-hydroxybuttersaeure oder derer salze enthaltende pharmazeutische zusammensetzungen und als arzneimittel verwendbare, von 3hydroxybutters|ure abgeleitete verbindungen.
EP83200228A EP0087192B1 (fr) 1982-02-23 1983-02-15 Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel dérivé de cet acide et composés dérivés de l'acide 3-hydroxybutanoique utilisables comme médicament
ZA831019A ZA831019B (en) 1982-02-23 1983-02-15 Pharmaceutical compositions containing 3-hydroxybutanoic acid or a salt derived from this acid,and compounds derived from 3-hydroxybutanoic acid which can be used as medicaments
DE8383200228T DE3368601D1 (en) 1982-02-23 1983-02-15 Pharmaceutical compositions containg 3-hydroxybutanoic acid or its salts, and compounds derived from 3-hydroxybutanoic acid useful as medicaments
AU11624/83A AU560757B2 (en) 1982-02-23 1983-02-17 Pharmaceutical compositions containing 3-hydroxybutanoic acid or a salt derived from this acid, and compounds derived from 3-hydroxybutanoic acid which can be used as medicaments
PH28545A PH21561A (en) 1982-02-23 1983-02-21 Pharmaceutical compositions containing 3-hydroxy- butanoic acid or salt derived from this acid and compounds derived from 3-hydroxy butanoic acid which can be used as medicaments
IL67965A IL67965A0 (en) 1982-02-23 1983-02-21 Pharmaceutical compositions containing 3-hydroxybutanoic acid or a salt thereof,certain compounds derived from 3-hydroxybutanoic acid and their preparation
GR70556A GR77934B (enExample) 1982-02-23 1983-02-21
PT76267A PT76267A (fr) 1982-02-23 1983-02-21 Procede d'obtention de composes derives de l'acide 3-hydroxybu-tanoique et procede d'obtention de compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide
IE366/83A IE54561B1 (en) 1982-02-23 1983-02-22 Pharmaceutical compositions containing 3-hydroxybutanois acid or a salt derived from this acid, and compounds derived from 3-hydroxybutanoic acid which can be used as medicaments
US06/468,385 US4579955A (en) 1982-02-23 1983-02-22 Amino acid salts of 3-hydroxybutanoic acid
ES519991A ES519991A0 (es) 1982-02-23 1983-02-22 Procedimiento para la obtencion de compuestos derivados del acido 3-hidroxibutanoico.
NO830618A NO161909C (no) 1982-02-23 1983-02-22 Analogifremgangsmaate for fremstilling av farmasoeytisk anvendelige salter av 3-hydroksy-butansyre.
MX196357A MX156855A (es) 1982-02-23 1983-02-22 Procedimiento para preparar sales de acido 3-hidroxibutanoico
KR1019830000728A KR910000143B1 (ko) 1982-02-23 1983-02-23 3-히드록시부탄산 또는 이 산으로 부터 유도된 염의 제조방법
CA000422215A CA1203242A (fr) 1982-02-23 1983-02-23 Procede de preparation de sels derives de l'acide 3- hydroxybutanoique et d'une base organique aminee, et les sels ainsi obtenus
JP58029197A JPS58201746A (ja) 1982-02-23 1983-02-23 ３−ヒドロキシブタン酸またはこの酸から誘導された塩を含有する薬剤組成物、および３−ヒドロキシブタン酸から誘導され、医薬として使用できる化合物
DK081583A DK163235C (da) 1982-02-23 1983-02-23 Analogifremgangsmaade til fremstilling af farmaceutisk aktive 3-hydroxysmoersyresalte
FI830603A FI79523C (fi) 1982-02-23 1983-02-23 Foerfarande foer framstaellning av nya, terapeutiskt vaerdefulla salter av 3-hydroxismoersyra.
ES532880A ES8506283A1 (es) 1982-02-23 1984-05-28 Un procedimiento para obtener composiciones farmaceuticas que contienen un derivado del acido 3-hidroxibutanoico y de una base inorganica u organica nitrogenada.
US06/790,391 US4771074A (en) 1982-02-23 1985-10-23 Pharmaceutical compositions containing a salt derived from 3-hydroxybutanoic acid
AU69161/87A AU602329B2 (en) 1982-02-23 1987-02-23 Pharmaceutical compositions containing 3-hydroxybutanoic acid or a salt derived from this acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8203100A FR2521857B1 (fr) 1982-02-23 1982-02-23 Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee

Publications (2)

Publication Number Publication Date
FR2521857A1 FR2521857A1 (fr) 1983-08-26
FR2521857B1 true FR2521857B1 (fr) 1985-10-31

Family

ID=9271331

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8203100A Expired FR2521857B1 (fr) 1982-02-23 1982-02-23 Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee

Country Status (21)

Country Link
US (2) US4579955A (enExample)
EP (1) EP0087192B1 (enExample)
JP (1) JPS58201746A (enExample)
KR (1) KR910000143B1 (enExample)
AT (1) ATE24478T1 (enExample)
AU (2) AU560757B2 (enExample)
CA (1) CA1203242A (enExample)
DE (1) DE3368601D1 (enExample)
DK (1) DK163235C (enExample)
ES (2) ES519991A0 (enExample)
FI (1) FI79523C (enExample)
FR (1) FR2521857B1 (enExample)
GR (1) GR77934B (enExample)
IE (1) IE54561B1 (enExample)
IL (1) IL67965A0 (enExample)
MX (1) MX156855A (enExample)
NO (1) NO161909C (enExample)
NZ (1) NZ203279A (enExample)
PH (1) PH21561A (enExample)
PT (1) PT76267A (enExample)
ZA (1) ZA831019B (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2521857B1 (fr) * 1982-02-23 1985-10-31 Solvay Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee
US6020007A (en) * 1984-06-22 2000-02-01 Btg International Limited Fluid therapy with l-lactate and/or pyruvate anions
USRE38604E1 (en) 1984-06-22 2004-09-28 Btg International Limited Fluid therapy with L-lactate and/or pyruvate anions
US4777288A (en) * 1987-06-11 1988-10-11 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
BE1001209A3 (fr) * 1987-11-19 1989-08-22 Solvay Compositions pharmaceutiques contenant un derive de l'acide 3-hydroxybutanoique choisi parmi les oligomeres de cet acide et les esters de cet acide ou de ces oligomeres avec du 1,3-butanediol.
US5292774A (en) * 1988-07-26 1994-03-08 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Substitution fluid preparation comprising 3-hydroxy-butyric acid (β-hydroxybutric acid) and its salts
DE4113984C2 (de) * 1991-04-29 2002-05-08 Koehler Chemie Dr Franz Salze der 4-Hydroxy-Buttersäure
ES2051222B1 (es) * 1992-03-12 1995-02-16 Sanmiguel Gabriel Serrano Procedimiento de neutralizacion de acido alfa-hidroxietanoico.
JP4598203B2 (ja) 1995-12-01 2010-12-15 ビーティージー・インターナショナル・リミテッド 脳機能改善剤
CN1315473C (zh) * 1997-03-17 2007-05-16 英国技术集团国际有限公司 治疗组合物
US6323237B1 (en) 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
US20090253781A1 (en) * 2002-05-24 2009-10-08 Btg International Limited Therapeutic compositions
US6316038B1 (en) 1997-03-17 2001-11-13 Btg International Limited Therapeutic compositions
US6613356B1 (en) 2000-10-10 2003-09-02 Victor Vlahakos Weight loss medication and method
GB0420856D0 (en) * 2004-09-20 2004-10-20 Ketocytonyx Inc Cns modulators
WO2006020137A2 (en) * 2004-07-16 2006-02-23 Ketocytonyx Inc. Oligomeric compounds
EP1778615A4 (en) * 2004-07-20 2010-01-06 Btg Int Ltd OLIGOMERE KETONE COMPOUNDS
WO2006012490A2 (en) * 2004-07-23 2006-02-02 Ketocytonyx Inc. Ketogenic saccharides
US20070197645A1 (en) * 2004-09-21 2007-08-23 Martin Keith F Treatment of adhd
WO2006034361A2 (en) * 2004-09-21 2006-03-30 Ketocytonyx Inc. Dopaminergic mimetics
RU2302239C1 (ru) * 2006-07-14 2007-07-10 Михаил Владимирович Покровский Способ фармакологической коррекции ишемии конечности
WO2008053982A1 (en) 2006-10-30 2008-05-08 Ophtecs Corporation Composition for treating allergy
WO2014071389A1 (en) 2012-11-05 2014-05-08 Veech Richard L Ketone bodies to protect tissues from damage by ionizing radiation
HK1258020A1 (zh) 2015-11-19 2019-11-01 株式会社大塚制药工场 3-羟基异戊酸的一价阳离子盐的晶体及该晶体的制造方法
US11241403B2 (en) 2016-03-11 2022-02-08 Axcess Global Sciences, Llc Beta-hydroxybutyrate mixed salt compositions and methods of use
US11103470B2 (en) 2017-11-22 2021-08-31 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US10925843B2 (en) 2018-04-18 2021-02-23 Axcess Global Sciences, Llc Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate
US12599579B2 (en) 2016-04-19 2026-04-14 Axcess Global Sciences, Llc Compositions and compounds containing ketone bodies and/or ketone body precursors and one or more amino acids
US12496283B2 (en) 2016-04-19 2025-12-16 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate and related compounds in humans
US11944598B2 (en) 2017-12-19 2024-04-02 Axcess Global Sciences, Llc Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer
US12622889B2 (en) 2016-04-19 2026-05-12 Axcess Global Sciences, Llc S-β-hydroxybutyrate esters for improving metabolic function
US12533346B2 (en) 2016-04-19 2026-01-27 Axcess Global Sciences, Llc Administration of berberine metabolites
US11806324B2 (en) 2018-04-18 2023-11-07 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies
US12109182B2 (en) 2016-04-19 2024-10-08 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate and related compounds in humans
US12329734B2 (en) 2017-12-19 2025-06-17 Axcess Global Sciences, Llc Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow
US11202769B2 (en) 2017-11-22 2021-12-21 Axcess Global Sciences, Llc Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function
US12521378B2 (en) 2016-04-19 2026-01-13 Axcess Global Sciences, Llc Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans
US20230346721A1 (en) 2018-04-18 2023-11-02 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies
JP6710098B2 (ja) * 2016-05-10 2020-06-17 大阪瓦斯株式会社 栄養剤組成物及び栄養補助食品
RU2018145506A (ru) * 2016-06-24 2020-07-27 Оцука Фармасьютикал Фэктори, Инк. Кристаллическая аминокислотная соль 3-гидроксиизовалериановой кислоты и способ ее получения
US12090129B2 (en) 2017-11-22 2024-09-17 Axcess Global Sciences, Llc Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use
US12472200B2 (en) 2019-05-15 2025-11-18 Axcess Global Sciences, Llc Autobiotic compositions and method for promoting healthy gut microbiome
US11950616B2 (en) 2019-06-21 2024-04-09 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
US12167993B2 (en) 2019-06-21 2024-12-17 Axcess Global Sciences, Llc Non-vasoconstricting energy-promoting compositions containing ketone bodies
US11969430B1 (en) 2023-03-10 2024-04-30 Axcess Global Sciences, Llc Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance
CN112341331B (zh) * 2019-08-07 2023-04-07 辽宁科硕营养科技股份有限公司 一种3-羟基丁酸盐及其制备方法与应用
US12186297B2 (en) 2020-08-26 2025-01-07 Axcess Global Sciences, Llc Compositions and methods for increasing lean-to-fat mass ratio
WO2024192165A1 (en) * 2023-03-14 2024-09-19 The Board Of Trustees Of The Leland Stanford Junior University N-beta-hydroxybutyryl-amino acids and related compositions and methods
AU2024343036A1 (en) * 2023-09-11 2026-02-12 Societe Des Produits Nestle S.A. Polymorphs and compositions comprising same
WO2026109941A1 (en) * 2024-11-22 2026-05-28 Société des Produits Nestlé S.A. D-bhb (d-beta-hydroxybutyrate) for use in the treatment of long chain fatty acid oxydation deficiency (lc-faod)

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US2101097A (en) * 1934-07-26 1937-12-07 Wm S Merrell Co Products for rendering the urine bacteriostatic
US2799684A (en) * 1954-06-18 1957-07-16 Food Chemical And Res Lab Inc Crystalline compounds of tryptophane and methods of manufacturing them
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DE2733202A1 (de) * 1976-08-04 1978-02-09 Agroferm Ag Verfahren zur herstellung der d(-)-3-hydroxybuttersaeure
US4412943A (en) * 1981-02-23 1983-11-01 Kao Soap Co., Ltd. Liquid detergent composition
FR2521857B1 (fr) * 1982-02-23 1985-10-31 Solvay Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee

Also Published As

Publication number Publication date
DK81583D0 (da) 1983-02-23
DE3368601D1 (en) 1987-02-05
ES8500240A1 (es) 1984-10-01
GR77934B (enExample) 1984-09-25
DK81583A (da) 1983-08-24
ES519991A0 (es) 1984-10-01
IE54561B1 (en) 1989-11-22
IE830366L (en) 1983-08-23
NO161909C (no) 1989-10-11
ATE24478T1 (de) 1987-01-15
FI830603A0 (fi) 1983-02-23
AU602329B2 (en) 1990-10-11
KR840003414A (ko) 1984-09-08
ZA831019B (en) 1983-11-30
PT76267A (fr) 1983-03-01
ES532880A0 (es) 1985-07-01
FI830603L (fi) 1983-08-24
CA1203242A (fr) 1986-04-15
NZ203279A (en) 1985-04-30
AU1162483A (en) 1983-09-01
AU560757B2 (en) 1987-04-16
FI79523B (fi) 1989-09-29
IL67965A0 (en) 1983-06-15
NO161909B (no) 1989-07-03
EP0087192B1 (fr) 1986-12-30
NO830618L (no) 1983-08-24
FI79523C (fi) 1990-01-10
FR2521857A1 (fr) 1983-08-26
DK163235C (da) 1992-06-29
PH21561A (en) 1987-12-11
DK163235B (da) 1992-02-10
MX156855A (es) 1988-10-07
EP0087192A1 (fr) 1983-08-31
JPS58201746A (ja) 1983-11-24
US4771074A (en) 1988-09-13
US4579955A (en) 1986-04-01
ES8506283A1 (es) 1985-07-01
KR910000143B1 (ko) 1991-01-21
AU6916187A (en) 1987-05-21

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