KR900000076A - 딜티아젬(diltiazem) 공급용의 제형(dosage form) - Google Patents

딜티아젬(diltiazem) 공급용의 제형(dosage form) Download PDF

Info

Publication number
KR900000076A
KR900000076A KR1019880011405A KR880011405A KR900000076A KR 900000076 A KR900000076 A KR 900000076A KR 1019880011405 A KR1019880011405 A KR 1019880011405A KR 880011405 A KR880011405 A KR 880011405A KR 900000076 A KR900000076 A KR 900000076A
Authority
KR
South Korea
Prior art keywords
formulation
diltiazem
wall
molecular weight
weight
Prior art date
Application number
KR1019880011405A
Other languages
English (en)
Other versions
KR960006062B1 (ko
Inventor
에스.엘. 웡 패트릭스
구이타르드 게오르지 브이
더에위스 필릭쓰
코르테세 리챠드
Original Assignee
에드워드 엘. 맨델
알자 코포레이숀
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에드워드 엘. 맨델, 알자 코포레이숀 filed Critical 에드워드 엘. 맨델
Publication of KR900000076A publication Critical patent/KR900000076A/ko
Application granted granted Critical
Publication of KR960006062B1 publication Critical patent/KR960006062B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음.

Description

딜티아젬(diltiazem) 공급용의 제형(dosage form)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 장시간에 걸쳐 위장계에 유용한 약제 딜티아젬(drug diltiazem)을 구강투여하도록 형성되고 칫수를 맞춘 삼투제제로 만들어진 제형(dosage form)의 도면.
제2a도 및 제2b도는 제형의 구조를 설명하기 위해 제형의 벽부분을 제거한 제1도의 제형을 부분적으로 개방한 도면.
제3도는 본 발명에 의해 구비된 제형에 대한 딜티아젬의 방출속도를 설명하는 그래프.
제4도는 24시간에 걸쳐 방출누적된 딜티아젬의 량을 설명하는 그래프.
* 도면의 주요부분에 대한 부호의 설명
10 : 제형(dosage form) 11 : 몸체부재
12 : 벽 13 : 통로
14 : 구획 15 : 딜티아젬
16 : 조성물

Claims (8)

  1. (a) 둘레를 싸고 형성하는 벽과; (b) 구획(compartment)과; (c) 딜티아젬과 그의 제약학적으로 허용가능한 염, 2, 500, 000-4, 000, 000의 분자량을 포함하는 0.5중량%-15중량%의 폴리아크릴산, 4, 000, 000-5, 500, 000의 분자량을 포함하는 0.5중량%-20중량%의 폴리(에틸렌옥시드), 35, 000-40, 000의 분자량을 포함하는 0.5중량%의 폴리(비닐 필로리돈)으로 구성된 그룹으로부터 선택된 성분을 70중량%-96중량%를 포함하는 상기 구획속의 딜티아젬 조성물과; (d) 6, 200-7, 500, 000의 분자량을 포함하는 70중량%-95중량%의 폴리(에틸렌옥시드), 9, 000-16, 000의 분자량을 포함하는 1중량%-15중량%의 히드록시프로필메틸셀룰로오스를 포함하는 상기 구획내의 푸쉬 조성물(push composition)과; (e) 상기 장치로부터 딜티아젬을 공급하기 위한 상기 벽내의 적어도 하나의 통로를 포함하는 딜티아젬공급용 제형.
  2. 제1항에 있어서, 딜티아젬이 시간당 공급량을 실질적으로 영차 비율(zero order rate)로 공급됨을 특징으로 하는 제형.
  3. 제1항에 있어서, 벽이 셀룰로오스 아세테이트를 포함하는 제형.
  4. 제1항에 있어서, 벽이 히드록시프로필메틸셀룰로오스를 포함하는 제형.
  5. 제1항에 있어서, 벽이 39.8%의 아세틸 함량을 가지는 셀룰로오스 아세테이트를 포함하는 제형.
  6. 제1항에 있어서, 벽이 에틸 셀룰로오스를 포함하는 제형.
  7. 제1항에 있어서, 벽이 적어도 부분적으로 미세다공성 조성물을 포함하는 제형.
  8. 제1항에 있어서, 푸쉬 조성물이 염화나트륨을 포함하는 제형.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880011405A 1988-06-02 1988-09-02 딜티아젬(diltiazem) 공급용의 제형(dosage form) KR960006062B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/201,519 US4859470A (en) 1988-06-02 1988-06-02 Dosage form for delivering diltiazem
US07/201,519 1988-06-02

Publications (2)

Publication Number Publication Date
KR900000076A true KR900000076A (ko) 1990-01-30
KR960006062B1 KR960006062B1 (ko) 1996-05-08

Family

ID=22746162

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880011405A KR960006062B1 (ko) 1988-06-02 1988-09-02 딜티아젬(diltiazem) 공급용의 제형(dosage form)

Country Status (25)

Country Link
US (1) US4859470A (ko)
JP (1) JP2590226B2 (ko)
KR (1) KR960006062B1 (ko)
AR (1) AR241635A1 (ko)
AT (1) AT394311B (ko)
AU (1) AU612398B2 (ko)
BE (1) BE1001935A3 (ko)
CA (1) CA1311687C (ko)
CH (1) CH675208A5 (ko)
DE (1) DE3829941C2 (ko)
DK (1) DK175396B1 (ko)
ES (1) ES2008813A6 (ko)
FI (1) FI92553C (ko)
FR (1) FR2632306B1 (ko)
GB (1) GB2219205B (ko)
GR (1) GR1000197B (ko)
IE (1) IE61861B1 (ko)
IT (1) IT1223799B (ko)
LU (1) LU87327A1 (ko)
MX (1) MX174157B (ko)
NL (1) NL194747C (ko)
NO (1) NO174766C (ko)
PT (1) PT88405B (ko)
SE (1) SE503508C2 (ko)
ZA (1) ZA886436B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL92966A (en) * 1989-01-12 1995-07-31 Pfizer Hydrogel-operated release devices
US5030452A (en) * 1989-01-12 1991-07-09 Pfizer Inc. Dispensing devices powered by lyotropic liquid crystals
US5108756A (en) * 1989-01-12 1992-04-28 Pfizer Inc. Dispensing devices powered by lyotropic liquid crystals
US5112614A (en) * 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5208037A (en) * 1991-04-22 1993-05-04 Alza Corporation Dosage forms comprising polymers comprising different molecular weights
US6283951B1 (en) * 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US6524620B2 (en) 1998-07-20 2003-02-25 Andrx Pharmaceuticals, Inc. Diltiazem controlled release formulation and method of manufacture
US6562375B1 (en) 1999-08-04 2003-05-13 Yamanouchi Pharmaceuticals, Co., Ltd. Stable pharmaceutical composition for oral use
CN1193792C (zh) * 1999-08-04 2005-03-23 山之内制药株式会社 稳定的口服医药组合物
US20060153914A1 (en) * 1999-12-10 2006-07-13 Biovail Laboratories International S.R.L. Chronotherapeutic diltiazem formulations and the administration thereof
US7108866B1 (en) 1999-12-10 2006-09-19 Biovall Laboratories International Srl Chronotherapeutic diltiazem formulations and the administration thereof
US6753011B2 (en) 2000-01-14 2004-06-22 Osmotica Corp Combined diffusion/osmotic pumping drug delivery system
US6352721B1 (en) * 2000-01-14 2002-03-05 Osmotica Corp. Combined diffusion/osmotic pumping drug delivery system
AR040682A1 (es) * 2002-07-25 2005-04-13 Pharmacia Corp Forma de dosificacion una vez al dia de pramipexol
EP2431027A1 (en) 2004-08-13 2012-03-21 Boehringer Ingelheim International GmbH Extended release pellet formulation containing Pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
BRPI0513847A (pt) 2004-08-13 2008-05-20 Boehringer Ingelheim Int formulação de comprimido de liberação extendida contendo pramipexol ou um sal farmaceuticamente aceitável do mesmo, método para a fabricação do mesmo e uso do mesmo

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) * 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
GB1478759A (en) * 1974-11-18 1977-07-06 Alza Corp Process for forming outlet passageways in pills using a laser
US4063064A (en) * 1976-02-23 1977-12-13 Coherent Radiation Apparatus for tracking moving workpiece by a laser beam
US4111202A (en) * 1976-11-22 1978-09-05 Alza Corporation Osmotic system for the controlled and delivery of agent over time
US4160452A (en) * 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4285987A (en) * 1978-10-23 1981-08-25 Alza Corporation Process for manufacturing device with dispersion zone
US4200098A (en) * 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4235236A (en) * 1979-02-12 1980-11-25 Alza Corporation Device for dispensing drug by combined diffusional and osmotic operations
IT1153487B (it) * 1982-04-15 1987-01-14 Prophin Lab Spa Prodotti farmaceutici in forma-ritardo e procedimento per ottenerli
NZ206600A (en) * 1983-05-11 1987-01-23 Alza Corp Osmotic drug delivery device
US4783337A (en) * 1983-05-11 1988-11-08 Alza Corporation Osmotic system comprising plurality of members for dispensing drug
IE56999B1 (en) * 1983-12-22 1992-03-11 Elan Corp Plc Pharmaceutical formulation
IT1206166B (it) * 1984-07-26 1989-04-14 Sigma Tau Ind Farmaceuti Dispositivo per rilasciare una sostanza in un fluido di dissoluzione con cinetica di ordine zero e procedimento per la sua preparazione
US4624847A (en) * 1985-04-22 1986-11-25 Alza Corporation Drug delivery device for programmed delivery of beneficial drug
EP0205336B1 (en) * 1985-06-11 1991-09-11 Teijin Limited Oral sustained release pharmaceutical preparation
US4753802A (en) * 1986-03-19 1988-06-28 Alza Corporation Verapamil dosage form
ES2032205T3 (es) * 1986-11-14 1993-01-16 Ciba-Geigy Ag Procedimiento para la obtencion de un sistema osmotico oral para la administracion de metoprolol.

Also Published As

Publication number Publication date
MX174157B (es) 1994-04-25
NO174766B (no) 1994-03-28
DK485688A (da) 1989-12-03
AT394311B (de) 1992-03-10
US4859470A (en) 1989-08-22
FI884057A0 (fi) 1988-09-02
FI92553B (fi) 1994-08-31
JPH01313432A (ja) 1989-12-18
IT1223799B (it) 1990-09-29
AU612398B2 (en) 1991-07-11
ATA214588A (de) 1991-09-15
IE61861B1 (en) 1994-11-30
IE882642L (en) 1989-12-02
FR2632306A1 (fr) 1989-12-08
DK175396B1 (da) 2004-09-27
KR960006062B1 (ko) 1996-05-08
AR241635A1 (es) 1992-10-30
FI884057A (fi) 1989-12-03
GB2219205A (en) 1989-12-06
GR880100574A (en) 1990-05-11
ZA886436B (en) 1989-05-30
NO883838D0 (no) 1988-08-29
NL194747B (nl) 2002-10-01
CH675208A5 (ko) 1990-09-14
NO883838L (no) 1989-12-04
DE3829941A1 (de) 1989-12-14
GB8820461D0 (en) 1988-09-28
GB2219205B (en) 1992-07-15
JP2590226B2 (ja) 1997-03-12
PT88405A (pt) 1990-06-29
ES2008813A6 (es) 1989-08-01
IT8867791A0 (it) 1988-09-02
SE503508C2 (sv) 1996-06-24
AU2152788A (en) 1989-12-07
DK485688D0 (da) 1988-09-01
BE1001935A3 (fr) 1990-04-17
SE8803085L (sv) 1989-12-03
NL8802181A (nl) 1990-01-02
FR2632306B1 (fr) 1990-11-16
PT88405B (pt) 1995-07-18
GR1000197B (el) 1992-03-20
SE8803085D0 (sv) 1988-09-02
NO174766C (no) 1994-07-06
CA1311687C (en) 1992-12-22
LU87327A1 (fr) 1989-03-08
DE3829941C2 (de) 1997-07-03
FI92553C (fi) 1994-12-12
NL194747C (nl) 2003-02-04

Similar Documents

Publication Publication Date Title
KR900000076A (ko) 딜티아젬(diltiazem) 공급용의 제형(dosage form)
KR930701156A (ko) 경시적 약물 전달을 위한 제형
ATE151285T1 (de) Orale arzneimittel mit kolonspezifischer freisetzung
KR950007841A (ko) 트라마돌 염을 함유하는 서방성 약물 제제
KR920702216A (ko) 아세틸 d-카르니틴의 녹내장 치료에의 용도
KR870008594A (ko) 베라파밀제형
KR880002502A (ko) 산에 민감한 유익한 약제의 투여용 제형(劑形)
AR012995A1 (es) Uso de un sensibilizador a insulina y de un agente antihiperglucemico para la preparacion de medicamentos y composiciones farmaceuticas que contienedichos compuestos.
CO5700796A2 (es) Composiciones que contienen piperacilina y tazobactam utiles para inyecciones
BR9609696A (pt) Administração oral unidades separadas
KR880009634A (ko) 슈도에페드린 브롬페니라민 요법의 개량
KR870008583A (ko) 슈도에페드린, 브롬페니라민 요법
KR960000247A (ko) 사이클로스포린a 함유 조성물 및 그의 제조방법
ES2098496T3 (es) Forma medicamentosa aplicable por via peroral para el tratamiento de estados de insuficiencia de dopamina en el sistema nervioso central.
ATE259823T1 (de) Tricyclische erythromycinderivate
ES2131517T3 (es) Composicion farmaceutica de uso oftalmologico que comprende un agente antiinflamatorio no esteroide y un agente anticongestivo.
CO4230093A1 (es) Derivados del indol y sus usos medicos
KR830002510A (ko) 생물학적 활성화합물과 하이드록시알킬 전분으로 구성되는 조성물
IT1301968B1 (it) Derivati di eritromicina ad attivita' antibiotica
KR870009716A (ko) 클로르페니라민 제형
KR920019365A (ko) 디리트로마이신을 함유하는 약학 제형
EE9600202A (et) Toimeaine pärsitud vabanemisega karbamasepiini ravimvorm
KR880005944A (ko) 삼투성 연속 분배 경구용 전달 시스템
ES2064104T3 (es) Procedimiento de preparacion de composiciones farmaceuticas del tipo de liberacion prolongada destinadas a la administracion por via oral.
ATE212840T1 (de) Oral anzuwendende feste arzneizubereitungen mit modulierter wirkstoffabgabe enthaltend nicorandil und verfahren zu deren herstellung

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20020430

Year of fee payment: 7

LAPS Lapse due to unpaid annual fee