KR900014412A - [3-c16-c18)-알칸술피닐-및-술포닐-2-메톡시메틸프로필-]-(2-트리메틸 암모니오에틸) 인삼염, 그의 제법 및 이들 화합물을 함유하는 약제 조성물 - Google Patents
[3-c16-c18)-알칸술피닐-및-술포닐-2-메톡시메틸프로필-]-(2-트리메틸 암모니오에틸) 인삼염, 그의 제법 및 이들 화합물을 함유하는 약제 조성물 Download PDFInfo
- Publication number
- KR900014412A KR900014412A KR1019900002942A KR900002942A KR900014412A KR 900014412 A KR900014412 A KR 900014412A KR 1019900002942 A KR1019900002942 A KR 1019900002942A KR 900002942 A KR900002942 A KR 900002942A KR 900014412 A KR900014412 A KR 900014412A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- chlorine
- methoxymethylpropyl
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 14
- 150000003839 salts Chemical class 0.000 title claims abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- -1 ammonioethyl Chemical group 0.000 title abstract 2
- 241000208340 Araliaceae Species 0.000 title 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 title 1
- 235000003140 Panax quinquefolius Nutrition 0.000 title 1
- 235000008434 ginseng Nutrition 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 2
- 229910052801 chlorine Inorganic materials 0.000 claims 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims 4
- 239000000460 chlorine Substances 0.000 claims 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- QXEQVPDRSQYMPV-UHFFFAOYSA-N CCCCCCCCCCCCCCCCCCS(CC(CC(COP([O-])(O)=O)[N+](C)(C)C)COC)(=O)=O Chemical class CCCCCCCCCCCCCCCCCCS(CC(CC(COP([O-])(O)=O)[N+](C)(C)C)COC)(=O)=O QXEQVPDRSQYMPV-UHFFFAOYSA-N 0.000 claims 1
- SZQZSQFHECBPSV-UHFFFAOYSA-N CCCCCCCCCCCCCCCCS(CC(CC(COP([O-])(O)=O)[N+](C)(C)C)COC)(=O)=O Chemical compound CCCCCCCCCCCCCCCCS(CC(CC(COP([O-])(O)=O)[N+](C)(C)C)COC)(=O)=O SZQZSQFHECBPSV-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012050 conventional carrier Substances 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 claims 1
- 229940006461 iodide ion Drugs 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 종양 세포를 후로부터의 날들에 대해 종양크기를 비교한 그래프,
제2도는 종양 세포를 접종한 후 28일되는 날에 종양 무게를 나타낸 그래프.
Claims (6)
- 하기 일반식(Ⅰ)의 화합물, 그의 입체이성질체 뿐만아니라 약제학적으로 허용가능한 그의 염:상기식에서,n은 1또는 2이며 R은 포화된 C16-C18의 직쇄 알킬기이다.
- (3-헥사데실술포닐-2-메톡시메틸프로필)-(2-트리메틸암모니오에틸) 인산염 및 (3-옥타데실술포닐-2-메톡시메틸프로필)-(2-트리메틸암모니오에틸) 인산염 뿐만아니라 그의 입체이성질체.
- Ⅰ)라세미체 또는 거울상이성질체로 존재할 수 있는 하기 일반식(Ⅱ)의 화합물을 산화제로 처리하거나, 또는 Ⅱ)라세미체 또는 거울상이성질체로 존재할 수 있는 하기 일반식 (Ⅲ)의 화합물을 a) 산 결합체의 존재하에서 하기 일반식(Ⅳ)의 화합물과 반응시키고 그 반응 생성물을 트리메틸아민으로 처리함으로써 X가 염소 원자인 경우에는 아니노화(반응)에 앞서 선택적인 가수분해가 일어나게 하거나, 또는 b)하기 일반식(Ⅴ)의 화합물로 전환시킨다음, 이를 하기 일반식(Ⅵ)의 화합물과 반응시키고, T가 염소 또는 브롬원자인 경우에는 이와같이 생성한 중간 생성물을 트리메틸아민으로 사차화하거나, 또는c)산-또는 수형성제의 존재하에서 하기 일반식(Ⅶ)의 화합물과 반응시키고, 임의로는 내부 염으로 전환시키고, 그후 만일 필요하다면, 라세미 화합물을 계속해서 광학 이성질체 및/또는 약제학적으로 허용가능한 염으로 전환시킴을 특징으로 하는 하기 일반식(Ⅰ)의 화합물의 제법:상기식에서,n은 1또는 2이고, R은 포화된 C16-C18의 직쇄 알킬이고, X는 염소원자이고 Y는 브롬원자이거나, 또는 X와 Y는 서로함께 산소원자를 나타내고, M은 히드룩실 그룹, 염소나 브롬원자 또는 알킬티오기이고, T는 염소 또는 브롬원자 또는기이며,은 염화, 브롬화 또는 요오드화 이온이다.
- 제1항에 있어서, 제3항의 방법으로 제조한 화합물.
- 적어도 1종의 제 1 또는 2항의 화합물뿐만 아니라 통상의 담체 또는 보조제를 함유하는 약제 조성물.
- 제 1 또는 2항중의 어느항의 종량 치료용 화합물의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3906952.4 | 1989-03-04 | ||
| DE3906952A DE3906952A1 (de) | 1989-03-04 | 1989-03-04 | (3-(c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)6(pfeil abwaerts)-c(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)8(pfeil abwaerts))alkansulfinyl- und sulfonyl-2-methoxymethyl-propyl)-(2-trimethylammonio-ethyl) phosphate, verfahren zu deren herstellung diese verbindungen enthaltende arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR900014412A true KR900014412A (ko) | 1990-10-23 |
Family
ID=6375519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019900002942A KR900014412A (ko) | 1989-03-04 | 1990-03-05 | [3-c16-c18)-알칸술피닐-및-술포닐-2-메톡시메틸프로필-]-(2-트리메틸 암모니오에틸) 인삼염, 그의 제법 및 이들 화합물을 함유하는 약제 조성물 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5543402A (ko) |
| EP (1) | EP0395849B1 (ko) |
| JP (1) | JPH0341027A (ko) |
| KR (1) | KR900014412A (ko) |
| AT (1) | ATE121409T1 (ko) |
| AU (1) | AU633304B2 (ko) |
| CA (1) | CA2011209A1 (ko) |
| DD (1) | DD292259A5 (ko) |
| DE (2) | DE3906952A1 (ko) |
| FI (1) | FI93122C (ko) |
| HU (1) | HU204057B (ko) |
| IE (1) | IE900743L (ko) |
| IL (1) | IL93598A (ko) |
| MX (1) | MX19722A (ko) |
| NO (1) | NO901008L (ko) |
| NZ (1) | NZ232692A (ko) |
| PT (1) | PT93324B (ko) |
| RU (1) | RU2035466C1 (ko) |
| ZA (1) | ZA901601B (ko) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929217A1 (de) * | 1989-09-02 | 1991-03-07 | Boehringer Mannheim Gmbh | Verwendung von phospholipid-derivaten als antivirale arzneimittel und neue phospholipide |
| GB8928580D0 (en) * | 1989-12-19 | 1990-02-21 | Scras | 3-(n-methyl-n-alkylamino)-methoxymethyl-propanol phosphocholine derivatives |
| DE4222910A1 (de) * | 1992-07-11 | 1994-01-13 | Asta Medica Ag | Neue Phospholipidderivate |
| US6172050B1 (en) | 1992-07-11 | 2001-01-09 | Asta Medica Aktiengesellschaft | Phospholipid derivatives |
| WO1994002153A1 (en) * | 1992-07-22 | 1994-02-03 | Boehringer Mannheim Gmbh | Use of sulphur containing phospholipids for treating leishmaniasis |
| ES2381775T3 (es) | 2000-08-04 | 2012-05-31 | Dmi Biosciences, Inc. | Procedimiento del uso de dicetopiperazinas y composición que las contiene |
| KR100469556B1 (ko) * | 2001-11-17 | 2005-02-02 | 주식회사 건축사사무소다인그룹 | 도어 잠금장치 |
| CN1615314A (zh) * | 2001-11-21 | 2005-05-11 | 海德堡医药有限责任公司 | 用作抗肿瘤药的核苷的磷脂衍生物 |
| DK1571970T3 (da) * | 2002-10-02 | 2011-11-28 | Dmi Biosciences Inc | Diagnose og monitorering af sygdomme |
| EP2799114A3 (en) | 2003-05-15 | 2015-02-18 | Ampio Pharmaceuticals, Inc. | Treatment of T-cell mediated diseases |
| JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ，インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
| WO2012033792A2 (en) | 2010-09-07 | 2012-03-15 | Dmi Acquisition Corp. | Treatment of diseases |
| MX2014003856A (es) | 2011-10-10 | 2015-01-16 | Ampio Pharmaceuticals Inc | Dispositivos medicos implantables con tolerancia inmune incrementada y metodos para hacerlos e implantarlos. |
| MY167804A (en) | 2011-10-10 | 2018-09-26 | Ampio Pharmaceuticals Inc | Treatment of degenerative joint disease |
| EP2771007B1 (en) | 2011-10-28 | 2018-04-04 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
| JP6588005B2 (ja) | 2013-03-15 | 2019-10-09 | アンピオ ファーマシューティカルズ，インコーポレイテッド | 軟骨形成を刺激するために使用される医薬組成物 |
| RU2736513C2 (ru) | 2014-08-18 | 2020-11-17 | Ампио Фармасьютикалз, Инк. | Лечение патологических состояний суставов |
| US11389512B2 (en) | 2015-06-22 | 2022-07-19 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2009341C3 (de) * | 1970-02-27 | 1979-06-21 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | 3-Octadecyloxy-propanol-(l)-phosphorsäure-monocholinester und Verfahren zu dessen Herstellung |
| DE2619686C2 (de) * | 1976-05-04 | 1986-08-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verwendung eines Lysolecithins zur Tumorbehandlung |
| DE2619715A1 (de) * | 1976-05-04 | 1977-11-24 | Max Planck Gesellschaft | Tumor-antigen und verfahren zu dessen herstellung |
| GB2046092B (en) * | 1979-03-05 | 1983-11-02 | Toyama Chemical Co Ltd | Pharmaceutical composition containing a lysophospholid and a phospholipid |
| EP0050327B1 (de) * | 1980-10-21 | 1984-06-20 | Roche Diagnostics GmbH | Neue schwefelhaltige Phospholipide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE3127503A1 (de) * | 1981-07-11 | 1983-02-17 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue phospholipide, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3304870A1 (de) * | 1983-02-12 | 1984-08-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue phospholipide, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
-
1989
- 1989-03-04 DE DE3906952A patent/DE3906952A1/de not_active Withdrawn
-
1990
- 1990-02-26 EP EP90103661A patent/EP0395849B1/de not_active Expired - Lifetime
- 1990-02-26 AT AT90103661T patent/ATE121409T1/de not_active IP Right Cessation
- 1990-02-26 DE DE59008915T patent/DE59008915D1/de not_active Expired - Fee Related
- 1990-02-27 NZ NZ232692A patent/NZ232692A/en unknown
- 1990-02-28 DD DD90338238A patent/DD292259A5/de not_active IP Right Cessation
- 1990-02-28 AU AU50596/90A patent/AU633304B2/en not_active Ceased
- 1990-03-01 IL IL9359890A patent/IL93598A/en not_active IP Right Cessation
- 1990-03-01 MX MX1972290A patent/MX19722A/es unknown
- 1990-03-02 PT PT93324A patent/PT93324B/pt not_active IP Right Cessation
- 1990-03-02 HU HU901280A patent/HU204057B/hu not_active IP Right Cessation
- 1990-03-02 FI FI901096A patent/FI93122C/fi not_active IP Right Cessation
- 1990-03-02 JP JP2051584A patent/JPH0341027A/ja active Pending
- 1990-03-02 IE IE900743A patent/IE900743L/xx unknown
- 1990-03-02 ZA ZA901601A patent/ZA901601B/xx unknown
- 1990-03-02 RU SU904743486A patent/RU2035466C1/ru active
- 1990-03-02 NO NO90901008A patent/NO901008L/no unknown
- 1990-03-05 KR KR1019900002942A patent/KR900014412A/ko not_active Application Discontinuation
- 1990-03-05 CA CA002011209A patent/CA2011209A1/en not_active Abandoned
-
1993
- 1993-07-23 US US08/095,478 patent/US5543402A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5543402A (en) | 1996-08-06 |
| CA2011209A1 (en) | 1990-09-04 |
| EP0395849B1 (de) | 1995-04-19 |
| DE3906952A1 (de) | 1990-09-06 |
| ZA901601B (en) | 1990-12-28 |
| FI901096A0 (fi) | 1990-03-02 |
| IL93598A (en) | 1994-06-24 |
| AU5059690A (en) | 1990-09-06 |
| FI93122C (fi) | 1995-02-27 |
| HU204057B (en) | 1991-11-28 |
| NO901008L (no) | 1990-09-05 |
| HU901280D0 (en) | 1990-05-28 |
| DD292259A5 (de) | 1991-07-25 |
| NO901008D0 (no) | 1990-03-02 |
| DE59008915D1 (de) | 1995-05-24 |
| PT93324B (pt) | 1996-02-29 |
| IE900743L (en) | 1990-09-04 |
| EP0395849A1 (de) | 1990-11-07 |
| PT93324A (pt) | 1990-11-07 |
| HUT53111A (en) | 1990-09-28 |
| FI93122B (fi) | 1994-11-15 |
| JPH0341027A (ja) | 1991-02-21 |
| ATE121409T1 (de) | 1995-05-15 |
| NZ232692A (en) | 1992-06-25 |
| IL93598A0 (en) | 1990-12-23 |
| AU633304B2 (en) | 1993-01-28 |
| MX19722A (es) | 1993-11-01 |
| RU2035466C1 (ru) | 1995-05-20 |
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