KR900003491B1 - 이포스파미드 동결건조물 및 이의 제조방법 - Google Patents

이포스파미드 동결건조물 및 이의 제조방법 Download PDF

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Publication number
KR900003491B1
KR900003491B1 KR1019870012077A KR870012077A KR900003491B1 KR 900003491 B1 KR900003491 B1 KR 900003491B1 KR 1019870012077 A KR1019870012077 A KR 1019870012077A KR 870012077 A KR870012077 A KR 870012077A KR 900003491 B1 KR900003491 B1 KR 900003491B1
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KR
South Korea
Prior art keywords
phosphamide
weight
solution
hexitol
ifosfamide
Prior art date
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Expired
Application number
KR1019870012077A
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English (en)
Korean (ko)
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KR880004814A (ko
Inventor
자우에르비어 디이터
담만 우베-페터
이작 오토
Original Assignee
아스타 파마 아크티엔게 젤샤프트
게하르트 노바크, 귄터 스타인메츠
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Publication of KR880004814A publication Critical patent/KR880004814A/ko
Application granted granted Critical
Publication of KR900003491B1 publication Critical patent/KR900003491B1/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
  • Amplifiers (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Control Of El Displays (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019870012077A 1986-10-31 1987-10-30 이포스파미드 동결건조물 및 이의 제조방법 Expired KR900003491B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3637089.4 1986-10-31
DE3637089 1986-10-31

Publications (2)

Publication Number Publication Date
KR880004814A KR880004814A (ko) 1988-06-27
KR900003491B1 true KR900003491B1 (ko) 1990-05-21

Family

ID=6312873

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870012077A Expired KR900003491B1 (ko) 1986-10-31 1987-10-30 이포스파미드 동결건조물 및 이의 제조방법

Country Status (25)

Country Link
EP (1) EP0265812B1 (https=)
JP (1) JPS63159319A (https=)
KR (1) KR900003491B1 (https=)
AT (1) ATE55250T1 (https=)
AU (1) AU598602B2 (https=)
CA (1) CA1314231C (https=)
DD (1) DD262582A5 (https=)
DE (1) DE3764235D1 (https=)
DK (1) DK169308B1 (https=)
EG (1) EG18333A (https=)
ES (1) ES2017982B3 (https=)
FI (1) FI87140C (https=)
GE (1) GEP19971025B (https=)
GR (1) GR3000708T3 (https=)
HU (1) HU197987B (https=)
IL (1) IL84312A (https=)
IN (1) IN168119B (https=)
LV (1) LV10051B (https=)
MX (1) MX8958A (https=)
NO (1) NO873860L (https=)
PT (1) PT86032B (https=)
RU (1) RU1836079C (https=)
UA (1) UA11075A (https=)
YU (1) YU197387A (https=)
ZA (1) ZA878183B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0334083B1 (de) * 1988-03-19 1991-07-24 ASTA Pharma Aktiengesellschaft Ifosfamid-Mesna-Lyophilisat und Verfahren zu dessen Herstellung
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
WO1995007083A1 (en) * 1993-09-10 1995-03-16 F.H. Faulding & Co. Limited Ifosfamide lyophilisate composition
DE19529057B4 (de) * 1995-08-08 2007-12-13 Baxter Healthcare S.A. Ifosfamid-Lyophilisat-Zubereitungen
DE69928500T2 (de) * 1998-03-03 2006-08-03 Eli Lilly And Co., Indianapolis Pharmazeutische zusammensetzung enthaltend den phospholipase inhibitor natrium-[[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-phenylmethyl)-1 h-indol-4-yl]oxy]acetat
CA2497898C (en) * 2002-09-05 2012-02-07 Bharat Serums & Vaccines Ltd. Liquid stable composition of oxazaphosphorine with mesna
CN100463678C (zh) * 2002-12-02 2009-02-25 印度血清及疫苗有限公司 用于肠胃外给药的异环磷酰胺组合物及其制备方法
US8436190B2 (en) * 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
BRPI0715279A2 (pt) * 2006-09-29 2013-06-11 Infa Sa sistema de embalagem, sistema de embalagem para uma composiÇço farmacÊutica, mÉtodo para transferir uma composiÇço farmcÊutica para administraÇço por infusço intravenosa, uso de um sistema de embalagem, kit para administraÇço parenteral de fÁrmacos com um acesso intravenoso e kit admnistraÇço parenteral de princÍpios ativos
CN105900385B (zh) * 2014-12-04 2019-08-27 华为技术有限公司 在数据通信网中的负载分配

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732340A (en) * 1966-07-11 1973-05-08 Asta Werke Ag Chem Fab N',o-propylene phosphoric acid ester diamides
DE2750207A1 (de) * 1977-05-09 1978-11-16 Walton J Smith Gefriergetrocknete zusammensetzungen, insbesondere gefriergetrocknete pharmazeutische praeparate und verfahren zu deren herstellung
DE3279834D1 (en) * 1981-12-31 1989-08-31 Asta Pharma Ag 4-sulfido-oxaza phosphorines and their use in the treatment of cancer, and in immunosuppression
US4537883A (en) * 1982-11-12 1985-08-27 Mead Johnson & Company Lyophilized cyclophosphamide

Also Published As

Publication number Publication date
DE3764235D1 (de) 1990-09-13
LV10051A (lv) 1994-05-10
IN168119B (https=) 1991-02-09
AU598602B2 (en) 1990-06-28
IL84312A (en) 1991-11-21
EP0265812B1 (de) 1990-08-08
DK569687D0 (da) 1987-10-30
IL84312A0 (en) 1988-03-31
PT86032A (de) 1987-11-01
EG18333A (en) 1993-12-30
UA11075A (uk) 1996-12-25
DK169308B1 (da) 1994-10-10
LV10051B (en) 1995-06-20
NO873860L (no) 1988-05-02
NO873860D0 (no) 1987-09-15
HUT44932A (en) 1988-05-30
RU1836079C (ru) 1993-08-23
GEP19971025B (en) 1997-04-06
DK569687A (da) 1988-05-01
EP0265812A1 (de) 1988-05-04
CA1314231C (en) 1993-03-09
PT86032B (pt) 1990-08-31
DD262582A5 (de) 1988-12-07
ZA878183B (en) 1988-05-02
JPH0543684B2 (https=) 1993-07-02
KR880004814A (ko) 1988-06-27
FI87140B (fi) 1992-08-31
HU197987B (en) 1989-07-28
GR3000708T3 (en) 1991-10-10
FI874727A0 (fi) 1987-10-27
ES2017982B3 (es) 1991-03-16
JPS63159319A (ja) 1988-07-02
YU197387A (en) 1988-12-31
FI87140C (fi) 1992-12-10
MX8958A (es) 1993-12-01
AU8052987A (en) 1988-05-05
ATE55250T1 (de) 1990-08-15
FI874727L (fi) 1988-05-01

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KR900003491B1 (ko) 이포스파미드 동결건조물 및 이의 제조방법
EP1058547B1 (en) Pharmaceutical compositions containing the phospholipase inhibitor sodium 3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-phenylmethyl)-1h-indol-4-yl]oxy]acetate
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KR20180041814A (ko) 유기용매 유리 동결건조 시클로포스파미드의 제조방법
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