DE3368601D1 - Pharmaceutical compositions containg 3-hydroxybutanoic acid or its salts, and compounds derived from 3-hydroxybutanoic acid useful as medicaments - Google Patents
Pharmaceutical compositions containg 3-hydroxybutanoic acid or its salts, and compounds derived from 3-hydroxybutanoic acid useful as medicamentsInfo
- Publication number
- DE3368601D1 DE3368601D1 DE8383200228T DE3368601T DE3368601D1 DE 3368601 D1 DE3368601 D1 DE 3368601D1 DE 8383200228 T DE8383200228 T DE 8383200228T DE 3368601 T DE3368601 T DE 3368601T DE 3368601 D1 DE3368601 D1 DE 3368601D1
- Authority
- DE
- Germany
- Prior art keywords
- hydroxybutanoic acid
- pharmaceutical compositions
- medicaments
- salts
- compounds derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 title abstract 6
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000001412 amines Chemical class 0.000 abstract 2
- 230000000302 ischemic effect Effects 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 208000031229 Cardiomyopathies Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000009109 curative therapy Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001477 organic nitrogen group Chemical group 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8203100A FR2521857B1 (fr) | 1982-02-23 | 1982-02-23 | Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3368601D1 true DE3368601D1 (en) | 1987-02-05 |
Family
ID=9271331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8383200228T Expired DE3368601D1 (en) | 1982-02-23 | 1983-02-15 | Pharmaceutical compositions containg 3-hydroxybutanoic acid or its salts, and compounds derived from 3-hydroxybutanoic acid useful as medicaments |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US4579955A (enExample) |
| EP (1) | EP0087192B1 (enExample) |
| JP (1) | JPS58201746A (enExample) |
| KR (1) | KR910000143B1 (enExample) |
| AT (1) | ATE24478T1 (enExample) |
| AU (2) | AU560757B2 (enExample) |
| CA (1) | CA1203242A (enExample) |
| DE (1) | DE3368601D1 (enExample) |
| DK (1) | DK163235C (enExample) |
| ES (2) | ES519991A0 (enExample) |
| FI (1) | FI79523C (enExample) |
| FR (1) | FR2521857B1 (enExample) |
| GR (1) | GR77934B (enExample) |
| IE (1) | IE54561B1 (enExample) |
| IL (1) | IL67965A0 (enExample) |
| MX (1) | MX156855A (enExample) |
| NO (1) | NO161909C (enExample) |
| NZ (1) | NZ203279A (enExample) |
| PH (1) | PH21561A (enExample) |
| PT (1) | PT76267A (enExample) |
| ZA (1) | ZA831019B (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2521857B1 (fr) * | 1982-02-23 | 1985-10-31 | Solvay | Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee |
| US6020007A (en) * | 1984-06-22 | 2000-02-01 | Btg International Limited | Fluid therapy with l-lactate and/or pyruvate anions |
| USRE38604E1 (en) | 1984-06-22 | 2004-09-28 | Btg International Limited | Fluid therapy with L-lactate and/or pyruvate anions |
| US4777288A (en) * | 1987-06-11 | 1988-10-11 | Pfizer Inc. | Process for preparing a 4,4-diphenylbutanoic acid derivative |
| BE1001209A3 (fr) * | 1987-11-19 | 1989-08-22 | Solvay | Compositions pharmaceutiques contenant un derive de l'acide 3-hydroxybutanoique choisi parmi les oligomeres de cet acide et les esters de cet acide ou de ces oligomeres avec du 1,3-butanediol. |
| US5292774A (en) * | 1988-07-26 | 1994-03-08 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Substitution fluid preparation comprising 3-hydroxy-butyric acid (β-hydroxybutric acid) and its salts |
| DE4113984C2 (de) * | 1991-04-29 | 2002-05-08 | Koehler Chemie Dr Franz | Salze der 4-Hydroxy-Buttersäure |
| ES2051222B1 (es) * | 1992-03-12 | 1995-02-16 | Sanmiguel Gabriel Serrano | Procedimiento de neutralizacion de acido alfa-hidroxietanoico. |
| JP4598203B2 (ja) | 1995-12-01 | 2010-12-15 | ビーティージー・インターナショナル・リミテッド | 脳機能改善剤 |
| CN1315473C (zh) * | 1997-03-17 | 2007-05-16 | 英国技术集团国际有限公司 | 治疗组合物 |
| US6323237B1 (en) | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
| US20090253781A1 (en) * | 2002-05-24 | 2009-10-08 | Btg International Limited | Therapeutic compositions |
| US6316038B1 (en) | 1997-03-17 | 2001-11-13 | Btg International Limited | Therapeutic compositions |
| US6613356B1 (en) | 2000-10-10 | 2003-09-02 | Victor Vlahakos | Weight loss medication and method |
| GB0420856D0 (en) * | 2004-09-20 | 2004-10-20 | Ketocytonyx Inc | Cns modulators |
| WO2006020137A2 (en) * | 2004-07-16 | 2006-02-23 | Ketocytonyx Inc. | Oligomeric compounds |
| EP1778615A4 (en) * | 2004-07-20 | 2010-01-06 | Btg Int Ltd | OLIGOMERE KETONE COMPOUNDS |
| WO2006012490A2 (en) * | 2004-07-23 | 2006-02-02 | Ketocytonyx Inc. | Ketogenic saccharides |
| US20070197645A1 (en) * | 2004-09-21 | 2007-08-23 | Martin Keith F | Treatment of adhd |
| WO2006034361A2 (en) * | 2004-09-21 | 2006-03-30 | Ketocytonyx Inc. | Dopaminergic mimetics |
| RU2302239C1 (ru) * | 2006-07-14 | 2007-07-10 | Михаил Владимирович Покровский | Способ фармакологической коррекции ишемии конечности |
| WO2008053982A1 (en) | 2006-10-30 | 2008-05-08 | Ophtecs Corporation | Composition for treating allergy |
| WO2014071389A1 (en) | 2012-11-05 | 2014-05-08 | Veech Richard L | Ketone bodies to protect tissues from damage by ionizing radiation |
| HK1258020A1 (zh) | 2015-11-19 | 2019-11-01 | 株式会社大塚制药工场 | 3-羟基异戊酸的一价阳离子盐的晶体及该晶体的制造方法 |
| US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
| US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| US12599579B2 (en) | 2016-04-19 | 2026-04-14 | Axcess Global Sciences, Llc | Compositions and compounds containing ketone bodies and/or ketone body precursors and one or more amino acids |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| US12622889B2 (en) | 2016-04-19 | 2026-05-12 | Axcess Global Sciences, Llc | S-β-hydroxybutyrate esters for improving metabolic function |
| US12533346B2 (en) | 2016-04-19 | 2026-01-27 | Axcess Global Sciences, Llc | Administration of berberine metabolites |
| US11806324B2 (en) | 2018-04-18 | 2023-11-07 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US11202769B2 (en) | 2017-11-22 | 2021-12-21 | Axcess Global Sciences, Llc | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function |
| US12521378B2 (en) | 2016-04-19 | 2026-01-13 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans |
| US20230346721A1 (en) | 2018-04-18 | 2023-11-02 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies |
| JP6710098B2 (ja) * | 2016-05-10 | 2020-06-17 | 大阪瓦斯株式会社 | 栄養剤組成物及び栄養補助食品 |
| RU2018145506A (ru) * | 2016-06-24 | 2020-07-27 | Оцука Фармасьютикал Фэктори, Инк. | Кристаллическая аминокислотная соль 3-гидроксиизовалериановой кислоты и способ ее получения |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| CN112341331B (zh) * | 2019-08-07 | 2023-04-07 | 辽宁科硕营养科技股份有限公司 | 一种3-羟基丁酸盐及其制备方法与应用 |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| WO2024192165A1 (en) * | 2023-03-14 | 2024-09-19 | The Board Of Trustees Of The Leland Stanford Junior University | N-beta-hydroxybutyryl-amino acids and related compositions and methods |
| AU2024343036A1 (en) * | 2023-09-11 | 2026-02-12 | Societe Des Produits Nestle S.A. | Polymorphs and compositions comprising same |
| WO2026109941A1 (en) * | 2024-11-22 | 2026-05-28 | Société des Produits Nestlé S.A. | D-bhb (d-beta-hydroxybutyrate) for use in the treatment of long chain fatty acid oxydation deficiency (lc-faod) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2101097A (en) * | 1934-07-26 | 1937-12-07 | Wm S Merrell Co | Products for rendering the urine bacteriostatic |
| US2799684A (en) * | 1954-06-18 | 1957-07-16 | Food Chemical And Res Lab Inc | Crystalline compounds of tryptophane and methods of manufacturing them |
| NL279760A (enExample) * | 1961-06-17 | |||
| US3830931A (en) * | 1972-11-06 | 1974-08-20 | Felice S De | Carnitine and its use in the treatment of arrhythmia and impaired cardiac function |
| US3879537A (en) * | 1973-09-04 | 1975-04-22 | Scott Eugene J Van | Treatment of ichthyosiform dermatoses |
| DE2733202A1 (de) * | 1976-08-04 | 1978-02-09 | Agroferm Ag | Verfahren zur herstellung der d(-)-3-hydroxybuttersaeure |
| US4412943A (en) * | 1981-02-23 | 1983-11-01 | Kao Soap Co., Ltd. | Liquid detergent composition |
| FR2521857B1 (fr) * | 1982-02-23 | 1985-10-31 | Solvay | Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee |
-
1982
- 1982-02-23 FR FR8203100A patent/FR2521857B1/fr not_active Expired
-
1983
- 1983-02-15 DE DE8383200228T patent/DE3368601D1/de not_active Expired
- 1983-02-15 ZA ZA831019A patent/ZA831019B/xx unknown
- 1983-02-15 NZ NZ203279A patent/NZ203279A/en unknown
- 1983-02-15 AT AT83200228T patent/ATE24478T1/de active
- 1983-02-15 EP EP83200228A patent/EP0087192B1/fr not_active Expired
- 1983-02-17 AU AU11624/83A patent/AU560757B2/en not_active Ceased
- 1983-02-21 GR GR70556A patent/GR77934B/el unknown
- 1983-02-21 PT PT76267A patent/PT76267A/pt not_active IP Right Cessation
- 1983-02-21 PH PH28545A patent/PH21561A/en unknown
- 1983-02-21 IL IL67965A patent/IL67965A0/xx not_active IP Right Cessation
- 1983-02-22 NO NO830618A patent/NO161909C/no unknown
- 1983-02-22 ES ES519991A patent/ES519991A0/es active Granted
- 1983-02-22 IE IE366/83A patent/IE54561B1/en not_active IP Right Cessation
- 1983-02-22 MX MX196357A patent/MX156855A/es unknown
- 1983-02-22 US US06/468,385 patent/US4579955A/en not_active Expired - Fee Related
- 1983-02-23 CA CA000422215A patent/CA1203242A/fr not_active Expired
- 1983-02-23 JP JP58029197A patent/JPS58201746A/ja active Pending
- 1983-02-23 FI FI830603A patent/FI79523C/fi not_active IP Right Cessation
- 1983-02-23 KR KR1019830000728A patent/KR910000143B1/ko not_active Expired
- 1983-02-23 DK DK081583A patent/DK163235C/da not_active IP Right Cessation
-
1984
- 1984-05-28 ES ES532880A patent/ES8506283A1/es not_active Expired
-
1985
- 1985-10-23 US US06/790,391 patent/US4771074A/en not_active Expired - Fee Related
-
1987
- 1987-02-23 AU AU69161/87A patent/AU602329B2/en not_active Ceased
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: SOLVAY (S.A.), BRUESSEL/BRUXELLES, BE |
|
| 8339 | Ceased/non-payment of the annual fee |