KR900008113B1 - 플루오로알릴아민 유도체 및 이의 제조방법 - Google Patents

플루오로알릴아민 유도체 및 이의 제조방법 Download PDF

Info

Publication number
KR900008113B1
KR900008113B1 KR1019850004968A KR850004968A KR900008113B1 KR 900008113 B1 KR900008113 B1 KR 900008113B1 KR 1019850004968 A KR1019850004968 A KR 1019850004968A KR 850004968 A KR850004968 A KR 850004968A KR 900008113 B1 KR900008113 B1 KR 900008113B1
Authority
KR
South Korea
Prior art keywords
mao
compound
hydrogen
fluoroallylamine
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019850004968A
Other languages
English (en)
Korean (ko)
Other versions
KR860001048A (ko
Inventor
알렉산더 맥도날드 이안
Original Assignee
메렐 다우 파마슈티칼스 인코포레이티드
개리 디. 스트리트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 메렐 다우 파마슈티칼스 인코포레이티드, 개리 디. 스트리트 filed Critical 메렐 다우 파마슈티칼스 인코포레이티드
Publication of KR860001048A publication Critical patent/KR860001048A/ko
Application granted granted Critical
Publication of KR900008113B1 publication Critical patent/KR900008113B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/42—Halogenated unsaturated alcohols acyclic
    • C07C33/423—Halogenated unsaturated alcohols acyclic containing only double bonds as unsaturation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1019850004968A 1984-07-13 1985-07-12 플루오로알릴아민 유도체 및 이의 제조방법 Expired KR900008113B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63055684A 1984-07-13 1984-07-13
US630556 1984-07-13
US745127 1984-07-13

Publications (2)

Publication Number Publication Date
KR860001048A KR860001048A (ko) 1986-02-22
KR900008113B1 true KR900008113B1 (ko) 1990-10-31

Family

ID=24527644

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850004968A Expired KR900008113B1 (ko) 1984-07-13 1985-07-12 플루오로알릴아민 유도체 및 이의 제조방법

Country Status (20)

Country Link
EP (1) EP0168013B1 (https=)
JP (1) JPS61257952A (https=)
KR (1) KR900008113B1 (https=)
AR (1) AR240043A1 (https=)
AT (1) ATE32711T1 (https=)
AU (1) AU575973B2 (https=)
CA (1) CA1256453A (https=)
DE (1) DE3561723D1 (https=)
DK (1) DK166878C (https=)
ES (1) ES545111A0 (https=)
FI (1) FI84057C (https=)
GB (1) GB2162518B (https=)
HU (1) HU195181B (https=)
IE (1) IE58305B1 (https=)
IL (1) IL75739A (https=)
NO (1) NO161313C (https=)
NZ (1) NZ212675A (https=)
PH (1) PH21647A (https=)
PT (1) PT80805B (https=)
ZA (1) ZA855101B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3683604D1 (de) * 1985-12-05 1992-03-05 Merrell Dow Pharma Nichtaromatische fluoralkylamin-mao-inhibitoren.
EP0283168A3 (en) * 1987-03-16 1989-06-14 American Home Products Corporation Fluorooxirane carboxylates
US4822812A (en) * 1987-05-21 1989-04-18 Merrell Dow Pharmaceuticals Inc. β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition
US5059714A (en) * 1988-02-25 1991-10-22 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5252608A (en) * 1988-02-25 1993-10-12 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US4965288A (en) * 1988-02-25 1990-10-23 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5120764A (en) * 1988-11-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. Inhibitors of lysyl oxidase
US5488188A (en) * 1994-09-29 1996-01-30 Merrell Dow Pharmaceuticals Inc. Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
AU2013255103B2 (en) 2012-05-02 2016-09-29 Syntara Limited Substituted 3-haloallylamine inhibitors of SSAO and uses thereof
AU2023331414A1 (en) * 2022-08-29 2025-03-27 Syntara Limited Novel selective inhibitors of lysyl oxidases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1027611A (en) * 1962-01-04 1966-04-27 May & Baker Ltd Phenoxy- and phenylthio-alkylamines and acid addition salts thereof
US3205136A (en) * 1962-12-24 1965-09-07 Smith Kline French Lab Antidepressant phenyloxyalkylamines
US3513198A (en) * 1965-10-22 1970-05-19 Hoffmann La Roche Aryloxy- and arylthio-acetylenic amines and the salts thereof
CH485681A (de) * 1966-06-03 1970-02-15 Ciba Geigy Verfahren zur Herstellung von schwefelhaltigen Aminen

Also Published As

Publication number Publication date
ATE32711T1 (de) 1988-03-15
NZ212675A (en) 1988-02-29
FI84057C (fi) 1991-10-10
DK166878C (da) 1993-12-13
IL75739A0 (en) 1985-11-29
ES8603809A1 (es) 1986-01-01
GB8517454D0 (en) 1985-08-14
PT80805B (pt) 1987-09-18
FI852748L (fi) 1986-01-14
ES545111A0 (es) 1986-01-01
FI84057B (fi) 1991-06-28
CA1256453A (en) 1989-06-27
GB2162518B (en) 1987-11-18
AR240043A1 (es) 1990-01-31
DK320585A (da) 1986-01-14
JPH0530823B2 (https=) 1993-05-11
DK166878B (da) 1993-07-26
EP0168013B1 (en) 1988-03-02
IE58305B1 (en) 1993-09-08
PH21647A (en) 1988-01-13
JPS61257952A (ja) 1986-11-15
KR860001048A (ko) 1986-02-22
IE851746L (en) 1986-01-13
NO852810L (no) 1986-01-14
AU4466085A (en) 1986-01-16
AU575973B2 (en) 1988-08-11
IL75739A (en) 1988-07-31
ZA855101B (en) 1986-05-28
FI852748A0 (fi) 1985-07-11
EP0168013A1 (en) 1986-01-15
DK320585D0 (da) 1985-07-12
GB2162518A (en) 1986-02-05
NO161313C (no) 1989-08-02
PT80805A (en) 1985-08-01
DE3561723D1 (de) 1988-04-07
HU195181B (en) 1988-04-28
HUT38604A (en) 1986-06-30
NO161313B (no) 1989-04-24

Similar Documents

Publication Publication Date Title
US3466376A (en) Ortho - alkenylphenoxy - hydroxyalkyl derivatives in the treatment of cardiac and vascular diseases
KR890002756B1 (ko) 알릴아민 mao 억제제의 제조 방법
KR900008113B1 (ko) 플루오로알릴아민 유도체 및 이의 제조방법
TWI841532B (zh) 以稠合雙環吡唑治療代謝疾病之方法
TWI848911B (zh) 以三唑并吡啶治療rbp4相關疾病之方法
US4699928A (en) Fluoroallylamine derivatives
JPH0210128B2 (https=)
JP2911239B2 (ja) スクアレンエポキシダーゼの抑制剤としてのスクアレンのジ−及びテトラ−フルオロ類似体類
US4916151A (en) Method of treating parkinson's syndrome
KR900006125B1 (ko) 비방향족 플루오로알릴아민 및 이의 제조방법
DK172834B1 (da) Benzyldimethylsilylmethanaminer og farmaceutisk acceptable salte deraf
US3856951A (en) Substituted benzoic acid hypoliphemic agents
CA2202169A1 (fr) Derives metalloceniques du diarylethylene, leurs procedes de preparation et compositions pharmaceutiques contenant lesdits derives
US4562206A (en) Orally effective inotropic compounds
JP2954989B2 (ja) ビスフェノール誘導体での真性糖尿病処置法
JP2520244B2 (ja) 弗素化ジアミノアルキン誘導体
JPS63500796A (ja) アミノシクロアルキルアミドの抗不整脈剤用途
CA1190242A (en) 2-amino-3-hydroxyphenyl-3-butenoic acid derivatives
EP0937030B1 (en) 3-amino-propoxyphenyl derivatives (i)
EP0224924B1 (en) Non-aromatic fluorallylamine mao inhibitors
KR20010001219A (ko) 신규 아세트아미노펜 유도체 및 제조방법
JPH075460B2 (ja) 制癌剤
EP0518769A1 (fr) Nouveaux dérivés de benzoate d'éthanolamine, leur procédé de préparation et les compositions pharmaceutiques les renfermant
JPH0578242A (ja) アルドースレダクターゼ阻害剤

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

FPAY Annual fee payment

Payment date: 19991007

Year of fee payment: 10

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20001101

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20001101

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000